Ted M Dawson

Professor

1983 …2019
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Research Output 1983 2019

2007

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

Andres-Mateos, E., Perier, C., Zhang, L., Blanchard-Fillion, B., Greco, T. M., Thomas, B., Ko, H. S., Sasaki, M., Ischiropoulos, H., Przedborski, S., Dawson, T. M. & Dawson, V., Sep 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 37, p. 14807-14812 6 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Gene Deletion
Knockout Mice
Peroxidase
Movement Disorders

Dynamic and redundant regulation of LRRK2 and LRRK1 expression

Biskup, S., Moore, D. J., Rea, A., Lorenz-Deperieux, B., Coombes, C. E., Dawson, V., Dawson, T. M. & West, A. B., Nov 28 2007, In : BMC Neuroscience. 8, 102.

Research output: Contribution to journalArticle

Leucine
Phosphotransferases
Antibodies
Protein Kinases
Proteins

Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain

Higashi, S., Moore, D. J., Colebrooke, R. E., Biskup, S., Dawson, V., Arai, H., Dawson, T. M. & Emson, P. C., Jan 2007, In : Journal of Neurochemistry. 100, 2, p. 368-381 14 p.

Research output: Contribution to journalArticle

Leucine
Parkinson Disease
Brain
Phosphotransferases
Prosencephalon

Influence of duration of focal cerebral ischemia and neuronal nitric oxide synthase on translocation of apoptosis-inducing factor to the nucleus

Li, X., Nemoto, M., Xu, Z., Yu, S. W., Shimoji, M., Andrabi, S. A., Haince, J. F., Poirier, G. G., Dawson, T. M., Dawson, V. & Koehler, R. C., Jan 5 2007, In : Neuroscience. 144, 1, p. 56-65 10 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Nitric Oxide Synthase Type I
Brain Ischemia
Reperfusion
Ischemia

Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain

Higashi, S., Biskup, S., West, A. B., Trinkaus, D., Dawson, V., Faull, R. L. M., Waldvogel, H. J., Arai, H., Dawson, T. M., Moore, D. J. & Emson, P. C., Jun 25 2007, In : Brain Research. 1155, 1, p. 208-219 12 p.

Research output: Contribution to journalArticle

Parkinson Disease
Lewy Bodies
Brain
Lewy Body Disease
Putamen

MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity

Thomas, B., von Coelln, R., Mandir, A. S., Trinkaus, D. B., Farah, M. H., Leong Lim, K., Calingasan, N. Y., Flint Beal, M., Dawson, V. & Dawson, T. M., May 2007, In : Neurobiology of Disease. 26, 2, p. 312-322 11 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Locus Coeruleus
Neurotoxins
Substantia Nigra
Knockout Mice

Neurobiology of AIF and PARP in cerebral ischemia

Koh, D. W., Dawson, T. M. & Dawson, V., 2007, Handbook of Neurochemistry and Molecular Neurobiology: Acute Ischemic Injury and Repair in the Nervous System. Springer US, p. 19-31 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Apoptosis Inducing Factor
Neurobiology
Cell death
Brain Ischemia
Cell Death

Parkin and Neurodegeneration

Sriram, S. R., Dawson, V. & Dawson, T. M., Dec 14 2007, Protein Degradation. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 4. p. 211-236 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteolysis

Parkin and Neurodegeneration

Sriram, S. R., Dawson, V. & Dawson, T. M., Dec 13 2007, Protein Degradation. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 4. p. 211-236 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteolysis

Parkinson Disease: Molecular Insights

Savitt, J. M., Dawson, V. & Dawson, T. M., 2007, Molecular Neurology. Elsevier Inc., p. 221-239 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Parkinson Disease

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

West, A. B., Moore, D. J., Choi, C., Andrabi, S. A., Li, X., Dikeman, D., Biskup, S., Zhang, Z., Lim, K. L., Dawson, V. & Dawson, T. M., Jan 15 2007, In : Human Molecular Genetics. 16, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

Guanosine Triphosphate
Leucine
Parkinson Disease
Phosphotransferases
Mutation

Parkinson's disease genetic mutations increase cell susceptibility to stress: Mutant α-synuclein enhances H2O2- and Sin-1-induced cell death

Jiang, H., Wu, Y. C., Nakamura, M., Liang, Y., Tanaka, Y., Holmes, S., Dawson, V., Dawson, T. M., Ross, C. A. & Smith, W., Nov 2007, In : Neurobiology of Aging. 28, 11, p. 1709-1717 9 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Cell Death
Mutation
Lewy Bodies

Parkinson’s disease: Genetics and pathogenesis

Dawson, T. M., Jan 1 2007, CRC Press. 386 p.

Research output: Book/ReportBook

Parkinson Disease
Therapeutic Human Experimentation
Theoretical Models
Genes
Research

Predictors of diagnosis in Huntington disease

Langbehn, D. R., Paulsen, J. S., Hedges, P., McCusker, E., Pearce, S., Trent, R., Abwender, D., Como, P., Gardiner, I., Hickey, C., Kayson, E., Kieburtz, K., Marshall, F., Pearson, N., Shoulson, I., Zimmerman, C., Louis, E., Marder, K., Moskowitz, C., Polanco, C. & 101 others, Taylor, S., Zubin, N., Brown, C., Burke-Holder, J., Guttman, M., Russell, S., Stewart, D., Thomson, J., Sax, D. S., Saint-Hilaire, M., Gray, J., Hunter, C., Mercado, N., Siemers, E., Wojcieszek, J., Dawson, T. M., Leritz, E., Rosenblatt, A., Sherr, M., Young, C., Ashizawa, T., Beach, J., Jankovic, J., Jaglin, J., Shannon, K., Lundin, A., Francis, K., Lane, K., Auchus, A., Greenamyre, J. T., Hersch, S., Jones, R., Olson, D., Cha, J. H. J., Cudkowicz, M., Koroshetz, W., Rudolf, G., Sexton, P., Young, A. B., Albin, R., Wernette, K., Higgins, D. S., Reider, C., Hunt, V., Walker, F., Hauser, R., Sanchez-Ramos, J., Walker, A., Nance, M., Cleary, S., Rohs, G., Suchowersky, O., Duncan, K., Seeberger, L., Corey-Bloom, J., Swenson, M., Swerdlow, N., Paulson, H., Rodnitzky, R., Vining, L., Martin, W., Wieler, M., Facca, A., Rey, G., Weiner, W., Adler, C., Caviness, J., Lied, C., Newman, S., Feigin, A., Mazurkiewicz, J., Caplan, K., Cellar, J., Marek, K., Hayden, M., Raymond, L., Dure, L. S., Lane, J., Brown, D., Factor, S., Molho, E., Harrison, M., Manning, C., Rost-Ruffner, E., Adams, J., Cummings, R., Wheelock, V., Dubinsky, R., Gray, C., Catherine Bachoud-Levi, A., Meierkord, H., Friedman, J., Lannon, M., Lawrence, J., Rubin, A., Schwarz, R., Brocht, A., Claude, K., Goldstein, J., McDermott, M. & Oakes, D., May 2007, In : Neurology. 68, 20, p. 1710-1717 8 p.

Research output: Contribution to journalArticle

Huntington Disease
Signs and Symptoms
Neuropsychological Tests
Movement Disorders
Survival Analysis

Preface

Dawson, T. M., Jan 1 2007, Parkinson's Disease: Genetics and Pathogenesis. CRC Press, p. ix

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

Wong, E. S. P., Tan, J. M. M., Wang, C., Zhang, Z., Tay, S. P., Zaiden, N., Ko, H. S., Dawson, V., Dawson, T. M. & Lim, K. L., Apr 20 2007, In : Journal of Biological Chemistry. 282, 16, p. 12310-12318 9 p.

Research output: Contribution to journalArticle

Solubility
Cysteine
Dopamine
Parkinson Disease
Enzymes

Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain

Poitras, M. F., Koh, D. W., Yu, S. W., Andrabi, S. A., Mandir, A. S., Poirier, G. G., Dawson, V. & Dawson, T. M., Aug 10 2007, In : Neuroscience. 148, 1, p. 198-211 14 p.

Research output: Contribution to journalArticle

Brain
Poly(ADP-ribose) Polymerases
poly ADP-ribose glycohydrolase
Poly (ADP-Ribose) Polymerase-1
NAD

The role of PARKIN in parkinson’s disease

West, A. B., Dawson, V. & Dawson, T. M., Jan 1 2007, Parkinson's Disease: Genetics and Pathogenesis. CRC Press, p. 199-218 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Parkinson Disease
Glossopharyngeal Nerve
Hypokinesia
Dopaminergic Neurons
Neocortex

The Role of Stem Cells in Parkinson's Disease

Gupta, A. & Dawson, T. M., Jan 2007, In : Neurosurgery Clinics of North America. 18, 1, p. 129-142 14 p.

Research output: Contribution to journalArticle

Parkinson Disease
Stem Cells
Cell- and Tissue-Based Therapy
Hand
Ethics

The roles of kinases in familial Parkinson's disease

Cookson, M. R., Dauer, W., Dawson, T. M., Fon, E. A., Guo, M. & Shen, J., Oct 31 2007, In : Journal of Neuroscience. 27, 44, p. 11865-11868 4 p.

Research output: Contribution to journalArticle

Parkinson Disease
Phosphotransferases
Leucine
Mutation
Phosphoric Monoester Hydrolases

Unraveling the role of defective genes in Parkinson's disease

Dawson, T. M., 2007, In : Parkinsonism and Related Disorders. 13, SUPPL. 3

Research output: Contribution to journalArticle

Parkinson Disease
Genes
Hypokinesia
Dopaminergic Neurons
Tremor
2006

A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons

Riccio, A., Alvania, R. S., Lonze, B. E., Ramanan, N., Kim, T., Huang, Y., Dawson, T. M., Snyder, S. H. & Ginty, D. D., Jan 20 2006, In : Molecular Cell. 21, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Nitric Oxide
Phosphorylation
Gene Expression
Neurons

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

Yu, S. W., Andrabi, S. A., Wang, H., No, S. K., Poirier, G. G., Dawson, T. M. & Dawson, V., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18314-18319 6 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Poly Adenosine Diphosphate Ribose
Polymers
Cell Death
Glycoside Hydrolases

A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease

The NINDS NET-PD Investigators, 2006, In : Neurology. 66, 5, p. 664-671 8 p.

Research output: Contribution to journalArticle

Medical Futility
Minocycline
Creatine
Parkinson Disease
Clinical Trials

Diagnosis and treatment of Parkinson disease: Molecules to medicine

Savitt, J. M., Dawson, V. & Dawson, T. M., Jul 3 2006, In : Journal of Clinical Investigation. 116, 7, p. 1744-1754 11 p.

Research output: Contribution to journalArticle

Parkinson Disease
Medicine
Therapeutics
Dopamine
Modern 1601-history

EndoG is dispensable in embryogenesis and apoptosis

David, K. K., Sasaki, M., Yu, S. W., Dawson, T. M. & Dawson, V., Jul 2006, In : Cell Death and Differentiation. 13, 7, p. 1147-1155 9 p.

Research output: Contribution to journalArticle

Embryonic Development
Apoptosis
Cell Death
DNA Fragmentation
Gene Targeting

Identification of far upstream element-binding protein-1 as an authentic Parkin substrate

Ko, H. S., Seong, W. K., Sriram, S. R., Dawson, V. & Dawson, T. M., Jun 16 2006, In : Journal of Biological Chemistry. 281, 24, p. 16193-16196 4 p.

Research output: Contribution to journalArticle

Carrier Proteins
Amino Acyl-tRNA Synthetases
Parkinson Disease
Substrates
Parkinsonian Disorders

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of α-synucleinopathy

Von Coelln, R., Thomas, B., Andrabi, S. A., Kah, L. L., Savitt, J. M., Saffary, R., Stirling, W., Bruno, K., Hess, E. J., Lee, M. K., Dawson, V. & Dawson, T. M., Apr 5 2006, In : Journal of Neuroscience. 26, 14, p. 3685-3696 12 p.

Research output: Contribution to journalArticle

Synucleins
Inclusion Bodies
Lewy Bodies
Parkinson Disease
Ubiquitin-Protein Ligases

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Smith, W., Pei, Z., Jiang, H., Dawson, V., Dawson, T. M. & Ross, C. A., Oct 2006, In : Nature Neuroscience. 9, 10, p. 1231-1233 3 p.

Research output: Contribution to journalArticle

Leucine
Phosphotransferases
Parkinson Disease
GTP Phosphohydrolases
Guanosine Triphosphate

Lessons from Drosophila models of DJ-1 deficiency.

Moore, D. J., Dawson, V. & Dawson, T. M., 2006, In : Science of aging knowledge environment : SAGE KE. 2006, 2

Research output: Contribution to journalArticle

Drosophila
Phenotype
Nerve Degeneration
Molecular Chaperones
Parkinsonian Disorders

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

Biskup, S., Moore, D. J., Celsi, F., Higashi, S., West, A. B., Andrabi, S. A., Kurkinen, K., Yu, S. W., Savitt, J. M., Waldvogel, H. J., Faull, R. L. M., Emson, P. C., Torp, R., Ottersen, O. P., Dawson, T. M. & Dawson, V., Nov 2006, In : Annals of Neurology. 60, 5, p. 557-569 13 p.

Research output: Contribution to journalArticle

Leucine
Phosphotransferases
Brain
Lysosomes
Mitochondria

Mining for survival genes

Dawson, V. & Dawson, T. M., 2006, In : Biochemical Society Transactions. 34, 6, p. 1307-1309 3 p.

Research output: Contribution to journalArticle

Neurology
Brain
Animals
Animal Models
Genes

Neuroprotection by pharmacologic blockade of the GAPDH death cascade

Hara, M. R., Thomas, B., Cascio, M. B., Bae, B. I., Hester, L. D., Dawson, V., Dawson, T. M., Sawa, A. & Snyder, S. H., Mar 7 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 10, p. 3887-3889 3 p.

Research output: Contribution to journalArticle

Glyceraldehyde-3-Phosphate Dehydrogenases
Selegiline
Dopamine
Cell Death
Corpus Striatum

Parkin and defective ubiquitination in Parkinson's disease

Dawson, T. M., 2006, In : Journal of Neural Transmission, Supplement. 70, p. 209-213 5 p.

Research output: Contribution to journalArticle

Ubiquitination
Lewy Bodies
alpha-Synuclein
Parkinson Disease
Dopaminergic Neurons

Parkin Blushed by PINK1

Tan, J. M. M. & Dawson, T. M., May 18 2006, In : Neuron. 50, 4, p. 527-529 3 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Dopaminergic Neurons
Male Infertility
Drosophila
Parkinson Disease
Ubiquitin
Lysine
Ubiquitination
Parkinson Disease
Synucleins

Poly(ADP-ribose) (PAR) polymer is a signal

Andrabi, S. A., No, S. K., Yu, S. W., Wang, H., Koh, D. W., Sasaki, M., Klaus, J. A., Otsuka, T., Zhang, Z., Koehler, R. C., Hurn, P. D., Poirier, G. G., Dawson, V. & Dawson, T. M., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18308-18313 6 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Polymers
Cell Death
N-Methylaspartate
Ischemia

Role of nitric oxide in Parkinson's disease

Zhang, L., Dawson, V. & Dawson, T. M., Jan 2006, In : Pharmacology and Therapeutics. 109, 1-2, p. 33-41 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Nitric Oxide
Neurodegenerative Diseases
Nervous System
DNA Damage

Taming the clot-buster tPA

Dawson, T. M. & Dawson, V., Sep 2006, In : Nature Medicine. 12, 9, p. 993-994 2 p.

Research output: Contribution to journalArticle

Tissue Plasminogen Activator
Thrombosis
Blood
Stroke
Hemorrhage

Ubiquitination by Parkin - Implications in Parkinson's disease

Ravichandran, S., Dawson, T. M. & Dawson, V., 2006, The Proteasome in Neurodegeneration. Springer US, p. 213-224 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ubiquitination
Parkinson Disease
Lewy Bodies
Poisons
Substantia Nigra
2005

Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease

Shimoji, M., Zhang, L., Mandir, A. S., Dawson, V. & Dawson, T. M., Mar 24 2005, In : Molecular Brain Research. 134, 1, p. 103-108 6 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Inclusion Bodies
Parkinson Disease
Synucleins
Probenecid

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death

Ko, H. S., Von Coelln, R., Sriram, S. R., Kim, S. W., Chung, K. K. K., Pletnikova, O., Troncoso, J. C., Johnson, B., Saffary, R., Goh, E. L., Song, H., Park, B. J., Kim, M. J., Kim, S., Dawson, V. & Dawson, T. M., Aug 31 2005, In : Journal of Neuroscience. 25, 35, p. 7968-7978 11 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Parkinsonian Disorders
Cell Death
Parkinson Disease
Dopaminergic Neurons

Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

Li, W., West, N., Colla, E., Pletnikova, O., Troncoso, J. C., Marsh, L., Dawson, T. M., Jäkälä, P., Hartmann, T., Price, D. L. & Lee, M. K., Feb 8 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 6, p. 2162-2167 6 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Mutation
Cultured Cells
Brain

Alpha-synuclein and Parkinson's disease: Implications from the screening of more than 1,900 patients

Berg, D., Niwar, M., Maass, S., Zimprich, A., Möller, J. C., Wuellner, U., Schmitz-Hübsch, T., Klein, C., Tan, E. K., Schöls, L., Marsh, L., Dawson, T. M., Janetzky, B., Müller, T., Woitalla, D., Kostic, V., Pramstaller, P. P., Oertel, W. H., Bauer, P., Krueger, R. & 2 others, Gasser, T. & Riess, O., Sep 2005, In : Movement disorders : official journal of the Movement Disorder Society. 20, 9, p. 1191-1194 4 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Parkinson Disease
Mutation
Mutation Rate

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

Wang, C., Tan, J. M. M., Ho, M. W. L., Zaiden, N., Siew, H. W., Chew, C. L. C., Pei, W. E., Tit, M. L., Dawson, T. M. & Kah, L. L., Apr 2005, In : Journal of Neurochemistry. 93, 2, p. 422-431 10 p.

Research output: Contribution to journalArticle

Point Mutation
Solubility
Parkinson Disease
Mutation
Enzyme activity

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

Moore, D. J., Zhang, L., Troncoso, J. C., Lee, M. K., Hattori, N., Mizuno, Y., Dawson, T. M. & Dawson, V., Jan 1 2005, In : Human Molecular Genetics. 14, 1, p. 71-84 14 p.

Research output: Contribution to journalArticle

Parkinson Disease
Oxidative Stress
Mutation
Ubiquitination
Synucleins

Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases

Pletnikova, O., West, N., Lee, M. K., Rudow, G. L., Skolasky, R., Dawson, T. M., Marsh, L. & Troncoso, J. C., Aug 2005, In : Neurobiology of Aging. 26, 8, p. 1183-1192 10 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Body Disease
Lewy Bodies
Parkinson Disease
Brain

Bcl-x is required for proper development of the mouse: Substantia nigra

Savitt, J. M., Jang, S. S., Mu, W., Dawson, V. & Dawson, T. M., Jul 20 2005, In : Journal of Neuroscience. 25, 29, p. 6721-6728 8 p.

Research output: Contribution to journalArticle

Substantia Nigra
Genes
Neurons
Corpus Striatum
Gene Knockout Techniques

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

Smith, W., Jiang, H., Pei, Z., Tanaka, Y., Morita, H., Sawa, A., Dawson, V., Dawson, T. M. & Ross, C. A., Dec 15 2005, In : Human Molecular Genetics. 14, 24, p. 3801-3811 11 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Endoplasmic Reticulum Stress
Cell Death
Parkinson Disease
Caspase 12

Failures and successes of clinical trials for Parkinson disease treatments

Dawson, T. M., Dec 2005, In : Retina. 25, 8 SUPPL.

Research output: Contribution to journalArticle

Treatment Failure
Parkinson Disease
Clinical Trials