1991 …2020

Research output per year

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Research Output

Anti-tumor necrosis factor antibody impairs the therapeutic effect of ceftriaxone in murine pneumococcal pneumonia

Rijneveld, A. W., Florquin, S., Hartung, T., Speelman, P. & Van Der Poll, T., Jul 15 2003, In : Journal of Infectious Diseases. 188, 2, p. 282-285 4 p.

Research output: Contribution to journalArticle

A Perspective and a New Integrated Computational Strategy for Skin Sensitization Assessment

Alves, V. M., Capuzzi, S. J., Braga, R. C., Borba, J. V. B., Silva, A. C., Luechtefeld, T., Hartung, T., Andrade, C. H., Muratov, E. N. & Tropsha, A., Mar 5 2018, In : ACS Sustainable Chemistry and Engineering. 6, 3, p. 2845-2859 15 p.

Research output: Contribution to journalReview article

Applicability of the Monocyte Activation Test (MAT) for hyperimmune sera in the routine of the quality control laboratory: Comparison with the Rabbit Pyrogen Test (RPT)

da Silva, C. C., Presgrave, O. A. F., Hartung, T., de Moraes, A. M. L. & Delgado, I. F., Apr 1 2016, In : Toxicology in Vitro. 32, p. 70-75 6 p.

Research output: Contribution to journalArticle

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

Tollefsen, K. E., Scholz, S., Cronin, M. T., Edwards, S. W., de Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A. & Patlewicz, G., Dec 1 2014, In : Regulatory Toxicology and Pharmacology. 70, 3, p. 629-640 12 p.

Research output: Contribution to journalArticle

A primer on systematic reviews in toxicology

Hoffmann, S., de Vries, R. B. M., Stephens, M. L., Beck, N. B., Dirven, H. A. A. M., Fowle, J. R., Goodman, J. E., Hartung, T., Kimber, I., Lalu, M. M., Thayer, K., Whaley, P., Wikoff, D. & Tsaioun, K., May 13 2017, (Accepted/In press) In : Archives of Toxicology. p. 1-25 25 p.

Research output: Contribution to journalArticle

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches

Scott, L., Eskes, C., Hoffmann, S., Adriaens, E., Alepée, N., Bufo, M., Clothier, R., Facchini, D., Faller, C., Guest, R., Harbell, J., Hartung, T., Kamp, H., Varlet, B. L., Meloni, M., McNamee, P., Osborne, R., Pape, W., Pfannenbecker, U., Prinsen, M. & 9 others, Seaman, C., Spielmann, H., Stokes, W., Trouba, K., Berghe, C. V. D., Goethem, F. V., Vassallo, M., Vinardell, P. & Zuang, V., Feb 1 2010, In : Toxicology in Vitro. 24, 1, p. 1-9 9 p.

Research output: Contribution to journalReview article

Are in vitro tests suitable for regulatory use?

Hartung, T. & Daston, G., Sep 25 2009, In : Toxicological Sciences. 111, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

Basketter, D. A., Clewell, H., Kimber, I., Rossi, A., Blaauboer, B., Burrier, R., Daneshian, M., Eskes, C., Goldberg, A., Hasiwa, N., Hoffmann, S., Jaworska, J., Knudsen, T. B., Landsiedel, R., Leist, M., Locke, P., Maxwell, G., McKim, J., McVey, E. A., Ouédraogo, G. & 15 others, Patlewicz, G., Pelkonen, O., Roggen, E., Rovida, C., Ruhdel, I., Schwarz, M., Schepky, A., Schoeters, G., Skinner, N., Trentz, K., Turner, M., Vanparys, P., Yager, J., Zurlo, J. & Hartung, T., 2012, In : ALTEX. 29, 1, p. 5-91 87 p.

Research output: Contribution to journalReview article

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

Basketter, D. A., Clewell, H., Kimber, I., Rossi, A., Blaauboer, B., Burrier, R., Daneshian, M., Eskes, C., Goldberg, A., Hasiwa, N., Hoffmann, S., Jaworska, J., Knudsen, T. B., Landsiedel, R., Leist, M., Locke, P., Maxwell, G., McKim, J., McVey, E. A., Ouédraogo, G. & 15 others, Patlewicz, G., Pelkonen, O., Roggen, E., Rovida, C., Ruhdel, I., Schwarz, M., Schepky, A., Schoeters, G., Skinner, N., Trentz, K., Turner, M., Vanparys, P., Yager, J., Zurlo, J. & Hartung, T., 2012, In : ALTEX. 29, 1, p. 3-91 89 p.

