1991 …2020

Research output per year

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Research Output

Article

1 Fundamentals of a an evidence-based toxicology: 1.1 Opening statement

Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, p. 93-94 2 p.

Research output: Contribution to journalArticle

21st Century Cell Culture for 21st Century Toxicology

Pamies, D. & Hartung, T., Jan 17 2017, In : Chemical Research in Toxicology. 30, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

3S - Systematic, systemic, and systems biology and toxicology

Smirnova, L., Kleinstreuer, N., Corvi, R., Levchenko, A., Fitzpatrick, S. C. & Hartung, T., Jan 1 2018, In : Altex. 35, 2, p. 139-162 24 p.

Research output: Contribution to journalArticle

4.8 Current schemes for decision-making in toxicology

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

4.9 Current information sources for hazard identification

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.2 Evidence-based tools in toxicological hazard identification

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.3 Evidence-based tools in toxicological decision-making

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.4 Possible improvement of information sources on hazard and risk

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5.6 An online portal to evidence-based toxicology

Kinsner, A., Griesinger, C., Hoffmann, S., Coecke, S., Bowe, G., Campana, C. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

5 Steps toward an evidence-based toxicology: 5.1 Evidence-based tools in toxicological basic research

Griesinger, C., Hoffmann, S., Kinsner, A., Coecke, S. & Hartung, T., Feb 1 2009, In : Human and Experimental Toxicology. 28, 2-3, 1 p.

Research output: Contribution to journalArticle

Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia

Knapp, S., Hareng, L., Rijneveld, A. W., Bresser, P., Van Der Zee, J. S., Florquin, S., Hartung, T. & Van Der Poll, T., Apr 15 2004, In : Journal of Infectious Diseases. 189, 8, p. 1506-1514 9 p.

Research output: Contribution to journalArticle

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Pamies, D., Bal-Price, A., Chesné, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M., Jan 1 2018, In : ALTEX. 35, 3, p. 353-378 26 p.

Research output: Contribution to journalArticle

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., Danen, E., van Ravenzwaay, B., Kamp, H., Gardner, I., Godoy, P., Bois, F. Y., Braeuning, A., Reif, R., Oesch, F., Drasdo, D. & 33 others, Höhme, S., Schwarz, M., Hartung, T., Braunbeck, T., Beltman, J., Vrieling, H., Sanz, F., Forsby, A., Gadaleta, D., Fisher, C., Kelm, J., Fluri, D., Ecker, G., Zdrazil, B., Terron, A., Jennings, P., van der Burg, B., Dooley, S., Meijer, A. H., Willighagen, E., Martens, M., Evelo, C., Mombelli, E., Taboureau, O., Mantovani, A., Hardy, B., Koch, B., Escher, S., van Thriel, C., Cadenas, C., Kroese, D., van de Water, B. & Hengstler, J. G., Nov 1 2017, In : Archives of Toxicology. 91, 11, p. 3477-3505 29 p.

Research output: Contribution to journalArticle

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment

Scholz, S., Sela, E., Blaha, L., Braunbeck, T., Galay-Burgos, M., García-Franco, M., Guinea, J., Klüver, N., Schirmer, K., Tanneberger, K., Tobor-Kapłon, M., Witters, H., Belanger, S., Benfenati, E., Creton, S., Cronin, M. T. D., Eggen, R. I. L., Embry, M., Ekman, D., Gourmelon, A. & 23 others, Halder, M., Hardy, B., Hartung, T., Hubesch, B., Jungmann, D., Lampi, M. A., Lee, L., Léonard, M., Küster, E., Lillicrap, A., Luckenbach, T., Murk, A. J., Navas, J. M., Peijnenburg, W., Repetto, G., Salinas, E., Schüürmann, G., Spielmann, H., Tollefsen, K. E., Walter-Rohde, S., Whale, G., Wheeler, J. R. & Winter, M. J., Dec 1 2013, In : Regulatory Toxicology and Pharmacology. 67, 3, p. 506-530 25 p.

