Takashi Tsukamoto

Associate Professor

1990 …2019
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  • 6 Similar Profiles
Glutamate Carboxypeptidase II Medicine & Life Sciences
Glutaminase Medicine & Life Sciences
D-Amino-Acid Oxidase Medicine & Life Sciences
Glutamic Acid Medicine & Life Sciences
Serine Medicine & Life Sciences
Glutamine Medicine & Life Sciences
Neuralgia Medicine & Life Sciences
Hydrolysis Chemical Compounds

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Research Output 1990 2019

  • 90 Article
  • 1 Conference contribution

Discovery of Benzamidine- And 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists

Prchalová, E., Hin, N., Thomas, A. G., Veeravalli, V., Ng, J., Alt, J., Rais, R., Rojas, C., Li, Z., Hihara, H., Aoki, M., Yoshizawa, K., Nishioka, T., Suzuki, S., Kopajtic, T., Chatrath, S., Liu, Q., Dong, X., Slusher, B. S. & Tsukamoto, T., Sep 26 2019, In : Journal of medicinal chemistry. 62, 18, p. 8631-8641 11 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
HEK293 Cells
Opioid Receptors
Sensory Receptor Cells

Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold

Stepanek, O., Hin, N., Thomas, A. G., Dash, R. P., Alt, J., Rais, R., Rojas, C., Slusher, B. & Tsukamoto, T., May 15 2019, In : European Journal of Medicinal Chemistry. 170, p. 276-289 14 p.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase

Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase

Zimmermann, S. C., Duvall, B. & Tsukamoto, T., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 46-59 14 p.

Research output: Contribution to journalArticle

Glutamic Acid

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

Udupa, S., Nguyen, S., Hoang, G., Nguyen, T., Quinones, A., Pham, K., Asaka, R., Nguyen, K., Zhang, C., Elgogary, A., Jung, J. G., Xu, Q., Fu, J., Thomas, A. G., Tsukamoto, T., Hanes, J. S., Slusher, B., Cooper, A. J. L. & Le Thi, Q. H., Jan 1 2019, In : Proteomics. 1800451.

Research output: Contribution to journalArticle

Open Access
glutamine-pyruvate aminotransferase
glutamine - phenylpyruvate transaminase
Enzyme inhibition
Pancreatic Neoplasms

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

Rojas, C., Barnaeva, E., Thomas, A. G., Hu, X., Southall, N., Marugan, J., Chaudhuri, A. D., Yoo, S. W., Hin, N., Stepanek, O., Wu, Y., Zimmermann, S. C., Gadiano, A. G., Tsukamoto, T., Rais, R., Haughey, N., Ferrer, M. & Slusher, B., Dec 1 2018, In : Scientific Reports. 8, 1, 17715.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase