Tanguy Lim Seiwert

Assistant Professor

19992019
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Research Output 1999 2019

2019

A pilot study of the pan-class I PI3K inhibitor buparlisib in combination with cetuximab in patients with recurrent or metastatic head and neck cancer

Brisson, R. J., Kochanny, S., Arshad, S., Dekker, A., DeSouza, J. A., Saloura, V., Vokes, E. E. & Seiwert, T. Y., Jan 1 2019, (Accepted/In press) In : Head and Neck.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Phosphatidylinositol 3-Kinases
Maximum Tolerated Dose
Cetuximab
NVP-BKM120

Comparative analysis of the phase III clinical trials of anti-PD1 monotherapy in head and neck squamous cell carcinoma patients (CheckMate 141 and KEYNOTE 040)

Pai, S. I., Faivre, S., Licitra, L., Machiels, J. P., Vermorken, J. B., Bruzzi, P., Gruenwald, V., Giglio, R. E., Leemans, C. R., Lim Seiwert, T. & Soulieres, D., Apr 3 2019, In : Journal for immunotherapy of cancer. 7, 1, 96.

Research output: Contribution to journalReview article

Open Access
Phase III Clinical Trials
Survival
docetaxel
Standard of Care
Clinical Trials

Development and validation of a combined hypoxia and immune prognostic classifier for head and neck cancer

Brooks, J. M., Menezes, A. N., Ibrahim, M., Archer, L., Lal, N., Bagnall, C. J., Von Zeidler, S. V., Valentine, H. R., Spruce, R. J., Batis, N., Bryant, J. L., Hartley, M., Kaul, B., Ryan, G. B., Bao, R., Khattri, A., Lee, S. P., Ogbureke, K. U. E., Middleton, G., Tennant, D. A. & 7 others, Beggs, A. D., Deeks, J., West, C. M. L., Cazier, J. B., Willcox, B. E., Seiwert, T. Y. & Mehanna, H., Sep 1 2019, In : Clinical Cancer Research. 25, 17, p. 5315-5328 14 p.

Research output: Contribution to journalArticle

Open Access
Head and Neck Neoplasms
Atlases
Neoplasms
Biomarkers
Genome

Identification and validation of novel microenvironment-based immune molecular subgroups of head and neck squamous cell carcinoma: Implications for immunotherapy

Chen, Y. P., Wang, Y. Q., Lv, J. W., Li, Y. Q., Chua, M. L. K., Le, Q. T., Lee, N., Dimitrios Colevas, A., Lim Seiwert, T., Hayes, D. N., Riaz, N., Vermorken, J. B., O'Sullivan, B., He, Q. M., Yang, X. J., Tang, L. L., Mao, Y. P., Sun, Y., Liu, N. & Ma, J., Jan 1 2019, In : Annals of Oncology. 30, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Immunotherapy
Neoplasms
Macrophages
RNA Sequence Analysis
Tumor-Infiltrating Lymphocytes

Identification of neoantigen-specific T cells and their targets: implications for immunotherapy of head and neck squamous cell carcinoma

Ren, L., Leisegang, M., Deng, B., Matsuda, T., Kiyotani, K., Kato, T., Harada, M., Park, J. H., Saloura, V., Lim Seiwert, T., Vokes, E., Agrawal, N. & Nakamura, Y., Apr 3 2019, In : OncoImmunology. 8, 4, e1568813.

Research output: Contribution to journalArticle

Open Access
Immunotherapy
T-Cell Antigen Receptor
T-Lymphocytes
Tumor Microenvironment
Carcinoma, squamous cell of head and neck

Immune profiles in primary squamous cell carcinoma of the head and neck

Saloura, V., Izumchenko, E., Zuo, Z., Bao, R., Korzinkin, M., Ozerov, I., Zhavoronkov, A., Sidransky, D., Bedi, A., Hoque, M. O., Koeppen, H., Keck, M. K., Khattri, A., London, N., Kotlov, N., Fatima, A., Vougiouklakis, T., Nakamura, Y., Lingen, M., Agrawal, N. & 5 others, Savage, P. A., Kron, S., Kline, J., Kowanetz, M. & Seiwert, T. Y., Sep 1 2019, In : Oral Oncology. 96, p. 77-88 12 p.

