Sushant Kachhap

Assistant Professor

20002019
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Research Output 2000 2019

2019

Erratum to: Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy (Nature Communications, (2018), 9, 1, (4972), 10.1038/s41467-018-07411-7)

Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. & Qian, D. Z., Dec 1 2019, In : Nature Communications. 10, 1, 164.

Research output: Contribution to journalComment/debate

hypoxia
Androgens
therapy
switches
communication

Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40

Ignacio, D. N., Mason, K. D., Hackett-Morton, E. C., Albanese, C., Ringer, L., Wagner, W. D., Wang, P. C., Carducci, M. A., Kachhap, S., Paller, C., Mendonca, J., Li-Ying Chan, L., Lin, B., Hartle, D. K., Green, J. E., Brown, C. A. & Hudson, T. S., Jan 1 2019, In : Heliyon. 5, 1, e01128.

Research output: Contribution to journalArticle

HSP40 Heat-Shock Proteins
Vitis
Cell Cycle Checkpoints
Prostatic Neoplasms
Skin
2018

Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy

Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. & Qian, D. Z., Dec 1 2018, In : Nature Communications. 9, 1, 4972.

Research output: Contribution to journalArticle

hypoxia
Androgen Receptors
Androgens
therapy
switches
2017

The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion

Sharma, A., Mendonca, J., Ying, J., Kim, H. S., Verdone, J. E., Zarif, J., Carducci, M. A., Hammers, H., Pienta, K. & Kachhap, S., 2017, In : Molecular Oncology. 11, 6, p. 655-669 15 p.

Research output: Contribution to journalArticle

myc Genes
Tumor Suppressor Genes
Cell Movement
Prostate
Down-Regulation
2016

C/EBPβ regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion

Barakat, D. J., Mendonca, J., Barberi, T., Zhang, J., Kachhap, S., Paz-Priel, I. & Friedman, A. D., May 28 2016, In : Cancer Letters. 375, 1, p. 152-161 10 p.

Research output: Contribution to journalArticle

Lysosomes
Autophagy
Prostatic Neoplasms
Proteasome Endopeptidase Complex
Heterografts

Extreme Response to High-dose Testosterone in BRCA2- and ATM-mutated Prostate Cancer

Teply, B. A., Kachhap, S., Eisenberger, M. & Denmeade, S. R., 2016, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Testosterone
Prostatic Neoplasms
2015

NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability

Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Mendonca, J., Sharmaa, A., Mohseni, M., Rosen, D. M., Scharpf, R. B., Cidado, J., Cochran, R. L., Parsons, H. A., Dalton, W., Erlanger, B., Button, B., Cravero, K., Kyker-Snowman, K., Beaver, J., Kachhap, S., Hurley, P. & 2 others, Lauring, J. & Park, B. H., Sep 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. 11583-11588 6 p.

Research output: Contribution to journalArticle

Centrosome
Genomic Instability
Homeostasis
Genes
Neoplasms

Transcriptome sequencing in prostate cancer identifies inter-tumor heterogeneity

Mendonca, J., Sharma, A. & Kachhap, S., May 1 2015, In : Asian Journal of Andrology. 17, 3, p. 435-436 2 p.

Research output: Contribution to journalArticle

Neoplastic Gene Expression Regulation
Fusion Oncogene Proteins
Genetic Heterogeneity
Gene Expression Profiling
Transcriptome
2014

Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer

Paller, C., Wissing, M. D., Mendonca, J., Sharma, A., Kim, E., Kim, H. S., Kortenhorst, M. S. Q., Gerber, S., Rosen, M., Shaikh, F., Zahurak, M. L., Rudek-Renaut, M., Hammers, H., Rudin, C. M., Carducci, M. A. & Kachhap, S., Oct 1 2014, In : Cancer Medicine. 3, 5, p. 1322-1335 14 p.

