Ted M Dawson

Professor

1983 …2019
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Research Output 1983 2019

1999

Glutamate-stimulated calcium activation of Ras/Erk pathway mediated by nitric oxide

Yun, H. Y., Dawson, V. & Dawson, T. M., Sep 1999, In : Diabetes Research and Clinical Practice. 45, 2-3, p. 113-115 3 p.

Research output: Contribution to journalArticle

Glutamic Acid
Nitric Oxide
Calcium
Neuronal Plasticity
N-Methylaspartate

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., Mcauliffe, W. G., Dawson, V., Dawson, T. M. & Przedborski, S., Dec 1999, In : Nature Medicine. 5, 12, p. 1403-1409 7 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Nitric Oxide Synthase Type II
Parkinson Disease
Gliosis
Dopaminergic Neurons

Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis

Facchinetti, F., Sasaki, M., Cutting, F. B., Zhai, P., MacDonald, J. E., Reif, D., Beal, M. F., Huang, P. L., Dawson, T. M., Gurney, M. E. & Dawson, V., Jun 1999, In : Neuroscience. 90, 4, p. 1483-1492 10 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Transgenic Mice
Copper
Zinc
Peroxynitrous Acid

Mechanisms and structural determinants of HIV-1 coat protein, gp41- induced neurotoxicity

Adamson, D. C., Kopnisky, K. L., Dawson, T. M. & Dawson, V., Jan 1 1999, In : Journal of Neuroscience. 19, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

AIDS Dementia Complex
Nitric Oxide Synthase Type I
Capsid Proteins
HIV-1
Nitric Oxide Synthase

Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats

Toung, T. J., Bhardwaj, A., Dawson, V., Dawson, T. M., Traystman, R. J. & Hurn, P. D., Jun 1999, In : Stroke. 30, 6, p. 1279-1285 7 p.

Research output: Contribution to journalArticle

Tacrolimus
Middle Cerebral Artery Infarction
Reperfusion
Nitric Oxide
Ischemia

Nitric oxide synthase in cardiac sarcoplasmic reticulum

Xu, K. Y., Huso, D. L., Dawson, T. M., Bredt, D. S. & Becker, L., Jan 19 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 2, p. 657-662 6 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum
Nitric Oxide Synthase
Myocardium
Protein Isoforms
Spin Trapping

Nocturnal motor coordination deficits in neuronal nitric oxide synthase knock-out mice

Kriegsfeld, L. J., Eliasson, M. J. L., Demas, G. E., Blackshaw, S., Dawson, T. M., Nelson, R. J. & Snyder, S. H., Mar 1999, In : Neuroscience. 89, 2, p. 311-315 5 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Knockout Mice
Neurons
Cerebellum
Nitric Oxide

Nuclear targeting of mutant huntingtin increases toxicity

Peters, M. F., Nucifora, F., Kushi, J., Seaman, H. C., Cooper, J. K., Herring, W. J., Dawson, V., Dawson, T. M. & Ross, C. A., Aug 1999, In : Molecular and Cellular Neuroscience. 14, 2, p. 121-128 8 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Nuclear Localization Signals
Intranuclear Inclusion Bodies
Huntington Disease
Neurodegenerative Diseases

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism

Mandir, A. S., Przedborski, S., Jackson-Lewis, V., Wang, Z. Q., Simbulan- Rosenthal, C. M., Smulson, M. E., Hoffman, B. E., Guastella, D. B., Dawson, V. & Dawson, T. M., May 11 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 10, p. 5774-5779 6 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Poly(ADP-ribose) Polymerases
Parkinsonian Disorders
Nuclear Proteins
DNA Damage

Rate and severity of HIV-associated dementia (HAD): Correlations with Gp41 and iNOS

Adamson, D. C., McArthur, J. C., Dawson, T. M. & Dawson, V., 1999, In : Molecular Medicine. 5, 2, p. 98-109 12 p.

Research output: Contribution to journalArticle

AIDS Dementia Complex
Nitric Oxide Synthase
Tubulin
Nervous System Diseases
Acquired Immunodeficiency Syndrome

Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions

Engelender, S., Kaminsky, Z. A., Xin, G., Sharp, A. H., Amaravi, R. K., Kleiderlein, J. J., Margolis, R. L., Troncoso, J. C., Lanahan, A. A., Worley, P. F., Dawson, V., Dawson, T. M. & Ross, C. A., May 1999, In : Nature Genetics. 22, 1, p. 110-114 5 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Lewy Bodies
Inclusion Bodies
Proteins
1998

Free radicals as mediators of neuronal injury

Facchinetti, F., Dawson, V. & Dawson, T. M., 1998, In : Cellular and Molecular Neurobiology. 18, 6, p. 667-682 16 p.

