Sushant Kachhap

Assistant Professor

20002019

Research output per year

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Research Output

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2019

Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40

Ignacio, D. N., Mason, K. D., Hackett-Morton, E. C., Albanese, C., Ringer, L., Wagner, W. D., Wang, P. C., Carducci, M. A., Kachhap, S., Paller, C., Mendonca, J., Li-Ying Chan, L., Lin, B., Hartle, D. K., Green, J. E., Brown, C. A. & Hudson, T. S., Jan 1 2019, In : Heliyon. 5, 1, e01128.

Research output: Contribution to journalArticle

2018

Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. & Qian, D. Z., Dec 1 2018, In : Nature Communications. 9, 1, 4972.

Research output: Contribution to journalArticle

2017

The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion

Sharma, A., Mendonca, J., Ying, J., Kim, H. S., Verdone, J. E., Zarif, J., Carducci, M. A., Hammers, H., Pienta, K. & Kachhap, S., 2017, In : Molecular Oncology. 11, 6, p. 655-669 15 p.

Research output: Contribution to journalArticle

2016

C/EBPβ regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion

Barakat, D. J., Mendonca, J., Barberi, T., Zhang, J., Kachhap, S., Paz-Priel, I. & Friedman, A. D., May 28 2016, In : Cancer Letters. 375, 1, p. 152-161 10 p.

Research output: Contribution to journalArticle

Extreme Response to High-dose Testosterone in BRCA2- and ATM-mutated Prostate Cancer

Teply, B. A., Kachhap, S., Eisenberger, M. & Denmeade, S. R., 2016, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

2015

NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Mendonca, J., Sharmaa, A., Mohseni, M., Rosen, D. M., Scharpf, R. B., Cidado, J., Cochran, R. L., Parsons, H. A., Dalton, W., Erlanger, B., Button, B., Cravero, K., Kyker-Snowman, K., Beaver, J., Kachhap, S., Hurley, P. & 2 others, Lauring, J. & Park, B. H., Sep 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. 11583-11588 6 p.

Research output: Contribution to journalArticle

Transcriptome sequencing in prostate cancer identifies inter-tumor heterogeneity

Mendonca, J., Sharma, A. & Kachhap, S., May 1 2015, In : Asian Journal of Andrology. 17, 3, p. 435-436 2 p.

Research output: Contribution to journalArticle

2014

Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer

Paller, C., Wissing, M. D., Mendonca, J., Sharma, A., Kim, E., Kim, H. S., Kortenhorst, M. S. Q., Gerber, S., Rosen, M., Shaikh, F., Zahurak, M. L., Rudek-Renaut, M., Hammers, H., Rudin, C. M., Carducci, M. A. & Kachhap, S., Oct 1 2014, In : Cancer Medicine. 3, 5, p. 1322-1335 14 p.

Research output: Contribution to journalArticle

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

Mendonca, J., Sharma, A., Kim, H. S., Hammers, H., Meeker, A. K., Demarzo, A. M., Carducci, M. A., Kauffman, M., Shacham, S. & Kachhap, S., 2014, In : Oncotarget. 5, 15, p. 6102-6112 11 p.

Research output: Contribution to journalArticle

Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression

Wissing, M. D., Dadon, T., Kim, E., Piontek, K. B., Shim, J. S., Kaelber, N. S., Liu, J., Kachhap, S. & Nelkin, B. D., 2014, In : Oncology Reports. 32, 1, p. 419-424 6 p.

Research output: Contribution to journalArticle

2013

Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors

Kortenhorst, M. S. Q., Wissing, M. D., Rodriguez, R., Kachhap, S., Jans, J. J. M., van der Groep, P., Verheul, H. M. W., Gupta, A., Aiyetan, P. O., van der Wall, E., Carducci, M. A., Van Diest, P. J. & Marchionni, L., Sep 2013, In : Epigenetics. 8, 9, p. 907-920 14 p.

Research output: Contribution to journalArticle

Identification of cetrimonium bromide and irinotecan as compounds with synthetic lethality against NDRG1 deficient prostate cancer cells

Wissing, M. D., Mendonca, J., Kim, E., Kim, E., Shim, J. S., Kaelber, N. S., Kant, H., Hammers, H., Commes, T., Van Diest, P. J., Liu, J. & Kachhap, S., May 2013, In : Cancer Biology and Therapy. 14, 5, p. 401-410 10 p.

Research output: Contribution to journalArticle

Repurposing itraconazole as a treatment for advanced prostate cancer: A noncomparative randomized phase ii trial in men with metastatic castration-resistant prostate cancer

Antonarakis, E., Heath, E. I., Smith, D. C., Rathkopf, D., Blackford, A. L., Danila, D. C., King, S., Frost, A., Seun Ajiboye, A., Zhao, M., Mendonca, J., Kachhap, S., Rudek-Renaut, M. & Carducci, M. A., 2013, In : Oncologist. 18, 2, p. 163-173 11 p.

Research output: Contribution to journalArticle

Screening assay for blood vessel maturation inhibitors

Fu, C., van der Zwan, A., Gerber, S., Van Den Berg, S., No, E., C.H.Wang, W., Sheibani, N., Carducci, M. A., Kachhap, S. & Hammers, H. J., Aug 23 2013, In : Biochemical and Biophysical Research Communications. 438, 2, p. 364-369 6 p.

Research output: Contribution to journalArticle

Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors

Wissing, M. D., Mendonca, J., Kortenhorst, M. S. Q., Kaelber, N. S., Gonzalez, M., Kim, E., Hammers, H., Van Diest, P. J., Carducci, M. A. & Kachhap, S., Oct 1 2013, In : FASEB Journal. 27, 10, p. 4279-4293 15 p.

Research output: Contribution to journalArticle

Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment

Isaacs, J. T., Antony, L., Dalrymple, S. L., Brennen, W., Gerber, S., Hammers, H., Wissing, M., Kachhap, S., Luo, J., Xing, L., Bjork, P., Olsson, A., Bjork, A. & Leanderson, T., Jan 15 2013, In : Cancer Research. 73, 4, p. 1386-1399 14 p.

Research output: Contribution to journalArticle

2012

Metastasis: Genetics, mechanism, and diagnostic and therapeutic strategies

Gunduz, M., Gunduz, E., Beder, L., Pehlivan, D., Hatipoglu, O. F., Kachhap, S. & Grenman, R., 2012, In : Journal of Oncology. 390835.

Research output: Contribution to journalArticle

2011

Cigarette smoke and cancer

Kachhap, S., Keshamouni, V. G., Qian, D. Z. & Chatterjee, A., 2011, In : Journal of Oncology. 172678.

Research output: Contribution to journalArticle

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

Lin, J., Haffner, M. C., Zhang, Y., Lee, B. H., Brennen, W., Britton, J., Kachhap, S., Shim, J. S., Liu, J., Nelson, W. G., Yegnasubramanian, S. & Carducci, M. A., Mar 1 2011, In : Prostate. 71, 4, p. 333-343 11 p.

Research output: Contribution to journalArticle

2010

Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor

Kachhap, S., Rosmus, N., Collis, S. J., Kortenhorst, M. S. Q., Wissing, M. D., Hedayati, M., Shabbeer, S., Mendonca, J., Deangelis, J., Marchionni, L., Lin, J., Höti, N., Nortier, J. W. R., DeWeese, T., Hammers, H. & Carducci, M. A., 2010, In : PLoS One. 5, 6, e11208.

Research output: Contribution to journalArticle

2009

Fenugreek: A naturally occurring edible spice as an anticancer agent

Shabbeer, S., Sobolewski, M., Anchoori, R., Kachhap, S., Hidalgo, M., Carducci, M. A., Davidson, N., Carducci, M. A. & Khan, S. R., Feb 2009, In : Cancer Biology and Therapy. 8, 3, p. 272-278 7 p.

Research output: Contribution to journalArticle

2008

A multiple-loop, double-cube microarray design applied to prostate cancer cell lines with variable sensitivity to histone deacetylase inhibitors

Kortenhorst, M. S. Q., Zahurak, M., Shabbeer, S., Kachhap, S., Galloway, N., Parmigiani, G., Verheul, H. M. W. & Carducci, M. A., Nov 1 2008, In : Clinical Cancer Research. 14, 21, p. 6886-6894 9 p.

