Susan M Aja

Research Associate

19992019

Research output per year

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Research Output

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2019

MeCP2 deficiency disrupts kainate-induced presynaptic plasticity in the mossy fiber projections in the hippocampus

Bertoldi, M. L., Zalosnik, M. I., Fabio, M. C., Aja, S. M., Roth, G. A., Ronnett, G. V. & Degano, A. L., May 14 2019, In : Frontiers in Cellular Neuroscience. 13, 286.

Research output: Contribution to journalArticle

Open Access
2018

DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders

Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V., Dawson, T. M., Aja, S. M., Sesaki, H. & Pletnikov, M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 76.

Research output: Contribution to journalArticle

2017

Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance

Lopez, P., Aja, S. M., Aoki, K., Seldin, M. M., Lei, X., V Ronnett, G., Wong, G. W. & Schnaar, R. L., 2017, In : Glycobiology. 27, 1, p. 129-139 11 p.

Research output: Contribution to journalArticle

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

Kim, S. P., Frey, J. L., Li, Z., Kushwaha, P., Zoch, M. L., Tomlinson, R. E., Da, H., Aja, S. M., Noh, H. L., Kim, J. K., Hussain, M., Thorek, D. L. J., Wolfgang, M. J. & Riddle, R., Dec 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11238-E11247

Research output: Contribution to journalArticle

2016

D-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway

Jeon, Y., Aja, S., Ronnett, G. V. & Kim, E. K., Feb 19 2016, In : Biochemical and Biophysical Research Communications. 470, 4, p. 818-823 6 p.

Research output: Contribution to journalArticle

Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet

Slocum, S. L., Skoko, J. J., Wakabayashi, N., Aja, S., Yamamoto, M., Kensler, T. W. & Chartoumpekis, D. V., Feb 1 2016, In : Archives of Biochemistry and Biophysics. 591, p. 57-65 9 p.

Research output: Contribution to journalArticle

Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality

Lee, J., Choi, J., Aja, S., Scafidi, S. & Wolfgang, M. J., Feb 16 2016, In : Cell Reports. 14, 6, p. 1308-1316 9 p.

Research output: Contribution to journalArticle

2015

Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast

Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S., Wolfgang, M. J., Clemens, T. L. & Riddle, R. C., Jan 1 2015, In : Molecular and cellular biology. 35, 11, p. 1979-1991 13 p.

Research output: Contribution to journalArticle

2014

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

Park, M. J., Aja, S., Li, Q., Degano, A. L., Penati, J., Zhuo, J., Roe, C. R. & Ronnett, G. V., Jan 1 2014, In : PloS one. 9, 10, e0109527.

Research output: Contribution to journalArticle

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice

Lee, D. A., Yoo, S., Pak, T., Salvatierra, J., Velarde, E., Aja, S. & Blackshaw, S., Jan 1 2014, In : Frontiers in Neuroscience. 8 JUN, Article 157.

Research output: Contribution to journalArticle

Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation

McFadden, J. W., Aja, S., Li, Q., Bandaru, V. V. R., Kim, E. K., Haughey, N. J., Kuhajda, F. P. & Ronnett, G. V., Dec 26 2014, In : PloS one. 9, 12, e115642.

Research output: Contribution to journalArticle

2013

CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism

Peterson, J. M., Seldin, M. M., Wei, Z., Aja, S. & Wong, G. W., Aug 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 3, p. G214-G224

Research output: Contribution to journalArticle

CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction

Peterson, J. M., Wei, Z., Seldin, M. M., Byerly, M. S., Aja, S. & Wong, G. W., Sep 1 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 305, 5, p. R522-R533

Research output: Contribution to journalArticle

Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression

Byerly, M. S., Al Salayta, M., Swanson, R. D., Kwon, K., Peterson, J. M., Wei, Z., Aja, S., Moran, T. H., Blackshaw, S. & Wong, G. W., Apr 1 2013, In : European Journal of Neuroscience. 37, 7, p. 1033-1047 15 p.

Research output: Contribution to journalArticle

Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite

Byerly, M. S., Swanson, R. D., Semsarzadeh, N. N., McCulloh, P. S., Kwon, K., Aja, S., Moran, T. H., William Wong, G. & Blackshaw, S., Jun 15 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 12, p. R1085-R1095

Research output: Contribution to journalArticle

2012

A novel obesity model: Synphilin-1-induced hyperphagia and obesity in mice

Li, X., Tamashiro, K. L. K., Liu, Z., Bello, N. T., Wang, X., Aja, S., Bi, S., Ladenheim, E. E., Ross, C. A., Moran, T. H. & Smith, W. W., Sep 1 2012, In : International Journal of Obesity. 36, 9, p. 1215-1221 7 p.

Research output: Contribution to journalArticle

CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition

Peterson, J. M., Aja, S., Wei, Z. & Wong, G. W., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 1576-1587 12 p.

Research output: Contribution to journalArticle

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

Shin, M. K., Drager, L. F., Yao, Q., Bevans-Fonti, S., Yoo, D. Y., Jun, J. C., Aja, S., Bhanot, S. & Polotsky, V. Y., Oct 1 2012, In : PloS one. 7, 10, e46562.

Research output: Contribution to journalArticle

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H., West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., Seredenina, T., Arbez, N., Zhu, S., Sommers, K., Qian, J., Zhang, J., Mori, S., Yang, X. W., Tamashiro, K. L. K., Aja, S. & 10 others, Moran, T. H., Luthi-Carter, R., Martin, B., Maudsley, S., Mattson, M. P., Cichewicz, R. H., Ross, C. A., Holtzman, D. M., Krainc, D. & Duan, W., Jan 1 2012, In : Nature medicine. 18, 1, p. 153-158 6 p.

Research output: Contribution to journalArticle

Physiological oxygen level is critical for modeling neuronal metabolism in vitro

Zhu, J., Aja, S., Kim, E. K., Park, M. J., Ramamurthy, S., Jia, J., Hu, X., Geng, P. & Ronnett, G. V., Feb 1 2012, In : Journal of neuroscience research. 90, 2, p. 422-434 13 p.

Research output: Contribution to journalArticle

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., Aja, S., Ford, E., Fishell, G. & Blackshaw, S., May 1 2012, In : Nature neuroscience. 15, 5, p. 700-702 3 p.

Research output: Contribution to journalArticle

The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal

Gietzen, D. W. & Aja, S. M., Oct 2012, In : Molecular Neurobiology. 46, 2, p. 332-348 17 p.

Research output: Contribution to journalArticle

2011

Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity

Chao, P. T., Yang, L., Aja, S., Moran, T. H. & Bi, S., May 4 2011, In : Cell Metabolism. 13, 5, p. 573-583 11 p.

Research output: Contribution to journalArticle

Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

Kuhajda, F. P., Aja, S., Tu, Y., Han, W. F., Medghalchi, S. M., El Meskini, R., Landree, L. E., Peterson, J. M., Daniels, K., Wong, K., Wydysh, E. A., Townsend, C. A. & Ronnett, G. V., Jul 1 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 301, 1, p. R116-R130

Research output: Contribution to journalArticle

The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W. J., Sereda, S., Clerc, P., Polster, B. M., Aja, S. M., Pletnikov, M. V., Kensler, T. W., Shirihai, O. S., Iijima, M., Hussain, M. A. & Sesaki, H., Jul 1 2011, In : Molecular biology of the cell. 22, 13, p. 2235-2245 11 p.

Research output: Contribution to journalArticle

2010

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

Chiang, P. M., Ling, J., Jeong, Y. H., Price, D. L., Aja, S. M. & Wong, P. C., Sep 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16320-16324 5 p.

Research output: Contribution to journalArticle

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

Fulzele, K., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S., Hussain, M. A., Brüning, J. C. & Clemens, T. L., Jul 1 2010, In : Cell. 142, 2, p. 309-319 11 p.

Research output: Contribution to journalArticle

2009

AMPK in the brain: Its roles in energy balance and neuroprotection

Ronnett, G. V., Ramamurthy, S., Kleman, A. M., Landree, L. E. & Aja, S., May 1 2009, In : Journal of Neurochemistry. 109, SUPPL. 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity

Davis, L. M., Michaelides, M., Cheskin, L. J., Moran, T. H., Aja, S., Watkins, P. A., Pei, Z., Contoreggi, C., McCullough, K., Hope, B., Wang, G. J., Volkow, N. D. & Thanos, P. K., Feb 1 2009, In : Neuroendocrinology. 89, 2, p. 152-162 11 p.

Research output: Contribution to journalArticle

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

Shin, S., Wakabayashi, J., Yates, M. S., Wakabayashi, N., Dolan, P. M., Aja, S., Liby, K. T., Sporn, M. B., Yamamoto, M. & Kensler, T. W., Oct 12 2009, In : European Journal of Pharmacology. 620, 1-3, p. 138-144 7 p.

Research output: Contribution to journalArticle

2008

Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats

Mansouri, A., Aja, S., Moran, T. H., Ronnett, G., Kuhajda, F. P., Arnold, M., Geary, N., Langhans, W. & Leonhardt, M., Sep 1 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 295, 3, p. R799-R805

Research output: Contribution to journalArticle

Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight

Aja, S., Landree, L. E., Kleman, A. M., Medghalchi, S. M., Vadlamudi, A., McFadden, J. M., Aplasca, A., Hyun, J., Plummer, E., Daniels, K., Kemm, M., Townsend, C. A., Thupari, J. N., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V., Feb 1 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 2, p. R352-R361

Research output: Contribution to journalArticle

Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro

Kleman, A. M., Yuan, J. Y., Aja, S., Ronnett, G. V. & Landree, L. E., Jan 30 2008, In : Journal of Neuroscience Methods. 167, 2, p. 292-301 10 p.

Research output: Contribution to journalArticle

2007

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Gao, S., Kinzig, K. P., Aja, S., Scott, K. A., Keung, W., Kelly, S., Strynadka, K., Chohnan, S., Smith, W. W., Tamashiro, K. L. K., Ladenheim, E. E., Ronnett, G. V., Tu, Y., Birnbaum, M. J., Lopaschuk, G. D. & Moran, T. H., Oct 30 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 44, p. 17358-17363 6 p.

Research output: Contribution to journalArticle

2006

Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression

Aja, S., Ewing, C., Lin, J., Hyun, J. & Moran, T. H., Jan 1 2006, In : Peptides. 27, 1, p. 157-164 8 p.

Research output: Contribution to journalArticle

Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats

Aja, S., Bi, S., Knipp, S. B., McFadden, J. M., Ronnett, G. V., Kuhajda, F. P. & Moran, T. H., Jul 12 2006, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291, 1, p. R148-R154

Research output: Contribution to journalArticle

Leptin modulation of peripheral controls of meal size

Moran, T. H., Aja, S. & Ladenheim, E. E., Nov 30 2006, In : Physiology and Behavior. 89, 4, p. 511-516 6 p.

Research output: Contribution to journalArticle

2004

Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei

Miller, I., Ronnett, G. V., Moran, T. H. & Aja, S., Apr 9 2004, In : Neuroreport. 15, 5, p. 925-929 5 p.

Research output: Contribution to journalArticle

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

Kim, E. K., Miller, I., Aja, S., Landree, L. E., Pinn, M., McFadden, J., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19970-19976 7 p.

Research output: Contribution to journalArticle

2002

Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats

Aja, S., Robinson, B. M., Mills, K. J., Ladenheim, E. E. & Moran, T. H., Oct 2002, In : Behavioral Neuroscience. 116, 5, p. 918-921 4 p.

Research output: Contribution to journalArticle

2001
2000

Basolateral and central amygdaloid lesions leave aversion to dietary amino acid imbalance intact

Aja, S., Sisouvong, S., Barrett, J. A. & Gietzen, D. W., Jan 1 2000, In : Physiology and Behavior. 71, 5, p. 533-541 9 p.

Research output: Contribution to journalArticle

1999

CCK(A) and 5-HT3 receptors interact in anorectic responses to amino acid deficiency

Aja, S. M., Barrett, J. A. & Gietzen, D. W., Mar 1 1999, In : Pharmacology Biochemistry and Behavior. 62, 3, p. 487-491 5 p.

Research output: Contribution to journalArticle

DA1 receptor activity opposes anorectic responses to amino acid-imbalanced diets

Aja, S. M., Chan, P., Barrett, J. A. & Gietzen, D. W., Mar 1 1999, In : Pharmacology Biochemistry and Behavior. 62, 3, p. 493-498 6 p.

Research output: Contribution to journalArticle