Ted M Dawson

Professor

1983 …2019
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Research Output 1983 2019

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

Fiesel, F. C., Ando, M., Hudec, R., Hill, A. R., Castanedes-Casey, M., Caulfield, T. R., Moussaud-Lamodière, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Siuda, J., Chen, L., Dawson, V., Dawson, T. M., Wszolek, Z. K., Ross, O. A., Dickson, D. W. & Springer, W., Sep 1 2015, In : EMBO Reports. 16, 9, p. 1114-1130 17 p.

Research output: Contribution to journalArticle

Phosphorylation
Ubiquitin
Parkinson Disease
Brain
Mitochondria

[2] Nitric oxide toxicity in central nervous system cultures

Dawson, V. & Dawson, T. M., 1996, In : Methods in Neurosciences. 30, C, p. 26-43 18 p.

Research output: Contribution to journalArticle

Nitric Oxide
Central Nervous System

[20] Function of nitric oxide in neuronal cell death

Dawson, V. & Dawson, T. M., 1996, In : Methods in Neurosciences. 31, C, p. 228-240 13 p.

Research output: Contribution to journalArticle

Nitric Oxide
Cell Death
Noscapine
Phosphatidylinositols
Adenylyl Cyclases
Binding Sites
Brain

[6] NADPH Diaphorase staining

Dawson, T. M. & Dawson, V., 1996, In : Methods in Neurosciences. 31, C, p. 62-67 6 p.

Research output: Contribution to journalArticle

NADPH Dehydrogenase
Staining and Labeling

37-kDa laminin receptor precursor modulates cytotoxic necrotizing factor 1-mediated RhoA activation and bacterial uptake

Chung, J. W., Hong, S. J., Kim, K. J., Goti, D., Stins, M., Shin, S., Dawson, V., Dawson, T. M. & Kim, K. S., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16857-16862 6 p.

Research output: Contribution to journalArticle

Laminin Receptors
Chemical activation
rho GTP-Binding Proteins
Endothelial cells
Eukaryotic Cells

Abberant protein synthesis in G2019S LRRK2 drosophila parkinson disease-related phenotypes

Martin, I., Abalde-Atristain, L., Kim, J. W., Dawson, T. M. & Dawson, V., 2014, In : Fly. 8, 3, p. 165-169 5 p.

Research output: Contribution to journalArticle

Parkinson disease
Drosophila
protein synthesis
phenotype
ribosomal proteins

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

Higashi, S., Moore, D. J., Yamamoto, R., Minegishi, M., Sato, K., Togo, T., Katsuse, O., Uchikado, H., Furukawa, Y., Hino, H., Kosaka, K., Emson, P. C., Wada, K., Dawson, V., Dawson, T. M., Arai, H. & Iseki, E., Sep 1 2009, In : Journal of Neuropathology and Experimental Neurology. 68, 9, p. 994-1005 12 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Leucine
Phosphotransferases
Brain
Lewy Bodies

Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease

Nuytemans, K., Inchausti, V., Beecham, G. W., Wang, L., Dickson, D. W., Trojanowski, J. Q., Lee, V. M. Y., Mash, D. C., Frosch, M. P., Foroud, T. M., Honig, L. S., Montine, T. J., Dawson, T. M., Martin, E. R., Scott, W. K. & Vance, J. M., 2014, In : Movement disorders : official journal of the Movement Disorder Society. 29, 6, p. 827-830 4 p.

Research output: Contribution to journalArticle

Parkinson Disease
Autopsy
Haplotypes
Parkinsonian Disorders
Neurodegenerative Diseases

Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease

Shimoji, M., Zhang, L., Mandir, A. S., Dawson, V. & Dawson, T. M., Mar 24 2005, In : Molecular Brain Research. 134, 1, p. 103-108 6 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Inclusion Bodies
Parkinson Disease
Synucleins
Probenecid

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death

Ko, H. S., Von Coelln, R., Sriram, S. R., Kim, S. W., Chung, K. K. K., Pletnikova, O., Troncoso, J. C., Johnson, B., Saffary, R., Goh, E. L., Song, H., Park, B. J., Kim, M. J., Kim, S., Dawson, V. & Dawson, T. M., Aug 31 2005, In : Journal of Neuroscience. 25, 35, p. 7968-7978 11 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Parkinsonian Disorders
Cell Death
Parkinson Disease
Dopaminergic Neurons

A comprehensive screening of copy number variability in dementia with Lewy bodies

Kun-Rodrigues, C., Orme, T., Carmona, S., Hernandez, D. G., Ross, O. A., Eicher, J. D., Shepherd, C., Parkkinen, L., Darwent, L., Heckman, M. G., Scholz, S. W., Troncoso, J. C., Pletnikova, O., Dawson, T. M., Rosenthal, L. I. S., Ansorge, O., Clarimon, J., Lleo, A., Morenas-Rodriguez, E., Clark, L. & 48 others, Honig, L. S., Marder, K., Lemstra, A., Rogaeva, E., St. George-Hyslop, P., Londos, E., Zetterberg, H., Barber, I., Braae, A., Brown, K., Morgan, K., Troakes, C., Al-Sarraj, S., Lashley, T., Holton, J., Compta, Y., Van Deerlin, V., Serrano, G. E., Beach, T. G., Lesage, S., Galasko, D., Masliah, E., Santana, I., Pastor, P., Diez-Fairen, M., Aguilar, M., Tienari, P. J., Myllykangas, L., Oinas, M., Revesz, T., Lees, A., Boeve, B. F., Petersen, R. C., Ferman, T. J., Escott-Price, V., Graff-Radford, N., Cairns, N. J., Morris, J. C., Pickering-Brown, S., Mann, D., Halliday, G. M., Hardy, J., Trojanowski, J. Q., Dickson, D. W., Singleton, A., Stone, D. J., Guerreiro, R. & Bras, J., Mar 1 2019, In : Neurobiology of Aging. 75, p. 223.e1-223.e10

Research output: Contribution to journalArticle

Lewy Body Disease
Genome
Neurodegenerative Diseases
Genes
Dementia

Activation mechanisms of the E3 ubiquitin ligase parkin

Panicker, N., Dawson, V. & Dawson, T. M., Sep 15 2017, In : Biochemical Journal. 474, 18, p. 3075-3086 12 p.

Research output: Contribution to journalReview article

Ubiquitin-Protein Ligases
Parkinson Disease
Chemical activation
Genes
Phosphotransferases

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

Brahmachari, S., Ge, P., Lee, S. H., Kim, D., Karuppagounder, S., Kumar, M., Mao, X., Shin, J. H., Lee, Y., Pletnikova, O., Troncoso, J. C., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 1 2016, In : Journal of Clinical Investigation. 126, 8, p. 2970-2988 19 p.

Research output: Contribution to journalArticle

Synucleins
Protein-Tyrosine Kinases
Phosphotyrosine
Parkinson Disease
abl Genes
Adenosine Diphosphate
Nervous System
Nitric Oxide
Neurotransmitter Agents
Poly Adenosine Diphosphate Ribose
Adenosine Diphosphate
Nervous System
Nitric Oxide
Neurotransmitter Agents
Poly Adenosine Diphosphate Ribose

Adult conditional knockout of PGC-1α leads to loss of dopamine neurons

Jiang, H., Kang, S., Zhang, S., Karuppagounder, S., Xu, J., Lee, Y. K., Kang, B. G., Lee, Y., Zhang, J., Pletnikova, O., Troncoso, J. C., Pirooznia, S., Andrabi, S. A., Dawson, V. & Dawson, T. M., 2016, In : eNeuro. 3, 4, e0183-16.2016.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Parkinson Disease
Protein Isoforms
Peroxisome Proliferator-Activated Receptors
Mitochondrial Proteins

Advances in neuronal cell death 2007

Harraz, M., Dawson, T. M. & Dawson, V., Feb 2008, In : Stroke. 39, 2, p. 286-288 3 p.

Research output: Contribution to journalArticle

Cell Death
Autophagy
Brain
Caspases
Cell Cycle

Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

Li, W., West, N., Colla, E., Pletnikova, O., Troncoso, J. C., Marsh, L., Dawson, T. M., Jäkälä, P., Hartmann, T., Price, D. L. & Lee, M. K., Feb 8 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 6, p. 2162-2167 6 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Mutation
Cultured Cells
Brain

Aggressive behavior in male mice lacking the gene for neuronal nitric oxide synthase requires testosterone

Kriegsfeld, L. J., Dawson, T. M., Dawson, V., Nelson, R. J. & Snyder, S. H., Sep 19 1997, In : Brain Research. 769, 1, p. 66-70 5 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type I
Testosterone
Protein Isoforms
Aggression
Genes

A Hierarchical NGF Signaling Cascade Controls Ret-Dependent and Ret-Independent Events during Development of Nonpeptidergic DRG Neurons

Luo, W., Wickramasinghe, S. R., Savitt, J. M., Griffin, J. W., Dawson, T. M. & Ginty, D. D., Jun 7 2007, In : Neuron. 54, 5, p. 739-754 16 p.

