1991 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2017

Corrigendum to "The need for strategic development of safety sciences"

Busquet, F. & Hartung, T., Jan 1 2017, In : ALTEX. 34, 2, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Dear readers

ALTEX Editorial Team, Board of ALTEX Edition, Jan 1 2017, In : Altex. 34, 4, p. U2

Research output: Contribution to journalEditorial

Evolution of toxicological science: The need for change

Hartung, T., Jan 1 2017, In : International Journal of Risk Assessment and Management. 20, 1, p. 21-45 25 p.

Research output: Contribution to journalArticle

Food for thought: The need for strategic development of safety sciences

Busquet, F. & Hartung, T., Jan 1 2017, In : ALTEX. 34, 1, p. 3-21 19 p.

Research output: Contribution to journalArticle

Food for Thought .. the First Ten Years

Hartung, T., Jan 1 2017, In : ALTEX. 34, 2, p. 187-192 6 p.

Research output: Contribution to journalEditorial

Open Access

From in vivo to in vitro: The medical device testing paradigm shift

Myers, D. K., Goldberg, A., Poth, A., Wolf, M. F., Carraway, J., McKim, J., Coleman, K. P., Hutchinson, R., Brown, R., Krug, H. F., Bahinski, A. & Hartung, T., Jan 1 2017, In : Altex. 34, 4, p. 479-500 22 p.

Research output: Contribution to journalArticle

From the exposome to mechanistic understanding of chemical-induced adverse effects

Escher, B. I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S. K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J. J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J. & 16 others, Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G. W., Müller, A., Phillips, D. H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y. M., Trump, S., Walter-Rohde, S. & Wambaugh, J. F., Feb 1 2017, In : Environment International. 99, p. 97-106 10 p.

Research output: Contribution to journalReview article

Future Tox III: Bridges for translation

Juberg, D. R., Knudsen, T. B., Sander, M., Beck, N. B., Faustman, E. M., Mendrick, D. L., Fowle, J. R., Hartung, T., Tice, R. R., Lemazurier, E., Becker, R. A., Fitzpatrick, S. C., Daston, G. P., Harrill, A., Hines, R. N., Keller, D. A., Lipscomb, J. C., Watson, D., Bahadori, T. & Crofton, K. M., 2017, In : Toxicological Sciences. 155, 1, p. 22-31 10 p.

Research output: Contribution to journalArticle

Good cell culture practice for stem cells & stem-cell-derived models

Pamies, D., Bal-Price, A., Simeonov, A., Tagle, D., Allen, D., Gerhold, D., Yin, D., Pistollato, F., Inutsuka, T., Sullivan, K., Stacey, G., Salem, H., Leist, M., Daneshian, M., Vemuri, M. C., Mcfarland, R., Coecke, S., Fitzpatrick, S. C., Lakshmipathy, U., Mack, A. & 6 others, Wang, W. B., Yamazaki, D., Sekino, Y., Kanda, Y., Smirnova, L. & Hartung, T., Jan 1 2017, In : ALTEX. 34, 1, p. 95-132 38 p.

Research output: Contribution to journalArticle

Good cell culture practices &in vitro toxicology

Eskes, C., Boström, A. C., Bowe, G., Coecke, S., Hartung, T., Hendriks, G., Pamies, D., Piton, A. & Rovida, C., Mar 7 2017, (Accepted/In press) In : Toxicology in Vitro.

Research output: Contribution to journalArticle

Green Toxicology: a strategy for sustainable chemical and material development

Crawford, S. E., Hartung, T., Hollert, H., Mathes, B., van Ravenzwaay, B., Steger-Hartmann, T., Studer, C. & Krug, H. F., Dec 1 2017, In : Environmental Sciences Europe. 29, 1, 16.

Research output: Contribution to journalEditorial

Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity

Pendse, S. N., Maertens, A., Rosenberg, M., Roy, D., Fasani, R. A., Vantangoli, M. M., Madnick, S. J., Boekelheide, K., Fornace, A. J., Odwin, S. A., Yager, J. D., Hartung, T., Andersen, M. E. & McMullen, P. D., Apr 1 2017, In : Archives of Toxicology. 91, 4, p. 1749-1762 14 p.

Research output: Contribution to journalArticle

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance

Lee, J., Choi, J., Selen Alpergin, E. S., Zhao, L., Hartung, T., Scafidi, S., Riddle, R. & Wolfgang, M. J., Jul 18 2017, In : Cell Reports. 20, 3, p. 655-667 13 p.

Research output: Contribution to journalArticle

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H. W., Seol, Y. J., Zhang, Y. S., Shin, S. R., Zhao, L., Aleman, J., Hall, A. R., Shupe, T. D., Kleensang, A., Dokmeci, M. R., Jin Lee, S., Jackson, J. D., Yoo, J. J., Hartung, T., Khademhosseini, A., Soker, S. & 2 others, Bishop, C. E. & Atala, A., Dec 1 2017, In : Scientific reports. 7, 1, 8837.

