Ted M Dawson

Professor

1983 …2019
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Research Output 1983 2019

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2019

A comprehensive screening of copy number variability in dementia with Lewy bodies

Kun-Rodrigues, C., Orme, T., Carmona, S., Hernandez, D. G., Ross, O. A., Eicher, J. D., Shepherd, C., Parkkinen, L., Darwent, L., Heckman, M. G., Scholz, S. W., Troncoso, J. C., Pletnikova, O., Dawson, T. M., Rosenthal, L. I. S., Ansorge, O., Clarimon, J., Lleo, A., Morenas-Rodriguez, E., Clark, L. & 48 others, Honig, L. S., Marder, K., Lemstra, A., Rogaeva, E., St. George-Hyslop, P., Londos, E., Zetterberg, H., Barber, I., Braae, A., Brown, K., Morgan, K., Troakes, C., Al-Sarraj, S., Lashley, T., Holton, J., Compta, Y., Van Deerlin, V., Serrano, G. E., Beach, T. G., Lesage, S., Galasko, D., Masliah, E., Santana, I., Pastor, P., Diez-Fairen, M., Aguilar, M., Tienari, P. J., Myllykangas, L., Oinas, M., Revesz, T., Lees, A., Boeve, B. F., Petersen, R. C., Ferman, T. J., Escott-Price, V., Graff-Radford, N., Cairns, N. J., Morris, J. C., Pickering-Brown, S., Mann, D., Halliday, G. M., Hardy, J., Trojanowski, J. Q., Dickson, D. W., Singleton, A., Stone, D. J., Guerreiro, R. & Bras, J., Mar 1 2019, In : Neurobiology of Aging. 75, p. 223.e1-223.e10

Research output: Contribution to journalArticle

Lewy Body Disease
Genome
Neurodegenerative Diseases
Genes
Dementia

Assessment of APOE in atypical parkinsonism syndromes

Sabir, M. S., Blauwendraat, C., Ahmed, S., Serrano, G. E., Beach, T. G., Perkins, M., Rice, A. C., Masliah, E., Morris, C. M., Pihlstrom, L., Pantelyat, A., Resnick, S. M., Cookson, M. R., Hernandez, D. G., Albert, M., Dawson, T. M., Rosenthal, L. I. S., Houlden, H., Pletnikova, O., Troncoso, J. C. & 1 others, Scholz, S. W., Jul 1 2019, In : Neurobiology of Disease. 127, p. 142-146 5 p.

Research output: Contribution to journalArticle

Parkinsonian Disorders
Lewy Body Disease
Progressive Supranuclear Palsy
Multiple System Atrophy
Alzheimer Disease

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia

Panicker, N., Sarkar, S., Harischandra, D. S., Neal, M., Kam, T-I., Jin, H., Saminathan, H., Langley, M., Charli, A., Samidurai, M., Rokad, D., Ghaisas, S., Pletnikova, O., Dawson, V., Dawson, T. M., Anantharam, V., Kanthasamy, A. G. & Kanthasamy, A., Jun 3 2019, In : The Journal of experimental medicine. 216, 6, p. 1411-1430 20 p.

Research output: Contribution to journalArticle

Open Access
Synucleins
Inflammasomes
Microglia
Parkinson Disease
Phosphotransferases

Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis

Jin, J., Smith, M. D., Kersbergen, C. J., Kam, T-I., Viswanathan, M., Martin, K., Dawson, T. M., Dawson, V., Zack, D. J., Whartenby, K. & Calabresi, P., Jul 31 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Visual Pathways
Autoimmune Experimental Encephalomyelitis
Neuroglia
Pathology
Astrocytes

Heritability and genetic variance of dementia with Lewy bodies

for the International Parkinson's Disease Genomics Consortium, Jul 1 2019, In : Neurobiology of Disease. 127, p. 492-501 10 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Alzheimer Disease
Single Nucleotide Polymorphism
Parkinson Disease
Inborn Genetic Diseases
Open Access
Induced Pluripotent Stem Cells
Neurons
Brain
Prosencephalon
Organoids

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease

Brahmachari, S., Lee, S., Kim, S., Yuan, C., Karuppagounder, S., Ge, P., Shi, R., Kim, E. J., Liu, A., Kim, D., Quintin, S., Jiang, H., Kumar, M., Yun, S. P., Kam, T-I., Mao, X., Lee, Y., Swing, D. A., Tessarollo, L., Ko, H. S. & 2 others, Dawson, V. & Dawson, T. M., Aug 1 2019, In : Brain : a journal of neurology. 142, 8, p. 2380-2401 22 p.