Research output: Contribution to journalArticle

Diagnosis-Related Groups
Nerve Growth Factor
Neurons
Glial Cell Line-Derived Neurotrophic Factors
Nerve Growth Factor Receptor

A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy

Piard, J., Umanah, G., Harms, F. L., Abalde-Atristain, L., Amram, D., Chang, M., Chen, R., Alawi, M., Salpietro, V., Rees, M. I., Chung, S. K., Houlden, H., Verloes, A., Dawson, T. M., Dawson, V., Van Maldergem, L. & Kutsche, K., Mar 1 2018, In : Brain. 141, 3, p. 651-661 11 p.

Research output: Contribution to journalArticle

AMPA Receptors
Brain Diseases
Mutation
Adenosine Triphosphatases
Arthrogryposis

Alpha-synuclein and Parkinson's disease: Implications from the screening of more than 1,900 patients

Berg, D., Niwar, M., Maass, S., Zimprich, A., Möller, J. C., Wuellner, U., Schmitz-Hübsch, T., Klein, C., Tan, E. K., Schöls, L., Marsh, L., Dawson, T. M., Janetzky, B., Müller, T., Woitalla, D., Kostic, V., Pramstaller, P. P., Oertel, W. H., Bauer, P., Krueger, R. & 2 others, Gasser, T. & Riess, O., Sep 2005, In : Movement disorders : official journal of the Movement Disorder Society. 20, 9, p. 1191-1194 4 p.

Research output: Contribution to journalArticle

Synucleins
alpha-Synuclein
Parkinson Disease
Mutation
Mutation Rate

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

Wang, C., Tan, J. M. M., Ho, M. W. L., Zaiden, N., Siew, H. W., Chew, C. L. C., Pei, W. E., Tit, M. L., Dawson, T. M. & Kah, L. L., Apr 2005, In : Journal of Neurochemistry. 93, 2, p. 422-431 10 p.

Research output: Contribution to journalArticle

Point Mutation
Solubility
Parkinson Disease
Mutation
Enzyme activity

Alterations of dopamine receptor subtypes in the rat CNS following methamphetamine treatment

McCabe, R. T., Gehlert, D. R. & Dawson, T. M., 1985, In : Federation proceedings. 44, 6

Research output: Contribution to journalArticle

Methamphetamine
Dopamine Receptors

A lysosomal lair for a pathogenic protein pair

Dawson, T. M. & Dawson, V., Jul 13 2011, In : Science Translational Medicine. 3, 91, 91ps28.

Research output: Contribution to journalArticle

Parkinson Disease
Synucleins
Glucosylceramidase
Lysosomes
Proteins
Oligomerization
Protein Stability
Missense Mutation
Parkinson Disease
Mutation
Cyclic ADP-Ribose
Cyclic GMP-Dependent Protein Kinases
Nitric Oxide
Purkinje Cells
Glutamic Acid

An image registration pipeline for analysis of transsynaptic tracing in mice

Kutten, K. S., Eacker, S., Dawson, V., Dawson, T. M., Ratnanather, T. & Miller, M. I., 2016, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. SPIE, Vol. 9788. 978823

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Image registration
tracing
neurons
Neurons
brain

Animal models of neurodegenerative diseases

Dawson, T. M., Golde, T. E. & Lagier-Tourenne, C., Oct 1 2018, In : Nature Neuroscience. 21, 10, p. 1370-1379 10 p.

Research output: Contribution to journalReview article

Neurodegenerative Diseases
Animal Models
Parkinson Disease
Alzheimer Disease
Rodentia

Animal models of Parkinson's disease: Vertebrate genetics

Lee, Y., Dawson, V. & Dawson, T. M., 2012, In : Cold Spring Harbor perspectives in medicine. 2, 10, a009324.