Research output: Contribution to journalArticle

Neoplasms
Regulatory T-Lymphocytes
Mutation
Macrophages
Carcinoma, squamous cell of head and neck

Optima: A phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancer

Lim Seiwert, T., Foster, C. C., Blair, E. A., Karrison, T. G., Agrawal, N., Melotek, J. M., Portugal, L., Brisson, R. J., Dekker, A., Kochanny, S., Gooi, Z., Lingen, M. W., Villaflor, V. M., Ginat, D. T., Haraf, D. J. & Vokes, E. E., Feb 1 2019, In : Annals of Oncology. 30, 2, p. 297-302 6 p.

Research output: Contribution to journalArticle

Oropharyngeal Neoplasms
Chemoradiotherapy
Radiotherapy
Induction Chemotherapy
Clinical Trials

OPTIMA: a phase II dose and volume de-escalation trial for human papillomavirus-positive oropharyngeal cancer

Seiwert, T. Y., Foster, C. C., Blair, E. A., Karrison, T. G., Agrawal, N., Melotek, J. M., Portugal, L., Brisson, R. J., Dekker, A., Kochanny, S., Gooi, Z., Lingen, M. W., Villaflor, V. M., Ginat, D. T., Haraf, D. J. & Vokes, E. E., Oct 1 2019, In : Annals of oncology : official journal of the European Society for Medical Oncology. 30, 10, 1 p.

Research output: Contribution to journalArticle

Open Access
Oropharyngeal Neoplasms

Prognostic value of pre-treatment CT texture analysis in combination with change in size of the primary tumor in response to induction chemotherapy for HPV-positive oropharyngeal squamous cell carcinoma

Miller, T. A., Robinson, K. R., Li, H., Lim Seiwert, T., Haraf, D. J., Lan, L., Giger, M. L. & Ginat, D. T., Jan 1 2019, In : Quantitative Imaging in Medicine and Surgery. 9, 3, p. 399-408 10 p.

Research output: Contribution to journalArticle

Induction Chemotherapy
Squamous Cell Carcinoma
Neoplasms
Therapeutics
Entropy

Variations in HPV function are associated with survival in squamous cell carcinoma

Gleber-Netto, F. O., Rao, X., Guo, T., Xi, Y., Gao, M., Shen, L., Erikson, K., Kalu, N. N., Ren, S., Xu, G., Fisch, K. M., Akagi, K., Seiwert, T., Gillison, M., Frederick, M. J., Johnson, F. M., Wang, J., Myers, J. N., Califano, J., Skinner, H. D. & 1 others, Pickering, C. R., Jan 10 2019, In : JCI Insight. 4, 1, e124762.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Carcinoma
Survival
Neoplasms
Radiotherapy
Morbidity
2018

Definitive chemoradiation for locally-advanced oral cavity cancer: A 20-year experience

Foster, C. C., Melotek, J. M., Brisson, R. J., Lim Seiwert, T., Cohen, E. E. W., Stenson, K. M., Blair, E. A., Portugal, L., Gooi, Z., Agrawal, N., Vokes, E. E. & Haraf, D. J., May 1 2018, In : Oral Oncology. 80, p. 16-22 7 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Osteoradionecrosis
Mouth
Squamous Cell Carcinoma
Disease-Free Survival

Efficacy and safety of pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma: pooled analyses after long-term follow-up in KEYNOTE-012

Mehra, R., Lim Seiwert, T., Gupta, S., Weiss, J., Gluck, I., Eder, J. P., Burtness, B., Tahara, M., Keam, B., Kang, H., Muro, K., Geva, R., Chung, H. C., Lin, C. C., Aurora-Garg, D., Ray, A., Pathiraja, K., Cheng, J., Chow, L. Q. M. & Haddad, R., Jun 29 2018, (Accepted/In press) In : British Journal of Cancer. p. 1-7 7 p.

Research output: Contribution to journalArticle

Safety
Therapeutics
Carcinoma, squamous cell of head and neck
pembrolizumab
Survival

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy

Cristescu, R., Mogg, R., Ayers, M., Albright, A., Murphy, E., Yearley, J., Sher, X., Liu, X. Q., Lu, H., Nebozhyn, M., Zhang, C., Lunceford, J. K., Joe, A., Cheng, J., Webber, A. L., Ibrahim, N., Plimack, E. R., Ott, P. A., Lim Seiwert, T., Ribas, A. & 4 others, McClanahan, T. K., Tomassini, J. E., Loboda, A. & Kaufman, D., Oct 12 2018, In : Science. 362, 6411, eaar3593.