Research output: Contribution to journalArticle

A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation

Daneshian, M., Akbarsha, M. A., Blaauboer, B., Caloni, F., Cosson, P., Curren, R., Goldberg, A., Gruber, F., Ohl, F., Pfaller, W., Van Der Valk, J., Vinardell, P., Zurlo, J., Hartung, T. & Leist, M., Dec 30 2011, In : ALTEX. 28, 4, p. 341-352 12 p.

Research output: Contribution to journalArticle

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

Pamies, D., Barreras, P., Block, K., Makri, G., Kumar, A., Wiersma, D., Smirnova, L., Zhang, C., Bressler, J., Christian, K. M., Harris, G., Ming, G. L., Berlinicke, C. J., Kyro, K., Song, H., Pardo, C. A., Hartung, T. & Hogberg, H. T., Jan 1 2017, In : ALTEX. 34, 3, p. 362-376 15 p.

Research output: Contribution to journalArticle

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine

Plummer, S., Wallace, S., Ball, G., Lloyd, R., Schiapparelli, P., Quiñones-Hinojosa, A., Hartung, T. & Pamies, D., Dec 1 2019, In : Scientific reports. 9, 1, 1407.

Research output: Contribution to journalArticle

Alternative in vitro assays in nanomaterial toxicology

Hartung, T. & Sabbioni, E., Nov 1 2011, In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 3, 6, p. 545-573 29 p.

Research output: Contribution to journalArticle

Alternatives to animal experimentation in basic research

Gruber, F. P. & Hartung, T., Dec 1 2004, In : ALTEX. 21, SUPPL. 1, p. 3-31 29 p.

Research output: Contribution to journalArticle

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis

Smirnova, L., Harris, G., Delp, J., Valadares, M., Pamies, D., Hogberg, H. T., Waldmann, T., Leist, M. & Hartung, T., Nov 1 2016, In : Archives of Toxicology. 90, 11, p. 2725-2743 19 p.

Research output: Contribution to journalArticle

Alzheimer disease research in the 21st century: Past and current failures, new perspectives and funding priorities

Pistollato, F., Ohayon, E. L., Lam, A., Langley, G. R., Novak, T. J., Pamies, D., Perry, G., Trushina, E., Williams, R. S. B., Roher, A. E., Hartung, T., Harnad, S., Barnard, N., Morris, M. C., Lai, M. C., Merkley, R. & Charukeshi Chandrasekera, P., Jan 1 2016, In : Oncotarget. 7, 26, p. 38999-39016 18 p.

Research output: Contribution to journalArticle

Open Access

A model of human whole blood lymphokine release for in vitro and ex vivo use

Hermann, C., Von Aulock, S., Graf, K. & Hartung, T., Apr 1 2003, In : Journal of Immunological Methods. 275, 1-2, p. 69-79 11 p.

Research output: Contribution to journalArticle

A modular approach to the extended one-generation reproduction toxicity study

Moore, N., Bremer, S., Carmichael, N., Daston, G., Dent, M., Gaoua-Chapelle, W., Hallmark, N., Hartung, T., Holzum, B., Hübel, U., Meisters, M. L., Schneider, S., Van Ravenzwaay, B. & Hennes, C., Apr 1 2009, In : ATLA Alternatives to Laboratory Animals. 37, 2, p. 219-225 7 p.

Research output: Contribution to journalArticle

Analysis of draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., Jan 1 2016, In : ALTEX. 33, 2, p. 123-134 12 p.

Research output: Contribution to journalArticle

Analysis of publically available skin sensitization data from REACH registrations 2008-2014

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., 2016, In : Altex. 33, 2, p. 135-148 14 p.

Research output: Contribution to journalArticle

Analysis of public oral toxicity data from REACH registrations 2008-2014

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., 2016, In : Altex. 33, 2, p. 111-122 12 p.

Research output: Contribution to journalArticle

A new mechanism for IL-5-dependent helminth control: Neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5

Al-Qaoud, K. M., Pearlman, E., Hartung, T., Klukowski, J., Fleischer, B. & Hoerauf, A., Jan 1 2000, In : International Immunology. 12, 6, p. 899-908 10 p.