Research output: Contribution to journalArticle

Zinc Fingers
Synucleins
Parkinson Disease
Proteins
Amino Acyl-tRNA Synthetases

SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy

Yamada, T., Dawson, T. M., Yanagawa, T., Iijima, M. & Sesaki, H., Nov 1 2019, In : Autophagy. 15, 11, p. 2012-2018 7 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Ubiquitination
Mitochondrial Proteins
Mitochondrial Dynamics
Dynamins

The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration

Hinkle, J. T., Dawson, V. & Dawson, T. M., Jul 1 2019, In : Movement Disorders. 34, 7, p. 959-969 11 p.

Research output: Contribution to journalArticle

Astrocytes
Neuroglia
Pharmacology
Microglia
Translational Medical Research

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease

Kim, S., Kwon, S. H., Kam, T-I., Panicker, N., Karuppagounder, S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C., Shen, C., Lee, H., Kulkarni, S., Pasricha, P. J., Lee, G., Pomper, M. G., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 21 2019, In : Neuron. 103, 4, p. 627-641.e7

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Brain
Truncal Vagotomy
Pathology
2018

A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy

Piard, J., Umanah, G., Harms, F. L., Abalde-Atristain, L., Amram, D., Chang, M., Chen, R., Alawi, M., Salpietro, V., Rees, M. I., Chung, S. K., Houlden, H., Verloes, A., Dawson, T. M., Dawson, V., Van Maldergem, L. & Kutsche, K., Mar 1 2018, In : Brain. 141, 3, p. 651-661 11 p.

Research output: Contribution to journalArticle

AMPA Receptors
Brain Diseases
Mutation
Adenosine Triphosphatases
Arthrogryposis

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T-I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. & 13 others, Lee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature Medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

Microglia
Astrocytes
Parkinson Disease
Synucleins
Nervous System Diseases

DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders

Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V., Dawson, T. M., Aja, S. M., Sesaki, H. & Pletnikov, M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 76.

Research output: Contribution to journalArticle

Astrocytes
Psychiatry
Lactic Acid
Schizophrenia
Glucose

Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease

Hinkle, J. T., Perepezko, K., Mills, K., Mari, Z., Butala, A., Dawson, T. M., Pantelyat, A., Rosenthal, L. I. S. & Pontone, G. M., Jan 1 2018, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Primary Dysautonomias
Dopamine Plasma Membrane Transport Proteins
Parkinson Disease
Corpus Striatum
Constipation

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Jeong, G. R., Jang, E. H., Bae, J. R., Jun, S., Kang, H. C., Park, C. H., Shin, J. H., Yamamoto, Y., Tanaka-Yamamoto, K., Dawson, V., Dawson, T. M., Hur, E. M. & Lee, B. D., Feb 13 2018, In : Molecular Neurodegeneration. 13, 1, 8.

Research output: Contribution to journalArticle

rab GTP-Binding Proteins
Leucine
Phosphotransferases
Phosphorylation
Dopaminergic Neurons

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Kim, S., Yun, S. P., Lee, S., Umanah, G., Bandaru, V. V. R., Yin, X., Rhee, P., Karuppagounder, S., Kwon, S. H., Lee, H., Mao, X., Kim, D., Pandey, A., Lee, G., Dawson, V., Dawson, T. M. & Ko, H. S., Jan 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Synucleins
Glucosylceramidase
Gaucher Disease
Glycosphingolipids
Dopaminergic Neurons

Genetic analysis of neurodegenerative diseases in a pathology cohort

Blauwendraat, C., Pletnikova, O., Geiger, J. T., Murphy, N. A., Abramzon, Y., Rudow, G., Mamais, A., Sabir, M. S., Crain, B., Ahmed, S., Rosenthal, L. I. S., Bakker, C. C., Faghri, F., Chia, R., Ding, J., Dawson, T. M., Pantelyat, A., Albert, M., Nalls, M. A., Resnick, S. M. & 5 others, Ferrucci, L., Cookson, M. R., Hillis-Trupe, A., Troncoso, J. C. & Scholz, S. W., Jan 1 2018, (Accepted/In press) In : Neurobiology of Aging.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Pathology
Mutation
Phenotype
Genetic Research

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

Yamada, T., Murata, D., Adachi, Y., Itoh, K., Kameoka, S., Igarashi, A., Kato, T., Araki, Y., Huganir, R. L., Dawson, T. M., Yanagawa, T., Okamoto, K., Iijima, M. & Sesaki, H., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Ubiquitination
Liver
Mitochondria
Cullin Proteins

Onset and Remission of Psychosis in Parkinson's Disease: Pharmacologic and Motoric Markers

Hinkle, J. T., Perepezko, K., Bakker, C. C., Broen, M. P. G., Chin, K., Dawson, T. M., Johnson, V., Mari, Z., Marvel, C. L., Mills, K. A., Pantelyat, A., Pletnikova, O., Rosenthal, L. S., Shepard, M. D., Stevens, D. A., Troncoso, J. C., Wang, J. & Pontone, G. M., Jan 1 2018, In : Movement Disorders Clinical Practice. 5, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Psychotic Disorders
Parkinson Disease
Dopamine Agonists
Cholinergic Antagonists
Psychiatry

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T. H., Iwai, K., Dawson, V., Dawson, T. M. & Takahashi, R., Jan 1 2018, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

Synucleins
Multiple System Atrophy
Oligodendroglia
Inclusion Bodies
Neuroglia

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T-I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 others, Dawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

Synucleins
Poly Adenosine Diphosphate Ribose
Parkinson Disease
Adenosine
Poisons

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Xiong, Y., Neifert, S., Karuppagounder, S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S., Swing, D. A., Iacovitti, L., Tessarollo, L., Dawson, T. M. & Dawson, V., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1635-1640 6 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Transgenic Mice
Norepinephrine
Phosphotransferases
Parkinson Disease

Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease

Cholerton, B., Johnson, C. O., Fish, B., Quinn, J. F., Chung, K. A., Peterson-Hiller, A. L., Rosenthal, L. I. S., Dawson, T. M., Albert, M., Hu, S. C., Mata, I. F., Leverenz, J. B., Poston, K. L., Montine, T. J., Zabetian, C. P. & Edwards, K. L., Jan 1 2018, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Sex Characteristics
Parkinson Disease
Dementia
Demography
Neurobehavioral Manifestations

Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Xue, Y., Zhan, X., Sun, S., Karuppagounder, S., Xia, S., Dawson, V., Dawson, T. M., Laterra, J. J., Zhang, J. & Ying, M., Jan 1 2018, (Accepted/In press) In : Stem cells translational medicine.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Cell Differentiation
Myosin Type II
Messenger RNA
Induced Pluripotent Stem Cells

The AAA + ATPase Thorase is neuroprotective against ischemic injury

Zhang, J., Yang, J., Wang, H., Sherbini, O., Keuss, M. J., Umanah, G., Pai, E. L. L., Chi, Z., Paldanius, K. M. A., He, W., Wang, H., Andrabi, S. A., Dawson, T. M. & Dawson, V., Jan 1 2018, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Wounds and Injuries
Stroke
Glutamic Acid
Proteins

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

Yun, S. P., Kim, D., Kim, S., Kim, S., Karuppagounder, S., Kwon, S. H., Lee, S., Kam, T-I., Lee, S., Ham, S., Park, J. H., Dawson, V., Dawson, T. M., Lee, Y. & Ko, H. S., Jan 8 2018, In : Molecular Neurodegeneration. 13, 1, 1.

