1991 …2020

Research output per year

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Research Output

2001

Einfluss des Konservierungsmittels Thiomersal auf die Interleukin-1 Beta Ausschüttung humaner peripherer Blutzellen.

Translated title of the contribution: Effect of the preservative thiomersal on the release of interleukin-1 beta from human peripheral blood cellsFischer, M., Keller-Stanislawski, B., Schober-Bendixen, S., Schosser, R., Hacke, K., Hartung, T. & Montag, T., 2001, In : ALTEX : Alternativen zu Tierexperimenten. 18, 1, p. 47-49 3 p.

Research output: Contribution to journalArticle

EU Standards Measurements and Testing Project PL95-3407. Development of a standardized in vitro methodology for hepatic and renal toxicity testing

Wendel, A., Ryan, M. P., Hartung, T., Bach, P. H., Pfaller, W., Morin, J. P., Villa, P., Witkamp, R., Van Gompel, J. & Kilty, C. G., Jan 1 2001, In : ATLA Alternatives to Laboratory Animals. 29, 4, p. 493-495 3 p.

Research output: Contribution to journalReview article

Good Cell Culture Practice (GCCP)--eine Initiative zur Standardisierung und Qualitätssicherung von in vitro Arbeiten. Die Etablierung einer ECVAM Task Force on GCCP.

Translated title of the contribution: Good cell culture practice (GCCP)--an initiative for standardization and quality control of in vitro studies. The establishment of an ECVAM Task Force on GCCPHartung, T., Gstraunthaler, G., Coecke, S., Lewis, D., Blanck, O. & Balls, M., 2001, In : ALTEX : Alternativen zu Tierexperimenten. 18, 1, p. 75-78 4 p.

Research output: Contribution to journalArticle

Gründungsaufruf: Deutsche sepsis-gesellschaft e.V. (DSG)

Translated title of the contribution: Appeal for foundation: German association for sepsis (DSG)Adam, D., Albrecht, D. M., Bauhofer, A., Bhakdi, S., Bodmann, K. F., Böhm, D., Booke, M., Boldt, J., Bone, H. G., Brause, R. W., Briegel, J., Bruch, H. P., Brunkhorst, R., Brunkhorst, F. M., Brodt, H. R., Burchardi, H., Claus, R. A., Cobas-Meyer, M., Daschner, F., Dempfle, C. E. & 110 others, Drüge, G., Eckart, J., Eckardt, K. U., Engel, C., Engelmann, L., Ewert, R., Forst, H., Forycki, Z. F., Frank, U., Fröhlich, D., Gerlach, H., Glück, T., Goldstein, M., Gramm, H. J., Grimminger, Grass, G., Gründling, M., Hartog, C., Hartung, T., Heeg, K., Heene, D. L., Heininger, A., Hiddemann, W., Höffken, G., Hoffmeister, D., Holz, E., Hommel, J., Inthorn, D., Irlbeck, M., Jochum, M., Karzai, W., Kaul, M., Klöss, T., Kljucar, S., Kochs, E., Kropf, S., Kuckelt, W., Kujath, P., Kuse, E. R., Lazarus, G., Löffler, M., Lode, H., Maschmeyer, G., Mathiak, G., Meier-Hellmann, A., Müller, E., Müller-Werdan, U., Mutters, R., Neugebauer, E., Nierhaus, A., Ostermann, H., Otto, V., Parentin, T., Peter, K., Peters, J., Petrow, H., Pfeiffer, L., Pieper, A., Plauth, M., Quintel, M., Radermacher, P., Radke, J., Ragaller, M., Reill, L., Reinhart, K., Reith, H. B., Riess, H., Rietschel, E., Roewer, N., Rossaint, R., Ruf, B. R., Schäfer, J. H., Schaffartzik, W., Schelling, G., Schirrmeister, W., Schmitt, D. V., Schmitz, G., Schmucker, P., Schulte am Esch, J., Schumann, R. R., Schuster, H. P., Schütt, S., Seeger, W., Sengebusch, K., Spies, C., Stamme, C., Staubach, K. H., Straube, E., Stüber, F., Theilen, J., Thiery, J., Uhlig, S., Vangerow, B., Volk, H. D., Wagner, H. C. H., Wagner, K., Walther, P., Waydhas, C., Wegscheider, K., Weiler, N., Welte, T., Wendt, M., Werdan, K., Weyland, A., von Wichert, P., Wiegand-Löhnert, C., Wulf, H., Zabel, P., Zielmann, H. Z. & Zweigner, Z., 2001, In : Pneumologie. 55, 11, p. 527-528 2 p.