Research output: Contribution to journalArticle

Open Access

A new method to measure air-borne pyrogens based on human whole blood cytokine response

Kindinger, I., Daneshian, M., Baur, H., Gabrio, T., Hofmann, A., Fennrich, S., Von Aulock, S. & Hartung, T., Mar 2005, In : Journal of Immunological Methods. 298, 1-2, p. 143-153 11 p.

Research output: Contribution to journalArticle

A new strategy for the synthesis of dinucleotides loaded with glycosylated amino acids - Investigations on in vitro non-natural amino acid mutagenesis for glycoprotein synthesis

Röhrig, C. H., Retz, O. A., Hareng, L., Hartung, T. & Schmidt, R. R., Oct 1 2005, In : ChemBioChem. 6, 10, p. 1805-1816 12 p.

Research output: Contribution to journalArticle

Animal testing and its alternatives - the most important omics is economics

Meigs, L., Smirnova, L., Rovida, C., Leist, M. & Hartung, T., Jan 1 2018, In : ALTEX. 35, 3, p. 275-305 31 p.

Research output: Contribution to journalArticle

An in vitro pyrogen safety test for immune-stimulating components on surfaces

Hasiwa, M., Kullmann, K., von Aulock, S., Klein, C. & Hartung, T., Mar 1 2007, In : Biomaterials. 28, 7, p. 1367-1375 9 p.

Research output: Contribution to journalArticle

A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine

van Vliet, E., Morath, S., Eskes, C., Linge, J., Rappsilber, J., Honegger, P., Hartung, T. & Coecke, S., Jan 1 2008, In : NeuroToxicology. 29, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

ANP inhibits TNF-α-induced endothelial MCP-1 expression involvement of p38 MAPK and MKP-1

Weber, N. C., Blumenthal, S. B., Hartung, T., Vollmar, A. M. & Kiemer, A. K., Nov 1 2003, In : Journal of Leukocyte Biology. 74, 5, p. 932-941 10 p.

Research output: Contribution to journalArticle

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Zhong, X., Harris, G., Smirnova, L., Zufferey, V., Sá, R. D. C. D. S. E., Baldino Russo, F., Baleeiro Beltrao Braga, P. C., Chesnut, M., Zurich, M. G., Hogberg, H. T., Hartung, T. & Pamies, D., Feb 21 2020, In : Frontiers in Cellular Neuroscience. 14, 25.

Research output: Contribution to journalArticle

Open Access

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

Head, S. A., Shi, W., Zhao, L., Gorshkov, K., Pasunooti, K., Chen, Y., Deng, Z., Li, R. J., Shim, J. S., Tan, W., Hartung, T., Zhang, J., Zhao, Y., Colombini, M. & Liu, J. O., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. E7276-E7285

Research output: Contribution to journalArticle

Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation

Hattar, K., Van Bürck, S., Bickenbach, A., Grandel, U., Maus, U., Lohmeyer, J., Csernok, E., Hartung, T., Seeger, W., Grimminger, F. & Sibelius, U., Oct 1 2005, In : Journal of Leukocyte Biology. 78, 4, p. 992-1000 9 p.

Research output: Contribution to journalArticle

Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy

Sommer, C., Lindenlaub, T., Teuteberg, P., Schäfers, M., Hartung, T. & Toyka, K. V., Sep 14 2001, In : Brain research. 913, 1, p. 86-89 4 p.

Research output: Contribution to journalArticle

Anti-tumor necrosis factor antibody impairs the therapeutic effect of ceftriaxone in murine pneumococcal pneumonia

Rijneveld, A. W., Florquin, S., Hartung, T., Speelman, P. & Van Der Poll, T., Jul 15 2003, In : Journal of Infectious Diseases. 188, 2, p. 282-285 4 p.