Research output: Contribution to journalArticle

Tumor Biomarkers
Tumor Burden
Transcriptome
Immunotherapy
CD274 Antigen

Role of dental hardware in oral cavity squamous cell carcinoma in the low-risk nonsmoker nondrinker population

Yesensky, J. A., Hasina, R., Wroblewski, K. E., Bellairs, J., Gooi, Z., Saloura, V., Cipriani, N. A., Vokes, E. E., Portugal, L. G., Lim Seiwert, T., Blair, E. D. & Agrawal, N., Apr 1 2018, In : Head and Neck. 40, 4, p. 784-792 9 p.

Research output: Contribution to journalArticle

Mouth
Squamous Cell Carcinoma
Tooth
Orthodontic Brackets
Population

Similarity and difference in tumor-infiltrating lymphocytes in original tumor tissues and those of in vitro expanded populations in head and neck cancer

Ren, L., Matsuda, T., Deng, B., Kiyotani, K., Kato, T., Park, J. H., Lim Seiwert, T., Vokes, E. E., Agrawal, N. & Nakamura, Y., Jan 1 2018, In : Oncotarget. 9, 3, p. 3805-3814 10 p.

Research output: Contribution to journalArticle

Open Access
Tumor-Infiltrating Lymphocytes
Head and Neck Neoplasms
Population
Neoplasms
Mutation
2017

AHNS Series – Do you know your guidelines? Principles of treatment for nasopharyngeal cancer: A review of the National Comprehensive Cancer Network guidelines

Gooi, Z., Richmon, J., Agrawal, N., Blair, E., Portugal, L., Vokes, E., Lim Seiwert, T., de Souza, J., Saloura, V., Haraf, D., Goldenberg, D. & Chan, J., Feb 1 2017, In : Head and Neck. 39, 2, p. 201-205 5 p.

Research output: Contribution to journalArticle

Nasopharyngeal Neoplasms
Guidelines
Neoplasms
Head and Neck Neoplasms
Practice Guidelines

Characterization of the T-cell receptor repertoire and immune microenvironment in patients with locoregionally advanced squamous cell carcinoma of the head and neck

Saloura, V., Fatima, A., Zewde, M., Kiyotani, K., Brisson, R., Park, J. H., Ikeda, Y., Vougiouklakis, T., Bao, R., Khattri, A., Lim Seiwert, T., Cipriani, N., Lingen, M., Vokes, E. & Nakamura, Y., Aug 15 2017, In : Clinical Cancer Research. 23, 16, p. 4897-4907 11 p.

Research output: Contribution to journalArticle

Open Access
Papillomaviridae
T-Cell Antigen Receptor
Neoplasms
Chemoradiotherapy
Antigen Presentation

Clinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing Assays

Kadri, S., Long, B. C., Mujacic, I., Zhen, C. J., Wurst, M. N., Sharma, S., McDonald, N., Niu, N., Benhamed, S., Tuteja, J. H., Lim Seiwert, T., White, K. P., McNerney, M. E., Fitzpatrick, C., Wang, Y. L., Furtado, L. V. & Segal, J. P., Jan 1 2017, In : Journal of Molecular Diagnostics. 19, 1, p. 43-56 14 p.

Research output: Contribution to journalArticle

Benchmarking
Medicine
Neoplasms
Translational Medical Research
Gene Fusion

Expression and mutational analysis of c-CBL and its relationship to the MET receptor in head and neck squamous cell carcinoma

Rolle, C. E., Tan, Y. H. C., Lim Seiwert, T., Vora, S., Kanteti, R., Hasina, R., Carey, G. B., Surati, M., Weichselbaum, R. R., Lingen, M. W., Vokes, E. E. & Salgia, R., Jan 1 2017, In : Oncotarget. 8, 12, p. 18726-18734 9 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Protein Ligases
Loss of Heterozygosity
Tumor Cell Line
Single Nucleotide Polymorphism
Cell Survival

How standard is second-line cetuximab in recurrent or metastatic head and neck cancer in 2017?

