Takashi Tsukamoto

Associate Professor

1990 …2019
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Fingerprint Dive into the research topics where Takashi Tsukamoto is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Glutamate Carboxypeptidase II Medicine & Life Sciences
Glutaminase Medicine & Life Sciences
D-Amino-Acid Oxidase Medicine & Life Sciences
Glutamic Acid Medicine & Life Sciences
Serine Medicine & Life Sciences
Glutamine Medicine & Life Sciences
Neuralgia Medicine & Life Sciences
Hydrolysis Chemical Compounds

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Research Output 1990 2019

  • 89 Article
  • 1 Conference contribution

Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold

Stepanek, O., Hin, N., Thomas, A. G., Dash, R. P., Alt, J., Rais, R., Rojas, C., Slusher, B. & Tsukamoto, T., May 15 2019, In : European Journal of Medicinal Chemistry. 170, p. 276-289 14 p.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
Scaffolds
Metabolism
Plasmas
Ceramides

Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase

Zimmermann, S. C., Duvall, B. & Tsukamoto, T., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 46-59 14 p.

Research output: Contribution to journalArticle

Glutaminase
Kidney
Glutamine
Sulfides
Glutamic Acid

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

Udupa, S., Nguyen, S., Hoang, G., Nguyen, T., Quinones, A., Pham, K., Asaka, R., Nguyen, K., Zhang, C., Elgogary, A., Jung, J. G., Xu, Q., Fu, J., Thomas, A. G., Tsukamoto, T., Hanes, J. S., Slusher, B., Cooper, A. J. L. & Le Thi, Q. H., Jan 1 2019, In : Proteomics. 1800451.

Research output: Contribution to journalArticle

Open Access
glutamine-pyruvate aminotransferase
glutamine - phenylpyruvate transaminase
Glutaminase
Enzyme inhibition
Pancreatic Neoplasms

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

Rojas, C., Barnaeva, E., Thomas, A. G., Hu, X., Southall, N., Marugan, J., Chaudhuri, A. D., Yoo, S. W., Hin, N., Stepanek, O., Wu, Y., Zimmermann, S. C., Gadiano, A. G., Tsukamoto, T., Rais, R., Haughey, N., Ferrer, M. & Slusher, B., Dec 1 2018, In : Scientific Reports. 8, 1, 17715.

Research output: Contribution to journalArticle

Sphingomyelin Phosphodiesterase
Encephalitis
Astrocytes
Communication
Brain

Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors

Barinka, C., Novakova, Z., Hin, N., Bím, D., Ferraris, D. V., Duvall, B., Kabarriti, G., Tsukamoto, R., Budesinsky, M., Motlova, L., Rojas, C., Slusher, B., Rokob, T. A., Rulíšek, L. & Tsukamoto, T., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Glutamate Carboxypeptidase II
Carbamates
Glutamic Acid
Ligands
Catalytic Domain