Ted M Dawson

Professor

1983 …2019
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Research Output 1983 2019

2019

A comprehensive screening of copy number variability in dementia with Lewy bodies

Kun-Rodrigues, C., Orme, T., Carmona, S., Hernandez, D. G., Ross, O. A., Eicher, J. D., Shepherd, C., Parkkinen, L., Darwent, L., Heckman, M. G., Scholz, S. W., Troncoso, J. C., Pletnikova, O., Dawson, T. M., Rosenthal, L. I. S., Ansorge, O., Clarimon, J., Lleo, A., Morenas-Rodriguez, E., Clark, L. & 48 others, Honig, L. S., Marder, K., Lemstra, A., Rogaeva, E., St. George-Hyslop, P., Londos, E., Zetterberg, H., Barber, I., Braae, A., Brown, K., Morgan, K., Troakes, C., Al-Sarraj, S., Lashley, T., Holton, J., Compta, Y., Van Deerlin, V., Serrano, G. E., Beach, T. G., Lesage, S., Galasko, D., Masliah, E., Santana, I., Pastor, P., Diez-Fairen, M., Aguilar, M., Tienari, P. J., Myllykangas, L., Oinas, M., Revesz, T., Lees, A., Boeve, B. F., Petersen, R. C., Ferman, T. J., Escott-Price, V., Graff-Radford, N., Cairns, N. J., Morris, J. C., Pickering-Brown, S., Mann, D., Halliday, G. M., Hardy, J., Trojanowski, J. Q., Dickson, D. W., Singleton, A., Stone, D. J., Guerreiro, R. & Bras, J., Mar 1 2019, In : Neurobiology of Aging. 75, p. 223.e1-223.e10

Research output: Contribution to journalArticle

Lewy Body Disease
Genome
Neurodegenerative Diseases
Genes
Dementia

Assessment of APOE in atypical parkinsonism syndromes

Sabir, M. S., Blauwendraat, C., Ahmed, S., Serrano, G. E., Beach, T. G., Perkins, M., Rice, A. C., Masliah, E., Morris, C. M., Pihlstrom, L., Pantelyat, A., Resnick, S. M., Cookson, M. R., Hernandez, D. G., Albert, M., Dawson, T. M., Rosenthal, L. I. S., Houlden, H., Pletnikova, O., Troncoso, J. C. & 1 others, Scholz, S. W., Jul 1 2019, In : Neurobiology of Disease. 127, p. 142-146 5 p.

Research output: Contribution to journalArticle

Parkinsonian Disorders
Lewy Body Disease
Progressive Supranuclear Palsy
Multiple System Atrophy
Alzheimer Disease

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia

Panicker, N., Sarkar, S., Harischandra, D. S., Neal, M., Kam, T-I., Jin, H., Saminathan, H., Langley, M., Charli, A., Samidurai, M., Rokad, D., Ghaisas, S., Pletnikova, O., Dawson, V., Dawson, T. M., Anantharam, V., Kanthasamy, A. G. & Kanthasamy, A., Jun 3 2019, In : The Journal of experimental medicine. 216, 6, p. 1411-1430 20 p.

Research output: Contribution to journalArticle

Open Access
Synucleins
Inflammasomes
Microglia
Parkinson Disease
Phosphotransferases

Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis

Jin, J., Smith, M. D., Kersbergen, C. J., Kam, T-I., Viswanathan, M., Martin, K., Dawson, T. M., Dawson, V., Zack, D. J., Whartenby, K. & Calabresi, P., Jul 31 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Visual Pathways
Autoimmune Experimental Encephalomyelitis
Neuroglia
Pathology
Astrocytes

Heritability and genetic variance of dementia with Lewy bodies

for the International Parkinson's Disease Genomics Consortium, Jul 1 2019, In : Neurobiology of Disease. 127, p. 492-501 10 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Alzheimer Disease
Single Nucleotide Polymorphism
Parkinson Disease
Inborn Genetic Diseases
Open Access
Induced Pluripotent Stem Cells
Neurons
Brain
Prosencephalon
Organoids

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease

Brahmachari, S., Lee, S., Kim, S., Yuan, C., Karuppagounder, S., Ge, P., Shi, R., Kim, E. J., Liu, A., Kim, D., Quintin, S., Jiang, H., Kumar, M., Yun, S. P., Kam, T-I., Mao, X., Lee, Y., Swing, D. A., Tessarollo, L., Ko, H. S. & 2 others, Dawson, V. & Dawson, T. M., Aug 1 2019, In : Brain : a journal of neurology. 142, 8, p. 2380-2401 22 p.