Research output: Contribution to journalShort survey

Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis

Feterowski, C., Weighardt, H., Emmanuilidis, K., Hartung, T. & Holzmann, B., May 3 2001, In : European Journal of Immunology. 31, 4, p. 1268-1277 10 p.

Research output: Contribution to journalArticle

Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response

Lehner, M. D., Ittner, J., Bundschuh, D. S., Van Rooijen, N., Wendel, A. & Hartung, T., 2001, In : Infection and immunity. 69, 1, p. 463-471 9 p.

Research output: Contribution to journalArticle

Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different toll-like receptors independent of paracrine mediators

Lehner, M. D., Morath, S., Michelsen, K. S., Schumann, R. R. & Hartung, T., Apr 15 2001, In : Journal of Immunology. 166, 8, p. 5161-5167 7 p.

Research output: Contribution to journalArticle

Open Access

Induction of the chemokines IL-8 and MCP-1 in human whole blood by a cell-lysate of human fibroblast cells

Schneider, M. & Hartung, T., Jan 1 2001, In : Immunology Letters. 75, 2, p. 163-165 3 p.

Research output: Contribution to journalArticle

Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts

Pfeiffer, A., Bttcher, A., Ors, E., Kapinsky, M., Nagy, P., Bodnr, A., Spreitzer, I., Liebisch, G., Drobnik, W., Gempel, K., Horn, M., Holmer, S., Hartung, T., Multhoff, G., Schtz, G., Schindler, H., Ulmer, A. J., Heine, H., Stelter, F., Schtt, C. & 4 others, Rothe, G., Szlli, J., Damjanovich, S. & Schmitz, G., 2001, In : European Journal of Immunology. 31, 11, p. 3153-3164 12 p.

Research output: Contribution to journalArticle

Modulation of cytokine release in ex vivo-stimulated blood from borreliosis patients

Diterich, I., Härter, L., Hassler, D., Wendel, A. & Hartung, T., 2001, In : Infection and immunity. 69, 2, p. 687-694 8 p.

Research output: Contribution to journalArticle

Novel advanced in vitro methods for long-term toxicity testing

Pfaller, W., Balls, M., Clothier, R., Coecke, S., Dierickx, P., Ekwall, B., Hanley, B. A., Hartung, T., Prieto, P., Ryan, M. P., Schmuck, G., Šladowski, D., Vericat, J. A., Wendel, A., Wolf, A. & Zimmer, J., Sep 21 2001, In : ATLA Alternatives to Laboratory Animals. 29, 4, p. 393-426 34 p.

Research output: Contribution to journalArticle

Novel pyrogen tests based on the human fever reaction

Hartung, T., Aaberge, I., Berthold, S., Carlin, G., Charton, E., Coecke, S., Fennrich, S., Fischer, M., Gommer, M., Halder, M., Haslov, K., Jahnke, M., Montag-Lessing, T., Poole, S., Schechtman, L., Wendel, A. & Werner-Felmayer, G., Jan 1 2001, In : ATLA Alternatives to Laboratory Animals. 29, 2, p. 99-123 25 p.

Research output: Contribution to journalArticle

Schwann cell apoptosis in experimental autoimmune neuritis of the Lewis rat and the functional role of tumor necrosis factor-α

Weishaupt, A., Brück, W., Hartung, T., Toyka, K. V. & Gold, R., Jun 22 2001, In : Neuroscience Letters. 306, 1-2, p. 77-80 4 p.

Research output: Contribution to journalArticle

Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus

Morath, S., Geyer, A. & Hartung, T., Feb 5 2001, In : Journal of Experimental Medicine. 193, 3, p. 393-397 5 p.

Research output: Contribution to journalArticle

The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCs): Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2

Michelsen, K. S., Aicher, A., Mohaupt, M., Hartung, T., Dimmeler, S., Kirschning, C. J. & Schumann, R. R., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 25680-25686 7 p.

Research output: Contribution to journalArticle

The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects

Coecke, S., Bogni, A., Langezaal, I., Worth, A., Hartung, T. & Monshouwer, M., Oct 4 2001, In : Toxicology in Vitro. 15, 4-5, p. 553-556 4 p.

Research output: Contribution to journalArticle

Three Rs potential in the development and quality control of pharmaceuticals.

Hartung, T., 2001, In : ALTEX : Alternativen zu Tierexperimenten. 18 Suppl 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation

Opitz, B., Schröder, N. W. J., Spreitzer, I., Michelsen, K. S., Kirschning, C. J., Hallatschek, W., Zähringer, U., Hartung, T., Göbel, U. B. & Schumann, R. R., Jun 22 2001, In : Journal of Biological Chemistry. 276, 25, p. 22041-22047 7 p.