Research output: Contribution to journalArticle

Opinion versus evidence for the need to move away from animal testing

Hartung, T., 2017, In : Altex. 34, 2, p. 193-200 8 p.

Research output: Contribution to journalArticle

Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells

Ramirez, T., Strigun, A., Verlohner, A., Huener, H. A., Peter, E., Herold, M., Bordag, N., Mellert, W., Walk, T., Spitzer, M., Jiang, X., Sperber, S., Hofmann, T., Hartung, T., Kamp, H. & van Ravenzwaay, B., Sep 30 2017, (Accepted/In press) In : Archives of Toxicology. p. 1-14 14 p.

Research output: Contribution to journalArticle

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists & criteria for their selection & use

Aschner, M., Ceccatelli, S., Daneshian, M., Fritsche, E., Hasiwa, N., Hartung, T., Hogberg, H. T., Leist, M., Li, A., Mundy, W. R., Padilla, S., Piersma, A. H., Bal-Price, A., Seiler, A., Westerink, R. H., Zimmer, B. & Lein, P. J., Jan 1 2017, In : ALTEX. 34, 1, p. 49-74 26 p.

Research output: Contribution to journalArticle

Systems Toxicology: Real World Applications and Opportunities

Hartung, T., FitzGerald, R. E., Jennings, P., Mirams, G. R., Peitsch, M. C., Rostami-Hodjegan, A., Shah, I., Wilks, M. F. & Sturla, S. J., Apr 17 2017, In : Chemical research in toxicology. 30, 4, p. 870-882 13 p.

Research output: Contribution to journalReview article

Systems Toxicology II: A Special Issue

Hartung, T., Kavlock, R. & Sturla, S. J., Apr 17 2017, In : Chemical research in toxicology. 30, 4, 1 p.

Research output: Contribution to journalEditorial

The Threshold of Toxicological Concern for prenatal developmental toxicity in rats and rabbits

van Ravenzwaay, B., Jiang, X., Luechtefeld, T. & Hartung, T., Aug 1 2017, In : Regulatory Toxicology and Pharmacology. 88, p. 157-172 16 p.

Research output: Contribution to journalArticle

Thresholds of toxicological concern - Setting a threshold for testing below which there is little concern

Hartung, T., Jan 1 2017, In : ALTEX. 34, 3, p. 331-351 21 p.

Research output: Contribution to journalArticle

Whole blood cytokine response to local traffic-related particulate matter in peruvian children with and without asthma

Negherbon, J. P., Romero, K., Williams, DA. L., Guerrero-Preston, R. E., Hartung, T., Scott, A. L., Breysse, P. N., Checkley, W. & Hansel, N., Mar 30 2017, In : Frontiers in Pharmacology. 8, MAR, 157.

Research output: Contribution to journalArticle

2016

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis

Smirnova, L., Harris, G., Delp, J., Valadares, M., Pamies, D., Hogberg, H. T., Waldmann, T., Leist, M. & Hartung, T., Nov 1 2016, In : Archives of Toxicology. 90, 11, p. 2725-2743 19 p.

Research output: Contribution to journalArticle

Alzheimer disease research in the 21st century: Past and current failures, new perspectives and funding priorities

Pistollato, F., Ohayon, E. L., Lam, A., Langley, G. R., Novak, T. J., Pamies, D., Perry, G., Trushina, E., Williams, R. S. B., Roher, A. E., Hartung, T., Harnad, S., Barnard, N., Morris, M. C., Lai, M. C., Merkley, R. & Charukeshi Chandrasekera, P., Jan 1 2016, In : Oncotarget. 7, 26, p. 38999-39016 18 p.

Research output: Contribution to journalArticle

Open Access

Analysis of draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., Jan 1 2016, In : ALTEX. 33, 2, p. 123-134 12 p.

Research output: Contribution to journalArticle

Analysis of publically available skin sensitization data from REACH registrations 2008-2014

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., 2016, In : Altex. 33, 2, p. 135-148 14 p.

Research output: Contribution to journalArticle

Analysis of public oral toxicity data from REACH registrations 2008-2014

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., 2016, In : Altex. 33, 2, p. 111-122 12 p.

Research output: Contribution to journalArticle

Applicability of the Monocyte Activation Test (MAT) for hyperimmune sera in the routine of the quality control laboratory: Comparison with the Rabbit Pyrogen Test (RPT)

da Silva, C. C., Presgrave, O. A. F., Hartung, T., de Moraes, A. M. L. & Delgado, I. F., Apr 1 2016, In : Toxicology in Vitro. 32, p. 70-75 6 p.

Research output: Contribution to journalArticle

Arsenic Exposure and Immunotoxicity: a Review Including the Possible Influence of Age and Sex

Ferrario, D., Gribaldo, L. & Hartung, T., Mar 1 2016, In : Current environmental health reports. 3, 1, p. 1-12 12 p.

