Ted M Dawson

Professor

1983 …2020

Research output per year

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Research Output

2011

Neuronal activity regulates hippocampal miRNA expression

Eacker, S. M., Keuss, M. J., Berezikov, E., Dawson, V. L. & Dawson, T. M., Oct 3 2011, In : PloS one. 6, 10, e25068.

Research output: Contribution to journalArticle

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in parkinson's disease

Shin, J. H., Ko, H. S., Kang, H., Lee, Y., Lee, Y. I., Pletinkova, O., Troconso, J. C., Dawson, V. L. & Dawson, T. M., Mar 4 2011, In : Cell. 144, 5, p. 689-702 14 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)

Wang, Y., Kim, N. S., Haince, J. F., Kang, H. C., David, K. K., Andrabi, S. A., Poirier, G. G., Dawson, V. L. & Dawson, T. M., Apr 5 2011, In : Science signaling. 4, 167, ra20.

Research output: Contribution to journalArticle

Recent advances in the genetics of parkinson's disease

Martin, I., Dawson, V. L. & Dawson, T. M., Jul 13 2011, In : Annual Review of Genomics and Human Genetics. 12, p. 301-325 25 p.

Research output: Contribution to journalArticle

Resistance to MPTP-Neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation

Thomas, B., Mandir, A. S., West, N., Liu, Y., Andrabi, S. A., Stirling, W., Dawson, V. L., Dawson, T. M. & Lee, M. K., 2011, In : PloS one. 6, 1, e16706.

Research output: Contribution to journalArticle

The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior

Zhang, J., Wang, Y., Chi, Z., Keuss, M. J., Pai, Y. M. E., Kang, H. C., Shin, J. H., Bugayenko, A., Wang, H., Xiong, Y., Pletnikov, M. V., Mattson, M. P., Dawson, T. M. & Dawson, V. L., Apr 15 2011, In : Cell. 145, 2, p. 284-299 16 p.

Research output: Contribution to journalArticle

2010

Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia

Li, X., Klaus, J. A., Zhang, J., Xu, Z., Kibler, K. K., Andrabi, S. A., Rao, K., Yang, Z. J., Dawson, T. M., Dawson, V. L. & Koehler, R. C., May 1 2010, In : Journal of Neurochemistry. 113, 4, p. 1012-1022 11 p.

Research output: Contribution to journalArticle

Excitotoxic programmed cell death involves caspase-independent mechanisms

Kang, H. C., Dawson, T. M. & Dawson, V. L., Jan 1 2010, Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms. Springer US, p. 79-88 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Functional identification of neuroprotective molecules

Dai, C., Liang, D., Li, H., Sasaki, M., Dawson, T. M. & Dawson, V. L., Nov 24 2010, In : PloS one. 5, 11, e15008.

Research output: Contribution to journalArticle

Genetic Animal Models of Parkinson's Disease

Dawson, T. M., Ko, H. S. & Dawson, V. L., Jun 1 2010, In : Neuron. 66, 5, p. 646-661 16 p.

Research output: Contribution to journalReview article

GTPase activity plays a key role in the pathobiology of LRRK2

Xiong, Y., Coombes, C. E., Kilaru, A., Li, X., Gitler, A. D., Bowers, W. J., Dawson, V. L., Dawson, T. M. & Moore, D. J., Apr 2010, In : PLoS genetics. 6, 4

Research output: Contribution to journalArticle

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Lee, B. D., Shin, J. H., Vankampen, J., Petrucelli, L., West, A. B., Ko, H. S., Lee, Y. I., Maguire-Zeiss, K. A., Bowers, W. J., Federoff, H. J., Dawson, V. L. & Dawson, T. M., Sep 2010, In : Nature medicine. 16, 9, p. 998-1000 3 p.

Research output: Contribution to journalArticle

NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice

Zheng, S., Eacker, S. M., Hong, S. J., Gronostajski, R. M., Dawson, T. M. & Dawson, V. L., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2446-2456 11 p.

Research output: Contribution to journalArticle

Pathogenesis of Parkinson's Disease

Gupta, A. & Dawson, T. M., Jan 1 2010, In : Blue Books of Neurology. 34, C, p. 155-169 15 p.

Research output: Contribution to journalArticle

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., De Vries, R. L. A., Kim, J., May, J., Tocilescu, M. A., Liu, W., Ko, H. S., Magrané, J., Moore, D. J., Dawson, V. L., Grailhe, R., Dawson, T. M., Li, C., Tieu, K. & Przedborski, S., Feb 15 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 378-383 6 p.

Research output: Contribution to journalArticle

Reevaluation of phosphorylation sites in the parkinson disease-associated leucine-rich repeat kinase 2

Li, X., Moore, D. J., Xiong, Y., Dawson, T. M. & Dawson, V. L., Sep 17 2010, In : Journal of Biological Chemistry. 285, 38, p. 29569-29576 8 p.