Research output: Contribution to journalArticle

Parkinson Disease
Vertebrates
Animals
Animal Models
Inborn Genetic Diseases

Animal models of Parkinson's disease: vertebrate genetics.

Lee, Y., Dawson, V. L. & Dawson, T. M., Oct 2012, In : Cold Spring Harbor perspectives in medicine. 2, 10

Research output: Contribution to journalArticle

Parkinson Disease
Vertebrates
Animals
Animal Models
Inborn Genetic Diseases

Animal models of PD: Pieces of the same puzzle?

Dawson, T. M., Mandir, A. S. & Lee, M. K., Jul 18 2002, In : Neuron. 35, 2, p. 219-222 4 p.

Research output: Contribution to journalArticle

Parkinson Disease
Animal Models
Genetic Models
Genetic Predisposition to Disease
Neurodegenerative Diseases

A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons

Riccio, A., Alvania, R. S., Lonze, B. E., Ramanan, N., Kim, T., Huang, Y., Dawson, T. M., Snyder, S. H. & Ginty, D. D., Jan 20 2006, In : Molecular Cell. 21, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Nitric Oxide
Phosphorylation
Gene Expression
Neurons

A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism

Mandir, A. S., Simbulan-Rosenthal, C. M., Poitras, M. F., Lumpkin, J. R., Dawson, V., Smulson, M. E. & Dawson, T. M., Oct 2002, In : Journal of Neurochemistry. 83, 1, p. 186-192 7 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Parkinsonian Disorders
Post Translational Protein Processing
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

A novel neuronal messenger molecule in brain: The free radical, nitric oxide

Dawson, T. M., Dawson, V. & Snyder, S. H., Sep 1992, In : Annals of Neurology. 32, 3, p. 297-311 15 p.

Research output: Contribution to journalArticle

Free Radicals
Nitric Oxide
Brain
Vasodilator Agents
Nitric Oxide Synthase

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Wang, Y., An, R., Umanah, G., Park, H., Nambiar, K., Eacker, S., Kim, B., Bao, L., Harraz, M., Chang, C., Chen, R., Wang, J. E., Kam, T-I., Jeong, J. S., Xie, Z., Neifert, S., Qian, J., Andrabi, S. A., Blackshaw, S., Zhu, H. & 4 others, Song, H., Ming, G. L., Dawson, V. & Dawson, T. M., Oct 7 2016, In : Science. 354, 6308, aad6872.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
DNA Damage
Cell Death
Glutamic Acid
Macrophage Migration-Inhibitory Factors

A pilot clinical trial of creatine and minocycline in early parkinson disease: 18-month results

The NINDS NET-PD Investigators, 2008, In : Clinical Neuropharmacology. 31, 3, p. 141-150 10 p.

Research output: Contribution to journalArticle

Minocycline
Creatine
Parkinson Disease
Clinical Trials
Medical Futility

Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease

Wang, H., Shimoji, M., Yu, S. W., Dawson, T. M. & Dawson, V., 2003, In : Annals of the New York Academy of Sciences. 991, p. 132-139 8 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Poly(ADP-ribose) Polymerases
Parkinson Disease
Cell death
Chemical activation

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

Cregan, S. P., Fortin, A., MacLaurin, J. G., Callaghan, S. M., Cecconi, F., Yu, S. W., Dawson, T. M., Dawson, V., Park, D. S., Kroemer, G. & Slack, R. S., 2002, In : Journal of Cell Biology. 158, 3, p. 507-517 11 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Caspases
Cell Death
Wounds and Injuries
Neurons

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

Yu, S. W., Andrabi, S. A., Wang, H., No, S. K., Poirier, G. G., Dawson, T. M. & Dawson, V., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18314-18319 6 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
Poly Adenosine Diphosphate Ribose
Polymers
Cell Death
Glycoside Hydrolases

Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death

Wang, H., Yu, S. W., Koh, D. W., Lew, J., Coombs, C., Bowers, W., Federoff, H. J., Poirier, G. G., Dawson, T. M. & Dawson, V., Dec 1 2004, In : Journal of Neuroscience. 24, 48, p. 10963-10973 11 p.

Research output: Contribution to journalArticle

Apoptosis Inducing Factor
N-Methylaspartate
Caspases
Caspase Inhibitors
Phosphatidylserines

A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease

The NINDS NET-PD Investigators, 2006, In : Neurology. 66, 5, p. 664-671 8 p.