Research output: Contribution to journalReview article

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx, U., Andersson, T. B., Bahinski, A., Beilmann, M., Beken, S., Cassee, F. R., Cirit, M., Daneshian, M., Fitzpatrick, S., Frey, O., Gaertner, C., Giese, C., Griffith, L., Hartung, T., Heringa, M. B., Hoeng, J., De Jong, W. H., Kojima, H., Kuehnl, J., Leist, M. & 16 others, Luch, A., Maschmeyer, I., Sakharov, D., Sips, A. J. A. M., Steger-Hartmann, T., Tagle, D. A., Tonevitsky, A., Tralau, T., Tsyb, S., Van De Stolpe, A., Vandebriel, R., Vulto, P., Wang, J., Wiest, J., Rodenburg, M. & Roth, A., 2016, In : Altex. 33, 3, p. 272-321 50 p.

Research output: Contribution to journalArticle

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

Kilic, O., Pamies, D., Lavell, E., Schiapparelli, P., Feng, Y., Hartung, T., Bal-Price, A., Hogberg, H. T., Quinones-Hinojosa, A., Guerrero-Cazares, H. & Levchenko, A., Jan 1 2016, In : Lab on a Chip. 16, 21, p. 4152-4162 11 p.

Research output: Contribution to journalArticle

Can TTIP improve laboratory animal welfare in safety testing and 3Rs?

Busquet, F., Zurlo, J. & Hartung, T., Jan 1 2016, In : ILAR journal. 57, 3, p. 358-367 10 p.

Research output: Contribution to journalArticle

Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening

Tong, Z. B., Hogberg, H., Kuo, D., Sakamuru, S., Xia, M., Smirnova, L., Hartung, T. & Gerhold, D., 2016, (Accepted/In press) In : Journal of Applied Toxicology.

Research output: Contribution to journalArticle

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J. S., Slusher, B. & Le Thi, Q. H., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle

Detecting the broad spectrum of pyrogens with the human whole-blood monocyte activation test

Hartung, T., Borel, A. & Schmitz, G., Mar 1 2016, In : BioProcess International. 14, 3

Research output: Contribution to journalArticle

Editorial

Von Aulock, S., Gruber, F. P., Hartung, T., Hoesli, H. P., Hughes, M. M., Krummenacher, G., Mayr, P., Rauter, C., Zurlo, J. & Daneshian, M., 2016, In : Altex. 33, 4, p. U2

Research output: Contribution to journalEditorial

Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods

Tsaioun, K., Blaauboer, B. J. & Hartung, T., 2016, In : Altex. 33, 4, p. 343-358 16 p.

Research output: Contribution to journalArticle

Evidence-based toxicology

Hoffmann, S., Hartung, T. & Stephens, M. L., Sep 1 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 856. p. 231-241 11 p. (Advances in Experimental Medicine and Biology; vol. 856).

Research output: Chapter in Book/Report/Conference proceedingChapter

Food for thought... E-cigarettes and the need and opportunities for alternatives to animal testing

Hartung, T., 2016, In : Altex. 33, 3, p. 211-224 14 p.

Research output: Contribution to journalArticle

From big data to predictive analysis from In Vitro systems

Kleensang, A., Maertens, A. & Hartung, T., Nov 30 2016, Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine. CRC Press, p. 85-101 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

Kleensang, A., Vantangoli, M. M., Odwin-Dacosta, S., Andersen, M. E., Boekelheide, K., Bouhifd, M., Fornace, A. J., Li, H. H., Livi, C. B., Madnick, S., Maertens, A., Rosenberg, M., Yager, J. D., Zhaog, L. & Hartung, T., Jul 26 2016, In : Scientific reports. 6, 28994.

Research output: Contribution to journalArticle

Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., 2016, In : Altex. 33, 2, p. 95-109 15 p.

Research output: Contribution to journalArticle

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

Schmidt, B. Z., Lehmann, M., Gutbier, S., Nembo, E., Noel, S., Smirnova, L., Forsby, A., Hescheler, J., Avci, H. X., Hartung, T., Leist, M., Kobolák, J. & Dinnyés, A., Aug 4 2016, (Accepted/In press) In : Archives of Toxicology. p. 1-33 33 p.

Research output: Contribution to journalArticle

In Vivo, In Vitro, and stem cell technologies to predict human pharmacology and toxicology

Salem, H., Dorsey, R., Carmany, D. & Hartung, T., Nov 30 2016, Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine. CRC Press, p. 363-376 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Making big sense from big data in toxicology by read-across

Hartung, T., 2016, In : Altex. 33, 2, p. 83-93 11 p.

Research output: Contribution to journalArticle

Pathway-Based Approaches for Environmental Monitoring and Risk Assessment

Ankley, G., Escher, B., Hartung, T. & Shah, I., Nov 21 2016, In : Chemical Research in Toxicology. 29, 11, p. 1789-1790 2 p.

Research output: Contribution to journalEditorial

Pathway-Based Approaches for Environmental Monitoring and Risk Assessment

Ankley, G., Escher, B. I., Hartung, T. & Shaw, I., Oct 4 2016, In : Environmental Science and Technology. 50, 19, p. 10295-10296 2 p.

Research output: Contribution to journalComment/debate