Research output: Contribution to journalArticle

Synphilin-1 attenuates neuronal degeneration in the A53T α-synuclein transgenic mouse model

Smith, W. W., Liu, Z., Liang, Y., Masuda, N., Swing, D. A., Jenkins, N. A., Copeland, N. G., Troncoso, J. C., Pletnikov, M., Dawson, T. M., Martin, L. J., Moran, T. H., Lee, M. K., Borchelt, D. R. & Ross, C. A., Feb 25 2010, In : Human molecular genetics. 19, 11, p. 2087-2098 12 p., ddq086.

Research output: Contribution to journalArticle

The impact of genetic research on our understanding of Parkinson's disease

Martin, I., Dawson, V. L. & Dawson, T. M., Jan 1 2010, Progress in Brain Research. C ed. Elsevier B.V., p. 21-41 21 p. (Progress in Brain Research; vol. 183, no. C).

Research output: Chapter in Book/Report/Conference proceedingChapter

The role of parkin in familial and sporadic Parkinson's disease

Dawson, T. M. & Dawson, V. L., Dec 20 2010, In : Movement Disorders. 25, SUPPL. 1, p. S32-S39

Research output: Contribution to journalArticle

2009

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

Higashi, S., Moore, D. J., Yamamoto, R., Minegishi, M., Sato, K., Togo, T., Katsuse, O., Uchikado, H., Furukawa, Y., Hino, H., Kosaka, K., Emson, P. C., Wada, K., Dawson, V. L., Dawson, T. M., Arai, H. & Iseki, E., Sep 1 2009, In : Journal of neuropathology and experimental neurology. 68, 9, p. 994-1005 12 p.

Research output: Contribution to journalArticle

Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos)

Wang, Y., Kim, N. S., Li, X., Greer, P. A., Koehler, R. C., Dawson, V. L. & Dawson, T. M., Jul 1 2009, In : Journal of Neurochemistry. 110, 2, p. 687-696 10 p.

Research output: Contribution to journalArticle

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

Ko, H. S., Bailey, R., Smith, W. W., Liu, Z., Shin, J. H., Lee, Y. I., Zhang, Y. J., Jiang, H., Ross, C. A., Moore, D. J., Patterson, C., Petrucelli, L., Dawson, T. M. & Dawson, V. L., Feb 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. 2897-2902 6 p.

Research output: Contribution to journalArticle

Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

Daher, J. P. L., Ying, M., Banerjee, R., McDonald, R. S., Hahn, M. D., Yang, L., Beal, M. F., Thomas, B., Dawson, V. L., Dawson, T. M. & Moore, D. J., Aug 27 2009, In : Molecular neurodegeneration. 4, 1, 34.

Research output: Contribution to journalArticle

Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with α-synuclein inclusions

Waxman, E. A., Covy, J. P., Bukh, I., Li, X., Dawson, T. M. & Giasson, B. I., Jul 1 2009, In : Journal of neuropathology and experimental neurology. 68, 7, p. 785-796 12 p.

Research output: Contribution to journalArticle

Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease

Hoang, T., Choi, D. K., Nagai, M., Wu, D. C., Nagata, T., Prou, D., Wilson, G. L., Vila, M., Jackson-Lewis, V., Dawson, V. L., Dawson, T. M., Chesselet, M. F. & Przedborski, S., Oct 1 2009, In : Free Radical Biology and Medicine. 47, 7, p. 1049-1056 8 p.

Research output: Contribution to journalArticle

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila

Ng, C. H., Mok, S. Z. S., Koh, C., Ouyang, X., Fivaz, M. L., Tan, E. K., Dawson, V. L., Dawson, T. M., Yu, F. & Lim, K. L., Sep 9 2009, In : Journal of Neuroscience. 29, 36, p. 11257-11262 6 p.

Research output: Contribution to journalArticle

Parthanatos, A messenger of death

David, K. K., Andrabi, S. A., Dawson, T. M. & Dawson, V. L., Jan 1 2009, In : Frontiers in Bioscience. 14, 3, p. 1116-1128 13 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos

Wang, Y., Dawson, V. L. & Dawson, T. M., Aug 1 2009, In : Experimental Neurology. 218, 2, p. 193-202 10 p.

Research output: Contribution to journalReview article

Revelations and revolutions in the understanding of Parkinson's disease

Dawson, T. M., Moore, D. J. & West, A. B., Jul 1 2009, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1792, 7, p. 585-586 2 p.

Research output: Contribution to journalEditorial

Role of no in neurodegeneration

Lee, Y. I., Dawson, T. M. & Dawson, V. L., Jan 1 2009, Encyclopedia of Neuroscience. Elsevier Ltd, p. 415-420 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

SnapShot: Pathogenesis of Parkinson's Disease

Shin, J. H., Dawson, V. L. & Dawson, T. M., Oct 16 2009, In : Cell. 139, 2, p. 440.e1-440.e2

Research output: Contribution to journalShort survey

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

Tsang, A. H. K., Lee, Y. I. L., Ko, H. S., Savitt, J. M., Pletnikova, O., Troncoso, J. C., Dawson, V. L., Dawson, T. M. & Chung, K. K. K., Mar 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4900-4905 6 p.

Research output: Contribution to journalArticle

Understanding microRNAs in neurodegeneration

Eacker, S. M., Dawson, T. M. & Dawson, V. L., Dec 1 2009, In : Nature Reviews Neuroscience. 10, 12, p. 837-841 5 p.

Research output: Contribution to journalReview article

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)

Andres-Mateos, E., Mejias, R., Sasaki, M., Li, X., Lin, B. M., Biskup, S., Zhang, L., Banerjee, R., Thomas, B., Yang, L., Liu, G., Beal, M. F., Huso, D. L., Dawson, T. M. & Dawson, V. L., Dec 16 2009, In : Journal of Neuroscience. 29, 50, p. 15846-15850 5 p.

Research output: Contribution to journalArticle

2008

Advances in neuronal cell death 2007

Harraz, M. M., Dawson, T. M. & Dawson, V. L., Feb 1 2008, In : Stroke. 39, 2, p. 286-288 3 p.

Research output: Contribution to journalShort survey

A pilot clinical trial of creatine and minocycline in early parkinson disease: 18-month results

The NINDS NET-PD Investigators, Jan 1 2008, In : Clinical neuropharmacology. 31, 3, p. 141-150 10 p.

Research output: Contribution to journalArticle

Autophagy-mediated clearance of aggresomes is not a universal phenomenon

Wong, E. S. P., Tan, J. M. M., Soong, W. E., Hussein, K., Nukina, N., Dawson, V. I., Dawson, T. M., Cuervo, A. M. & Lim, K. L., Aug 2008, In : Human molecular genetics. 17, 16, p. 2570-2582 13 p.

Research output: Contribution to journalArticle

Genetic Models of Familial Parkinson's Disease

Ying, M., Dawson, V. L. & Dawson, T. M., Dec 1 2008, Parkinson's Disease. Elsevier Inc., p. 225-236 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy

Tan, J. M. M., Wong, E. S. P., Dawson, V. L., Dawson, T. M. & Lim, K. L., Feb 16 2008, In : Autophagy. 4, 2, p. 251-253 3 p.

Research output: Contribution to journalArticle

Open Access

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

Tan, J. M. M., Wong, E. S. P., Kirkpatrick, D. S., Pletnikova, O., Ko, H. S., Tay, S. P., Ho, M. W. L., Troncoso, J., Gygi, S. P., Lee, M. K., Dawson, V. L., Dawson, T. M. & Lim, K. L., Feb 1 2008, In : Human molecular genetics. 17, 3, p. 431-439 9 p.

Research output: Contribution to journalArticle

Mitochondrial and nuclear cross talk in cell death: Parthanatos

Andrabi, S. A., Dawson, T. M. & Dawson, V. L., Dec 2008, Mitochondria and Oxidative Stress in Neurodegenerative Disorders. Blackwell Publishing Inc., p. 233-241 9 p. (Annals of the New York Academy of Sciences; vol. 1147).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Morphometry of the human substantia nigra in ageing and Parkinson's disease

Rudow, G., O'Brien, R., Savonenko, A. V., Resnick, S. M., Zonderman, A. B., Pletnikova, O., Marsh, L., Dawson, T. M., Crain, B. J., West, M. J. & Troncoso, J. C., Apr 1 2008, In : Acta neuropathologica. 115, 4, p. 461-470 10 p.

Research output: Contribution to journalArticle

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis

Sen, N., Hara, M. R., Kornberg, M. D., Cascio, M. B., Bae, B. I., Shahani, N., Thomas, B., Dawson, T. M., Dawson, V. L., Snyder, S. H. & Sawa, A., Jul 1 2008, In : Nature cell biology. 10, 7, p. 866-873 8 p.

Research output: Contribution to journalArticle

Non-autonomous cell death in Parkinson's disease

Dawson, T. M., Jun 1 2008, In : The Lancet Neurology. 7, 6, p. 474-475 2 p.

Research output: Contribution to journalLetter

Parkin mediates the degradation-independent ubiquitination of Hsp70

Moore, D. J., West, A. B., Dikeman, D. A., Dawson, V. L. & Dawson, T. M., Jun 1 2008, In : Journal of Neurochemistry. 105, 5, p. 1806-1819 14 p.

Research output: Contribution to journalArticle

Parthanatos: PARP- and AIF-dependent programmed cell death

Dawson, V. & Dawson, T. M., Jan 1 2008, Beyond Apoptosis: Cellular Outcomes of Cancer Therapy. CRC Press, p. 143-156 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter