Ted M Dawson

Professor

1983 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1983 2019

2003

Nitric Oxide Protects Cardiac Sarcolemmal Membrane Enzyme Function and Ion Active Transport against Ischemia-induced Inactivation

Xu, K. Y., Kuppusamy, S. P., Wang, J. Q., Li, H., Cui, H., Dawson, T. M., Huang, P. L., Burnett, A., Kuppusamy, P. & Becker, L., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 41798-41803 6 p.

Research output: Contribution to journalArticle

Sarcolemma
Ion Transport
Nitric Oxide
Ischemia
Ions

Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age

Pawlyk, A. C., Giasson, B. I., Sampathu, D. M., Perez, F. A., Lim, K. L., Dawson, V., Dawson, T. M., Palmiter, R. D., Trojanowski, J. Q. & Lee, V. M. Y., Nov 28 2003, In : Journal of Biological Chemistry. 278, 48, p. 48120-48128 9 p.

Research output: Contribution to journalArticle

Brain
Parkinsonian Disorders
Salts
Monoclonal Antibodies
Movement Disorders

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

Nucifora, F., Ellerby, L. M., Wellington, C. L., Wood, J. D., Herring, W. J., Sawa, A., Hayden, M. R., Dawson, V., Dawson, T. M. & Ross, C. A., Apr 11 2003, In : Journal of Biological Chemistry. 278, 15, p. 13047-13055 9 p.

Research output: Contribution to journalArticle

Toxicity
Progressive Myoclonic Epilepsy
Cytoplasm
Glutamine
Mutant Proteins

Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity

Yu, S. W., Wang, H., Dawson, T. M. & Dawson, V., Dec 2003, In : Neurobiology of Disease. 14, 3, p. 303-317 15 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Cell Death
Caspases
Nervous System Diseases
Reperfusion Injury

Predictors of nursing home placement in Huntington disease

Wheelock, V. L., Tempkin, T., Marder, K., Nance, M., Myers, R. H., Zhao, H., Kayson, E., Orme, C., Shoulson, I., Hedges, P., McCusker, E., Pearce, S., Trent, R., Abwender, D., Como, P., Gardiner, I., Hickey, C., Kieburtz, K., Marshall, F., Pearson, N. & 79 others, Zimmerman, C., Louis, E., Moskowitz, C., Polanco, C., Zubin, N., Brown, C., Burkeholder, J., Guttman, M., Russell, S., Stewart, D., Thomson, J., Sax, D. S., Saint-Hilaire, M., Gray, J., Hunter, C., Mercado, N., Siemers, E., Wojeieszek, J., Dawson, T. M., Leritz, E., Rosenblatt, A., Sherr, M., Young, C., Ashizawa, T., Beach, J., Jankovic, J., Jaglin, J., Shannon, K., Lundin, A., Francis, K., Lane, K., Auchus, A., Greenamyre, J. T., Hersch, S., Jones, R., Olson, D., Cha, J. H. J., Cudkowicz, M., Koroshetz, W., Penney, J., Rudolf, G., Sexton, P., Young, A. B., Albin, R., Wernette, K., Higgins, D. S., Reider, C., Hunt, V., Walker, F., Hauscr, R., Sanchez-Ramos, J., Walker, A., Pantello, C., Rohs, G., Suchowersky, O., Duncan, K., Seeberger, L., Corey-Bloom, J., Paulsen, J., Swenson, M., Swerdlow, N., Martin, W., Wieler, M., Facca, A., Rey, G., Weiner, W., Adler, C., Caviness, J., Lied, C., Newman, S., Feigin, A., Mazurkiewicz, J., Caplan, K., Cellar, J., Marck, K., Hayden, M., Raymond, L., Dure, L. S. & Lane, J., Mar 25 2003, In : Neurology. 60, 6, p. 998-1001 4 p.

Research output: Contribution to journalArticle

Skilled Nursing Facilities
Huntington Disease
Nursing Homes
Institutionalization
Hypokinesia

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

Dawson, T. M. & Dawson, V., Jan 2003, In : Journal of Clinical Investigation. 111, 2, p. 145-151 7 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Mutation
Oxidative Stress
Proteins

Role for the Ubiquitin-Proteasome System in Parkinson's Disease and Other Neurodegenerative Brain Amyloidoses

Moore, D. J., Dawson, V. & Dawson, T. M., 2003, In : NeuroMolecular Medicine. 4, 1-2, p. 95-108 14 p.

Research output: Contribution to journalArticle

Amyloidosis
Proteasome Endopeptidase Complex
Ubiquitin
Parkinson Disease
Brain

SEPT5_v2 is a parkin-binding protein

Choi, P., Snyder, H., Petrucelli, L., Theisler, C., Chong, M., Zhang, Y., Lim, K., Chung, K. K. K., Kehoe, K., D'Adamio, L., Lee, J. M., Cochran, E., Bowser, R., Dawson, T. M. & Wolozin, B., Oct 7 2003, In : Molecular Brain Research. 117, 2, p. 179-189 11 p.

Research output: Contribution to journalArticle

Septins
Carrier Proteins
Ubiquitination
Ubiquitin
Proteins
Parkinson Disease
Ubiquitin
Synucleins
Lewy Bodies
Ubiquitin C
2002

Animal models of PD: Pieces of the same puzzle?

Dawson, T. M., Mandir, A. S. & Lee, M. K., Jul 18 2002, In : Neuron. 35, 2, p. 219-222 4 p.

Research output: Contribution to journalArticle

Parkinson Disease
Animal Models
Genetic Models
Genetic Predisposition to Disease
Neurodegenerative Diseases

A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism

Mandir, A. S., Simbulan-Rosenthal, C. M., Poitras, M. F., Lumpkin, J. R., Dawson, V., Smulson, M. E. & Dawson, T. M., Oct 2002, In : Journal of Neurochemistry. 83, 1, p. 186-192 7 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Parkinsonian Disorders
Post Translational Protein Processing
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

Cregan, S. P., Fortin, A., MacLaurin, J. G., Callaghan, S. M., Cecconi, F., Yu, S. W., Dawson, T. M., Dawson, V., Park, D. S., Kroemer, G. & Slack, R. S., 2002, In : Journal of Cell Biology. 158, 3, p. 507-517 11 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Caspases
Cell Death
Wounds and Injuries
Neurons

CREB family transcription factors inhibit neuronal suicide

Dawson, T. M. & Ginty, D. D., 2002, In : Nature Medicine. 8, 5, p. 450-451 2 p.

Research output: Contribution to journalArticle

Huntington Disease
Cell death
Suicide
Brain
Cell Death

Erratum: Preconditioning mediated neuroprotection through erythropoietin? (Lancet (January 12) (96))

Dawson, T. M., May 18 2002, In : The Lancet. 359, 9319, p. 1782 1 p.

Research output: Contribution to journalArticle

Erythropoietin
Neuroprotection

Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

Lee, M. K., Stirling, W., Xu, Y., Xu, E., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A. & Price, D. L., Jun 25 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 13, p. 8968-8973 6 p.

Research output: Contribution to journalArticle

Synucleins
Neurodegenerative Diseases
Transgenic Mice
Parkinson Disease
Mutation

Lack of nitric oxide synthase depresses ion transporting enzyme function in cardiac muscle

Zhou, L., Burnett, A., Huang, P. L., Becker, L., Kuppusamy, P., Kass, D. A., Donahue, J. K., Proud, D., Sham, J., Dawson, T. M. & Xu, K. Y., 2002, In : Biochemical and Biophysical Research Communications. 294, 5, p. 1030-1035 6 p.

Research output: Contribution to journalArticle

Calcium-Transporting ATPases
Sarcoplasmic Reticulum
Nitric Oxide Synthase
Adenosine Triphosphatases
Muscle

Mediation of poty(ADP-ribose) polymerase-1 - Dependent cell death by apoptosis-inducing factor

Yu, S. W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M. & Dawson, V., Jul 12 2002, In : Science. 297, 5579, p. 259-263 5 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Adenosine Diphosphate Ribose
Cell Death
Caspases
Mitochondria

Neuroprotective and neurorestorative strategies for Parkinson's disease

Dawson, T. M. & Dawson, V., Nov 1 2002, In : Nature Neuroscience. 5, SUPPL., p. 1058-1061 4 p.

Research output: Contribution to journalArticle

Parkinson Disease
Cell Death
Therapeutics

Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery

Goto, S., Xue, R., Sugo, N., Sawada, M., Blizzard, K. K., Poitras, M. F., Johns, D. C., Dawson, T. M., Dawson, V., Crain, B. J., Traystman, R. J., Mori, S. & Hurn, P. D., 2002, In : Stroke. 33, 4, p. 1101-1106 6 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Stroke
Middle Cerebral Artery Infarction
Reperfusion
Transfection

Preconditioning-mediated neuroprotection through erythropoietin?

Dawson, T. M., Jan 12 2002, In : The Lancet. 359, 9301, p. 96-97 2 p.

Research output: Contribution to journalArticle

Erythropoietin
Neuroprotection

Role of poly(ADP-Ribose) polymerase-1 in neurologic disorders

Poitras, M. F., Dawson, V. & Dawson, T. M., Jan 1 2002, PARP as a Therapeutic Target. CRC Press, p. 19-38 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Poly(ADP-ribose) Polymerases
Cell death
Nervous System Diseases
Cell Death
Neurons

The genetics of Parkinson's disease.

Lim, K. L., Dawson, V. & Dawson, T. M., Sep 2002, In : Current Neurology and Neuroscience Reports. 2, 5, p. 439-446 8 p.

Research output: Contribution to journalArticle

Inborn Genetic Diseases
Parkinson Disease
Genome
Genes
Genetic Predisposition to Disease

The orphan nuclear receptor, steroidogenic factor 1, regulates neuronal nitric oxide synthase gene expression in pituitary gonadotropes

Wei, X., Sasaki, M., Huang, H., Dawson, V. & Dawson, T. M., Dec 1 2002, In : Molecular Endocrinology. 16, 12, p. 2828-2839 12 p.

Research output: Contribution to journalArticle

Steroidogenic Factor 1
Orphan Nuclear Receptors
Nitric Oxide Synthase Type I
Gene Expression
Nitric Oxide Synthase
2001

Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase

Chiavegatto, S., Dawson, V., Mamounas, L. A., Koliatsos, V. E., Dawson, T. M. & Nelson, R. J., Jan 30 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 3, p. 1277-1281 5 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Aggression
Serotonin
Receptor, Serotonin, 5-HT1B
Nitric Oxide
Ischemic Preconditioning
Nitric Oxide
Drug Tolerance
Protective Agents
Oxidative Phosphorylation

FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle

Aghdasi, B., Ye, K., Resnick, A., Huang, A., Ha, H. C., Guo, X., Dawson, T. M., Dawson, V. & Snyder, S. H., Feb 27 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 5, p. 2425-2430 6 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Protein 1A
Tacrolimus Binding Proteins
Transforming Growth Factors
Growth Factor Receptors
Cell Cycle

Gene therapy to the rescue in Parkinson's disease

Mandir, A. S., Dawson, V. & Dawson, T. M., Mar 1 2001, In : Trends in Pharmacological Sciences. 22, 3, p. 103-105 3 p.

Research output: Contribution to journalArticle

Gene therapy
Genetic Therapy
Parkinson Disease
Glial Cell Line-Derived Neurotrophic Factor
Parkinsonian Disorders
NADPH Dehydrogenase
Nitric Oxide Synthase
Staining and Labeling
Protein Isoforms
Tissue

Identification by mRNA differential display of two up-regulated genes as candidate mediators of AIDS dementia

Wildemann, B., Haas, J., Stingele, K., Storch-Hagenlocher, B., McArthur, J. C., Dawson, T. M. & Dawson, V., 2001, In : Molecular Medicine. 7, 3, p. 193-199 7 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Dementia
Acquired Immunodeficiency Syndrome
Complementary DNA
Genes

Inducible expression of mutant α-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

Tanaka, Y., Engelender, S., Igarashi, S., Rao, R. K., Wanner, T., Tanzi, R. E., Sawa, A., Dawson, V., Dawson, T. M. & Ross, C. A., Apr 15 2001, In : Human Molecular Genetics. 10, 9, p. 919-926 8 p.

Research output: Contribution to journalArticle

Synucleins
Proteasome Endopeptidase Complex
Mitochondria
Apoptosis
Parkinson Disease

Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity

Nucifora, F., Sasaki, M., Peters, M. F., Huang, H., Cooper, J. K., Yamada, M., Takahashi, H., Tsuji, S., Troncoso, J. C., Dawson, V., Dawson, T. M. & Ross, C. A., Mar 23 2001, In : Science. 291, 5512, p. 2423-2428 6 p.

Research output: Contribution to journalArticle

Huntington Disease
CREB-Binding Protein
polyglutamine
atrophin-1
Transgenic Mice
Immunophilins
Dopaminergic Neurons
Mesencephalon
L 685818
Tacrolimus Binding Proteins

Neuroimmunophilins: Novel neuroprotective and neuroregenerative targets

Guo, X., Dillman, J. F., Dawson, V. & Dawson, T. M., 2001, In : Annals of Neurology. 50, 1, p. 6-16 11 p.

Research output: Contribution to journalArticle

Tacrolimus
Immunophilins
Neuroprotective Agents
Cyclosporine
Nervous System Trauma
Poisons
Metabolic Networks and Pathways
Nitric Oxide Synthase
Free Radicals
Blood Vessels

Parkin: Clinical aspects and neurobiology

Zhang, Y., Dawson, V. & Dawson, T. M., Dec 2001, In : Clinical Neuroscience Research. 1, 6, p. 467-482 16 p.

Research output: Contribution to journalArticle

Neurobiology
Ubiquitin-Protein Ligases
Parkinson Disease
Mutation
Ubiquitin

Parkin ubiquitinates the α-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease

Chung, K. K. K., Zhang, Y., Lim, K. L., Tanaka, Y., Huang, H., Gao, J., Ross, C. A., Dawson, V. & Dawson, T. M., 2001, In : Nature Medicine. 7, 10, p. 1144-1150 7 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Bodies
Parkinson Disease
Ubiquitin
Proteins

Reduction of functional N-methyl-D-aspartate receptors in neurons by RNase P-mediated cleavage of the NR1 mRNA

Yen, L., Gonzalez-Zulueta, M., Feldman, A., Yuan, Y., Fryer, H., Dawson, T. M., Dawson, V. & Kalb, R. G., 2001, In : Journal of Neurochemistry. 76, 5, p. 1386-1394 9 p.

Research output: Contribution to journalArticle

Ribonuclease P
N-Methyl-D-Aspartate Receptors
Neurons
Messenger RNA
Guide RNA
Ubiquitin
Neurodegenerative Diseases
Parkinson Disease
Poisons
Proteins
2000

Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism

Sasaki, M., Gonzalez-Zulueta, M., Huang, H., Herring, W. J., Ahn, S., Ginty, D. D., Dawson, V. & Dawson, T. M., Jul 18 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 15, p. 8617-8622 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Response Elements
Transcription Factors
Calcium
Exons

Neuronal ischaemic preconditioning [2]

Dawson, V. & Dawson, T. M., Nov 1 2000, In : Trends in Pharmacological Sciences. 21, 11, p. 423-424 2 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Neurons
Rats
Animals

New animal models for Parkinson's disease

Dawson, T. M., Apr 14 2000, In : Cell. 101, 2, p. 115-118 4 p.

Research output: Contribution to journalArticle

Animals

NMDA but not non-NMDA excitotoxicity is mediated by poly(ADP-ribose) polymerase

Mandir, A. S., Poitras, M. F., Berliner, A. R., Herring, W. J., Guastella, D. B., Feldman, A., Poirier, G. G., Wang, Z. Q., Dawson, T. M. & Dawson, V., Nov 1 2000, In : Journal of Neuroscience. 20, 21, p. 8005-8011 7 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
N-Methylaspartate
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
DNA Repair Enzymes
Excitatory Amino Acid Agonists

Oxidative stress and genetics in the pathogenesis of parkinson's disease

Zhang, Y., Dawson, V. & Dawson, T. M., 2000, In : Neurobiology of Disease. 7, 4, p. 240-250 11 p.

Research output: Contribution to journalArticle

Parkinson Disease
Oxidative Stress
Mutation
Secondary Parkinson Disease
Synucleins
Ubiquitin-Protein Ligases
Synaptic Vesicles
Fingers
Parkinsonian Disorders
Mutation

Parkinson's disease: Clinical manifestations and treatment

Dawson, T. M., 2000, In : International Review of Psychiatry. 12, 4, p. 263-269 7 p.

Research output: Contribution to journalArticle

Parkinson Disease
Therapeutics
Parkinsonian Disorders
Pallidotomy
Hypokinesia

Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning

Gonzalez-Zulueta, M., Feldman, A. B., Klesse, L. J., Kalb, R. G., Dillman, J. F., Parada, L. F., Dawson, T. M. & Dawson, V., Jan 4 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 1, p. 436-441 6 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins p21(ras)
Ischemic Preconditioning
Nitric Oxide
Phosphotransferases
Oxygen

Role of poly(ADP-ribose) polymerase mediating acute and chronic neuronal injury and neurodegeneration

Dawson, V. & Dawson, T. M., Jan 1 2000, Cell Death: The Role of Poly (ADP-ribose) Polymerase. CRC Press, p. 23-39 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Poly(ADP-ribose) Polymerases
Neurology
Cell death
Cell Death
Tissue

Stroke outcome in double-mutant antioxidant transgenic mice

Sampei, K., Mandir, A. S., Asano, Y., Wong, P. C., Traystman, R. J., Dawson, V., Dawson, T. M. & Hurn, P. D., 2000, In : Stroke. 31, 11, p. 2685-2691 7 p.

Research output: Contribution to journalArticle

Transgenic Mice
Antioxidants
Stroke
Nitric Oxide Synthase
Superoxides
1999

Circadian locomotor analysis of male mice lacking the gene for neuronal nitric oxide synthase (nNOS-/-)

Kriegsfeld, L. J., Demas, G. E., Lee, S. E., Dawson, T. M., Dawson, V. & Nelson, R. J., Feb 1999, In : Journal of Biological Rhythms. 14, 1, p. 20-27 8 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Suprachiasmatic Nucleus
nitric oxide
Nitric Oxide
Nitric Oxide Synthase
biological rhythms
mice
genes
neuronal nitric oxide synthase