Research output: Contribution to journalArticle

Zinc Fingers
Synucleins
Parkinson Disease
Proteins
Amino Acyl-tRNA Synthetases

SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy

Yamada, T., Dawson, T. M., Yanagawa, T., Iijima, M. & Sesaki, H., Nov 1 2019, In : Autophagy. 15, 11, p. 2012-2018 7 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Ubiquitination
Mitochondrial Proteins
Mitochondrial Dynamics
Dynamins

The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration

Hinkle, J. T., Dawson, V. & Dawson, T. M., Jul 1 2019, In : Movement Disorders. 34, 7, p. 959-969 11 p.

Research output: Contribution to journalArticle

Astrocytes
Neuroglia
Pharmacology
Microglia
Translational Medical Research

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease

Kim, S., Kwon, S. H., Kam, T-I., Panicker, N., Karuppagounder, S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C., Shen, C., Lee, H., Kulkarni, S., Pasricha, P. J., Lee, G., Pomper, M. G., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 21 2019, In : Neuron. 103, 4, p. 627-641.e7

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Brain
Truncal Vagotomy
Pathology
2018

A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy

Piard, J., Umanah, G., Harms, F. L., Abalde-Atristain, L., Amram, D., Chang, M., Chen, R., Alawi, M., Salpietro, V., Rees, M. I., Chung, S. K., Houlden, H., Verloes, A., Dawson, T. M., Dawson, V., Van Maldergem, L. & Kutsche, K., Mar 1 2018, In : Brain. 141, 3, p. 651-661 11 p.

Research output: Contribution to journalArticle

AMPA Receptors
Brain Diseases
Mutation
Adenosine Triphosphatases
Arthrogryposis

Animal models of neurodegenerative diseases

Dawson, T. M., Golde, T. E. & Lagier-Tourenne, C., Oct 1 2018, In : Nature Neuroscience. 21, 10, p. 1370-1379 10 p.

Research output: Contribution to journalReview article

Neurodegenerative Diseases
Animal Models
Parkinson Disease
Alzheimer Disease
Rodentia

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T-I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. & 13 others, Lee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature Medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

Microglia
Astrocytes
Parkinson Disease
Synucleins
Nervous System Diseases

DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders

Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V., Dawson, T. M., Aja, S. M., Sesaki, H. & Pletnikov, M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 76.

Research output: Contribution to journalArticle

Astrocytes
Psychiatry
Lactic Acid
Schizophrenia
Glucose

Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease

Hinkle, J. T., Perepezko, K., Mills, K., Mari, Z., Butala, A., Dawson, T. M., Pantelyat, A., Rosenthal, L. I. S. & Pontone, G. M., Jan 1 2018, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Primary Dysautonomias
Dopamine Plasma Membrane Transport Proteins
Parkinson Disease
Corpus Striatum
Constipation

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Jeong, G. R., Jang, E. H., Bae, J. R., Jun, S., Kang, H. C., Park, C. H., Shin, J. H., Yamamoto, Y., Tanaka-Yamamoto, K., Dawson, V., Dawson, T. M., Hur, E. M. & Lee, B. D., Feb 13 2018, In : Molecular Neurodegeneration. 13, 1, 8.

Research output: Contribution to journalArticle

rab GTP-Binding Proteins
Leucine
Phosphotransferases
Phosphorylation
Dopaminergic Neurons

Excitotoxic programmed cell death involves caspase-independent mechanisms

Dawson, T. M. & Dawson, V., Jan 1 2018, Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms: Second Edition. Springer International Publishing, p. 3-17 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

nucleases
caspases
Cell death
Caspases
cell death

Finding useful biomarkers for Parkinson s disease

Chen-Plotkin, A. S., Albin, R., Alcalay, R., Babcock, D., Bajaj, V., Bowman, D., Buko, A., Cedarbaum, J., Chelsky, D., Cookson, M. R., Dawson, T. M., Dewey, R., Foroud, T., Frasier, M., German, D., Gwinn, K., Huang, X., Kopil, C., Kremer, T., Lasch, S. & 20 others, Marek, K., Marto, J. A., Merchant, K., Mollenhauer, B., Naito, A., Potashkin, J., Reimer, A., Rosenthal, L. I. S., Saunders-Pullman, R., Scherzer, C. R., Sherer, T., Singleton, A., Sutherland, M., Thiele, I., Van Der Brug, M., Keuren-Jensen, K. V., Vaillancourt, D., Walt, D., West, A. & Zhang, J., Aug 15 2018, In : Science Translational Medicine. 10, 454, eaam6003.