Szturz, P., Lim Seiwert, T. & Vermorken, J. B., Jul 10 2017, In : Journal of Clinical Oncology. 35, 20, p. 2229-2231 3 p.

Research output: Contribution to journalComment/debate

Head and Neck Neoplasms
Cetuximab

IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade

Ayers, M., Lunceford, J., Nebozhyn, M., Murphy, E., Loboda, A., Kaufman, D. R., Albright, A., Cheng, J. D., Kang, S. P., Shankaran, V., Piha-Paul, S. A., Yearley, J., Lim Seiwert, T., Ribas, A. & McClanahan, T. K., Aug 1 2017, In : Journal of Clinical Investigation. 127, 8, p. 2930-2940 11 p.

Research output: Contribution to journalArticle

Open Access
Transcriptome
Messenger RNA
T-Lymphocytes
Neoplasms
Ligands

Immunotherapy for head and neck squamous cell carcinoma: A review of current and emerging therapeutic options

Moskovitz, J. M., Moy, J., Lim Seiwert, T. & Ferris, R. L., Jun 1 2017, In : Oncologist. 22, 6, p. 680-693 14 p.

Research output: Contribution to journalReview article

Open Access
Immunotherapy
Clinical Trials
Neoplasms
Therapeutics
Biomarkers

PD-L2 expression in human tumors: Relevance to anti-PD-1 therapy in cancer

Yearley, J. H., Gibson, C., Yu, N., Moon, C., Murphy, E., Juco, J., Lunceford, J., Cheng, J., Chow, L. Q. M., Lim Seiwert, T., Handa, M., Tomassini, J. E. & McClanahan, T., Jun 15 2017, In : Clinical Cancer Research. 23, 12, p. 3158-3167 10 p.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Stromal Cells
Ligands
Therapeutics
Disease-Free Survival

Pembrolizumab for platinum- and cetuximab-refractory head and neck cancer: Results from a single-arm, phase II study

Bauml, J., Lim Seiwert, T., Pfister, D. G., Worden, F., Liu, S. V., Gilbert, J., Saba, N. F., Weiss, J., Wirth, L., Sukari, A., Kang, H., Gibson, M. K., Massarelli, E., Powell, S., Meister, A., Shu, X., Cheng, J. D. & Haddad, R., May 10 2017, In : Journal of Clinical Oncology. 35, 14, p. 1542-1549 8 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Platinum
Ligands
Therapeutics
Safety
2016

Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results from the phase Ib KEYNOTE-012 expansion cohort

Chow, L. Q. M., Haddad, R., Gupta, S., Mahipal, A., Mehra, R., Tahara, M., Berger, R., Eder, J. P., Burtness, B., Lee, S. H., Keam, B., Kang, H., Muro, K., Weiss, J., Geva, R., Lin, C. C., Chung, H. C., Meister, A., Dolled-Filhart, M., Pathiraja, K. & 2 others, Cheng, J. D. & Lim Seiwert, T., Nov 10 2016, In : Journal of Clinical Oncology. 34, 32, p. 3838-3845 8 p.

Research output: Contribution to journalArticle

Biomarkers
Ligands
Disease-Free Survival
pembrolizumab
Carcinoma, squamous cell of head and neck

Final Results of a Randomized Phase 2 Trial Investigating the Addition of Cetuximab to Induction Chemotherapy and Accelerated or Hyperfractionated Chemoradiation for Locoregionally Advanced Head and Neck Cancer

Lim Seiwert, T., Melotek, J. M., Blair, E. A., Stenson, K. M., Salama, J. K., Witt, M. E., Brisson, R. J., Chawla, A., Dekker, A., Lingen, M. W., Kocherginsky, M., Villaflor, V. M., Cohen, E. E. W., Haraf, D. J. & Vokes, E. E., Sep 1 2016, In : International Journal of Radiation Oncology Biology Physics. 96, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

Induction Chemotherapy
chemotherapy
Head and Neck Neoplasms
induction
Disease-Free Survival

Growth factor expression mediates resistance to EGFR inhibitors in head and neck squamous cell carcinomas

Tepper, S. R., Zuo, Z., Khattri, A., Heß, J. & Lim Seiwert, T., May 1 2016, In : Oral Oncology. 56, p. 62-70 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Intercellular Signaling Peptides and Proteins
Therapeutics
Carcinoma, squamous cell of head and neck
Fibroblast Growth Factor 1

Methylation of RAD51B, XRCC3 and other homologous recombination genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head and neck, lung and cervix

Rieke, D. T., Ochsenreither, S., Klinghammer, K., Lim Seiwert, T., Klauschen, F., Tinhofer, I. & Keilholz, U., Jan 1 2016, In : Oncotarget. 7, 46, p. 75379-75393 15 p.

Research output: Contribution to journalArticle

Open Access
Homologous Recombination
Cervix Uteri
Methylation
Lung
Genes

Phase Ib study of duligotuzumab (MEHD7945A) plus cisplatin/5-fluorouracil or carboplatin/paclitaxel for first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck

Jimeno, A., Machiels, J. P., Wirth, L., Specenier, P., Lim Seiwert, T., Mardjuadi, F., Wang, X., Kapp, A. V., Royer-Joo, S., Penuel, E., McCall, B., Pirzkall, A. & Clement, P. M., Dec 15 2016, In : Cancer. 122, 24, p. 3803-3811 9 p.

Research output: Contribution to journalArticle

Open Access
Carboplatin
Paclitaxel
Fluorouracil
Cisplatin
Therapeutics

Phase I study of apitolisib (GDC-0980), dual phosphatidylinositol-3-kinase and mammalian target of rapamycin kinase inhibitor, in patients with advanced solid tumors

Dolly, S. O., Wagner, A. J., Bendell, J. C., Kindler, H. L., Krug, L. M., Lim Seiwert, T., Zauderer, M. G., Lolkema, M. P., Apt, D., Yeh, R. F., Fredrickson, J. O., Spoerke, J. M., Koeppen, H., Ware, J. A., Lauchle, J. O., Burris, H. A. & De Bono, J. S., Jun 15 2016, In : Clinical Cancer Research. 22, 12, p. 2874-2884 11 p.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositol 3-Kinase
Sirolimus
Phosphotransferases
Mesothelioma
Hyperglycemia

Response-adapted volume de-escalation (RAVD) in locally advanced head and neck cancer

Villaflor, V. M., Melotek, J. M., Karrison, T. G., Brisson, R. J., Blair, E. A., Portugal, L., De Souza, J. A., Ginat, D. T., Stenson, K. M., Langerman, A., Kocherginsky, M., Spiotto, M. T., Hannigan, N., Lim Seiwert, T., Cohen, E. E. W., Vokes, E. E. & Haraf, D. J., May 1 2016, In : Annals of Oncology. 27, 5, p. 908-913 6 p., mdw051.

Research output: Contribution to journalArticle

Open Access
Head and Neck Neoplasms
Induction Chemotherapy
Squamous Cell Neoplasms
Radiotherapy
Head

Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial

Lim Seiwert, T., Burtness, B., Mehra, R., Weiss, J., Berger, R., Eder, J. P., Heath, K., McClanahan, T., Lunceford, J., Gause, C., Cheng, J. D. & Chow, L. Q., Jul 1 2016, In : The Lancet Oncology. 17, 7, p. 956-965 10 p.

Research output: Contribution to journalArticle

Safety
Therapeutics
Carcinoma, squamous cell of head and neck
pembrolizumab
Drug-Related Side Effects and Adverse Reactions
2015

Comparison of outcomes of locoregionally advanced oropharyngeal and non-oropharyngeal squamous cell carcinoma over two decades

Das, L. C., Karrison, T. G., Witt, M. E., Muller, C., Stenson, K., Blair, E. A., Cohen, E. E. W., Lim Seiwert, T., Haraf, D. J. & Vokes, E. E., Jan 1 2015, In : Annals of Oncology. 26, 1, p. 198-205 8 p.

Research output: Contribution to journalArticle

Open Access
Squamous Cell Neoplasms
Head and Neck Neoplasms
Squamous Cell Carcinoma
Head
Survival

Ex vivo antibody-dependent cellular cytotoxicity inducibility predicts efficacy of cetuximab

Taylor, R. J., Saloura, V., Jain, A., Goloubeva, O., Wong, S., Kronsberg, S., Nagilla, M., Silpino, L., De Souza, J., Lim Seiwert, T., Vokes, E., Villaflor, V. & Cohen, E. E. W., May 1 2015, In : Cancer Immunology Research. 3, 5, p. 567-574 8 p.