Research output: Contribution to journalArticle

Open Access

Arsenic Exposure and Immunotoxicity: a Review Including the Possible Influence of Age and Sex

Ferrario, D., Gribaldo, L. & Hartung, T., Mar 1 2016, In : Current environmental health reports. 3, 1, p. 1-12 12 p.

Research output: Contribution to journalReview article

Arsenic induces telomerase expression and maintains telomere length in human cord blood cells

Ferrario, D., Collotta, A., Carfi, M., Bowe, G., Vahter, M., Hartung, T. & Gribaldo, L., Jun 16 2009, In : Toxicology. 260, 1-3, p. 132-141 10 p.

Research output: Contribution to journalArticle

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part I: Technical description

Koppelstaetter, C., Jennings, P., Ryan, M. P., Morin, J. P., Hartung, T. & Pfaller, W., Aug 6 2004, In : ALTEX. 21, 2, p. 51-60 10 p.

Research output: Contribution to journalArticle

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing part 2: Toxicological evaluation

Jennings, P., Koppelstaetter, C., Pfaller, W., Morin, J. P., Hartung, T. & Ryan, M. P., Aug 6 2004, In : ALTEX. 21, 2, p. 61-66 6 p.

Research output: Contribution to journalArticle

Assessment of pyrogenic contaminations with validated human whole-blood assay

Daneshian, M., Von Aulock, S. & Hartung, T., Nov 1 2009, In : Nature protocols. 4, 12, p. 1709-1721 13 p.

Research output: Contribution to journalArticle

A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues

Stadelmaier, A., Figueroa-Perez, I., Deininger, S., von Aulock, S., Hartung, T. & Schmidt, R. R., Sep 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 18, p. 6239-6254 16 p.

Research output: Contribution to journalArticle

A structured approach to identifying European critical infrastructures

Di Mauro, C., Bouchon, S., Logtmeijer, C., Pride, R. D., Hartung, T. & Nordvik, J. P., Jun 2010, In : International Journal of Critical Infrastructures. 6, 3, p. 277-292 16 p.

Research output: Contribution to journalArticle

A toxicology for the 21st century - Mapping the road ahead

Hartung, T., May 13 2009, In : Toxicological Sciences. 109, 1, p. 18-23 6 p.

Research output: Contribution to journalArticle

Open Access

Autophagy as an ultrastructural marker of heavy metal toxicity in human cord blood hematopoietic stem cells

Di Gioacchino, M., Petrarca, C., Perrone, A., Farina, M., Sabbioni, E., Hartung, T., Martino, S., Esposito, D. L., Lotti, L. V. & Mariani-Costantini, R., Mar 15 2008, In : Science of the Total Environment. 392, 1, p. 50-58 9 p.

Research output: Contribution to journalArticle

Availability, Standardization and Safety of Human Cells and Tissues for Drug Screening and Testing

Stacey, G. N. & Hartung, T., Nov 8 2006, Drug Testing in vitro: Breakthroughs and Trends in Cell Culture Technology. Wiley-VCH Verlag GmbH & Co. KGaA, p. 229-250 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Barriers to validation

Ahr, H. J., Alepée, N., Breier, S., Brekelmans, C., Cotgreave, I., Gribaldo, L., Dal Negro, G., De Silva, O., Hartung, T., Lacerda, A., Leblanc, B., Lecerf, C., Linge, J. P., Louhimies, S., Manou, I., Maxwell, G., Müller, K. K., Pape, W., Redhead, K., Schröder, K. R. & 3 others, Sladowski, D., Van Der Jagt, K. & Vanparys, P., Sep 1 2008, In : ATLA Alternatives to Laboratory Animals. 36, 4, p. 459-464 6 p.

Research output: Contribution to journalArticle

Beispiel eines neuen Einsatzbereichs des humanen Vollbluttests: Entwicklung eines Messverfahrens zur Abschätzung der gesundheitlichen Gefährdung durch luftgetragene mikrobielle Verunreinigungen.

Translated title of the contribution: A new application for the human whole blood test: development of an assay to assess the health risk of air-borne microbial contaminationsFennrich, S., Zucker, B. & Hartung, T., 2001, In : ALTEX : Alternativen zu Tierexperimenten. 18, 1, p. 41-46 6 p.

Research output: Contribution to journalArticle

Big-data and machine learning to revamp computational toxicology and its use in risk assessment

Luechtefeld, T., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicology Research. 7, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

Binding of surfactant protein D to lipoteichoic acid

Van De Watering, J. K., Van Eijk, M., Spreitzer, I., Härtung, T., Van Golde, L. M. G. & Batenburg, J. J., Dec 1 2000, In : Applied Cardiopulmonary Pathophysiology. 9, 3, 1 p.