Research output: Contribution to journalArticle

Oxidative stress
Free Radicals
Oxidative Stress
Tissue
Wounds and Injuries

Impaired ovulation in mice with targeted deletion of the neuronal isoform of nitric oxide synthase

Klein, S. L., Carnovale, D., Burnett, A., Wallach, E. E., Zacur, H. A., Crone, J. K., Dawson, V., Nelson, R. J. & Dawson, T. M., 1998, In : Molecular Medicine. 4, 10, p. 658-664 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Ovulation
Protein Isoforms
Oocytes
Oviducts

Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice

Jumrussirikul, P., Dinerman, J., Dawson, T. M., Dawson, V., Ekelund, U., Georgakopoulos, D., Schramm, L., Calkins, H., Snyder, S. H., Hare, J. M. & Berger, R. D., Oct 1 1998, In : Journal of Clinical Investigation. 102, 7, p. 1279-1285 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
GTP-Binding Proteins
Heart Rate
Nitric Oxide Synthase
Pertussis Toxin

Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity

Gonzalez-Zulueta, M., Ensz, L. M., Mukhina, G., Lebovitz, R. M., Zwacka, R. M., Engelhardt, J. F., Oberley, L. W., Dawson, V. & Dawson, T. M., Mar 15 1998, In : Journal of Neuroscience. 18, 6, p. 2040-2055 16 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
N-Methylaspartate
Superoxide Dismutase
Nitric Oxide
Neurons

mdx muscle pathology is independent of nNOS perturbation

Crosbie, R. H., Straub, V., Yun, H. Y., Lee, J. C., Rafael, J. A., Chamberlain, J. S., Dawson, V., Dawson, T. M. & Campbell, K. P., May 1998, In : Human Molecular Genetics. 7, 5, p. 823-829 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Dystrophin
Pathology
Muscles
Inbred mdx Mouse

Nitric oxide: Diverse actions in the central and peripheral nervous systems

Dawson, T. M., Gonzalez-Zulueta, M., Kusel, J. & Dawson, V., Mar 1998, In : Neuroscientist. 4, 2, p. 96-112 17 p.

Research output: Contribution to journalArticle

Peripheral Nervous System
Nitric Oxide
Central Nervous System
Synaptic Vesicles
Cytotoxins

Nitric oxide in brain development, plasticity, and disease: Preface

Mize, R. R., Dawson, T. M., Dawson, V. & Friedlander, M. J., 1998, In : Progress in Brain Research. 118

Research output: Contribution to journalArticle

Nitric Oxide
Brain

Nitric oxide in neurodegeneration

Dawson, V. & Dawson, T. M., 1998, In : Progress in Brain Research. 118, p. 215-229 15 p.

Research output: Contribution to journalArticle

Nitric Oxide
Nitric Oxide Synthase
Neurotransmitter Agents
AIDS Dementia Complex
Nitric Oxide Synthase Type I

Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21(ras)

Yun, H. Y., Gonzalez-Zulueta, M., Dawson, V. & Dawson, T. M., May 12 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 10, p. 5773-5778 6 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins p21(ras)
N-Methyl-D-Aspartate Receptors
Nitric Oxide
N-Methylaspartate
Nitric Oxide Synthase Type I

NMDAR1 glutamate receptor subunit isoforms in neostriatal, neocortical, and hippocampal nitric oxide synthase neurons

Weiss, S. W., Albers, D. S., Iadarola, M. J., Dawson, T. M., Dawson, V. & Standaert, D. G., Mar 1 1998, In : Journal of Neuroscience. 18, 5, p. 1725-1734 10 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Nitric Oxide Synthase
Protein Isoforms
Neurons
Nitric Oxide

Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways

Dawson, T. M., Sasaki, M., Gonzalez-Zulueta, M. & Dawson, V., 1998, In : Progress in Brain Research. 118, p. 3-11 9 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Nitric Oxide
Proto-Oncogene Proteins p21(ras)
Gene Expression
Neuronal Plasticity

The 12 kD FK506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility

Walensky, L. D., Dawson, T. M., Steiner, J. P., Sabatini, D. M., Suarez, J. D., Klinefelter, G. R. & Snyder, S. H., 1998, In : Molecular Medicine. 4, 8, p. 502-514 13 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Protein 1A
Tacrolimus Binding Proteins
Sperm Motility
Tacrolimus
Spermatozoa

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture

Cooper, J. K., Schilling, G., Peters, M. F., Herring, W. J., Sharp, A. H., Kaminsky, Z. A., Masone, J., Khan, F. A., Delanoy, M., Borchelt, D. R., Dawson, V., Dawson, T. M. & Ross, C. A., May 1998, In : Human Molecular Genetics. 7, 5, p. 783-790 8 p.

Research output: Contribution to journalArticle

Glutamine
Huntington Disease
Cell Culture Techniques
Intranuclear Inclusion Bodies
Cytoplasm
1997

Aggressive behavior in male mice lacking the gene for neuronal nitric oxide synthase requires testosterone

Kriegsfeld, L. J., Dawson, T. M., Dawson, V., Nelson, R. J. & Snyder, S. H., Sep 19 1997, In : Brain Research. 769, 1, p. 66-70 5 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Testosterone
Protein Isoforms
Aggression
Genes

Differential susceptibility to neurotoxicity mediated by neurotrophins and neuronal nitric oxide synthase

Samdani, A. F., Newcamp, C., Resink, A., Facchinetti, F., Hoffman, B. E., Dawson, V. & Dawson, T. M., 1997, In : Journal of Neuroscience. 17, 12, p. 4633-4641 9 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Nerve Growth Factors
Nitric Oxide Synthase
N-Methylaspartate
Feeder Cells

Dystrophin and nnos double knockout mice maintain dystrophic phenotype

Crosbie, R. H., Straub, V., Vnzke, D. P., Yun, H. Y., Chamberlain, J. S., Dawson, V., Dawson, T. M. & Campbell, K. P., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

dystrophin
Nitric Oxide Synthase Type I
Dystrophin
Knockout Mice
Phenotype

Effects of nitric oxide on neuroendocrine function and behavior

Nelson, R. J., Kriegsfeld, L. J., Dawson, V. & Dawson, T. M., Oct 1997, In : Frontiers in Neuroendocrinology. 18, 4, p. 463-491 29 p.

Research output: Contribution to journalArticle

Nitric Oxide
Neurotransmitter Agents
Blood Vessels
Peripheral Nervous System
Oxytocin

Inhibition of neuronal nitric oxide synthase increases aggressive behavior in mice

Demas, G. E., Eliasson, M. J. L., Dawson, T. M., Dawson, V., Kriegsfeld, L. J., Nelson, R. J. & Snyder, S. H., 1997, In : Molecular Medicine. 3, 9, p. 610-616 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Protein Isoforms
Aggression
Citrulline
Brain

Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity

Zhang, J., Dawson, V., Dawson, T. M. & Snyder, S. H., 1997, In : Biotechnology Advances. 15, 3-4, p. 771 1 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Administrative data processing
N-Methylaspartate
Ligases
Huntington Disease
Nitric Oxide Synthase Type I
Nitric Oxide Synthase Type II
Astrocytes
Nitric Oxide Synthase
Jurkat Cells

Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A

Steiner, J. P., Connolly, M. A., Valentine, H. L., Hamilton, G. S., Dawson, T. M., Hester, L. D. & Snyder, S. H., 1997, In : Nature Medicine. 3, 4, p. 421-428 8 p.

Research output: Contribution to journalArticle

Immunophilins
Tacrolimus
Sirolimus
Immunosuppressive Agents
Cyclosporine

Nitric oxide in health and disease of the nervous system

Yun, H. Y., Dawson, V. & Dawson, T. M., 1997, In : Molecular Psychiatry. 2, 4, p. 300-310 11 p.

Research output: Contribution to journalArticle

Nervous System Diseases
Nitric Oxide Synthase Type I
Nitric Oxide
Nitric Oxide Synthase Type III
Health

Nitric oxide synthase in models of focal ischemia

Samdani, A. F., Dawson, T. M. & Dawson, V., Jun 1997, In : Stroke. 28, 6, p. 1283-1288 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Protein Isoforms
Ischemia
Nitric Oxide
Brain Ischemia

NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre-and postsynaptic sites and in spines

Aoki, C., Rhee, J., Lubin, M. & Dawson, T. M., Mar 7 1997, In : Brain Research. 750, 1-2, p. 25-40 16 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Cerebral Cortex
Spine

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

Eliasson, M. J. L., Sampei, K., Mandir, A. S., Hurn, P. D., Traystman, R. J., Bao, J., Pieper, A., Wang, Z. Q., Dawson, T. M., Snyder, S. H. & Dawson, V., Oct 1997, In : Nature Medicine. 3, 10, p. 1089-1095 7 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Brain Ischemia
Genes
NAD
Nitric Oxide
Nitric Oxide Synthase Type I
Urethra
Arginine
Urinary Bladder
Genes
1996

[2] Nitric oxide toxicity in central nervous system cultures

Dawson, V. & Dawson, T. M., 1996, In : Methods in Neurosciences. 30, C, p. 26-43 18 p.

Research output: Contribution to journalArticle

Nitric Oxide
Central Nervous System

[20] Function of nitric oxide in neuronal cell death

Dawson, V. & Dawson, T. M., 1996, In : Methods in Neurosciences. 31, C, p. 228-240 13 p.

Research output: Contribution to journalArticle

Nitric Oxide
Cell Death

[6] NADPH Diaphorase staining

Dawson, T. M. & Dawson, V., 1996, In : Methods in Neurosciences. 31, C, p. 62-67 6 p.

Research output: Contribution to journalArticle

NADPH Dehydrogenase
Staining and Labeling

Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin

Bao, J., Sharp, A. H., Wagster, M. V., Becher, M., Schilling, G., Ross, C. A., Dawson, V. & Dawson, T. M., May 14 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 10, p. 5037-5042 6 p.

Research output: Contribution to journalArticle

Calmodulin
Huntington Disease
Proteins
Sepharose
Calcium

Free radicals and neuronal cell death

Dawson, V. & Dawson, T. M., 1996, In : Cell Death and Differentiation. 3, 1, p. 71-78 8 p.

Research output: Contribution to journalArticle

Free Radicals
Cell Death
Reactive Oxygen Species
Chemical Phenomena
Antioxidants

Generation of isoform-specific antibodies to nitric oxide synthases

Dawson, T. M. & Dawson, V., 1996, In : Methods in Enzymology. 268, p. 349-358 10 p.

Research output: Contribution to journalArticle

Macrophages
Nitric Oxide Synthase
Isoenzymes
Neurons
Rats
Nitric Oxide Synthase Type I
Brain
Huntington Disease
Neurons
Corpus Striatum

Immunologic NO synthase: Elevation in severe AIDS dementia and induction by HIV-1 gp41

Adamson, D. C., Wildemann, B., Sasaki, M., Glass, J. D., McArthur, J. C., Christov, V. I., Dawson, T. M. & Dawson, V., Dec 13 1996, In : Science. 274, 5294, p. 1917-1921 5 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase
Dementia
HIV-1
Acquired Immunodeficiency Syndrome
Nitric Oxide

Immunophilin regulation of neurotransmitter release

Steiner, J. P., Dawson, T. M., Fotuhi, M. & Snyder, S. H., 1996, In : Molecular Medicine. 2, 3, p. 325-333 9 p.

Research output: Contribution to journalArticle

Immunophilins
Tacrolimus
Synaptosomes
Neurotransmitter Agents
Immunosuppressive Agents

Immunosuppressants, immunophilins, and the nervous system

Dawson, T. M., 1996, In : Annals of Neurology. 40, 4, p. 559-560 2 p.

Research output: Contribution to journalArticle

Immunophilins
Tacrolimus
Organ Transplantation
Immunosuppressive Agents
Nervous System

Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw

Lam, H. H. D., Hanley, D. F., Trapp, B. D., Saito, S., Raja, S. N., Dawson, T. M. & Yamaguchi, H., Jun 7 1996, In : Neuroscience Letters. 210, 3, p. 201-204 4 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Formaldehyde
Spinal Cord
Injections
Neurons

Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex

Ruthazer, E. S., Gillespie, D. C., Dawson, T. M., Snyder, S. H. & Stryker, M. P., Jul 15 1996, In : Journal of Physiology. 494, 2, p. 519-527 9 p.

Research output: Contribution to journalArticle

ocular Dominance
omega-N-Methylarginine
Visual Cortex
Nitric Oxide Synthase
Arginine

Loss of nitric oxide synthase immunoreactivity in cerebral vasospasm

Pluta, R. M., Thompson, B. G., Dawson, T. M., Snyder, S. H., Boock, R. J. & Oldfield, E. H., Apr 1996, In : Journal of Neurosurgery. 84, 4, p. 648-654 7 p.

Research output: Contribution to journalArticle

Intracranial Vasospasm
Nitric Oxide Synthase
Middle Cerebral Artery
Adventitia
Subarachnoid Hemorrhage