Research output: Contribution to journalArticle

Whole blood cytokine response as a measure of immunotoxicity

Langezaal, I., Coecke, S. & Hartung, T., Oct 3 2001, In : Toxicology in Vitro. 15, 4-5, p. 313-318 6 p.

Research output: Contribution to journalArticle

2002

Comments on the use of bootstrap resampling to assess the uncertainty of cooper statistics

Hoffmann, S., Hartung, T., Beran, J. & Worth, A. P., Sep 1 2002, In : ATLA Alternatives to Laboratory Animals. 30, 5, p. 551-557 7 p.

Research output: Contribution to journalLetter

Comparison and validation of novel pyrogen tests based on the human fever reaction

Hartung, T., Poole, S., Montag-Lessing, T., Nibbeling, R., Werner-Felmayer, G., Jungi, T., Brügger, P., Coecke, S., Aaberge, I. & Berthold, S., Dec 2002, In : ATLA Alternatives to Laboratory Animals. 30, SUPPL. 2, p. 49-51 3 p.

Research output: Contribution to journalArticle

Comparison and validation of novel pyrogen tests based on the human fever reaction.

Schindler, S. & Hartung, T., 2002, In : Developments in biologicals. 111, p. 181-186 6 p.

Research output: Contribution to journalArticle

Comparison of eleven commercial tests for Chlamydia pneumoniae-specific immunoglobulin G in asymptomatic healthy individuals

Hermann, C., Graf, K., Groh, A., Straube, E. & Hartung, T., 2002, In : Journal of clinical microbiology. 40, 5, p. 1603-1609 7 p.

Research output: Contribution to journalArticle

Cytokine induction by purified lipoteichoic acids from various bacterial species - Role of LBP, sCD14, CD14 and failure to induce IL-12 and subsequent IFN-γ release

Hermann, C., Spreitzer, I., Schröder, N. W. J., Morath, S., Lehner, M. D., Fischer, W., Schütt, C., Schumann, R. R. & Hartung, T., 2002, In : European Journal of Immunology. 32, 2, p. 541-551 11 p.

Research output: Contribution to journalArticle

Determination of air-borne pyrogens by the in vitro pyrogen test (IPT) based on human whole blood cytokine response

Kindinger, I., Fennrich, S., Zucker, B., Linsel, G. & Hartung, T., Dec 1 2002, In : VDI Berichte. 1656, p. 499-507+568

Research output: Contribution to journalReview article

Distribution of clinically relevant Borrelia genospecies in ticks assessed by a novel, single-run, real-time PCR

Rauter, C., Oehme, R., Diterich, I., Engele, M. & Hartung, T., Jan 12 2002, In : Journal of clinical microbiology. 40, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

Endotoxin tolerance-mechanisms and beneficial effects in bacterial infection.

Lehner, M. D. & Hartung, T., 2002, In : Reviews of Physiology, Biochemistry and Pharmacology. 144, p. 95-141 47 p.

Research output: Contribution to journalReview article

Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release

Langezaal, I., Hoffmann, S., Hartung, T. & Coecke, S., Jan 1 2002, In : ATLA Alternatives to Laboratory Animals. 30, 6, p. 581-595 15 p.

Research output: Contribution to journalArticle

Good cell culture practice: ECVAM good cell culture practice task force report 1

Hartung, T., Balls, M., Bardouille, C., Blanck, O., Coecke, S., Gstraunthaler, G. & Lewis, D., 2002, In : ATLA Alternatives to Laboratory Animals. 30, 4, p. 407-414 8 p.

Research output: Contribution to journalArticle

Induction and regulation of endogenous granulocyte colony-stimulating factor formation

Hareng, L. & Hartung, T., Oct 1 2002, In : Biological Chemistry. 383, 10, p. 1501-1517 17 p.

Research output: Contribution to journalReview article

Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.

Ellingsen, E., Morath, S., Flo, T., Schromm, A., Hartung, T., Thiemermann, C., Espevik, T., Golenbock, D., Foster, D., Solberg, R., Aasen, A. & Wang, J., May 2002, In : Medical science monitor : international medical journal of experimental and clinical research. 8, 5, p. BR149-156

Research output: Contribution to journalArticle

Inhibition of cyclooxygenase-2 by natriuretic peptides

Kiemer, A. K., Lehner, M. D., Hartung, T. & Vollmar, A. M., 2002, In : Endocrinology. 143, 3, p. 846-852 7 p.

Research output: Contribution to journalArticle

Open Access

Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells

Dalpke, A. H., Frey, M., Morath, S., Hartung, T. & Heeg, K., Oct 2002, In : Immunobiology. 206, 4, p. 392-407 16 p.

Research output: Contribution to journalArticle

Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: Distinct alterations in IL-1 receptor-associated kinase

Jacinto, R., Hartung, T., McCall, C. & Li, L., Jun 15 2002, In : Journal of Immunology. 168, 12, p. 6136-6141 6 p.