Research output: Contribution to journalArticle

Open Access
Antibodies
Genotype
Disease-Free Survival
Natural Killer Cells
Tissue Donors

Genetic landscape of human papillomavirus-associated head and neck cancer and comparison to tobacco-related tumors

Hayes, D. N., Van Waes, C. & Lim Seiwert, T., Oct 10 2015, In : Journal of Clinical Oncology. 33, 29, p. 3227-3234 8 p.

Research output: Contribution to journalReview article

Medical Genetics
Head and Neck Neoplasms
Tobacco
Neoplasms
Neck

Genetic profiling of advanced radioactive iodine-resistant differentiated thyroid cancer and correlation with axitinib efficacy

Schechter, R. B., Nagilla, M., Joseph, L., Reddy, P., Khattri, A., Watson, S., Locati, L. D., Licitra, L., Greco, A., Pelosi, G., Carcangiu, M. L., Lingen, M. W., Lim Seiwert, T. & Cohen, E. E. W., Apr 10 2015, In : Cancer Letters. 359, 2, p. 269-274 6 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Iodine
Mutation
Disease-Free Survival
Neoplasms

Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing

Chung, C. H., Guthrie, V. B., Masica, D. L., Tokheim, C., Kang, H., Richmon, J., Agrawal, N., Fakhry, C., Quon, H., Subramaniam, R. M., Zuo, Z., Lim Seiwert, T., Chalmers, Z. R., Frampton, G. M., Ali, S. M., Yelensky, R., Stephens, P. J., Miller, V. A., Karchin, R. & Bishop, J. A., Jun 1 2015, In : Annals of Oncology. 26, 6, p. 1216-1223 8 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Neoplasms
Paraffin
Carcinoma, squamous cell of head and neck
In Situ Hybridization

HPV-Associated Head and Neck Cancer

Vokes, E. E., Agrawal, N. & Lim Seiwert, T., Dec 1 2015, In : Journal of the National Cancer Institute. 107, 12, p. djv344

Research output: Contribution to journalArticle

Papillomaviridae
Head and Neck Neoplasms
Oropharynx
Dermatoglyphics
Chemoradiotherapy

Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes

Keck, M. K., Zuo, Z., Khattri, A., Stricker, T. P., Brown, C. D., Imanguli, M., Rieke, D., Endhardt, K., Fang, P., Gelmann, J. B., DeBoer, R., El-Dinali, M., Aktolga, S., Lei, Z., Tan, P., Rozen, S. G., Salgia, R., Weichselbaum, R. R., Lingen, M. W., Story, M. D. & 5 others, Ang, K. K., Cohen, E. E. W., White, K. P., Vokes, E. E. & Lim Seiwert, T., Feb 15 2015, In : Clinical Cancer Research. 21, 4, p. 870-881 12 p.

Research output: Contribution to journalArticle

Open Access
Head and Neck Neoplasms
Neoplasms
Phenotype
Cluster Analysis
Cell Biology

Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas

Lim Seiwert, T., Zuo, Z., Keck, M. K., Khattri, A., Pedamallu, C. S., Stricker, T., Brown, C., Pugh, T. J., Stojanov, P., Cho, J., Lawrence, M. S., Getz, G., Brägelmann, J., DeBoer, R., Weichselbaum, R. R., Langerman, A., Portugal, L., Blair, E., Stenson, K., Lingen, M. W. & 4 others, Cohen, E. E. W., Vokes, E. E., White, K. P. & Hammerman, P. S., Feb 1 2015, In : Clinical Cancer Research. 21, 3, p. 632-641 10 p.

Research output: Contribution to journalArticle

Open Access
Papillomaviridae
Mutation
Neoplasms
Genes
Neoplasm Genes

Rare occurrence of EGFRvIII deletion in head and neck squamous cell carcinoma

Khattri, A., Zuo, Z., Brägelmann, J., Keck, M. K., El Dinali, M., Brown, C. D., Stricker, T., Munagala, A., Cohen, E. E. W., Lingen, M. W., White, K. P., Vokes, E. E. & Lim Seiwert, T., Jan 1 2015, In : Oral Oncology. 51, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Atlases
Carcinoma, squamous cell of head and neck
Real-Time Polymerase Chain Reaction
Immunohistochemistry

Reply to S. Chakraborty et al

Cohen, E. E. W., Kocherginsky, M., Karrison, T., Lim Seiwert, T., Haraf, D. J., Brockstein, B. & Vokes, E. E., Mar 10 2015, In : Journal of Clinical Oncology. 33, 8, p. 968-969 2 p.