Research output: Contribution to journalReview article

Ecosystem
Parkinson Disease
Biomarkers
Therapeutics
Datasets

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Kim, S., Yun, S. P., Lee, S., Umanah, G., Bandaru, V. V. R., Yin, X., Rhee, P., Karuppagounder, S., Kwon, S. H., Lee, H., Mao, X., Kim, D., Pandey, A., Lee, G., Dawson, V., Dawson, T. M. & Ko, H. S., Jan 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Synucleins
Glucosylceramidase
Gaucher Disease
Glycosphingolipids
Dopaminergic Neurons

Genetic analysis of neurodegenerative diseases in a pathology cohort

Blauwendraat, C., Pletnikova, O., Geiger, J. T., Murphy, N. A., Abramzon, Y., Rudow, G., Mamais, A., Sabir, M. S., Crain, B., Ahmed, S., Rosenthal, L. I. S., Bakker, C. C., Faghri, F., Chia, R., Ding, J., Dawson, T. M., Pantelyat, A., Albert, M., Nalls, M. A., Resnick, S. M. & 5 others, Ferrucci, L., Cookson, M. R., Hillis-Trupe, A., Troncoso, J. C. & Scholz, S. W., Jan 1 2018, (Accepted/In press) In : Neurobiology of Aging.

Research output: Contribution to journalArticle

Neurodegenerative Diseases
Pathology
Mutation
Phenotype
Genetic Research
Disruptive, Impulse Control, and Conduct Disorders
Dyskinesias
Parkinson Disease
Dopamine

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

Yamada, T., Murata, D., Adachi, Y., Itoh, K., Kameoka, S., Igarashi, A., Kato, T., Araki, Y., Huganir, R. L., Dawson, T. M., Yanagawa, T., Okamoto, K., Iijima, M. & Sesaki, H., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Ubiquitination
Liver
Mitochondria
Cullin Proteins

Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., Blagosklonny, M. V. & 149 others, Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Cohen, G. M., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D'Angiolella, V., Dawson, T. M., Dawson, V., De Laurenzi, V., De Maria, R., Debatin, K. M., Deberardinis, R. J., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, V. M., Dixon, S. J., Duckett, C. S., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Fimia, G. M., Fulda, S., García-Sáez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D. R., Greene, L. A., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J. M., Harris, I. S., Hengartner, M. O., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, P. J., Juin, P. P., Kaiser, W. J., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Knight, R. A., Kumar, S., Lee, S. W., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lowe, S. W., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J. C., Martin, S. J., Martinou, J. C., Medema, J. P., Mehlen, P., Meier, P., Melino, S., Miao, E. A., Molkentin, J. D., Moll, U. M., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pereira, D. M., Pervaiz, S., Peter, M. E., Piacentini, M., Pinton, P., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rehm, M., Rizzuto, R., Rodrigues, C. M. P., Rubinsztein, D. C., Rudel, T., Ryan, K. M., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H. U., Sistigu, A., Stockwell, B. R., Strasser, A., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, M. G., Villunger, A., Virgin, H. W., Vousden, K. H., Vucic, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, Y., Wells, J. A., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G. & Kroemer, G., Mar 1 2018, In : Cell Death and Differentiation. 25, 3, p. 486-541 56 p.

Research output: Contribution to journalReview article

Terminology
Cell Death
Apoptosis
Cell Aging
Autophagy

Onset and Remission of Psychosis in Parkinson's Disease: Pharmacologic and Motoric Markers

Hinkle, J. T., Perepezko, K., Bakker, C. C., Broen, M. P. G., Chin, K., Dawson, T. M., Johnson, V., Mari, Z., Marvel, C. L., Mills, K. A., Pantelyat, A., Pletnikova, O., Rosenthal, L. S., Shepard, M. D., Stevens, D. A., Troncoso, J. C., Wang, J. & Pontone, G. M., Jan 1 2018, In : Movement Disorders Clinical Practice. 5, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Psychotic Disorders
Parkinson Disease
Dopamine Agonists
Cholinergic Antagonists
Psychiatry

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T. H., Iwai, K., Dawson, V., Dawson, T. M. & Takahashi, R., Jan 1 2018, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

Synucleins
Multiple System Atrophy
Oligodendroglia
Inclusion Bodies
Neuroglia

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T-I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 others, Dawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

Synucleins
Poly Adenosine Diphosphate Ribose
Parkinson Disease
Adenosine
Poisons

Reply: ATAD1 encephalopathy and stiff baby syndrome: A recognizable clinical presentation

Piard, J., Umanah, G., Harms, F. L., Abalde-Atristain, L., Amram, D., Chang, M., Chen, R., Alawi, M., Salpietro, V., Rees, M. I., Chung, S. K., Houlden, H., Verloes, A., Dawson, T. M., Dawson, V., Van Maldergem, L. & Kutsche, K., Jun 1 2018, In : Brain. 141, 6, p. e50

Research output: Contribution to journalLetter

Brain Diseases
Hyperexplexia hereditary

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Xiong, Y., Neifert, S., Karuppagounder, S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S., Swing, D. A., Iacovitti, L., Tessarollo, L., Dawson, T. M. & Dawson, V., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1635-1640 6 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Transgenic Mice
Norepinephrine
Phosphotransferases
Parkinson Disease

Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease

Cholerton, B., Johnson, C. O., Fish, B., Quinn, J. F., Chung, K. A., Peterson-Hiller, A. L., Rosenthal, L. I. S., Dawson, T. M., Albert, M., Hu, S. C., Mata, I. F., Leverenz, J. B., Poston, K. L., Montine, T. J., Zabetian, C. P. & Edwards, K. L., Jan 1 2018, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Sex Characteristics
Parkinson Disease
Dementia
Demography
Neurobehavioral Manifestations

Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Xue, Y., Zhan, X., Sun, S., Karuppagounder, S., Xia, S., Dawson, V., Dawson, T. M., Laterra, J. J., Zhang, J. & Ying, M., Jan 1 2018, (Accepted/In press) In : Stem cells translational medicine.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Cell Differentiation
Myosin Type II
Messenger RNA
Induced Pluripotent Stem Cells

The AAA + ATPase Thorase is neuroprotective against ischemic injury

Zhang, J., Yang, J., Wang, H., Sherbini, O., Keuss, M. J., Umanah, G., Pai, E. L. L., Chi, Z., Paldanius, K. M. A., He, W., Wang, H., Andrabi, S. A., Dawson, T. M. & Dawson, V., Jan 1 2018, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Wounds and Injuries
Stroke
Glutamic Acid
Proteins

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

Yun, S. P., Kim, D., Kim, S., Kim, S., Karuppagounder, S., Kwon, S. H., Lee, S., Kam, T-I., Lee, S., Ham, S., Park, J. H., Dawson, V., Dawson, T. M., Lee, Y. & Ko, H. S., Jan 8 2018, In : Molecular Neurodegeneration. 13, 1, 1.

Research output: Contribution to journalArticle

Synucleins
Glucosylceramidase
Gaucher Disease
Parkinsonian Disorders
Mutation
2017

Activation mechanisms of the E3 ubiquitin ligase parkin

Panicker, N., Dawson, V. & Dawson, T. M., Sep 15 2017, In : Biochemical Journal. 474, 18, p. 3075-3086 12 p.

Research output: Contribution to journalReview article

Ubiquitin-Protein Ligases
Parkinson Disease
Chemical activation
Genes
Phosphotransferases

Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis

Zhang, J., Li, X., Kwansa, H., Kim, Y. T., Yi, L., Hong, G., Andrabi, S. A., Dawson, V., Dawson, T. M., Koehler, R. C. & Yang, Z. J., Jun 1 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 6, p. 1982-1993 12 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Apoptosis Inducing Factor
Acidosis
Poly Adenosine Diphosphate Ribose
Cell Death

C-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential

Brahmachari, S., Karuppagounder, S., Ge, P., Lee, S., Dawson, V., Dawson, T. M. & Ko, H. S., 2017, In : Journal of Parkinson's Disease. 7, 4, p. 589-601 13 p.

Research output: Contribution to journalReview article

Parkinson Disease
Oxidative Stress
Therapeutics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Cell death mechanisms of neurodegeneration

Fan, J., Dawson, T. M. & Dawson, V., 2017, Advances in Neurobiology. Springer New York LLC, Vol. 15. p. 403-425 23 p. (Advances in Neurobiology; vol. 15).

Research output: Chapter in Book/Report/Conference proceedingChapter

Neurodegenerative diseases
Cell death
Neurodegenerative Diseases
Cell Death
Autophagy

Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis

Hinkle, J. T., Perepezko, K., Bakker, C. C., Dawson, T. M., Johnson, V., Mari, Z., Marvel, C. L., Mills, K. A., Pantelyat, A., Pletnikova, O., Rosenthal, L. S., Shepard, M. D., Stevens, D. A., Troncoso, J. C., Wang, J. & Pontone, G. M., 2017, (Accepted/In press) In : International Journal of Geriatric Psychiatry.

Research output: Contribution to journalArticle

Psychotic Disorders
Parkinson Disease
Language
Odds Ratio
Cognitive Dysfunction

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

Puschmann, A., Fiesel, F. C., Caulfield, T. R., Hudec, R., Ando, M., Truban, D., Hou, X., Ogaki, K., Heckman, M. G., James, E. D., Swanberg, M., Jimenez-Ferrer, I., Hansson, O., Opala, G., Siuda, J., Boczarska-Jedynak, M., Friedman, A., Koziorowski, D., Aasly, J. O., Lynch, T. & 12 others, Mellick, G. D., Mohan, M., Silburn, P. A., Sanotsky, Y., Vilariño-Güell, C., Farrer, M. J., Chen, L., Dawson, V. L., Dawson, V., Dawson, T. M., Ross, O. A. & Springer, W., Jan 1 2017, In : Brain : a journal of neurology. 140, p. 98-117 20 p.

Research output: Contribution to journalArticle

Parkinson Disease
Heterozygote
Mutation
Odds Ratio
PTEN-induced putative kinase

Markers of impaired motor and cognitive volition in Parkinson's disease: Correlates of dopamine dysregulation syndrome, impulse control disorder, and dyskinesias

Hinkle, J. T., Perepezko, K., Rosenthal, L. I. S., Mills, K., Pantelyat, A., Mari, Z., Tochen, L., Bang, J. Y., Gudavalli, M., Yoritomo, N., Butala, A., Bakker, C. C., Johnson, V., Moukheiber, E., Dawson, T. M. & Pontone, G. M., Jan 1 2017, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Disruptive, Impulse Control, and Conduct Disorders
Dyskinesias
Parkinson Disease
Dopamine
Psychotic Disorders

Mitochondrial mechanisms of neuronal cell death: Potential the rapeutics

Dawson, T. M. & Dawson, V., Jan 6 2017, In : Annual Review of Pharmacology and Toxicology. 57, p. 437-454 18 p.

Research output: Contribution to journalReview article

Cell death
Cell Death
Mitochondria
Nervous System Diseases
Neurodegenerative diseases

Models of LRRK2-associated parkinson’s disease

Xiong, Y., Dawson, T. M. & Dawson, V., Apr 1 2017, Advances in Neurobiology. Springer New York LLC, Vol. 14. p. 163-191 29 p. (Advances in Neurobiology; vol. 14).

Research output: Chapter in Book/Report/Conference proceedingChapter

Leucine
Parkinson Disease
Phosphotransferases
Animal Models
Animals

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W. S., Peterson, T. C., Wilton, D. K., Frouin, A., Napier, B. A., Panicker, N., Kumar, M., Buckwalter, M. S., Rowitch, D. H., Dawson, V., Dawson, T. M., Stevens, B. & 1 others, Barres, B. A., Jan 26 2017, In : Nature. 541, 7638, p. 481-487 7 p.

Research output: Contribution to journalArticle

Microglia
Astrocytes
Neurons
Oligodendroglia
Neurodegenerative Diseases

Nitric Oxide Signaling in Neurodegeneration and Cell Death

Dawson, T. M. & Dawson, V., 2017, (Accepted/In press) In : Advances in Pharmacology.

