Ted M Dawson

Professor

1983 …2019
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Research Output 1983 2019

2005

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin

Sriram, S. R., Li, X., Ko, H. S., Chung, K. K. K., Wong, E., Lim, K. L., Dawson, V. & Dawson, T. M., Sep 1 2005, In : Human Molecular Genetics. 14, 17, p. 2571-2586 16 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitination
Solubility
Mutation
Parkinson Disease

Genetics of parkinson’s disease

Sriram, S. R., Dawson, V. & Dawson, T. M., Jan 1 2005, Neurogenetics: Scientific and Clinical Advances. CRC Press, p. 621-641 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Molecular Medicine
Cell Engineering
Baltimore
Inborn Genetic Diseases
Neurology
Gene Library
Nitric Oxide
Genes
Gene Expression
Gene expression

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

Smith, W., Pei, Z., Jiang, H., Moore, D. J., Liang, Y., West, A. B., Dawson, V., Dawson, T. M. & Ross, C. A., Dec 20 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 51, p. 18676-18681 6 p.

Research output: Contribution to journalArticle

Leucine
Phosphotransferases
Parkinson Disease
Synucleins
Proteins

Mediation of cell death by poly(ADP-ribose) polymerase-1

Koh, D. W., Dawson, T. M. & Dawson, V., Jul 2005, In : Pharmacological Research. 52, 1 SPEC. ISS., p. 5-14 10 p.

Research output: Contribution to journalArticle

Cell Death
Adenosine Diphosphate
Apoptosis Inducing Factor
Poly Adenosine Diphosphate Ribose
Caspases

Mitochondrial localization of the Parkinson's disease related protein DJ-1: Implications for pathogenesis

Zhang, L., Shimoji, M., Thomas, B., Moore, D. J., Yu, S. W., Marupudi, N. I., Torp, R., Torgner, I. A., Ottersen, O. P., Dawson, T. M. & Dawson, V., Jul 15 2005, In : Human Molecular Genetics. 14, 14, p. 2063-2073 11 p.

Research output: Contribution to journalArticle

Neuroblastoma
Parkinson Disease
Mitochondria
Cell Fractionation
Mutation

Molecular pathophysiology of Parkinson's disease

Moore, D. J., West, A. B., Dawson, V. & Dawson, T. M., 2005, In : Annual Review of Neuroscience. 28, p. 57-87 31 p.

Research output: Contribution to journalArticle

Parkinson Disease
Dopaminergic Neurons
Movement Disorders
Genetic Association Studies
Substantia Nigra

Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons

Son, J. H., Kawamata, H., Yoo, M. S., Kim, D. J., Lee, Y. K., Kim, S. Y., Dawson, T. M., Zhang, H., Sulzer, D., Yang, L., Beal, M. F., Degiorgio, L. A., Chun, H. S., Baker, H. & Peng, C., Aug 2005, In : Journal of Neurochemistry. 94, 4, p. 1040-1053 14 p.

Research output: Contribution to journalArticle

Septins
Dopaminergic Neurons
Neurons
Substantia Nigra
Corpus Striatum

Nitric oxide, S-nitrosylation and neurodegeneration

Chung, K. K. K., Dawson, T. M. & Dawson, V., Sep 5 2005, In : Cellular and molecular biology (Noisy-le-Grand, France). 51, 3, p. 247-254 8 p.

Research output: Contribution to journalArticle

Nitric Oxide
Oxidative stress
Oxidative Stress
Biological Phenomena
Molecules

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: Implications for lewy body formation

Kah, L. L., Chew, K. C. M., Tan, J. M. M., Wang, C., Chung, K. K. K., Zhang, Y., Tanaka, Y., Smith, W., Engelender, S., Ross, C. A., Dawson, V. & Dawson, T. M., Feb 23 2005, In : Journal of Neuroscience. 25, 8, p. 2002-2009 8 p.

Research output: Contribution to journalArticle

Lewy Bodies
Ubiquitination
Ubiquitin
Ligases
Lysine

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

West, A. B., Moore, D. J., Biskup, S., Bugayenko, A., Smith, W., Ross, C. A., Dawson, V. & Dawson, T. M., Nov 15 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 46, p. 16842-16847 6 p.

Research output: Contribution to journalArticle

Leucine
Parkinson Disease
Phosphotransferases
Mutation
Genes

Poly(ADP-ribosyl)ation regulation of life and death in the nervous system

Koh, D. W., Dawson, T. M. & Dawson, V., Apr 2005, In : Cellular and Molecular Life Sciences. 62, 7-8, p. 760-768 9 p.

Research output: Contribution to journalArticle

Neurology
Cell death
Adenosine Diphosphate
Nervous System
Cell Death

Recent advances in our understanding of Parkinson's disease

Kim, S. W., Ko, H. S., Dawson, V. & Dawson, T. M., 2005, In : Drug Discovery Today: Disease Mechanisms. 2, 4, p. 427-433 7 p.

Research output: Contribution to journalArticle

Parkinson Disease
Protein Folding
Ubiquitin
Neurodegenerative Diseases
Proteolysis

S-nitrosylation in Parkinson's disease and related neurodegenerative disorders

Chung, K. K. K., Dawson, V. & Dawson, T. M., 2005, In : Methods in Enzymology. 396, p. 139-150 12 p.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Parkinson Disease
Nitric Oxide
Oxidative stress
Oxidative Stress

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

Wang, C., Ko, H. S., Thomas, B., Tsang, F., Chew, K. C. M., Tay, S. P., Ho, M. W. L., Lim, T. M., Soong, T. W., Pletnikova, O., Troncoso, J. C., Dawson, V., Dawson, T. M. & Lim, K. L., Dec 15 2005, In : Human Molecular Genetics. 14, 24, p. 3885-3897 13 p.

Research output: Contribution to journalArticle

Solubility
Parkinson Disease
Mutation
Dopamine
Brain

The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin

Yu, W. P., Tan, J. M. M., Chew, K. C. M., Oh, T., Kolatkar, P., Venkatesh, B., Dawson, T. M. & Lim, K. L., Feb 14 2005, In : Gene. 346, p. 97-104 8 p.

Research output: Contribution to journalArticle

Takifugu
Genes
Tetraodontiformes
Parkinsonian Disorders
Human Genome

The involvement of nitric oxide in the enhanced expression of μ-opioid receptors during intestinal inflammation in mice

Pol, O., Sasaki, M., Jiménez, N., Dawson, V., Dawson, T. M. & Puig, M. M., Jul 2005, In : British Journal of Pharmacology. 145, 6, p. 758-766 9 p.

Research output: Contribution to journalArticle

Opioid Receptors
Nitric Oxide
Inflammation
Gastrointestinal Transit
Morphine

The road to survival goes through PARG

Koh, D. W., Dawson, V. & Dawson, T. M., Mar 2005, In : Cell cycle (Georgetown, Tex.). 4, 3, p. 397-399 3 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerases
poly ADP-ribose glycohydrolase
Genes
Maintenance

To die or grow: Parkinson's disease and cancer

West, A. B., Dawson, V. & Dawson, T. M., Jul 2005, In : Trends in Neurosciences. 28, 7, p. 348-352 5 p.

Research output: Contribution to journalArticle

Parkinson Disease
Neoplasms
Genes
Proteasome Endopeptidase Complex
Ubiquitin

α-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells

Smith, W., Margolis, R. L., Li, X., Troncoso, J. C., Lee, M. K., Dawson, V., Dawson, T. M., Iwatsubo, T. & Ross, C. A., Jun 8 2005, In : Journal of Neuroscience. 25, 23, p. 5544-5552 9 p.

Research output: Contribution to journalArticle

Synucleins
Inclusion Bodies
Phosphorylation
Lewy Bodies
Parkinson Disease
2004

Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death

Wang, H., Yu, S. W., Koh, D. W., Lew, J., Coombs, C., Bowers, W., Federoff, H. J., Poirier, G. G., Dawson, T. M. & Dawson, V., Dec 1 2004, In : Journal of Neuroscience. 24, 48, p. 10963-10973 11 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
N-Methylaspartate
Caspases
Caspase Inhibitors
Phosphatidylserines

Astroglia Induce Cytotoxic Effects on Brain Tumors via a Nitric Oxide-dependent Pathway Both in Vitro and in Vivo

Samdani, A. F., Kuchner, E. B., Rhines, L., Adamson, D. C., Lawson, C., Tyler, B. M., Brem, H., Dawson, V., Dawson, T. M., Piepmeier, J. M., Parsa, A. T., Lichtor, T., Glick, R. P. & Westphal, M., May 2004, In : Neurosurgery. 54, 5, p. 1231-1238 8 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Astrocytes
Nitric Oxide
Cytokines
Tumor Cell Line

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

Petrucelli, L., Dickson, D., Kehoe, K., Taylor, J., Snyder, H., Grover, A., De Lucia, M., McGowan, E., Lewis, J., Prihar, G., Kim, J., Dillmann, W. H., Browne, S. E., Hall, A., Voellmy, R., Tsuboi, Y., Dawson, T. M., Wolozin, B., Hardy, J. & Hutton, M., Apr 1 2004, In : Human Molecular Genetics. 13, 7, p. 703-714 12 p.

Research output: Contribution to journalArticle

Ubiquitination
Ligases
Ubiquitin
Synucleins
Tauopathies

Cortical interneurons become activated by deafferentation and instruct the apoptosis of pyramidal neurons

Koliatsos, V. E., Dawson, T. M., Kecojevic, A., Zhou, Y., Wang, Y. F. & Huang, K. X., Sep 28 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 39, p. 14264-14269 6 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Interneurons
Apoptosis
Neurons
Peripheral Nervous System

Deadly conversations: Nuclear-mitochondrial cross-talk

Dawson, V. & Dawson, T. M., Aug 2004, In : Journal of Bioenergetics and Biomembranes. 36, 4 SPEC.ISS., p. 287-294 8 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Mitochondria
Peroxynitrous Acid
Caspase Inhibitors
Caspases

Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality

Koh, D. W., Lawler, A. M., Poitras, M. F., Sasaki, M., Wattler, S., Nehls, M. C., Stöger, T., Poirier, G. G., Dawson, V. & Dawson, T. M., Dec 21 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 51, p. 17699-17704 6 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
DNA Damage
Vitamin K 3
Methylnitronitrosoguanidine
Genomic Instability

Identification and analysis of plasticity-induced late-response genes

Hong, S. J., Li, H., Becker, K. G., Dawson, V. & Dawson, T. M., Feb 17 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 7, p. 2145-2150 6 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Genes
Drug Tolerance
Ischemic Preconditioning
N-Methylaspartate
Libraries
Nitric Oxide
Genes
Neurons
Proteins

Intracellular Signaling: Mediators and Protective Responses

Dawson, V. & Dawson, T. M., Mar 19 2004, Stroke: Pathophysiology, Diagnosis, and Management. Elsevier Inc., p. 895-902 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Levodopa and the progression of parkinson’s disease

The parkinson study group, Dec 9 2004, In : New England Journal of Medicine. 351, 24, p. 2498-2508 11 p.

Research output: Contribution to journalArticle

Levodopa
Parkinson Disease
Placebos
Dopamine Plasma Membrane Transport Proteins
Neuroimaging

Loss of locus coeruleus neurons and reduced startle in parkin null mice

Von Coelln, R., Thomas, B., Savitt, J. M., Lim, K. L., Sasaki, M., Hess, E. J., Dawson, V. & Dawson, T. M., Jul 20 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 29, p. 10744-10749 6 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Parkinsonian Disorders
Parkinson Disease
Neurons
Mutation

Mechanism of neurodegenerative disease: Role of the ubiquitin proteasome system

Petrucelli, L. & Dawson, T. M., 2004, In : Annals of Medicine. 36, 4, p. 315-320 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Neurodegenerative Diseases
Poisons
Parkinson Disease

Neuroprotective agents for clinical trials in Parkinson's disease: A systematic assessment [1] (multiple letters)

Diguet, E., Gross, C. E., Bezard, E., Tison, F., Stefanova, N., Wenning, G. K., Ravina, B., Fagan, S., Hart, R., Hovinga, C., Murphy, D., Dawson, T. M. & Marler, J., Jan 13 2004, In : Neurology. 62, 1, p. 158-159 2 p.

Research output: Contribution to journalArticle

NO parkin in Parkinson's disease [5] (multiple letters)

Lancaster, J. R., Chung, K. K. K., Dawson, V. & Dawson, T. M., Jun 25 2004, In : Science. 304, 5679, p. 1905 1 p.

Research output: Contribution to journalArticle

MPTP Poisoning
S-Nitrosoglutathione
Ubiquitin-Protein Ligases
Nitric Oxide Donors
Parkinson Disease

Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling

Hong, S. J., Dawson, T. M. & Dawson, V., May 2004, In : Trends in Pharmacological Sciences. 25, 5, p. 259-264 6 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Poly(ADP-ribose) Polymerases
Cell death
Cell Death
Mitochondria

Parkin and Hsp70 sacked by BAG5

Chung, K. K. K. & Dawson, T. M., Dec 16 2004, In : Neuron. 44, 6, p. 899-901 3 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Parkinson Disease
Dopaminergic Neurons
Neurons
Mutation

Parkin-associated Parkinson's disease

Von Coelln, R., Dawson, V. & Dawson, T. M., Oct 2004, In : Cell and Tissue Research. 318, 1, p. 175-184 10 p.

Research output: Contribution to journalArticle

Parkinsonian Disorders
Parkinson Disease
Ubiquitin-Protein Ligases
Ligases
Ubiquitin

PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury

Hagberg, H., Wilson, M. A. A., Matsushita, H., Zhu, C., Lange, M., Gustavsson, M., Poitras, M. F., Dawson, T. M., Dawson, V., Northington, F. & Johnston, M. V., Sep 2004, In : Journal of Neurochemistry. 90, 5, p. 1068-1075 8 p.

Research output: Contribution to journalArticle

Brain Injuries
Brain
Ischemia
Genes
Poly(ADP-ribose) Polymerases

Psychiatric comorbidities in patients with Parkinson disease and psychosis

Marsh, L., Williams, J. R., Rocco, M., Grill, S., Munro, C. & Dawson, T. M., Jul 27 2004, In : Neurology. 63, 2, p. 293-300 8 p.

Research output: Contribution to journalArticle

Psychotic Disorders
Parkinson Disease
Psychiatry
Comorbidity
Caregivers

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

Chung, K. K. K., Thomas, B., Li, X., Pletnikova, O., Troncoso, J. C., Marsh, L., Dawson, V. & Dawson, T. M., May 28 2004, In : Science. 304, 5675, p. 1328-1331 4 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitination
Parkinson Disease
Lewy Body Disease
Dopaminergic Neurons

What have genetically engineered mice taught us about ischemic injury?

Liang, D., Dawson, T. M. & Dawson, V., Mar 2004, In : Current Molecular Medicine. 4, 2, p. 207-225 19 p.

Research output: Contribution to journalArticle

Brain
Stroke
Wounds and Injuries
Western World
Genetically Modified Animals
2003

37-kDa laminin receptor precursor modulates cytotoxic necrotizing factor 1-mediated RhoA activation and bacterial uptake

Chung, J. W., Hong, S. J., Kim, K. J., Goti, D., Stins, M., Shin, S., Dawson, V., Dawson, T. M. & Kim, K. S., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16857-16862 6 p.

Research output: Contribution to journalArticle

Laminin Receptors
Chemical activation
rho GTP-Binding Proteins
Endothelial cells
Eukaryotic Cells
Oligomerization
Protein Stability
Missense Mutation
Parkinson Disease
Mutation

Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease

Wang, H., Shimoji, M., Yu, S. W., Dawson, T. M. & Dawson, V., 2003, In : Annals of the New York Academy of Sciences. 991, p. 132-139 8 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Poly(ADP-ribose) Polymerases
Parkinson Disease
Cell death
Chemical activation

BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development

Fannjiang, Y., Kim, C. H., Huganir, R. L., Zou, S., Lindsten, T., Thompson, C. B., Mito, T., Traystman, R. J., Larsen, T., Griffin, D., Mandir, A. S., Dawson, T. M., Dike, S., Sappington, A. L., Kerr, D. A., Jonas, E. A., Kaczmarek, L. K. & Hardwick, J. M., Apr 1 2003, In : Developmental Cell. 4, 4, p. 575-585 11 p.

Research output: Contribution to journalArticle

Neurons
Viruses
Switches
Cell death
Virus Diseases

Caught in the act: α-synuclein is the culprit in Parkinson's disease

Eriksen, J. L., Dawson, T. M., Dickson, D. W. & Petrucelli, L., Oct 30 2003, In : Neuron. 40, 3, p. 453-456 4 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Poisons
Pedigree
Proteins

Genetics of Parkinson's disease: What do mutations in DJ-1 tell us?

Moore, D. J., Dawson, V. & Dawson, T. M., Sep 1 2003, In : Annals of Neurology. 54, 3, p. 281-282 2 p.

Research output: Contribution to journalArticle

Intracellular Signaling Peptides and Proteins
Inborn Genetic Diseases
Oncogene Proteins
Age of Onset
Parkinson Disease

Molecular Pathways of Neurodegeneration in Parkinson's Disease

Dawson, T. M. & Dawson, V., Oct 31 2003, In : Science. 302, 5646, p. 819-822 4 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Dopaminergic Neurons
Neuroprotective Agents
Ubiquitin-Protein Ligases

Neuroprotective agents for clinical trials in Parkinson's disease: A systematic assessment

Ravina, B. M., Fagan, S. C., Hart, R. G., Hovinga, C. A., Murphy, D. D., Dawson, T. M. & Marler, J. R., Apr 22 2003, In : Neurology. 60, 8, p. 1234-1240 7 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Parkinson Disease
Clinical Trials
Drug Evaluation
Blood-Brain Barrier

New insights into Parkinson's disease

Chung, K. K. K., Dawson, V. & Dawson, T. M., Oct 2003, In : Journal of Neurology, Supplement. 250, 3, p. 15-24 10 p.

Research output: Contribution to journalArticle

Parkinson Disease
Mutation
Synucleins
Inborn Genetic Diseases
Ubiquitin