Research output: Contribution to journalLetter

Antineoplastic Combined Chemotherapy Protocols
Head and Neck Neoplasms
Squamous Cell Carcinoma

WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck

Saloura, V., Cho, H. S., Kiyotani, K., Alachkar, H., Zuo, Z., Nakakido, M., Tsunoda, T., Lim Seiwert, T., Lingen, M., Licht, J., Nakamura, Y. & Hamamoto, R., Feb 1 2015, In : Molecular Cancer Research. 13, 2, p. 293-304 12 p.

Research output: Contribution to journalArticle

Open Access
Wolf-Hirschhorn Syndrome
Carcinogenesis
Cell Cycle
Epithelium
Carcinoma, squamous cell of head and neck
2014

A randomized, phase II study of afatinib versus cetuximab in metastatic or recurrent squamous cell carcinoma of the head and neck

Lim Seiwert, T., Fayette, J., Cupissol, D., del Campo, J. M., Clement, P. M., Hitt, R., Degardin, M., Zhang, W., Blackman, A., Ehrnrooth, E. & Cohen, E. E. W., Jan 1 2014, In : Annals of Oncology. 25, 9, p. 1813-1820 8 p., mdu216.

Research output: Contribution to journalArticle

Open Access
Research Personnel
Epidermal Growth Factor Receptor
BIBW 2992
Carcinoma, squamous cell of head and neck
Cetuximab
Head and Neck Neoplasms
Survival
Patient Preference
Radiotherapy
Quality of Life

DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer

Lim Seiwert, T., Wang, X. Z., Heitmann, J., Villegas-Bergazzi, V., Sprott, K., Finn, S., O'Regan, E., Farrow, A. D., Weichselbaum, R. R., Lingen, M. W., Cohen, E. E. W., Stenson, K., Weaver, D. T. & Vokes, E. E., Jul 14 2014, In : PloS one. 9, 7, e102112.

Research output: Contribution to journalArticle

Open Access
Chemotherapy
Biomarkers
Head and Neck Neoplasms
DNA repair
DNA Repair

Impact of warm ischemia on phosphorylated biomarkers in head and neck squamous cell carcinoma

Tower, J. I., Lingen, M. W., Lim Seiwert, T. & Langerman, A., Jan 1 2014, In : American Journal of Translational Research. 6, 5, p. 548-557 10 p.

Research output: Contribution to journalArticle

Warm Ischemia
Biomarkers
Tissue
Phosphorylation
Ischemia

Met and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma

Kanteti, R., Dhanasingh, I., Kawada, I., Lennon, F. E., Arif, Q., Bueno, R., Hasina, R., Husain, A. N., Vigneswaran, W., Lim Seiwert, T., Kindler, H. L. & Salgia, R., Sep 15 2014, In : PloS one. 9, 9, e105919.

Research output: Contribution to journalArticle

Open Access
mesothelioma
phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
therapeutics
Mesothelioma

Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer

Cohen, E. E. W., Karrison, T. G., Kocherginsky, M., Mueller, J., Egan, R., Huang, C. H., Brockstein, B. E., Agulnik, M. B., Mittal, B. B., Yunus, F., Samant, S., Raez, L. E., Mehra, R., Kumar, P., Ondrey, F., Marchand, P., Braegas, B., Lim Seiwert, T., Villaflor, V. M., Haraf, D. J. & 1 others, Vokes, E. E., Sep 1 2014, In : Journal of Clinical Oncology. 32, 25, p. 2735-2743 9 p.

Research output: Contribution to journalArticle

Induction Chemotherapy
Head and Neck Neoplasms
Chemoradiotherapy
Survival
docetaxel

Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer

Heitmann, J., Geeleher, P., Zuo, Z., Weichselbaum, R. R., Vokes, E. E., Fetscher, S. & Lim Seiwert, T., Jan 1 2014, In : Oral Oncology. 50, 9, p. 825-831 7 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Homologous Recombination
Cell Line
Breast Neoplasms
DNA Repair-Deficiency Disorders