Research Output 2002 2016

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Article
2016

Iron limitation triggers early egress by the intracellular bacterial pathogen legionella pneumophila

O'Connor, T. J., Zheng, H., VanRheenen, S. M., Ghosh, S., Cianciotto, N. P. & Isberg, R. R. 2016 In : Infection and Immunity. 84, 8, p. 2185-2197 13 p.

Research output: Research - peer-reviewArticle

Legionella pneumophila
Iron
Growth
Siderophores
Carrier Proteins
2014

IMAD, a genetic screening strategy for dissecting complex interactions between a pathogen and its host

O'Connor, T. J. & Isberg, R. R. 2014 In : Nature Protocols. 9, 8, p. 1916-1930 15 p.

Research output: Research - peer-reviewArticle

Insertional Mutagenesis
Genetic Testing
Mutagenesis
Pathogens
Screening
2012

Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen

O'Connor, T. J., Boyd, D., Dorer, M. S. & Isberg, R. R. Dec 14 2012 In : Science. 338, 6113, p. 1440-1444 5 p.

Research output: Research - peer-reviewArticle

Virulence
Antibiosis
Bacterial RNA
Host-Pathogen Interactions
Legionella pneumophila

The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation

Choy, A., Dancourt, J., Mugo, B., O'Connor, T. J., Isberg, R. R., Melia, T. J. & Roy, C. R. Nov 23 2012 In : Science. 338, 6110, p. 1072-1076 5 p.

Research output: Research - peer-reviewArticle

Legionella
Autophagy
Proteins
Legionella pneumophila
Bacterial Proteins
2011
Legionella pneumophila
Host Specificity
Genome
Growth
Genomic Islands

The E Block motif is associated with Legionella pneumophila translocated substrates

Huang, L., Boyd, D., Amyot, W. M., Hempstead, A. D., Luo, Z. Q., O'Connor, T. J., Chen, C., Machner, M., Montminy, T. & Isberg, R. R. Feb 2011 In : Cellular Microbiology. 13, 2, p. 227-245 19 p.

Research output: Research - peer-reviewArticle

Legionella pneumophila
Proteins
Glutamates
Genes
Bacterial Proteins
2009

The Legionella pneumophila replication vacuole: Making a cosy niche inside host cells

Isberg, R. R., O'Connor, T. J. & Heidtman, M. 2009 In : Nature Reviews Microbiology. 7, 1, p. 13-24 12 p.

Research output: Research - peer-reviewArticle

Legionella pneumophila
Vacuoles
Membranes
Growth
Aerosols
2006

Members of a Legionella pneumophila family of proteins with ExoU (Phospholipase A) active sites are translocated to target cells

Vanrheenen, S. M., Luo, Z. Q., O'Connor, T. & Isberg, R. R. Jun 2006 In : Infection and Immunity. 74, 6, p. 3597-3606 10 p.

Research output: Research - peer-reviewArticle

Legionella pneumophila
Phospholipases A
Catalytic Domain
Proteins
Vacuoles
2005

Pivotal roles for the receiver domain in the mechanism of action of the response regulator RamR of Streptomyces coelicolor

O'Connor, T. J. & Nodwell, J. R. Sep 2 2005 In : Journal of Molecular Biology. 351, 5, p. 1030-1047 18 p.

Research output: Research - peer-reviewArticle

Streptomyces coelicolor
DNA
Proteins
Operon
Morphogenesis
2002
Streptomyces coelicolor
Hyphae
Morphogenesis
Genes
Anti-Bacterial Agents