Susan Aja

Research output

Research output per year 1999 2006 2008 2012 2013 2014 2022 2023 2023

• 61 Article
• 2 Comment/debate
• 1 Chapter
• 1 Editorial
• 1 More
  • 1 Review article

Research output per year

Research output per year

Search results

• 2023

  CTRP13 ablation improves systemic glucose and lipid metabolism

  Chen, F., Sarver, D. C., Saqib, M., Zhou, M., Aja, S., Seldin, M. M. & Wong, G. W., Dec 2023, In: Molecular Metabolism. 78, 101824.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipid Metabolism 100%
  • Intra-Abdominal Fat 87%
  • Knockout Mice 71%
  • Glucose 65%
  • Liver 53%

• Dysregulated systemic metabolism in a Down syndrome mouse model

  Sarver, D. C., Xu, C., Velez, L. M., Aja, S., Jaffe, A. E., Seldin, M. M., Reeves, R. H. & Wong, G. W., Feb 2023, In: Molecular Metabolism. 68, 101666.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Down Syndrome 100%
  • Aneuploidy 51%
  • High Fat Diet 32%
  • Dyslipidemias 31%
  • Genes 25%

• Hypermetabolism in mice carrying a near-complete human chromosome 21

  Sarver, D. C., Xu, C., Rodriguez, S., Aja, S., Jaffe, A. E., Gao, F. J., Delannoy, M., Periasamy, M., Kazuki, Y., Oshimura, M., Reeves, R. H. & Wong, G. W., 2023, In: eLife. 12, e86023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sarcolipin 100%
  • Chromosomes, Human, Pair 21 70%
  • Reticulum 69%
  • Thermogenesis 66%
  • Calcium-Transporting ATPases 65%

• Kynurenine pathway metabolism evolves with development of preclinical and scleroderma-associated pulmonary arterial hypertension

  Simpson, C. E., Ambade, A. S., Harlan, R., Roux, A., Aja, S., Graham, D., Shah, A. A., Hummers, L. K., Hemnes, A. R., Leopold, J. A., Horn, E. M., Berman-Rosenzweig, E. S., Grunig, G., Aldred, M. A., Barnard, J., Comhair, S. A. A., Tang, W. H. W., Griffiths, M., Rischard, F., Frantz, R. P., & 6 othersErzurum, S. C., Beck, G. J., Hill, N. S., Mathai, S. C., Hassoun, P. M. & Damico, R. L., Nov 2023, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 325, 5, p. L617-L627

  Research output: Contribution to journal › Article › peer-review

  • Kynurenine 100%
  • Pulmonary Arterial Hypertension 87%
  • Systemic Scleroderma 45%
  • Tryptophan 18%
  • Tryptophan Oxygenase 17%

• Metabolic profiling of in vivo right ventricular function and exercise performance in pulmonary arterial hypertension

  Simpson, C. E., Coursen, J., Hsu, S., Gough, E. K., Harlan, R., Roux, A., Aja, S., Graham, D., Kauffman, M., Suresh, K., Tedford, R. J., Kolb, T. M., Mathai, S. C., Hassoun, P. M. & Damico, R. L., Jun 1 2023, In: American journal of physiology. Lung cellular and molecular physiology. 324, 6, p. L836-L848

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Right Ventricular Function 100%
  • Pulmonary Arterial Hypertension 93%
  • Exercise 51%
  • Arginine 26%
  • Biological Availability 26%

• Mitochondrial β-oxidation of adiposederived fatty acids by osteoblasts fuels parathyroid hormone-induced bone formation

  Alekos, N. S., Kushwaha, P., Kim, S. P., Li, Z., Abood, A., Dirckx, N., Aja, S., Kodama, J., Garcia-Diaz, J. G., Otsuru, S., Rendina-Ruedy, E., Wolfgang, M. J. & Riddle, R. C., Mar 22 2023, In: JCI Insight. 8, 6, e165604.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Parathyroid Hormone 100%
  • Osteoblasts 94%
  • Osteogenesis 87%
  • Fatty Acids 84%
  • Adipocytes 47%

• Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression

  Kim, S. P., Seward, A. H., Garcia-Diaz, J., Alekos, N., Gould, N. R., Aja, S., Stains, J. P., Wolfgang, M. J. & Riddle, R. C., Jul 21 2023, In: iScience. 26, 7, 106999.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peroxisome Proliferator-Activated Receptors 100%
  • Osteoblasts 79%
  • Osteogenesis 72%
  • Fats 62%
  • Bone and Bones 36%

• Serendipitous Discovery of T Cell–Produced KLK1b22 as a Regulator of Systemic Metabolism

  Arwood, M. L., Sun, I. H., Patel, C. H., Sun, I. M., Oh, M. H., Bettencourt, I. A., Claiborne, M. D., Chan-Li, Y., Zhao, L., Waickman, A. T., Mavrothalassitis, O., Wen, J., Aja, S. & Powell, J. D., Jun 1 2023, In: ImmunoHorizons. 7, 6, p. 493-507 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T-Lymphocytes 100%
  • Kallikreins 82%
  • Glucose 81%
  • Beige Adipose Tissue 55%
  • Peptide Hydrolases 54%
• 2022

  CTRP11 contributes modestly to systemic metabolism and energy balance

  Sarver, D. C., Xu, C., Carreno, D., Arking, A., Terrillion, C. E., Aja, S. & Wong, G. W., Jun 2022, In: FASEB Journal. 36, 6, e22347.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Energy Balance 100%
  • Knockout Mice 66%
  • Energy Metabolism 65%
  • Metabolic 58%
  • Pharmacological Metabolism 55%

• CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding

  Sarver, D. C., Xu, C., Aja, S. & Wong, G. W., 2022, In: American Journal of Physiology - Endocrinology and Metabolism. 322, 6, p. E480-E493

  Research output: Contribution to journal › Article › peer-review

  • Knockout Mice 100%
  • Fasting 87%
  • Eating 82%
  • Meals 39%
  • Food Deprivation 29%

• Erratum: Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition (Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition (2010) 142(2) (309–319), (S0092867410006203), (10.1016/j.cell.2010.06.002))

  Fulzele, K., Riddle, R., DiGirolamo, D., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S., Hussain, M., Brüning, J. C. & Clemens, T., Feb 17 2022, In: Cell. 185, 4, p. 746 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • 8-hydroxy-7-iodo-5-quinolinesulfonic acid 100%
  • Insulin Receptor 98%
  • Osteocalcin 94%
  • Insulin Derivative 88%
  • Body Composition 85%

• Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons

  Alexandris, A. S., Ryu, J., Rajbhandari, L., Harlan, R., McKenney, J., Wang, Y., Aja, S., Graham, D., Venkatesan, A. & Koliatsos, V. E., Sep 2022, In: Neurobiology of Disease. 171, 105808.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Wallerian Degeneration 100%
  • Niacin 87%
  • NAD 72%
  • Axons 61%
  • Cyclic ADP-Ribose 15%
• 2021

  CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution

  Wang, Q., Hernández-Ochoa, E. O., Viswanathan, M. C., Blum, I. D., Do, D. C., Granger, J. M., Murphy, K. R., Wei, A. C., Aja, S., Liu, N., Antonescu, C. M., Florea, L. D., Talbot, C. C., Mohr, D., Wagner, K. R., Regot, S., Lovering, R. M., Gao, P., Bianchet, M. A., Wu, M. N., & 4 othersCammarato, A., Schneider, M. F., Bever, G. S. & Anderson, M. E., Dec 1 2021, In: Nature communications. 12, 1, 3175.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • vertebrates 100%
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 95%
  • Reactive Oxygen Metabolite 70%
  • Vertebrates 67%
  • Reactive Oxygen Species 59%
• 2020

  Loss of CTRP4 alters adiposity and food intake behaviors in obese mice

  Sarver, D. C., Stewart, A. N., Rodriguez, S., Little, H. C., Aja, S. & Wong, G. W., Dec 15 2020, In: American Journal of Physiology - Endocrinology and Metabolism. 319, 6, p. E1084-E1100

  Research output: Contribution to journal › Article › peer-review

  • Obese Mice 100%
  • Adiposity 85%
  • Knockout Mice 74%
  • Eating 61%
  • Weight Gain 24%
  1 Scopus citations

• Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice

  Yoo, S., Cha, D., Kim, S., Jiang, L., Cooke, P., Adebesin, M., Wolfe, A., Riddle, R., Aja, S. & Blackshaw, S., Oct 1 2020, In: Glia. 68, 10, p. 1987-2000 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Median Eminence 91%
  • Arcuate Nucleus of Hypothalamus 89%
  • Adipose Tissue 59%
  • Obesity 49%
  • Fats 17%
  9 Scopus citations
• 2019

  FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors

  Lei, X., Liu, L., Terrillion, C. E., Karuppagounder, S. S., Cisternas, P., Lay, M., Martinelli, D. C., Aja, S., Dong, X., Pletnikov, M. V. & Wong, G. W., Dec 2019, In: FASEB Journal. 33, 12, p. 14734-14747 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Knockout Mice 100%
  • Eating 82%
  • Food 77%
  • Brain 53%
  • Dopamine 51%
  6 Scopus citations

• MeCP2 deficiency disrupts kainate-induced presynaptic plasticity in the mossy fiber projections in the hippocampus

  Bertoldi, M. L., Zalosnik, M. I., Fabio, M. C., Aja, S., Roth, G. A., Ronnett, G. V. & Degano, A. L., May 14 2019, In: Frontiers in Cellular Neuroscience. 13, 286.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Deficiency 100%
  • Cytosine 91%
  • Kainic Acid 89%
  • Carrier Proteins 64%
  • Hippocampus 61%
  3 Scopus citations
• 2018

  DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders

  Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V. L., Dawson, T. M., Aja, S., Sesaki, H. & Pletnikov, M. V., Dec 1 2018, In: Translational psychiatry. 8, 1, 76.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Astrocytes 100%
  • Lactic Acid 96%
  • Schizophrenia 88%
  • Mental Disorders 88%
  • Glucose 14%
  17 Scopus citations
• 2017

  Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance

  Lopez, P. H. H., Aja, S., Aoki, K., Seldin, M. M., Lei, X., V Ronnett, G., Wong, G. W. & Schnaar, R. L., 2017, In: Glycobiology. 27, 1, p. 129-139 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 100%
  • beta-galactoside alpha-2,3-sialyltransferase 90%
  • Insulin Derivative 52%
  • Insulin Resistance 41%
  • Obesity 35%
  10 Scopus citations

• Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

  Kim, S. P., Frey, J. L., Li, Z., Kushwaha, P., Zoch, M. L., Tomlinson, R. E., Da, H., Aja, S., Noh, H. L., Kim, J. K., Hussain, M., Thorek, D., Wolfgang, M. J. & Riddle, R. C., Dec 26 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11238-E11247

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Body Composition 100%
  • Adipocytes 96%
  • Adipose Tissue 33%
  • Catenins 25%
  • Dependovirus 25%
  49 Scopus citations
• 2016

  D-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway

  Jeon, Y., Aja, S., Ronnett, G. V. & Kim, E. K., Feb 19 2016, In: Biochemical and Biophysical Research Communications. 470, 4, p. 818-823 6 p.

  Research output: Contribution to journal › Article › peer-review

  • inositol phosphate glycan 100%
  • Neuropeptides 55%
  • Insulin Derivative 44%
  • Orexigenic 41%
  • Eating 41%
  8 Scopus citations

• Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet

  Slocum, S. L., Skoko, J. J., Wakabayashi, N., Aja, S., Yamamoto, M., Kensler, T. W. & Chartoumpekis, D. V., Feb 1 2016, In: Archives of Biochemistry and Biophysics. 591, p. 57-65 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipogenic 100%
  • High Fat Diet 57%
  • Glucose 42%
  • Cytoprotective 40%
  • Lipogenesis 35%
  43 Scopus citations

• Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality

  Lee, J., Choi, J., Aja, S., Scafidi, S. & Wolfgang, M. J., Feb 16 2016, In: Cell Reports. 14, 6, p. 1308-1316 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brown Adipose Tissue 100%
  • Brown 85%
  • Fatty Acids 69%
  • Fatty Acid 66%
  • Obesity 57%
  28 Scopus citations
• 2015

  Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast

  Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S., Wolfgang, M. J., Clemens, T. L. & Riddle, R. C., 2015, In: Molecular and cellular biology. 35, 11, p. 1979-1991 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Osteoblasts 100%
  • Fatty Acids 89%
  • Bone and Bones 62%
  • Catenins 33%
  • Osteocytes 32%
  71 Scopus citations
• 2014

  Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

  Park, M. J., Aja, S., Li, Q., Degano, A. L., Penati, J., Zhuo, J., Roe, C. R. & Ronnett, G. V., 2014, In: PloS one. 9, 10, e0109527.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • triheptanoin 100%
  • Mouse Mecp2 protein 98%
  • Rett Syndrome 69%
  • Metabolome 57%
  • Longevity 45%
  35 Scopus citations

• Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice

  Lee, D. A., Yoo, S., Pak, T., Salvatierra, J., Velarde, E., Aja, S. & Blackshaw, S., 2014, In: Frontiers in Neuroscience. 8 JUN, Article 157.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sex Factors 100%
  • Neurogenesis 81%
  • Young Adult 61%
  • Median Eminence 58%
  • Hypothalamus 56%
  44 Scopus citations

• Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation

  McFadden, J. W., Aja, S., Li, Q., Bandaru, V. V. R., Kim, E. K., Haughey, N. J., Kuhajda, F. P. & Ronnett, G. V., Dec 26 2014, In: PloS one. 9, 12, e115642.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • beta oxidation 100%
  • inflammation 81%
  • palmitates 78%
  • Fatty Acids 76%
  • neurons 74%
  35 Scopus citations

• Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice

  Wei, Z., Lei, X., Petersen, P. S., Aja, S. & Wong, G. W., Apr 1 2014, In: American Journal of Physiology - Endocrinology and Metabolism. 306, 7, p. E779-E790

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Knockout Mice 100%
  • Insulin Resistance 89%
  • Eating 82%
  • Insulin 74%
  • Energy Intake 73%
  63 Scopus citations
• 2013

  CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism

  Peterson, J. M., Seldin, M. M., Wei, Z., Aja, S. & Wong, G. W., Aug 1 2013, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 3, p. G214-G224

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triglycerides 100%
  • Diet 85%
  • Liver 64%
  • Transgenic Mice 47%
  • High Fat Diet 35%
  81 Scopus citations

• CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction

  Peterson, J. M., Wei, Z., Seldin, M. M., Byerly, M. S., Aja, S. & Wong, G. W., Sep 1 2013, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 305, 5, p. R522-R533

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transgenic Mice 100%
  • Obesity 78%
  • Diet 76%
  • Skeletal Muscle 66%
  • High Fat Diet 56%
  79 Scopus citations

• Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression

  Byerly, M. S., Al Salayta, M., Swanson, R. D., Kwon, K., Peterson, J. M., Wei, Z., Aja, S., Moran, T. H., Blackshaw, S. & Wong, G. W., Apr 2013, In: European Journal of Neuroscience. 37, 7, p. 1033-1047 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuropeptide Y 100%
  • Estrogen Receptors 80%
  • Gene Expression 51%
  • Meals 28%
  • Rhombencephalon 19%
  20 Scopus citations

• Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite

  Byerly, M. S., Swanson, R. D., Semsarzadeh, N. N., McCulloh, P. S., Kwon, K., Aja, S., Moran, T. H., William Wong, G. & Blackshaw, S., Jun 15 2013, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 12, p. R1085-R1095

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nerve Growth Factors 100%
  • Appetite 96%
  • Eating 58%
  • Neurons 57%
  • Brain-Derived Neurotrophic Factor 49%
  23 Scopus citations
• 2012

  A novel obesity model: Synphilin-1-induced hyperphagia and obesity in mice

  Li, X., Tamashiro, K. L. K., Liu, Z., Bello, N. T., Wang, X., Aja, S., Bi, S., Ladenheim, E. E., Ross, C. A., Moran, T. H. & Smith, W. W., Sep 2012, In: International Journal of Obesity. 36, 9, p. 1215-1221 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hyperphagia 100%
  • Eating 60%
  • Obesity 55%
  • Body Weight 45%
  • Hyperinsulinism 35%
  10 Scopus citations

• CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition

  Peterson, J. M., Aja, S., Wei, Z. & Wong, G. W., Jan 6 2012, In: Journal of Biological Chemistry. 287, 2, p. 1576-1587 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acetyl-CoA Carboxylase 100%
  • Acetyl-CoA 90%
  • AMP-Activated Protein Kinases 88%
  • Fatty Acids 62%
  • Fatty Acid 59%
  104 Scopus citations

• Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

  Shin, M. K., Drager, L. F., Yao, Q., Bevans-Fonti, S., Yoo, D. Y., Jun, J. C., Aja, S., Bhanot, S. & Polotsky, V. Y., Oct 1 2012, In: PloS one. 7, 10, e46562.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • hypoxia-inducible factor 1 100%
  • Antisense Oligonucleotide 87%
  • Hypoxia-Inducible Factor 1 79%
  • Antisense Oligonucleotides 72%
  • high fat diet 67%
  40 Scopus citations

• Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

  Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H., West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., Seredenina, T., Arbez, N., Zhu, S., Sommers, K., Qian, J., Zhang, J., Mori, S., Yang, X. W., Tamashiro, K. L. K., Aja, S., & 10 othersMoran, T. H., Luthi-Carter, R., Martin, B., Maudsley, S., Mattson, M. P., Cichewicz, R. H., Ross, C. A., Holtzman, D. M., Krainc, D. & Duan, W., Jan 2012, In: Nature medicine. 18, 1, p. 153-158 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sirtuin 1 100%
  • Neuroprotective 95%
  • Huntington Disease 83%
  • Metabolic 61%
  • Deacetylation 44%
  235 Scopus citations

• Physiological oxygen level is critical for modeling neuronal metabolism in vitro

  Zhu, J., Aja, S., Kim, E. K., Park, M. J., Ramamurthy, S., Jia, J., Hu, X., Geng, P. & Ronnett, G. V., Feb 2012, In: Journal of neuroscience research. 90, 2, p. 422-434 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxygen 100%
  • In Vitro Techniques 61%
  • Adenosine Monophosphate 44%
  • Glucose 37%
  • Protein Kinases 36%
  19 Scopus citations

• Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

  Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., Aja, S., Ford, E., Fishell, G. & Blackshaw, S., May 2012, In: Nature neuroscience. 15, 5, p. 700-702 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Median Eminence 91%
  • Neurogenesis 76%
  • Diet 49%
  • Neurons 44%
  • Hypothalamus 33%
  290 Scopus citations

• The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal

  Gietzen, D. W. & Aja, S. M., Oct 2012, In: Molecular Neurobiology. 46, 2, p. 332-348 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Essential Amino Acids 100%
  • Meals 68%
  • Amino Acids 53%
  • Diet 52%
  • Brain 37%
  24 Scopus citations
• 2011

  Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity

  Chao, P. T., Yang, L., Aja, S., Moran, T. H. & Bi, S., May 4 2011, In: Cell Metabolism. 13, 5, p. 573-583 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brown Adipocytes 100%
  • Neuropeptide Y 81%
  • Hypothalamus 65%
  • Obesity 48%
  • Diet 48%
  142 Scopus citations

• Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

  Kuhajda, F. P., Aja, S., Tu, Y., Han, W. F., Medghalchi, S. M., El Meskini, R., Landree, L. E., Peterson, J. M., Daniels, K., Wong, K., Wydysh, E. A., Townsend, C. A. & Ronnett, G. V., Jul 2011, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 301, 1, p. R116-R130

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha-glycerophosphoric acid 100%
  • Acyltransferases 98%
  • Adiposity 72%
  • Obese Mice 63%
  • Insulin Resistance 56%
  22 Scopus citations

• The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

  Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W. J., Sereda, S., Clerc, P., Polster, B. M., Aja, S. M., Pletnikov, M. V., Kensler, T. W., Shirihai, O. S., Iijima, M., Hussain, M. A. & Sesaki, H., Jul 1 2011, In: Molecular biology of the cell. 22, 13, p. 2235-2245 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dynamins 100%
  • GTP Phosphohydrolases 85%
  • Insulin-Secreting Cells 80%
  • Adenosine Triphosphate 58%
  • Mitochondrial DNA 52%
  100 Scopus citations
• 2010

  Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

  Chiang, P. M., Ling, J., Jeong, Y. H., Price, D. L., Aja, S. M. & Wong, P. C., Sep 14 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16320-16324 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Embryonic Stem Cells 100%
  • Adipose Tissue 78%
  • DNA-Binding Proteins 70%
  • Down-Regulation 65%
  • Obesity 65%
  188 Scopus citations

• Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

  Fulzele, K., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S., Hussain, M. A., Brüning, J. C. & Clemens, T. L., Jul 2010, In: Cell. 142, 2, p. 309-319 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Insulin Receptor 100%
  • Insulin Derivative 90%
  • Body Composition 87%
  • Osteoblasts 84%
  • Osteocalcin 80%
  528 Scopus citations
• 2009

  AMPK in the brain: Its roles in energy balance and neuroprotection

  Ronnett, G. V., Ramamurthy, S., Kleman, A. M., Landree, L. E. & Aja, S., May 2009, In: Journal of Neurochemistry. 109, SUPPL. 1, p. 17-23 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Energy Balance 100%
  • Adenosine Monophosphate 80%
  • Neuroprotection 75%
  • Adenosine 69%
  • Protein Kinases 66%
  203 Scopus citations

• Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity

  Davis, L. M., Michaelides, M., Cheskin, L. J., Moran, T. H., Aja, S., Watkins, P. A., Pei, Z., Contoreggi, C., McCullough, K., Hope, B., Wang, G. J., Volkow, N. D. & Thanos, P. K., Feb 2009, In: Neuroendocrinology. 89, 2, p. 152-162 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Zucker Rats 100%
  • Leptin Receptors 96%
  • Hyperphagia 92%
  • Bromocriptine 91%
  • Dopamine Plasma Membrane Transport Proteins 91%
  51 Scopus citations

• Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

  Shin, S., Wakabayashi, J., Yates, M. S., Wakabayashi, N., Dolan, P. M., Aja, S., Liby, K. T., Sporn, M. B., Yamamoto, M. & Kensler, T. W., Oct 12 2009, In: European Journal of Pharmacology. 620, 1-3, p. 138-144 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole 100%
  • Triterpenes 64%
  • High Fat Diet 51%
  • Obesity 35%
  • Liver 6%
  192 Scopus citations
• 2008

  AMP-activated protein kinase in the brain

  Ronnett, G. V. & Aja, S., Sep 2008, In: International Journal of Obesity. 32, p. S42-S48

  Research output: Contribution to journal › Review article › peer-review

  • AMP-Activated Protein Kinases 100%
  • Brain 41%
  • Energy Metabolism 15%
  • Fatty Acids 14%
  • Eating 12%
  9 Scopus citations

• Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats

  Mansouri, A., Aja, S., Moran, T. H., Ronnett, G., Kuhajda, F. P., Arnold, M., Geary, N., Langhans, W. & Leonhardt, M., Sep 2008, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 295, 3, p. R799-R805

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intraperitoneal Injections 100%
  • Psychological Inhibition 83%
  • Eating 76%
  • Meals 45%
  • Fatty Acid Synthases 13%
  10 Scopus citations

• Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight

  Aja, S., Landree, L. E., Kleman, A. M., Medghalchi, S. M., Vadlamudi, A., McFadden, J. M., Aplasca, A., Hyun, J., Plummer, E., Daniels, K., Kemm, M., Townsend, C. A., Thupari, J. N., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V., Feb 2008, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 2, p. R352-R361

  Research output: Contribution to journal › Article › peer-review

  • Carnitine 100%
  • Transferases 85%
  • Eating 63%
  • Body Weight 59%
  • Pharmacology 55%
  52 Scopus citations