Research output: Contribution to journalArticle

Aurora Kinases
Histone Deacetylase Inhibitors
Prostatic Neoplasms
Heterografts
Therapeutics

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

Mendonca, J., Sharma, A., Kim, H. S., Hammers, H., Meeker, A. K., Demarzo, A. M., Carducci, M. A., Kauffman, M., Shacham, S. & Kachhap, S., 2014, In : Oncotarget. 5, 15, p. 6102-6112 11 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Prostatic Neoplasms
Therapeutics
Apoptosis
Cell Cycle Checkpoints

Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression

Wissing, M. D., Dadon, T., Kim, E., Piontek, K. B., Shim, J. S., Kaelber, N. S., Liu, J., Kachhap, S. & Nelkin, B. D., 2014, In : Oncology Reports. 32, 1, p. 419-424 6 p.

Research output: Contribution to journalArticle

Tilorone
Cyclin-Dependent Kinase 5
Prostatic Neoplasms
Growth
Ethacridine
2013

Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors

Kortenhorst, M. S. Q., Wissing, M. D., Rodriguez, R., Kachhap, S., Jans, J. J. M., van der Groep, P., Verheul, H. M. W., Gupta, A., Aiyetan, P. O., van der Wall, E., Carducci, M. A., Van Diest, P. J. & Marchionni, L., Sep 2013, In : Epigenetics. 8, 9, p. 907-920 14 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Prostatic Neoplasms
Histone Deacetylases
Cell Line
Therapeutics

Identification of cetrimonium bromide and irinotecan as compounds with synthetic lethality against NDRG1 deficient prostate cancer cells

Wissing, M. D., Mendonca, J., Kim, E., Kim, E., Shim, J. S., Kaelber, N. S., Kant, H., Hammers, H., Commes, T., Van Diest, P. J., Liu, J. & Kachhap, S., May 2013, In : Cancer Biology and Therapy. 14, 5, p. 401-410 10 p.

Research output: Contribution to journalArticle

irinotecan
Prostatic Neoplasms
Genes
Gene Knockdown Techniques
cetrimonium

Repurposing itraconazole as a treatment for advanced prostate cancer: A noncomparative randomized phase ii trial in men with metastatic castration-resistant prostate cancer

Antonarakis, E., Heath, E. I., Smith, D. C., Rathkopf, D., Blackford, A. L., Danila, D. C., King, S., Frost, A., Seun Ajiboye, A., Zhao, M., Mendonca, J., Kachhap, S., Rudek-Renaut, M. & Carducci, M. A., 2013, In : Oncologist. 18, 2, p. 163-173 11 p.

Research output: Contribution to journalArticle

Itraconazole
Castration
Prostatic Neoplasms
Arm
Disease-Free Survival

Screening assay for blood vessel maturation inhibitors

Fu, C., van der Zwan, A., Gerber, S., Van Den Berg, S., No, E., C.H.Wang, W., Sheibani, N., Carducci, M. A., Kachhap, S. & Hammers, H. J., Aug 23 2013, In : Biochemical and Biophysical Research Communications. 438, 2, p. 364-369 6 p.

Research output: Contribution to journalArticle

Pericytes
Blood vessels
Blood Vessels
Assays
Screening

Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors

Wissing, M. D., Mendonca, J., Kortenhorst, M. S. Q., Kaelber, N. S., Gonzalez, M., Kim, E., Hammers, H., Van Diest, P. J., Carducci, M. A. & Kachhap, S., Oct 1 2013, In : FASEB Journal. 27, 10, p. 4279-4293 15 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Prostatic Neoplasms
Cells
Cell Line
Assays

Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment

Isaacs, J. T., Antony, L., Dalrymple, S. L., Brennen, W., Gerber, S., Hammers, H., Wissing, M., Kachhap, S., Luo, J., Xing, L., Bjork, P., Olsson, A., Bjork, A. & Leanderson, T., Jan 15 2013, In : Cancer Research. 73, 4, p. 1386-1399 14 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Survival
Pharmaceutical Preparations
Phase III Clinical Trials
Histone Deacetylases
2012

Metastasis: Genetics, mechanism, and diagnostic and therapeutic strategies

Gunduz, M., Gunduz, E., Beder, L., Pehlivan, D., Hatipoglu, O. F., Kachhap, S. & Grenman, R., 2012, In : Journal of Oncology. 390835.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Therapeutics
2011

Cigarette smoke and cancer

Kachhap, S., Keshamouni, V. G., Qian, D. Z. & Chatterjee, A., 2011, In : Journal of Oncology. 172678.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Neoplasms

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

Lin, J., Haffner, M. C., Zhang, Y., Lee, B. H., Brennen, W., Britton, J., Kachhap, S., Shim, J. S., Liu, J., Nelson, W. G., Yegnasubramanian, S. & Carducci, M. A., Mar 1 2011, In : Prostate. 71, 4, p. 333-343 11 p.

Research output: Contribution to journalArticle

Disulfiram
Prostatic Neoplasms
Cytosine
DNA
Methyltransferases
2010

Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor

Kachhap, S., Rosmus, N., Collis, S. J., Kortenhorst, M. S. Q., Wissing, M. D., Hedayati, M., Shabbeer, S., Mendonca, J., Deangelis, J., Marchionni, L., Lin, J., Höti, N., Nortier, J. W. R., DeWeese, T., Hammers, H. & Carducci, M. A., 2010, In : PLoS One. 5, 6, e11208.

Research output: Contribution to journalArticle

E2F1 Transcription Factor
Recombinational DNA Repair
homologous recombination
prostatic neoplasms
DNA repair
2009

Fenugreek: A naturally occurring edible spice as an anticancer agent

Shabbeer, S., Sobolewski, M., Anchoori, R., Kachhap, S., Hidalgo, M., Carducci, M. A., Davidson, N., Carducci, M. A. & Khan, S. R., Feb 2009, In : Cancer Biology and Therapy. 8, 3, p. 272-278 7 p.

Research output: Contribution to journalArticle

Trigonella
Spices
Antineoplastic Agents
Growth
Prostate
2008

A multiple-loop, double-cube microarray design applied to prostate cancer cell lines with variable sensitivity to histone deacetylase inhibitors

Kortenhorst, M. S. Q., Zahurak, M., Shabbeer, S., Kachhap, S., Galloway, N., Parmigiani, G., Verheul, H. M. W. & Carducci, M. A., Nov 1 2008, In : Clinical Cancer Research. 14, 21, p. 6886-6894 9 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Prostatic Neoplasms
Cell Line
Valproic Acid
Oligonucleotide Array Sequence Analysis
2007

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck

Zhou, S., Kachhap, S., Sun, W., Wu, G., Chuang, A., Poeta, L., Grumbine, L., Mithani, S. K., Chatterjee, A., Koch, W. M., Westra, W. H., Maitra, A., Glazer, C., Carducci, M. A., Sidransky, D., McFate, T., Verma, A. & Califano, J. A., May 1 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 18, p. 7540-7545 6 p.

Research output: Contribution to journalArticle

Squamous Cell Neoplasms
Head and Neck Neoplasms
Mitochondrial DNA
Mutation
Neoplasms

Multiple molecular pathways explain the anti-proliferative effect of valproic acid on prostate cancer cells in vitro and in vivo

Shabbeer, S., Kortenhorst, M. S. Q., Kachhap, S., Galloway, N., Rodriguez, R. & Carducci, M. A., Jul 1 2007, In : Prostate. 67, 10, p. 1099-1110 12 p.

Research output: Contribution to journalArticle

Valproic Acid
Prostatic Neoplasms
Cell Cycle Checkpoints
Cell Line
Histone Deacetylase Inhibitors

The N-Myc down regulated gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin

Kachhap, S., Faith, D., Qian, D. Z., Shabbeer, S., Galloway, N. L., Pili, R., Denmeade, S. R., Demarzo, A. M. & Carducci, M. A., Sep 5 2007, In : PLoS One. 2, 9, e844.

Research output: Contribution to journalArticle

cadherins
Recycling
Cadherins
recycling
Transferrin
2006

Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α

Qian, D. Z., Kachhap, S., Collis, S. J., Verheul, H. M. W., Carducci, M. A., Atadja, P. & Pili, R., Sep 1 2006, In : Cancer Research. 66, 17, p. 8814-8821 8 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Histone Deacetylases
Histone Deacetylase Inhibitors
Transcriptional Activation
Proteins
2004

Blocking angiogenesis and histone deacetylases in prostate and breast cancer bearing mice

Qian, D. Z., Wang, X., Kachhap, S., Kato, Y., Wei, Y., Zhang, L. & Atadja, P., Oct 2004, In : Cancer Biology and Therapy. 3, 10, p. 297-928 632 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Prostatic Neoplasms
Breast Neoplasms

Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic

Kachhap, S. & Singh, K. K., Dec 1 2004, In : Molecular Cancer. 3, 32.

Research output: Contribution to journalArticle

Uracil-DNA Glycosidase
Mitochondria
Uracil
Repair
Cells

The histone deacetylase inhibitor NVP-LAQ824 Inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584

Qian, D. Z., Wang, X., Kachhap, S., Kato, Y., Wei, Y., Zhang, L., Atadja, P. & Pili, R., Sep 15 2004, In : Cancer Research. 64, 18, p. 6626-6634 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor
Histone Deacetylase Inhibitors
Protein-Tyrosine Kinases
Neoplasms
Vascular Endothelial Growth Factor A
2003

Mitochondrial impairment in p53-deficient human cancer cells

Zhou, S., Kachhap, S. & Singh, K. K., May 2003, In : Mutagenesis. 18, 3, p. 287-292 6 p.

Research output: Contribution to journalArticle

Oxidoreductases
Mitochondrial DNA
Cells
Mutation
Messenger RNA
2002

Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells

Delsite, R., Kachhap, S., Anbazhagan, R., Gabrielson, E. & Singh, K. K., Nov 12 2002, In : Molecular Cancer. 1, 6.

Research output: Contribution to journalArticle

Mitochondria
Cell signaling
Genes
Communication
Cells
2001

Effect of ω-3 fatty acid (docosahexanoic acid) on BRCA1 gene expression and growth in MCF-7 cell line

Kachhap, S., Dange, P. P., Santani, R. H., Sawant, S. S. & Ghosh, S. N., 2001, In : Cancer Biotherapy and Radiopharmaceuticals. 16, 3, p. 257-263 7 p.

Research output: Contribution to journalArticle

BRCA1 Gene
MCF-7 Cells
Fatty Acids
Gene Expression
Cell Line

Implication of BRCA1 gene in breast cancer

Kachhap, S. & Ghosh, S. N., 2001, In : Indian Journal of Experimental Biology. 39, 5, p. 391-400 10 p.

Research output: Contribution to journalArticle

BRCA1 Gene
Genes
Breast Neoplasms
Ovarian Neoplasms
DNA Repair

Reduced expression of the BRCA1 gene and increased chromosomal instability in MCF-7 cell line

Kachhap, S., Vetale, S. P., Dange, P. & Ghosh, S. N., 2001, In : Cell Biology International. 25, 6, p. 547-551 5 p.

Research output: Contribution to journalArticle

BRCA1 Gene
Chromosomal Instability
MCF-7 Cells
Chromosome Aberrations
Cell Line
2000

Effect of ω-6 polyunsaturated fatty acid (linoleic acid) on BRCA1 gene expression in MCF-7 cell line

Kachhap, S., Dange, P. & Nath Ghosh, S., Jun 30 2000, In : Cancer Letters. 154, 2, p. 115-120 6 p.

Research output: Contribution to journalArticle

BRCA1 Gene
MCF-7 Cells
Linoleic Acid
Unsaturated Fatty Acids
Estradiol