Research output: Contribution to journalArticle

Medical Futility
Minocycline
Creatine
Parkinson Disease
Clinical Trials

A randomized clinical trial of high-dosage coenzyme Q10 in early parkinson disease no evidence of benefit

The Parkinson Study Group QE3 Investigators & Dawson, T. M., 2014, In : JAMA Neurology. 75, 1, p. 543-552 10 p.

Research output: Contribution to journalArticle

coenzyme Q10
Parkinson Disease
Randomized Controlled Trials
Placebos
Tremor

ArfGAP1 is a GTPase activating protein for LRRK2: Reciprocal regulation of ArfGAP1 by LRRK2

Xiong, Y., Yuan, C., Chen, R., Dawson, T. M. & Dawson, V., Mar 14 2012, In : Journal of Neuroscience. 32, 11, p. 3877-3886 10 p.

Research output: Contribution to journalArticle

GTPase-Activating Proteins
Leucine
Phosphotransferases
GTP Phosphohydrolases
Guanosine Triphosphate

Assessment of APOE in atypical parkinsonism syndromes

Sabir, M. S., Blauwendraat, C., Ahmed, S., Serrano, G. E., Beach, T. G., Perkins, M., Rice, A. C., Masliah, E., Morris, C. M., Pihlstrom, L., Pantelyat, A., Resnick, S. M., Cookson, M. R., Hernandez, D. G., Albert, M., Dawson, T. M., Rosenthal, L. I. S., Houlden, H., Pletnikova, O., Troncoso, J. C. & 1 others, Scholz, S. W., Jul 1 2019, In : Neurobiology of Disease. 127, p. 142-146 5 p.

Research output: Contribution to journalArticle

Parkinsonian Disorders
Lewy Body Disease
Progressive Supranuclear Palsy
Multiple System Atrophy
Alzheimer Disease

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

Moore, D. J., Zhang, L., Troncoso, J. C., Lee, M. K., Hattori, N., Mizuno, Y., Dawson, T. M. & Dawson, V., Jan 1 2005, In : Human Molecular Genetics. 14, 1, p. 71-84 14 p.

Research output: Contribution to journalArticle

Parkinson Disease
Oxidative Stress
Mutation
Ubiquitination
Synucleins

Association of GBA mutations and the E326K polymorphism with motor and cognitive progression in parkinson disease

Davis, M. Y., Johnson, C. O., Leverenz, J. B., Weintraub, D., Trojanowski, J. Q., Chen-Plotkin, A., Van Deerlin, V. M., Quinn, J. F., Chung, K. A., Peterson-Hiller, A. L., Rosenthal, L. I. S., Dawson, T. M., Albert, M., Goldman, J. G., Stebbins, G. T., Bernard, B., Wszolek, Z. K., Ross, O. A., Dickson, D. W., Eidelberg, D. & 10 others, Mattis, P. J., Niethammer, M., Yearout, D., Hu, S. C., Cholerton, B. A., Smith, M., Mata, I. F., Montine, T. J., Edwards, K. L. & Zabetian, C. P., Oct 1 2016, In : JAMA Neurology. 73, 10, p. 1217-1224 8 p.

Research output: Contribution to journalArticle

Parkinson Disease
Mutation
Genotype
Tremor
Gait

Astroglia Induce Cytotoxic Effects on Brain Tumors via a Nitric Oxide-dependent Pathway Both in Vitro and in Vivo

Samdani, A. F., Kuchner, E. B., Rhines, L., Adamson, D. C., Lawson, C., Tyler, B. M., Brem, H., Dawson, V., Dawson, T. M., Piepmeier, J. M., Parsa, A. T., Lichtor, T., Glick, R. P. & Westphal, M., May 2004, In : Neurosurgery. 54, 5, p. 1231-1238 8 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Astrocytes
Nitric Oxide
Cytokines
Tumor Cell Line

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents

Haince, J. F., Kozlov, S., Dawson, V., Dawson, T. M., Hendzel, M. J., Lavin, M. F. & Poirier, G. G., Jun 1 2007, In : Journal of Biological Chemistry. 282, 22, p. 16441-16453 13 p.

Research output: Contribution to journalArticle

Poly Adenosine Diphosphate Ribose
Ataxia Telangiectasia
DNA Damage
Adenosine Diphosphate
DNA