Takashi Tsukamoto

Associate Professor

School of Medicine

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6 Similar Profiles

Glutamate Carboxypeptidase II Medicine & Life Sciences

Glutaminase Medicine & Life Sciences

D-Amino-Acid Oxidase Medicine & Life Sciences

Glutamic Acid Medicine & Life Sciences

Serine Medicine & Life Sciences

Glutamine Medicine & Life Sciences

Neuralgia Medicine & Life Sciences

Hydrolysis Chemical Compounds

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Research Output 1990 2019

90 Article
1 Conference contribution

Discovery of Benzamidine- And 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists

Prchalová, E., Hin, N., Thomas, A. G., Veeravalli, V., Ng, J., Alt, J., Rais, R., Rojas, C., Li, Z., Hihara, H., Aoki, M., Yoshizawa, K., Nishioka, T., Suzuki, S., Kopajtic, T., Chatrath, S., Liu, Q., Dong, X., Slusher, B. S. & Tsukamoto, T., Sep 26 2019, In : Journal of medicinal chemistry. 62, 18, p. 8631-8641 11 p.

Research output: Contribution to journal › Article

G-Protein-Coupled Receptors

HEK293 Cells

Opioid Receptors

Sensory Receptor Cells

Analgesics

Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold

Stepanek, O., Hin, N., Thomas, A. G., Dash, R. P., Alt, J., Rais, R., Rojas, C., Slusher, B. & Tsukamoto, T., May 15 2019, In : European Journal of Medicinal Chemistry. 170, p. 276-289 14 p.

Research output: Contribution to journal › Article

Sphingomyelin Phosphodiesterase

Scaffolds

Metabolism

Plasmas

Ceramides

Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase

Zimmermann, S. C., Duvall, B. & Tsukamoto, T., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 46-59 14 p.

Research output: Contribution to journal › Article

Glutaminase

Kidney

Glutamine

Sulfides

Glutamic Acid

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

Udupa, S., Nguyen, S., Hoang, G., Nguyen, T., Quinones, A., Pham, K., Asaka, R., Nguyen, K., Zhang, C., Elgogary, A., Jung, J. G., Xu, Q., Fu, J., Thomas, A. G., Tsukamoto, T., Hanes, J. S., Slusher, B., Cooper, A. J. L. & Le Thi, Q. H., Jan 1 2019, In : Proteomics. 1800451.

Research output: Contribution to journal › Article

Open Access

glutamine-pyruvate aminotransferase

glutamine - phenylpyruvate transaminase

Glutaminase

Enzyme inhibition

Pancreatic Neoplasms

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

Rojas, C., Barnaeva, E., Thomas, A. G., Hu, X., Southall, N., Marugan, J., Chaudhuri, A. D., Yoo, S. W., Hin, N., Stepanek, O., Wu, Y., Zimmermann, S. C., Gadiano, A. G., Tsukamoto, T., Rais, R., Haughey, N., Ferrer, M. & Slusher, B., Dec 1 2018, In : Scientific Reports. 8, 1, 17715.

Research output: Contribution to journal › Article

Sphingomyelin Phosphodiesterase

Encephalitis

Astrocytes

Communication

Brain