Research output: Contribution to journalArticle

Open Access

Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection

Lehner, M. D., Schwoebel, F., Kotlyarov, A., Leist, M., Gaestel, M. & Hartung, T., May 1 2002, In : Journal of Immunology. 168, 9, p. 4667-4673 7 p.

Research output: Contribution to journalArticle

Open Access

Molecular aspects of anti-inflammatory action of G-CSF

Boneberg, E. M. & Hartung, T., Jan 1 2002, In : Inflammation Research. 51, 3, p. 119-128 10 p.

Research output: Contribution to journalReview article

Potential for immune reconstitution through G-CSF treatment of HIV patients

Von Aulock, S. & Hartung, T., Jun 11 2002, In : Archivum Immunologiae et Therapiae Experimentalis. 50, 2, p. 111-120 10 p.

Research output: Contribution to journalReview article

Profound differences in leukocyte-endothelial cell responses to lipopolysaccharide versus lipoteichoic acid

Yipp, B. G., Andonegui, G., Howlett, C. J., Robbins, S. M., Hartung, T., Ho, M. & Kubes, P., May 1 2002, In : Journal of Immunology. 168, 9, p. 4650-4658 9 p.

Research output: Contribution to journalArticle

Open Access

Structural decomposition and heterogeneity of commercial lipoteichoic acid preparations

Morath, S., Geyer, A., Spreitzer, I., Hermann, C. & Hartung, T., Jan 31 2002, In : Infection and immunity. 70, 2, p. 938-944 7 p.

Research output: Contribution to journalArticle

Synthetic lipoteichoic acid from Staphylococcus aureus is a potent stimulus of cytokine release

Morath, S., Stadelmaier, A., Geyer, A., Schmidt, R. R. & Hartung, T., Jun 17 2002, In : Journal of Experimental Medicine. 195, 12, p. 1635-1640 6 p.

Research output: Contribution to journalArticle

Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide

Lorenz, E., Patel, D. D., Hartung, T. & Schwartz, D. A., Sep 2002, In : Infection and immunity. 70, 9, p. 4892-4896 5 p.

Research output: Contribution to journalArticle

2003

A model of human whole blood lymphokine release for in vitro and ex vivo use

Hermann, C., Von Aulock, S., Graf, K. & Hartung, T., Apr 1 2003, In : Journal of Immunological Methods. 275, 1-2, p. 69-79 11 p.

Research output: Contribution to journalArticle

ANP inhibits TNF-α-induced endothelial MCP-1 expression involvement of p38 MAPK and MKP-1

Weber, N. C., Blumenthal, S. B., Hartung, T., Vollmar, A. M. & Kiemer, A. K., Nov 1 2003, In : Journal of Leukocyte Biology. 74, 5, p. 932-941 10 p.

Research output: Contribution to journalArticle

Anti-tumor necrosis factor antibody impairs the therapeutic effect of ceftriaxone in murine pneumococcal pneumonia

Rijneveld, A. W., Florquin, S., Hartung, T., Speelman, P. & Van Der Poll, T., Jul 15 2003, In : Journal of Infectious Diseases. 188, 2, p. 282-285 4 p.

Research output: Contribution to journalArticle

Borrelia burgdorferi-induced tolerance as a model of persistence via immunosuppression

Diterich, I., Rauter, C., Kirschning, C. J. & Hartung, T., Jul 1 2003, In : Infection and immunity. 71, 7, p. 3979-3987 9 p.

Research output: Contribution to journalArticle

Characterization of the Cytokine Immune Response in Children Who Have Experienced an Episode of Typical Hemolytic-Uremic Syndrome

Westerholt, S., Pieper, A. K., Griebel, M., Volk, H. D., Hartung, T. & Oberhoffer, R., Nov 1 2003, In : Clinical and Diagnostic Laboratory Immunology. 10, 6, p. 1090-1095 6 p.

Research output: Contribution to journalArticle

Comparison of the reactivity of human and rabbit blood towards pyrogenic stimuli.

Schindler, S., Bristow, A., Cartmell, T., Hartung, T. & Fennrich, S., 2003, In : ALTEX : Alternativen zu Tierexperimenten. 20, 2, p. 59-63 5 p.

Research output: Contribution to journalArticle

Cyclic AMP increases endogenous granulocyte colony-stimulating factor formation in monocytes and THP-1 macrophages despite attenuated TNF-α formation

Hareng, L., Meergans, T., von Aulock, S., Volk, H. D. & Hartung, T., Aug 1 2003, In : European Journal of Immunology. 33, 8, p. 2287-2296 10 p.

Research output: Contribution to journalReview article