Research Output per year
Fingerprint Dive into the research topics where Takashi Tsukamoto is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Glutamate Carboxypeptidase II
Medicine & Life Sciences
Glutaminase
Medicine & Life Sciences
D-Amino-Acid Oxidase
Medicine & Life Sciences
Glutamic Acid
Medicine & Life Sciences
Serine
Medicine & Life Sciences
Glutamine
Medicine & Life Sciences
Neuralgia
Medicine & Life Sciences
Hydrolysis
Chemical Compounds
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 1990 2019
Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold
Stepanek, O., Hin, N., Thomas, A. G., Dash, R. P., Alt, J., Rais, R., Rojas, C., Slusher, B. & Tsukamoto, T., May 15 2019, In : European Journal of Medicinal Chemistry. 170, p. 276-289 14 p.Research output: Contribution to journal › Article
Sphingomyelin Phosphodiesterase
Scaffolds
Metabolism
Plasmas
Ceramides
Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase
Zimmermann, S. C., Duvall, B. & Tsukamoto, T., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 46-59 14 p.Research output: Contribution to journal › Article
Glutaminase
Kidney
Glutamine
Sulfides
Glutamic Acid
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer
Udupa, S., Nguyen, S., Hoang, G., Nguyen, T., Quinones, A., Pham, K., Asaka, R., Nguyen, K., Zhang, C., Elgogary, A., Jung, J. G., Xu, Q., Fu, J., Thomas, A. G., Tsukamoto, T., Hanes, J. S., Slusher, B., Cooper, A. J. L. & Le Thi, Q. H., Jan 1 2019, In : Proteomics. 1800451.Research output: Contribution to journal › Article
Open Access
glutamine-pyruvate aminotransferase
glutamine - phenylpyruvate transaminase
Glutaminase
Enzyme inhibition
Pancreatic Neoplasms
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation
Rojas, C., Barnaeva, E., Thomas, A. G., Hu, X., Southall, N., Marugan, J., Chaudhuri, A. D., Yoo, S. W., Hin, N., Stepanek, O., Wu, Y., Zimmermann, S. C., Gadiano, A. G., Tsukamoto, T., Rais, R., Haughey, N., Ferrer, M. & Slusher, B., Dec 1 2018, In : Scientific Reports. 8, 1, 17715.Research output: Contribution to journal › Article
Sphingomyelin Phosphodiesterase
Encephalitis
Astrocytes
Communication
Brain
Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors
Barinka, C., Novakova, Z., Hin, N., Bím, D., Ferraris, D. V., Duvall, B., Kabarriti, G., Tsukamoto, R., Budesinsky, M., Motlova, L., Rojas, C., Slusher, B., Rokob, T. A., Rulíšek, L. & Tsukamoto, T., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.Research output: Contribution to journal › Article
Glutamate Carboxypeptidase II
Carbamates
Glutamic Acid
Ligands
Catalytic Domain