Research output: Contribution to journalArticle

2007

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck

Zhou, S., Kachhap, S., Sun, W., Wu, G., Chuang, A., Poeta, L., Grumbine, L., Mithani, S. K., Chatterjee, A., Koch, W. M., Westra, W. H., Maitra, A., Glazer, C., Carducci, M. A., Sidransky, D., McFate, T., Verma, A. & Califano, J. A., May 1 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 18, p. 7540-7545 6 p.

Research output: Contribution to journalArticle

Multiple molecular pathways explain the anti-proliferative effect of valproic acid on prostate cancer cells in vitro and in vivo

Shabbeer, S., Kortenhorst, M. S. Q., Kachhap, S., Galloway, N., Rodriguez, R. & Carducci, M. A., Jul 1 2007, In : Prostate. 67, 10, p. 1099-1110 12 p.

Research output: Contribution to journalArticle

The N-Myc down regulated gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin

Kachhap, S., Faith, D., Qian, D. Z., Shabbeer, S., Galloway, N. L., Pili, R., Denmeade, S. R., Demarzo, A. M. & Carducci, M. A., Sep 5 2007, In : PLoS One. 2, 9, e844.

Research output: Contribution to journalArticle

2006

Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α

Qian, D. Z., Kachhap, S., Collis, S. J., Verheul, H. M. W., Carducci, M. A., Atadja, P. & Pili, R., Sep 1 2006, In : Cancer Research. 66, 17, p. 8814-8821 8 p.

Research output: Contribution to journalArticle

2004

Blocking angiogenesis and histone deacetylases in prostate and breast cancer bearing mice

Qian, D. Z., Wang, X., Kachhap, S., Kato, Y., Wei, Y., Zhang, L. & Atadja, P., Oct 2004, In : Cancer Biology and Therapy. 3, 10, p. 297-928 632 p.

Research output: Contribution to journalArticle

Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic

Kachhap, S. & Singh, K. K., Dec 1 2004, In : Molecular Cancer. 3, 32.

Research output: Contribution to journalArticle

The histone deacetylase inhibitor NVP-LAQ824 Inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584

Qian, D. Z., Wang, X., Kachhap, S., Kato, Y., Wei, Y., Zhang, L., Atadja, P. & Pili, R., Sep 15 2004, In : Cancer Research. 64, 18, p. 6626-6634 9 p.

Research output: Contribution to journalArticle

2003

Mitochondrial impairment in p53-deficient human cancer cells

Zhou, S., Kachhap, S. & Singh, K. K., May 2003, In : Mutagenesis. 18, 3, p. 287-292 6 p.

Research output: Contribution to journalArticle

2002

Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells

Delsite, R., Kachhap, S., Anbazhagan, R., Gabrielson, E. & Singh, K. K., Nov 12 2002, In : Molecular Cancer. 1, 6.

Research output: Contribution to journalArticle

2001

Effect of ω-3 fatty acid (docosahexanoic acid) on BRCA1 gene expression and growth in MCF-7 cell line

Kachhap, S., Dange, P. P., Santani, R. H., Sawant, S. S. & Ghosh, S. N., 2001, In : Cancer Biotherapy and Radiopharmaceuticals. 16, 3, p. 257-263 7 p.

Research output: Contribution to journalArticle

Implication of BRCA1 gene in breast cancer

Kachhap, S. & Ghosh, S. N., 2001, In : Indian Journal of Experimental Biology. 39, 5, p. 391-400 10 p.

Research output: Contribution to journalArticle

Reduced expression of the BRCA1 gene and increased chromosomal instability in MCF-7 cell line

Kachhap, S., Vetale, S. P., Dange, P. & Ghosh, S. N., 2001, In : Cell Biology International. 25, 6, p. 547-551 5 p.

Research output: Contribution to journalArticle

2000

Effect of ω-6 polyunsaturated fatty acid (linoleic acid) on BRCA1 gene expression in MCF-7 cell line

Kachhap, S., Dange, P. & Nath Ghosh, S., Jun 30 2000, In : Cancer Letters. 154, 2, p. 115-120 6 p.

Research output: Contribution to journalArticle