Research output: Contribution to journalArticle

Biological and medical applications of a brain-on-a-chip

Pamies, D., Hartung, T. & Hogberg, H. T., Sep 1 2014, In : Experimental Biology and Medicine. 239, 9, p. 1096-1107 12 p.

Research output: Contribution to journalArticle

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx, U., Andersson, T. B., Bahinski, A., Beilmann, M., Beken, S., Cassee, F. R., Cirit, M., Daneshian, M., Fitzpatrick, S., Frey, O., Gaertner, C., Giese, C., Griffith, L., Hartung, T., Heringa, M. B., Hoeng, J., De Jong, W. H., Kojima, H., Kuehnl, J., Leist, M. & 16 others, Luch, A., Maschmeyer, I., Sakharov, D., Sips, A. J. A. M., Steger-Hartmann, T., Tagle, D. A., Tonevitsky, A., Tralau, T., Tsyb, S., Van De Stolpe, A., Vandebriel, R., Vulto, P., Wang, J., Wiest, J., Rodenburg, M. & Roth, A., 2016, In : Altex. 33, 3, p. 272-321 50 p.

Research output: Contribution to journalArticle

Blood cytokine response of low-dose molgramostim (rhGM-CSF)-treated patients

Hartung, T., Von Aulock, S., Freitag, M., Höxtermann, S., Stücker, M., Hoffmann, K., Altmeyer, P., Kottke, A. & Wendel, A., Jan 1 2000, In : Cytokine. 12, 10, p. 1570-1574 5 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi-induced tolerance as a model of persistence via immunosuppression

Diterich, I., Rauter, C., Kirschning, C. J. & Hartung, T., Jul 1 2003, In : Infection and immunity. 71, 7, p. 3979-3987 9 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi s.l., the infectious agent of Lyme borreliosis.

Diterich, I. & Hartung, T., 2001, In : Contributions to microbiology. 8, p. 72-89 18 p.

Research output: Contribution to journalReview article

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

Kilic, O., Pamies, D., Lavell, E., Schiapparelli, P., Feng, Y., Hartung, T., Bal-Price, A., Hogberg, H. T., Quinones-Hinojosa, A., Guerrero-Cazares, H. & Levchenko, A., 2016, In : Lab on a Chip. 16, 21, p. 4152-4162 11 p.

Research output: Contribution to journalArticle

Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages

Liljeroos, M., Vuolteenaho, R., Morath, S., Hartung, T., Hallman, M. & Ojaniemi, M., Mar 1 2007, In : Cellular Signalling. 19, 3, p. 625-633 9 p.

Research output: Contribution to journalArticle

Building shared experience to advance practical application of pathway-based toxicology: Liver toxicity mode-of-action

Willett, C., Rae, J. C., Goyak, K. O., Minsavage, G., Westmoreland, C., Andersen, M., Avigan, M., Duché, D., Harris, G., Hartung, T., Jaeschke, H., Kleensang, A., Landesmann, B., Martos, S., Matevia, M., Toole, C., Rowan, A., Schultz, T., Seed, J., Senior, J. & 4 others, Shah, I., Subramanian, K., Vinken, M. & Watkins, P., 2014, In : ALTEX. 31, 4, p. 500-519 20 p.

Research output: Contribution to journalArticle

Cancer-related thromboembolic disease in patients with solid tumours: A retrospective analysis

Harrington, K. J., Bateman, A. R., Syrigos, K. N., Rintoul, R., Bhidayasiri, R., McCormack, M. & Thomas, H., Jul 1 1997, In : Annals of Oncology. 8, 7, p. 669-673 5 p.

Research output: Contribution to journalArticle

Can TTIP improve laboratory animal welfare in safety testing and 3Rs?

Busquet, F., Zurlo, J. & Hartung, T., Jan 1 2016, In : ILAR journal. 57, 3, p. 358-367 10 p.

Research output: Contribution to journalArticle

CD36 is a sensor of diacylglycerides

Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zähringer, U. & Beutler, B., Feb 3 2005, In : Nature. 433, 7025, p. 523-527 5 p.

Research output: Contribution to journalArticle

Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages

Scheel, O., Papavlassopoulos, M., Blunck, R., Gebert, A., Hartung, T., Zähringer, U., Seydel, U. & Schromm, A. B., Jul 1 2006, In : Infection and immunity. 74, 7, p. 4354-4356 3 p.

Research output: Contribution to journalArticle

Cell activation of human macrophages by lipoteichoic acid is strongly attenuated by lipopolysaccharide-binding protein

Mueller, M., Stamme, C., Draing, C., Hartung, T., Seydel, U. & Schromm, A. B., Oct 20 2006, In : Journal of Biological Chemistry. 281, 42, p. 31448-31456 9 p.

Research output: Contribution to journalArticle

cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4

Spiller, S., Dreher, S., Meng, G., Grabiec, A., Thomas, W., Hartung, T., Pfeffer, K., Hochrein, H., Brade, H., Bessler, W., Wagner, H. & Kirschning, C. J., May 4 2007, In : Journal of Biological Chemistry. 282, 18, p. 13190-13198 9 p.

Research output: Contribution to journalArticle

Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36

Nilsen, N. J., Deininger, S., Nonstad, U., Skjeldal, F., Husebye, H., Rodionov, D., Von Aulock, S., Hartung, T., Lien, E., Bakke, O. & Espevik, T., Jul 1 2008, In : Journal of Leukocyte Biology. 84, 1, p. 280-291 12 p.

Research output: Contribution to journalArticle

cGMP-mediated inhibition of TNF-α production by the atrial natriuretic peptide in murine macrophages

Kiemer, A. K., Hartung, T. & Vollmar, A. M., Jul 1 2000, In : Journal of Immunology. 165, 1, p. 175-181 7 p.

Research output: Contribution to journalArticle

Open Access

Characterisation of cadmium chloride induced molecular and functional alterations in airway epithelial cells

Forti, E., Bulgheroni, A., Cetin, Y., Hartung, T., Jennings, P., Pfaller, W. & Prieto, P., 2010, In : Cellular Physiology and Biochemistry. 25, 1, p. 159-168 10 p.

Research output: Contribution to journalArticle

Characteristics of surfactant protein A and D binding to lipoteichoic acid and peptidoglycan, 2 major cell wall components of gram-positive bacteria

Van de Wetering, J. K., Van Eijk, M., Van Golde, L. M. G., Hartung, T., Van Strijp, J. A. G. & Batenburg, J. J., Nov 1 2001, In : Journal of Infectious Diseases. 184, 9, p. 1143-1151 9 p.

Research output: Contribution to journalArticle

Characterization of the Cytokine Immune Response in Children Who Have Experienced an Episode of Typical Hemolytic-Uremic Syndrome

Westerholt, S., Pieper, A. K., Griebel, M., Volk, H. D., Hartung, T. & Oberhoffer, R., Nov 1 2003, In : Clinical and Diagnostic Laboratory Immunology. 10, 6, p. 1090-1095 6 p.

Research output: Contribution to journalArticle

Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening

Tong, Z. B., Hogberg, H., Kuo, D., Sakamuru, S., Xia, M., Smirnova, L., Hartung, T. & Gerhold, D., 2016, (Accepted/In press) In : Journal of Applied Toxicology.

Research output: Contribution to journalArticle

Chemical regulators have overreached

Hartung, T. & Rovida, C., Aug 27 2009, In : Nature. 460, 7259, p. 1080-1081 2 p.

Research output: Contribution to journalComment/debate

Chemical respiratory allergy: Opportunities for hazard identification and characterisation

Kimber, I., Agius, R., Basketter, D. A., Corsini, E., Cullinan, P., Dearman, R. J., Gimenez-Arnau, E., Greenwell, L., Hartung, T., Kuper, F., Maestrelli, P., Roggen, E., Rovida, C. & Casati, S., May 2007, In : ATLA Alternatives to Laboratory Animals. 35, 2, p. 243-265 23 p.

Research output: Contribution to journalArticle

Chip, Chip, Hurra! Die Amerikaner feiern den Gen-Chip--feiern wir mit?

Translated title of the contribution: Hip, hip, hurrah! Americans celebrate Gen-Chip--are we celebrating too?Hartung, T., 2000, In : ALTEX : Alternativen zu Tierexperimenten. 17, 2, p. 101-102 2 p.

Research output: Contribution to journalArticle

CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological data

Russo, D. P., Kim, M. T., Wang, W., Pinolini, D., Shende, S., Strickland, J., Hartung, T. & Zhu, H., Feb 1 2017, In : Bioinformatics (Oxford, England). 33, 3, p. 464-466 3 p.

Research output: Contribution to journalArticle

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J., Slusher, B. S. & Le, A., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle