Ted M Dawson

Professor

1983 …2019
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Research Output 1983 2019

2010

Effect of fenbendazole on three behavioral tests in male C57BL/6N mice

Gadad, B. S., Daher, J. P. L., Hutchinson, E., Brayton, C., Dawson, T. M., Pletnikov, M. & Watson, J., Nov 2010, In : Journal of the American Association for Laboratory Animal Science. 49, 6, p. 821-825 5 p.

Research output: Contribution to journalArticle

fenbendazole
mice
testing
diet
histopathology
Poly(ADP-ribose) Polymerases
Transient Ischemic Attack
Cell Death
Apoptosis Inducing Factor
Wounds and Injuries

Excitotoxic programmed cell death involves caspase-independent mechanisms

Kang, H. C., Dawson, T. M. & Dawson, V., 2010, Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms. Springer US, p. 79-88 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Caspases
Cell Death
Autophagy
Necrosis
Apoptosis Inducing Factor

Functional identification of neuroprotective molecules

Dai, C., Liang, D., Li, H., Sasaki, M., Dawson, T. M. & Dawson, V., Nov 24 2010, In : PLoS One. 5, 11, e15008.

Research output: Contribution to journalArticle

Genes
Neurodegenerative diseases
Molecules
Cloning
neurodegenerative diseases

Genetic Animal Models of Parkinson's Disease

Dawson, T. M., Ko, H. S. & Dawson, V., Jun 2010, In : Neuron. 66, 5, p. 646-661 16 p.

Research output: Contribution to journalArticle

Genetic Models
Parkinson Disease
Animal Models
Synucleins
Lewy Bodies

GTPase activity plays a key role in the pathobiology of LRRK2

Xiong, Y., Coombes, C. E., Kilaru, A., Li, X., Gitler, A. D., Bowers, W. J., Dawson, V., Dawson, T. M. & Moore, D. J., Apr 2010, In : PLoS Genetics. 6, 4

Research output: Contribution to journalArticle

GTP Phosphohydrolases
guanosinetriphosphatase
Leucine
leucine
phosphotransferases (kinases)

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Lee, B. D., Shin, J. H., Vankampen, J., Petrucelli, L., West, A. B., Ko, H. S., Lee, Y. I., Maguire-Zeiss, K. A., Bowers, W. J., Federoff, H. J., Dawson, V. & Dawson, T. M., Sep 2010, In : Nature Medicine. 16, 9, p. 998-1000 3 p.

Research output: Contribution to journalArticle

Leucine
Parkinson Disease
Phosphotransferases
Nerve Degeneration
Neurons

NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice

Zheng, S., Eacker, S., Hong, S. J., Gronostajski, R. M., Dawson, T. M. & Dawson, V., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2446-2456 11 p.

Research output: Contribution to journalArticle

NFI Transcription Factors
N-Methylaspartate
Neuroprotective Agents
N-Methyl-D-Aspartate Receptors
Neurons

Pathogenesis of Parkinson's Disease

Gupta, A. & Dawson, T. M., Jan 1 2010, In : Blue Books of Neurology. 34, C, p. 155-169 15 p.

Research output: Contribution to journalArticle

Parkinson Disease
Synucleins
Phosphotransferases
Leucine
Research
Proto-Oncogene Proteins c-abl
Ubiquitination
Protein-Tyrosine Kinases
Tyrosine
Amino Acyl-tRNA Synthetases

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., De Vries, R. L. A., Kim, J., May, J., Tocilescu, M. A., Liu, W., Ko, H. S., Magrané, J., Moore, D. J., Dawson, V., Grailhe, R., Dawson, T. M., Li, C., Tieu, K. & Przedborski, S., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 378-383 6 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondria
Autophagy
Parkinson Disease
Mitochondrial Turnover

Reevaluation of phosphorylation sites in the parkinson disease-associated leucine-rich repeat kinase 2

Li, X., Moore, D. J., Xiong, Y., Dawson, T. M. & Dawson, V., Sep 17 2010, In : Journal of Biological Chemistry. 285, 38, p. 29569-29576 8 p.

Research output: Contribution to journalArticle

Phosphorylation
Leucine
Parkinson Disease
Phosphotransferases
Protein Interaction Domains and Motifs

Role of no in neurodegeneration

Lee, Y. I., Dawson, T. M. & Dawson, V., 2010, Encyclopedia of Neuroscience. Elsevier Ltd, p. 415-420 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nitric Oxide
Citrulline
Aptitude
Essential Amino Acids
Nitric Oxide Synthase

Synphilin-1 attenuates neuronal degeneration in the A53T α-synuclein transgenic mouse model

Smith, W., Liu, Z., Liang, Y., Masuda, N., Swing, D. A., Jenkins, N. A., Copeland, N. G., Troncoso, J. C., Pletnikov, M., Dawson, T. M., Martin, L. J., Moran, T. H., Lee, M. K., Borchelt, D. R. & Ross, C. A., Feb 25 2010, In : Human Molecular Genetics. 19, 11, p. 2087-2098 12 p., ddq086.

Research output: Contribution to journalArticle

Synucleins
Transgenic Mice
Parkinson Disease
Parkinsonian Disorders
Caspase 3

The impact of genetic research on our understanding of Parkinson's disease

Martin, I., Dawson, V. & Dawson, T. M., 2010, In : Progress in Brain Research. 183, C, p. 21-41 21 p.

Research output: Contribution to journalArticle

Genetic Research
Parkinson Disease
Genes
Proteasome Endopeptidase Complex
Ubiquitin
Parkinson Disease
Ubiquitin-Protein Ligases
Mutation
Proteins
2009

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

Higashi, S., Moore, D. J., Yamamoto, R., Minegishi, M., Sato, K., Togo, T., Katsuse, O., Uchikado, H., Furukawa, Y., Hino, H., Kosaka, K., Emson, P. C., Wada, K., Dawson, V., Dawson, T. M., Arai, H. & Iseki, E., Sep 1 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 9, p. 994-1005 12 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Leucine
Phosphotransferases
Brain
Lewy Bodies

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)

Wang, Y., Kim, N. S., Li, X., Greer, P. A., Koehler, R. C., Dawson, V. & Dawson, T. M., Jul 2009, In : Journal of Neurochemistry. 110, 2, p. 687-696 10 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Calpain
Poly(ADP-ribose) Polymerases
Cell death
Cell Death

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

Ko, H. S., Bailey, R., Smith, W., Liu, Z., Shin, J. H., Lee, Y. I., Zhang, Y. J., Jiang, H., Ross, C. A., Moore, D. J., Patterson, C., Petrucelli, L., Dawson, T. M. & Dawson, V., Feb 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. 2897-2902 6 p.

Research output: Contribution to journalArticle

Ubiquitination
Leucine
Phosphotransferases
Parkinson Disease
tanespimycin

Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

Daher, J. P. L., Ying, M., Banerjee, R., McDonald, R. S., Hahn, M. D., Yang, L., Beal, M. F., Thomas, B., Dawson, V., Dawson, T. M. & Moore, D. J., 2009, In : Molecular Neurodegeneration. 4, 1, 34.

Research output: Contribution to journalArticle

Synucleins
Corpus Striatum
Dopaminergic Neurons
Transgenic Mice
Dopamine

Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with α-synuclein inclusions

Waxman, E. A., Covy, J. P., Bukh, I., Li, X., Dawson, T. M. & Giasson, B. I., Jul 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 7, p. 785-796 12 p.

Research output: Contribution to journalArticle

Synucleins
Leucine
Phosphotransferases
HSP90 Heat-Shock Proteins
Proteasome Endopeptidase Complex

Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease

Hoang, T., Choi, D. K., Nagai, M., Wu, D. C., Nagata, T., Prou, D., Wilson, G. L., Vila, M., Jackson-Lewis, V., Dawson, V., Dawson, T. M., Chesselet, M. F. & Przedborski, S., Oct 1 2009, In : Free Radical Biology and Medicine. 47, 7, p. 1049-1056 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
DNA Damage
Parkinson Disease
Nitric Oxide Synthase Type I

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila

Ng, C. H., Mok, S. Z. S., Koh, C., Ouyang, X., Fivaz, M. L., Tan, E. K., Dawson, V., Dawson, T. M., Yu, F. & Lim, K. L., Sep 9 2009, In : Journal of Neuroscience. 29, 36, p. 11257-11262 6 p.

Research output: Contribution to journalArticle

Leucine
Drosophila
Phosphotransferases
Diptera
Rotenone

Parthanatos, A messenger of death

David, K. K., Andrabi, S. A., Dawson, T. M. & Dawson, V., Jan 1 2009, In : Frontiers in bioscience : a journal and virtual library. 14, 3, p. 1116-1128 13 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Cell death
Cell Death
Poly Adenosine Diphosphate Ribose
Mythology

Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos

Wang, Y., Dawson, V. & Dawson, T. M., Aug 2009, In : Experimental Neurology. 218, 2, p. 193-202 10 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Poly Adenosine Diphosphate Ribose
Polymers
Nervous System Diseases
Mitochondria

Revelations and revolutions in the understanding of Parkinson's disease

Dawson, T. M., Moore, D. J. & West, A. B., Jul 2009, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1792, 7, p. 585-586 2 p.

Research output: Contribution to journalArticle

alpha-Synuclein
Protein-Serine-Threonine Kinases
Parkinson Disease
Mitochondria

SnapShot: Pathogenesis of Parkinson's Disease

Shin, J. H., Dawson, V. & Dawson, T. M., Oct 16 2009, In : Cell. 139, 2

Research output: Contribution to journalArticle

Parkinson Disease

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

Tsang, A. H. K., Lee, Y. I. L., Ko, H. S., Savitt, J. M., Pletnikova, O., Troncoso, J. C., Dawson, V., Dawson, T. M. & Chung, K. K. K., Mar 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4900-4905 6 p.

Research output: Contribution to journalArticle

Parkinson Disease
Ubiquitin-Protein Ligases
Apoptosis
RING Finger Domains
Cell Survival

Understanding microRNAs in neurodegeneration

Eacker, S., Dawson, T. M. & Dawson, V., Dec 2009, In : Nature Reviews Neuroscience. 10, 12, p. 837-841 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Poisons
Nervous System
Proteins

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)

Andres-Mateos, E., Mejias, R., Sasaki, M., Li, X., Lin, B. M., Biskup, S., Zhang, L., Banerjee, R., Thomas, B., Yang, L., Liu, G., Beal, M. F., Huso, D. L., Dawson, T. M. & Dawson, V., Dec 16 2009, In : Journal of Neuroscience. 29, 50, p. 15846-15850 5 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Knockout Mice
Leucine
Hypersensitivity
Phosphotransferases
2008

Advances in neuronal cell death 2007

Harraz, M., Dawson, T. M. & Dawson, V., Feb 2008, In : Stroke. 39, 2, p. 286-288 3 p.

Research output: Contribution to journalArticle

Cell Death
Autophagy
Brain
Caspases
Cell Cycle

A pilot clinical trial of creatine and minocycline in early parkinson disease: 18-month results

The NINDS NET-PD Investigators, 2008, In : Clinical Neuropharmacology. 31, 3, p. 141-150 10 p.

Research output: Contribution to journalArticle

Minocycline
Creatine
Parkinson Disease
Clinical Trials
Medical Futility

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

Wong, E. S. P., Tan, J. M. M., Soong, W. E., Hussein, K., Nukina, N., Dawson, V., Dawson, T. M., Cuervo, A. M. & Lim, K. L., Aug 2008, In : Human Molecular Genetics. 17, 16, p. 2570-2582 13 p.

Research output: Contribution to journalArticle

Autophagy
Desmin
Synucleins
Inclusion Bodies
Cultured Cells

Genetic Models of Familial Parkinson's Disease

Ying, M., Dawson, V. & Dawson, T. M., 2008, Parkinson's Disease. Elsevier Inc., p. 225-236 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synucleins
Genetic Models
Parkinson Disease
Transgenic Mice
Phosphotransferases

Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy

Tan, J. M. M., Wong, E. S. P., Dawson, V., Dawson, T. M. & Lim, K. L., Feb 16 2008, In : Autophagy. 4, 2, p. 251-253 3 p.

Research output: Contribution to journalArticle

Polyubiquitin
Autophagy
Ubiquitin
Lysine
Ubiquitination

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

Tan, J. M. M., Wong, E. S. P., Kirkpatrick, D. S., Pletnikova, O., Ko, H. S., Tay, S. P., Ho, M. W. L., Troncoso, J. C., Gygi, S. P., Lee, M. K., Dawson, V., Dawson, T. M. & Lim, K. L., Feb 1 2008, In : Human Molecular Genetics. 17, 3, p. 431-439 9 p.

Research output: Contribution to journalArticle

Ubiquitination
Ubiquitin
Neurodegenerative Diseases
Lysine
Proteins

Mitochondrial and nuclear cross talk in cell death: Parthanatos

Andrabi, S. A., Dawson, T. M. & Dawson, V., Dec 2008, Annals of the New York Academy of Sciences. Vol. 1147. p. 233-241 9 p. (Annals of the New York Academy of Sciences; vol. 1147).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Poly(ADP-ribose) Polymerases
Cell death
Cell Death
Apoptosis Inducing Factor
Tissue

Morphometry of the human substantia nigra in ageing and Parkinson's disease

Rudow, G., O'Brien, R., Savonenko, A., Resnick, S. M., Zonderman, A. B., Pletnikova, O., Marsh, L., Dawson, T. M., Crain, B. J., West, M. J. & Troncoso, J. C., Apr 2008, In : Acta Neuropathologica. 115, 4, p. 461-470 10 p.

Research output: Contribution to journalArticle

Substantia Nigra
Parkinson Disease
Neurons
Tyrosine 3-Monooxygenase
Hypertrophy

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

Sen, N., Hara, M. R., Kornberg, M., Cascio, M. B., Bae, B. I., Shahani, N., Thomas, B., Dawson, T. M., Dawson, V., Snyder, S. H. & Sawa, A., Jul 2008, In : Nature Cell Biology. 10, 7, p. 866-873 8 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Glyceraldehyde-3-Phosphate Dehydrogenases
Nitric Oxide
Apoptosis
Cell Death

Non-autonomous cell death in Parkinson's disease

Dawson, T. M., Jun 2008, In : The Lancet Neurology. 7, 6, p. 474-475 2 p.

Research output: Contribution to journalArticle

Brain Tissue Transplantation
Fetal Tissue Transplantation
Lewy Bodies
Nerve Degeneration
alpha-Synuclein

Parkin mediates the degradation-independent ubiquitination of Hsp70

Moore, D. J., West, A. B., Dikeman, D. A., Dawson, V. & Dawson, T. M., Jun 2008, In : Journal of Neurochemistry. 105, 5, p. 1806-1819 14 p.

Research output: Contribution to journalArticle

Ubiquitination
Ubiquitin-Protein Ligases
Degradation
Brain
Substrates

Parthanatos: PARP- and AIF-dependent programmed cell death

Dawson, V. & Dawson, T. M., Jan 1 2008, Beyond Apoptosis: Cellular Outcomes of Cancer Therapy. CRC Press, p. 143-156 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell death
Neurology
Cell Death
Nervous System
Apoptosis

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

Gagné, J. P., Isabelle, M., Lo, K. S., Bourassa, S., Hendzel, M. J., Dawson, V., Dawson, T. M. & Poirier, G. G., Dec 2008, In : Nucleic Acids Research. 36, 22, p. 6959-6976 18 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Proteome
Carrier Proteins
Adenosine Diphosphate
Biological Phenomena

Role of tuberin in neuronal degeneration

Habib, S. L., Michel, D., Masliah, E., Thomas, B., Ko, H. S., Dawson, T. M., Abboud, H., Clark, R. A. & Imam, S. Z., Jun 2008, In : Neurochemical Research. 33, 6, p. 1113-1116 4 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Alzheimer Disease
Phosphorylation
Tuberous Sclerosis
Frontal Lobe

The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2

Wang, L., Xie, C., Greggio, E., Parisiadou, L., Shim, H., Sun, L., Chandran, J., Lin, X., Lai, C., Yang, W. J., Moore, D. J., Dawson, T. M., Dawson, V., Chiosis, G., Cookson, M. R. & Cai, H., Mar 26 2008, In : Journal of Neuroscience. 28, 13, p. 3384-3391 8 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Leucine
Phosphotransferases
Parkinson Disease
Mutation

Value of genetic models in understanding the cause and mechanisms of Parkinson's disease

Moore, D. J. & Dawson, T. M., 2008, In : Current Neurology and Neuroscience Reports. 8, 4, p. 288-296 9 p.

Research output: Contribution to journalArticle

Genetic Models
Parkinson Disease
Synucleins
Lewy Bodies
Dopaminergic Neurons

What causes cell death in Parkinson's disease?

Gupta, A., Dawson, V. & Dawson, T. M., Dec 2008, In : Annals of Neurology. 64, SUPPL. 2

Research output: Contribution to journalArticle

Parkinson Disease
Cause of Death
Cell Death
Inborn Genetic Diseases
Mutation
2007

A Hierarchical NGF Signaling Cascade Controls Ret-Dependent and Ret-Independent Events during Development of Nonpeptidergic DRG Neurons

Luo, W., Wickramasinghe, S. R., Savitt, J. M., Griffin, J. W., Dawson, T. M. & Ginty, D. D., Jun 7 2007, In : Neuron. 54, 5, p. 739-754 16 p.

Research output: Contribution to journalArticle

Diagnosis-Related Groups
Nerve Growth Factor
Neurons
Glial Cell Line-Derived Neurotrophic Factors
Nerve Growth Factor Receptor

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents

Haince, J. F., Kozlov, S., Dawson, V., Dawson, T. M., Hendzel, M. J., Lavin, M. F. & Poirier, G. G., Jun 1 2007, In : Journal of Biological Chemistry. 282, 22, p. 16441-16453 13 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Ataxia Telangiectasia
DNA Damage
Adenosine Diphosphate
DNA