Research output: Contribution to journalArticle

Applicability of the Monocyte Activation Test (MAT) for hyperimmune sera in the routine of the quality control laboratory: Comparison with the Rabbit Pyrogen Test (RPT)

da Silva, C. C., Presgrave, O. A. F., Hartung, T., de Moraes, A. M. L. & Delgado, I. F., Apr 1 2016, In : Toxicology in Vitro. 32, p. 70-75 6 p.

Research output: Contribution to journalArticle

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

Tollefsen, K. E., Scholz, S., Cronin, M. T., Edwards, S. W., de Knecht, J., Crofton, K., Garcia-Reyero, N., Hartung, T., Worth, A. & Patlewicz, G., Dec 1 2014, In : Regulatory Toxicology and Pharmacology. 70, 3, p. 629-640 12 p.

Research output: Contribution to journalArticle

A primer on systematic reviews in toxicology

Hoffmann, S., de Vries, R. B. M., Stephens, M. L., Beck, N. B., Dirven, H. A. A. M., Fowle, J. R., Goodman, J. E., Hartung, T., Kimber, I., Lalu, M. M., Thayer, K., Whaley, P., Wikoff, D. & Tsaioun, K., May 13 2017, (Accepted/In press) In : Archives of Toxicology. p. 1-25 25 p.

Research output: Contribution to journalArticle

Are in vitro tests suitable for regulatory use?

Hartung, T. & Daston, G., Sep 25 2009, In : Toxicological Sciences. 111, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

Basketter, D. A., Clewell, H., Kimber, I., Rossi, A., Blaauboer, B., Burrier, R., Daneshian, M., Eskes, C., Goldberg, A., Hasiwa, N., Hoffmann, S., Jaworska, J., Knudsen, T. B., Landsiedel, R., Leist, M., Locke, P., Maxwell, G., McKim, J., McVey, E. A., Ouédraogo, G. & 15 others, Patlewicz, G., Pelkonen, O., Roggen, E., Rovida, C., Ruhdel, I., Schwarz, M., Schepky, A., Schoeters, G., Skinner, N., Trentz, K., Turner, M., Vanparys, P., Yager, J., Zurlo, J. & Hartung, T., 2012, In : ALTEX. 29, 1, p. 3-91 89 p.

Research output: Contribution to journalArticle

Open Access

Arsenic induces telomerase expression and maintains telomere length in human cord blood cells

Ferrario, D., Collotta, A., Carfi, M., Bowe, G., Vahter, M., Hartung, T. & Gribaldo, L., Jun 16 2009, In : Toxicology. 260, 1-3, p. 132-141 10 p.

Research output: Contribution to journalArticle

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part I: Technical description

Koppelstaetter, C., Jennings, P., Ryan, M. P., Morin, J. P., Hartung, T. & Pfaller, W., Aug 6 2004, In : ALTEX. 21, 2, p. 51-60 10 p.

Research output: Contribution to journalArticle

Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing part 2: Toxicological evaluation

Jennings, P., Koppelstaetter, C., Pfaller, W., Morin, J. P., Hartung, T. & Ryan, M. P., Aug 6 2004, In : ALTEX. 21, 2, p. 61-66 6 p.

Research output: Contribution to journalArticle

Assessment of pyrogenic contaminations with validated human whole-blood assay

Daneshian, M., Von Aulock, S. & Hartung, T., Nov 1 2009, In : Nature protocols. 4, 12, p. 1709-1721 13 p.

Research output: Contribution to journalArticle

A Staphylococcus aureus lipoteichoic acid (LTA) derived structural variant with two diacylglycerol residues

Stadelmaier, A., Figueroa-Perez, I., Deininger, S., von Aulock, S., Hartung, T. & Schmidt, R. R., Sep 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 18, p. 6239-6254 16 p.

Research output: Contribution to journalArticle

A structured approach to identifying European critical infrastructures

Di Mauro, C., Bouchon, S., Logtmeijer, C., Pride, R. D., Hartung, T. & Nordvik, J. P., Jun 2010, In : International Journal of Critical Infrastructures. 6, 3, p. 277-292 16 p.

Research output: Contribution to journalArticle