Research output: Contribution to journalArticle

Nitric Oxide
Cell Death
NADPH Dehydrogenase
Nitric Oxide Synthase Type I
Neurons

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases

Berger, N. A., Besson, V. C., Boulares, A. H., Bürkle, A., Chiarugi, A., Clark, R. S., Curtin, N. J., Cuzzocrea, S., Dawson, T. M., Dawson, V., Haskó, G., Liaudet, L., Moroni, F., Pacher, P., Radermacher, P., Salzman, A. L., Snyder, S. H., Soriano, F. G., Strosznajder, R. P., Sümegi, B. & 2 others, Swanson, R. A. & Szabo, C., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Acute Lung Injury
Therapeutics
Septic Shock
DNA Repair
Pancreatitis

Overexpression of Parkinson’s disease-associated mutation LRRK2 G2019S in mouse forebrain induces behavioral deficits and α-synuclein pathology

Xiong, Y., Neifert, S., Karuppagounder, S., Stankowski, J. N., Lee, B. D., Grima, J. C., Chen, G., Ko, H. S., Lee, Y., Swing, D., Tessarollo, L., Dawson, T. M. & Dawson, V., 2017, In : eNeuro. 4, 2, e0004.

Research output: Contribution to journalArticle

Synucleins
Prosencephalon
Leucine
Parkinson Disease
Phosphotransferases

Parkinson's disease biomarkers: Perspective from the NINDS Parkinson's Disease Biomarkers Program

Gwinn, K., David, K. K., Swanson-Fischer, C., Albin, R., Hillaire-Clarke, C. S., Sieber, B. A., Lungu, C., Bowman, F. D., Alcalay, R. N., Babcock, D., Dawson, T. M., Dewey, R. B., Foroud, T., German, D., Huang, X., Petyuk, V., Potashkin, J. A., Saunders-Pullman, R., Sutherland, M., Walt, D. R. & 6 others, West, A. B., Zhang, J., Chen-Plotkin, A., Scherzer, C. R., Vaillancourt, D. E. & Rosenthal, L. I. S., Jun 1 2017, In : Biomarkers in Medicine. 11, 6, p. 451-473 23 p.

Research output: Contribution to journalReview article

National Institute of Neurological Disorders and Stroke
Biomarkers
Parkinson Disease
Guidelines
Publications

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G., Kang, H., Ham, S., Kam, T-I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F. C., Springer, W., Dawson, V., Shin, J. H. & 1 others, Dawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journalArticle

Ubiquitination
Dopaminergic Neurons
Neurons
Phosphorylation
Substantia Nigra

Protein Translation in Parkinson's Disease

Kim, J. W., Abalde-Atristain, L., Jia, H., Martin, I., Dawson, T. M. & Dawson, V., Jan 6 2017, Parkinson's Disease: Molecular Mechanisms Underlying Pathology. Elsevier Inc., p. 245-279 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein Biosynthesis
Parkinson Disease
Pathology
Nucleotides
Neurons

Reply: Heterozygous PINK1 p.G411S in rapid eye movement sleep behaviour disorder

Puschmann, A., Fiesel, F. C., Caulfield, T. R., Hudec, R., Ando, M., Truban, D., Hou, X., Ogaki, K., Heckman, M. G., James, E. D., Swanberg, M., Jimenez-Ferrer, I., Hansson, O., Opala, G., Siuda, J., Boczarska-Jedynak, M., Friedman, A., Koziorowski, D., Rudzińska-Bar, M., Aasly, J. O. & 13 others, Lynch, T., Mellick, G. D., Mohan, M., Silburn, P. A., Sanotsky, Y., Vilarinõ-Güell, C., Farrer, M. J., Chen, L., Dawson, V., Dawson, T. M., Wszolek, Z. K., Ross, O. A. & Springer, W., 2017, In : Brain. 140, 6, p. e33

Research output: Contribution to journalLetter

REM Sleep Behavior Disorder

Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning

Pignatelli, M., Umanah, G., Ribeiro, S. P., Chen, R., Karuppagounder, S., Yau, H. J., Eacker, S., Dawson, V., Dawson, T. M. & Bonci, A., Jan 18 2017, In : Neuron. 93, 2, p. 425-440 16 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Dopaminergic Neurons
Fear
Learning
AMPA Receptors