Research output: Contribution to journalArticle

Synucleins
Glucosylceramidase
Gaucher Disease
Parkinsonian Disorders
Mutation
2017

Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis

Zhang, J., Li, X., Kwansa, H., Kim, Y. T., Yi, L., Hong, G., Andrabi, S. A., Dawson, V., Dawson, T. M., Koehler, R. C. & Yang, Z. J., Jun 1 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 6, p. 1982-1993 12 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Apoptosis Inducing Factor
Acidosis
Poly Adenosine Diphosphate Ribose
Cell Death

Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis

Hinkle, J. T., Perepezko, K., Bakker, C. C., Dawson, T. M., Johnson, V., Mari, Z., Marvel, C. L., Mills, K. A., Pantelyat, A., Pletnikova, O., Rosenthal, L. S., Shepard, M. D., Stevens, D. A., Troncoso, J. C., Wang, J. & Pontone, G. M., 2017, (Accepted/In press) In : International Journal of Geriatric Psychiatry.

Research output: Contribution to journalArticle

Psychotic Disorders
Parkinson Disease
Language
Odds Ratio
Cognitive Dysfunction

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

Puschmann, A., Fiesel, F. C., Caulfield, T. R., Hudec, R., Ando, M., Truban, D., Hou, X., Ogaki, K., Heckman, M. G., James, E. D., Swanberg, M., Jimenez-Ferrer, I., Hansson, O., Opala, G., Siuda, J., Boczarska-Jedynak, M., Friedman, A., Koziorowski, D., Aasly, J. O., Lynch, T. & 12 others, Mellick, G. D., Mohan, M., Silburn, P. A., Sanotsky, Y., Vilariño-Güell, C., Farrer, M. J., Chen, L., Dawson, V. L., Dawson, V., Dawson, T. M., Ross, O. A. & Springer, W., Jan 1 2017, In : Brain : a journal of neurology. 140, p. 98-117 20 p.

Research output: Contribution to journalArticle

Parkinson Disease
Heterozygote
Mutation
Odds Ratio
PTEN-induced putative kinase

Markers of impaired motor and cognitive volition in Parkinson's disease: Correlates of dopamine dysregulation syndrome, impulse control disorder, and dyskinesias

Hinkle, J. T., Perepezko, K., Rosenthal, L. I. S., Mills, K., Pantelyat, A., Mari, Z., Tochen, L., Bang, J. Y., Gudavalli, M., Yoritomo, N., Butala, A., Bakker, C. C., Johnson, V., Moukheiber, E., Dawson, T. M. & Pontone, G. M., Jan 1 2017, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Disruptive, Impulse Control, and Conduct Disorders
Dyskinesias
Parkinson Disease
Dopamine
Psychotic Disorders

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W. S., Peterson, T. C., Wilton, D. K., Frouin, A., Napier, B. A., Panicker, N., Kumar, M., Buckwalter, M. S., Rowitch, D. H., Dawson, V., Dawson, T. M., Stevens, B. & 1 others, Barres, B. A., Jan 26 2017, In : Nature. 541, 7638, p. 481-487 7 p.

Research output: Contribution to journalArticle

Microglia
Astrocytes
Neurons
Oligodendroglia
Neurodegenerative Diseases

Nitric Oxide Signaling in Neurodegeneration and Cell Death

Dawson, T. M. & Dawson, V., 2017, (Accepted/In press) In : Advances in Pharmacology.

Research output: Contribution to journalArticle

Nitric Oxide
Cell Death
NADPH Dehydrogenase
Nitric Oxide Synthase Type I
Neurons

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases

Berger, N. A., Besson, V. C., Boulares, A. H., Bürkle, A., Chiarugi, A., Clark, R. S., Curtin, N. J., Cuzzocrea, S., Dawson, T. M., Dawson, V., Haskó, G., Liaudet, L., Moroni, F., Pacher, P., Radermacher, P., Salzman, A. L., Snyder, S. H., Soriano, F. G., Strosznajder, R. P., Sümegi, B. & 2 others, Swanson, R. A. & Szabo, C., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Acute Lung Injury
Therapeutics
Septic Shock
DNA Repair
Pancreatitis

Overexpression of Parkinson’s disease-associated mutation LRRK2 G2019S in mouse forebrain induces behavioral deficits and α-synuclein pathology

Xiong, Y., Neifert, S., Karuppagounder, S., Stankowski, J. N., Lee, B. D., Grima, J. C., Chen, G., Ko, H. S., Lee, Y., Swing, D., Tessarollo, L., Dawson, T. M. & Dawson, V., 2017, In : eNeuro. 4, 2, e0004.

Research output: Contribution to journalArticle

Synucleins
Prosencephalon
Leucine
Parkinson Disease
Phosphotransferases

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G., Kang, H., Ham, S., Kam, T-I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F. C., Springer, W., Dawson, V., Shin, J. H. & 1 others, Dawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journalArticle

Ubiquitination
Dopaminergic Neurons
Neurons
Phosphorylation
Substantia Nigra

Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning

Pignatelli, M., Umanah, G., Ribeiro, S. P., Chen, R., Karuppagounder, S., Yau, H. J., Eacker, S., Dawson, V., Dawson, T. M. & Bonci, A., Jan 18 2017, In : Neuron. 93, 2, p. 425-440 16 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Dopaminergic Neurons
Fear
Learning
AMPA Receptors

T cells from patients with Parkinson's disease recognize α-synuclein peptides

Sulzer, D., Alcalay, R. N., Garretti, F., Cote, L., Kanter, E., Agin-Liebes, J., Liong, C., McMurtrey, C., Hildebrand, W. H., Mao, X., Dawson, V., Dawson, T. M., Oseroff, C., Pham, J., Sidney, J., Dillon, M. B., Carpenter, C., Weiskopf, D., Phillips, E., Mallal, S. & 4 others, Peters, B., Frazier, A., Lindestam Arlehamn, C. S. & Sette, A., Jun 29 2017, In : Nature. 546, 7660, p. 656-661 6 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
T-Lymphocytes
Peptides
Alleles

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Ando, M., Fiesel, F. C., Hudec, R., Caulfield, T. R., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V., Dawson, T. M., Bu, G., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In : Molecular Neurodegeneration. 12, 1, 32.

Research output: Contribution to journalArticle

Protein Stability
Ubiquitin
Phosphotransferases
Mutation
Mitochondrial Membranes

Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel

Umanah, G., Pignatelli, M., Yin, X., Chen, R., Crawford, J., Neifert, S., Scarffe, L., Behensky, A. A., Guiberson, N., Chang, M., Ma, E., Kim, J. W., Castro, C. C., Mao, X., Chen, L., Andrabi, S. A., Pletnikov, M., Pulver, A. E., Avramopoulos, D., Bonci, A. & 3 others, Valle, D., Dawson, T. M. & Dawson, V., Dec 13 2017, In : Science Translational Medicine. 9, 420, aah4985.

Research output: Contribution to journalArticle

Synaptic Transmission
Acids
Neuronal Plasticity
United States Food and Drug Administration
Adenosine Triphosphatases

Toward the human cellular microRNAome

McCall, M. N., Kim, M. S., Adil, M., Patil, A. H., Lu, Y., Mitchell, C. J., Leal-Rojas, P., Xu, J., Kumar, M., Dawson, V., Dawson, T. M., Baras, A., Rosenberg, A., Arking, D., Burns, K., Pandey, A. & Halushka, M. K., Oct 1 2017, In : Genome Research. 27, 10, p. 1769-1781 13 p.

Research output: Contribution to journalArticle

MicroRNAs
RNA
Cell Line
Regulator Genes
Adipose Tissue

Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes

Scott, L., Dawson, V. & Dawson, T. M., Jan 17 2017, (Accepted/In press) In : Experimental Neurology.

Research output: Contribution to journalArticle

Parkinson Disease
Genes
Mutation
Dopaminergic Neurons
Movement Disorders

Two approaches reveal a new paradigm of 'switchable or genetics-influenced allele-specific DNA methylation' with potential in human disease

Martos, S. N., Li, T., Ramos, R. B., Lou, D., Dai, H., Xu, J., Gao, G., Gao, Y., Wang, Q., An, C., Zhang, X., Jia, Y., Dawson, V., Dawson, T. M., Ji, H. K. & Wang, Z., Nov 14 2017, In : Cell Discovery. 3, 17038.

Research output: Contribution to journalArticle

Methylation
DNA Methylation
Alleles
Genes
Cell Line
2016

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

Brahmachari, S., Ge, P., Lee, S. H., Kim, D., Karuppagounder, S., Kumar, M., Mao, X., Shin, J. H., Lee, Y., Pletnikova, O., Troncoso, J. C., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 1 2016, In : Journal of Clinical Investigation. 126, 8, p. 2970-2988 19 p.

Research output: Contribution to journalArticle

Synucleins
Protein-Tyrosine Kinases
Phosphotyrosine
Parkinson Disease
abl Genes

Adult conditional knockout of PGC-1α leads to loss of dopamine neurons

Jiang, H., Kang, S., Zhang, S., Karuppagounder, S., Xu, J., Lee, Y. K., Kang, B. G., Lee, Y., Zhang, J., Pletnikova, O., Troncoso, J. C., Pirooznia, S., Andrabi, S. A., Dawson, V. & Dawson, T. M., 2016, In : eNeuro. 3, 4, e0183-16.2016.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Parkinson Disease
Protein Isoforms
Peroxisome Proliferator-Activated Receptors
Mitochondrial Proteins

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Wang, Y., An, R., Umanah, G., Park, H., Nambiar, K., Eacker, S., Kim, B., Bao, L., Harraz, M., Chang, C., Chen, R., Wang, J. E., Kam, T-I., Jeong, J. S., Xie, Z., Neifert, S., Qian, J., Andrabi, S. A., Blackshaw, S., Zhu, H. & 4 others, Song, H., Ming, G. L., Dawson, V. & Dawson, T. M., Oct 7 2016, In : Science. 354, 6308, aad6872.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
DNA Damage
Cell Death
Glutamic Acid
Macrophage Migration-Inhibitory Factors

Association of GBA mutations and the E326K polymorphism with motor and cognitive progression in parkinson disease

Davis, M. Y., Johnson, C. O., Leverenz, J. B., Weintraub, D., Trojanowski, J. Q., Chen-Plotkin, A., Van Deerlin, V. M., Quinn, J. F., Chung, K. A., Peterson-Hiller, A. L., Rosenthal, L. I. S., Dawson, T. M., Albert, M., Goldman, J. G., Stebbins, G. T., Bernard, B., Wszolek, Z. K., Ross, O. A., Dickson, D. W., Eidelberg, D. & 10 others, Mattis, P. J., Niethammer, M., Yearout, D., Hu, S. C., Cholerton, B. A., Smith, M., Mata, I. F., Montine, T. J., Edwards, K. L. & Zabetian, C. P., Oct 1 2016, In : JAMA Neurology. 73, 10, p. 1217-1224 8 p.

Research output: Contribution to journalArticle

Parkinson Disease
Mutation
Genotype
Tremor
Gait

C9orf72 Hexanucleotide repeat analysis in cases with pathologically confirmed dementia with lewy bodies

Geiger, J. T., Arthur, K. C., Dawson, T. M., Rosenthal, L. I. S., Pantelyat, A., Albert, M., Hillis-Trupe, A., Crain, B., Pletnikova, O., Troncoso, J. C. & Scholz, S. W., Sep 1 2016, In : Neurodegenerative Diseases. 16, 5-6, p. 370-372 3 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Polymerase chain reaction
Pathology
Mutation
Neurons
Parkinson Disease
Movement Disorders
Biomarkers
Odds Ratio
National Institute of Neurological Disorders and Stroke

Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity

Xu, J., Fan, J., Wang, X., Eacker, S., Kam, T-I., Chen, L., Yin, X., Zhu, J., Chi, Z., Jiang, H., Chen, R., Dawson, T. M. & Dawson, V., Apr 6 2016, In : Science Translational Medicine. 8, 333, ra48.

Research output: Contribution to journalArticle

Interneurons
Cell Death
Neurons
Pluripotent Stem Cells
Poly(ADP-ribose) Polymerases
Lewy Bodies
Locus Coeruleus
Gait
Parkinson Disease
Pathology