Research Output per year
Research Output
2019
MeCP2 deficiency disrupts kainate-induced presynaptic plasticity in the mossy fiber projections in the hippocampus
Bertoldi, M. L., Zalosnik, M. I., Fabio, M. C., Aja, S. M., Roth, G. A., Ronnett, G. V. & Degano, A. L., May 14 2019, In : Frontiers in Cellular Neuroscience. 13, 286.Research output: Contribution to journal › Article
Open Access
2018
DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders
Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V., Dawson, T. M., Aja, S. M., Sesaki, H. & Pletnikov, M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 76.Research output: Contribution to journal › Article
2017
Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance
Lopez, P., Aja, S. M., Aoki, K., Seldin, M. M., Lei, X., V Ronnett, G., Wong, G. W. & Schnaar, R. L., 2017, In : Glycobiology. 27, 1, p. 129-139 11 p.Research output: Contribution to journal › Article
Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes
Kim, S. P., Frey, J. L., Li, Z., Kushwaha, P., Zoch, M. L., Tomlinson, R. E., Da, H., Aja, S. M., Noh, H. L., Kim, J. K., Hussain, M., Thorek, D. L. J., Wolfgang, M. J. & Riddle, R., Dec 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11238-E11247Research output: Contribution to journal › Article
2016
D-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway
Jeon, Y., Aja, S., Ronnett, G. V. & Kim, E. K., Feb 19 2016, In : Biochemical and Biophysical Research Communications. 470, 4, p. 818-823 6 p.Research output: Contribution to journal › Article
Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet
Slocum, S. L., Skoko, J. J., Wakabayashi, N., Aja, S., Yamamoto, M., Kensler, T. W. & Chartoumpekis, D. V., Feb 1 2016, In : Archives of Biochemistry and Biophysics. 591, p. 57-65 9 p.Research output: Contribution to journal › Article
Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality
Lee, J., Choi, J., Aja, S., Scafidi, S. & Wolfgang, M. J., Feb 16 2016, In : Cell Reports. 14, 6, p. 1308-1316 9 p.Research output: Contribution to journal › Article
2015
Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast
Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S., Wolfgang, M. J., Clemens, T. L. & Riddle, R. C., Jan 1 2015, In : Molecular and cellular biology. 35, 11, p. 1979-1991 13 p.Research output: Contribution to journal › Article
2014
Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice
Park, M. J., Aja, S., Li, Q., Degano, A. L., Penati, J., Zhuo, J., Roe, C. R. & Ronnett, G. V., Jan 1 2014, In : PloS one. 9, 10, e0109527.Research output: Contribution to journal › Article
Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice
Lee, D. A., Yoo, S., Pak, T., Salvatierra, J., Velarde, E., Aja, S. & Blackshaw, S., Jan 1 2014, In : Frontiers in Neuroscience. 8 JUN, Article 157.Research output: Contribution to journal › Article
Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation
McFadden, J. W., Aja, S., Li, Q., Bandaru, V. V. R., Kim, E. K., Haughey, N. J., Kuhajda, F. P. & Ronnett, G. V., Dec 26 2014, In : PloS one. 9, 12, e115642.Research output: Contribution to journal › Article
Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice
Wei, Z., Lei, X., Petersen, P. S., Aja, S. & Wong, G. W., Apr 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 7, p. E779-E790Research output: Contribution to journal › Article
2013
CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism
Peterson, J. M., Seldin, M. M., Wei, Z., Aja, S. & Wong, G. W., Aug 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 3, p. G214-G224Research output: Contribution to journal › Article
CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction
Peterson, J. M., Wei, Z., Seldin, M. M., Byerly, M. S., Aja, S. & Wong, G. W., Sep 1 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 305, 5, p. R522-R533Research output: Contribution to journal › Article
Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression
Byerly, M. S., Al Salayta, M., Swanson, R. D., Kwon, K., Peterson, J. M., Wei, Z., Aja, S., Moran, T. H., Blackshaw, S. & Wong, G. W., Apr 1 2013, In : European Journal of Neuroscience. 37, 7, p. 1033-1047 15 p.Research output: Contribution to journal › Article
Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite
Byerly, M. S., Swanson, R. D., Semsarzadeh, N. N., McCulloh, P. S., Kwon, K., Aja, S., Moran, T. H., William Wong, G. & Blackshaw, S., Jun 15 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 12, p. R1085-R1095Research output: Contribution to journal › Article
2012
A novel obesity model: Synphilin-1-induced hyperphagia and obesity in mice
Li, X., Tamashiro, K. L. K., Liu, Z., Bello, N. T., Wang, X., Aja, S., Bi, S., Ladenheim, E. E., Ross, C. A., Moran, T. H. & Smith, W. W., Sep 1 2012, In : International Journal of Obesity. 36, 9, p. 1215-1221 7 p.Research output: Contribution to journal › Article
CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition
Peterson, J. M., Aja, S., Wei, Z. & Wong, G. W., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 1576-1587 12 p.Research output: Contribution to journal › Article
Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α
Shin, M. K., Drager, L. F., Yao, Q., Bevans-Fonti, S., Yoo, D. Y., Jun, J. C., Aja, S., Bhanot, S. & Polotsky, V. Y., Oct 1 2012, In : PloS one. 7, 10, e46562.Research output: Contribution to journal › Article
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H., West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., Seredenina, T., Arbez, N., Zhu, S., Sommers, K., Qian, J., Zhang, J., Mori, S., Yang, X. W., Tamashiro, K. L. K., Aja, S. & 10 others, , Jan 1 2012, In : Nature medicine. 18, 1, p. 153-158 6 p.Research output: Contribution to journal › Article
Physiological oxygen level is critical for modeling neuronal metabolism in vitro
Zhu, J., Aja, S., Kim, E. K., Park, M. J., Ramamurthy, S., Jia, J., Hu, X., Geng, P. & Ronnett, G. V., Feb 1 2012, In : Journal of neuroscience research. 90, 2, p. 422-434 13 p.Research output: Contribution to journal › Article
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., Aja, S., Ford, E., Fishell, G. & Blackshaw, S., May 1 2012, In : Nature neuroscience. 15, 5, p. 700-702 3 p.Research output: Contribution to journal › Article
The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal
Gietzen, D. W. & Aja, S. M., Oct 2012, In : Molecular Neurobiology. 46, 2, p. 332-348 17 p.Research output: Contribution to journal › Article
2011
Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity
Chao, P. T., Yang, L., Aja, S., Moran, T. H. & Bi, S., May 4 2011, In : Cell Metabolism. 13, 5, p. 573-583 11 p.Research output: Contribution to journal › Article
Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity
Kuhajda, F. P., Aja, S., Tu, Y., Han, W. F., Medghalchi, S. M., El Meskini, R., Landree, L. E., Peterson, J. M., Daniels, K., Wong, K., Wydysh, E. A., Townsend, C. A. & Ronnett, G. V., Jul 1 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 301, 1, p. R116-R130Research output: Contribution to journal › Article
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells
Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W. J., Sereda, S., Clerc, P., Polster, B. M., Aja, S. M., Pletnikov, M. V., Kensler, T. W., Shirihai, O. S., Iijima, M., Hussain, M. A. & Sesaki, H., Jul 1 2011, In : Molecular biology of the cell. 22, 13, p. 2235-2245 11 p.Research output: Contribution to journal › Article
2010
Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism
Chiang, P. M., Ling, J., Jeong, Y. H., Price, D. L., Aja, S. M. & Wong, P. C., Sep 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16320-16324 5 p.Research output: Contribution to journal › Article
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
Fulzele, K., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S., Hussain, M. A., Brüning, J. C. & Clemens, T. L., Jul 1 2010, In : Cell. 142, 2, p. 309-319 11 p.Research output: Contribution to journal › Article
2009
AMPK in the brain: Its roles in energy balance and neuroprotection
Ronnett, G. V., Ramamurthy, S., Kleman, A. M., Landree, L. E. & Aja, S., May 1 2009, In : Journal of Neurochemistry. 109, SUPPL. 1, p. 17-23 7 p.Research output: Contribution to journal › Article
Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity
Davis, L. M., Michaelides, M., Cheskin, L. J., Moran, T. H., Aja, S., Watkins, P. A., Pei, Z., Contoreggi, C., McCullough, K., Hope, B., Wang, G. J., Volkow, N. D. & Thanos, P. K., Feb 1 2009, In : Neuroendocrinology. 89, 2, p. 152-162 11 p.Research output: Contribution to journal › Article
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide
Shin, S., Wakabayashi, J., Yates, M. S., Wakabayashi, N., Dolan, P. M., Aja, S., Liby, K. T., Sporn, M. B., Yamamoto, M. & Kensler, T. W., Oct 12 2009, In : European Journal of Pharmacology. 620, 1-3, p. 138-144 7 p.Research output: Contribution to journal › Article
2008
Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats
Mansouri, A., Aja, S., Moran, T. H., Ronnett, G., Kuhajda, F. P., Arnold, M., Geary, N., Langhans, W. & Leonhardt, M., Sep 1 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 295, 3, p. R799-R805Research output: Contribution to journal › Article
Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight
Aja, S., Landree, L. E., Kleman, A. M., Medghalchi, S. M., Vadlamudi, A., McFadden, J. M., Aplasca, A., Hyun, J., Plummer, E., Daniels, K., Kemm, M., Townsend, C. A., Thupari, J. N., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V., Feb 1 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 2, p. R352-R361Research output: Contribution to journal › Article
Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro
Kleman, A. M., Yuan, J. Y., Aja, S., Ronnett, G. V. & Landree, L. E., Jan 30 2008, In : Journal of Neuroscience Methods. 167, 2, p. 292-301 10 p.Research output: Contribution to journal › Article
2007
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
Gao, S., Kinzig, K. P., Aja, S., Scott, K. A., Keung, W., Kelly, S., Strynadka, K., Chohnan, S., Smith, W. W., Tamashiro, K. L. K., Ladenheim, E. E., Ronnett, G. V., Tu, Y., Birnbaum, M. J., Lopaschuk, G. D. & Moran, T. H., Oct 30 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 44, p. 17358-17363 6 p.Research output: Contribution to journal › Article
2006
Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression
Aja, S., Ewing, C., Lin, J., Hyun, J. & Moran, T. H., Jan 1 2006, In : Peptides. 27, 1, p. 157-164 8 p.Research output: Contribution to journal › Article
Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats
Aja, S., Bi, S., Knipp, S. B., McFadden, J. M., Ronnett, G. V., Kuhajda, F. P. & Moran, T. H., Jul 12 2006, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291, 1, p. R148-R154Research output: Contribution to journal › Article
Leptin modulation of peripheral controls of meal size
Moran, T. H., Aja, S. & Ladenheim, E. E., Nov 30 2006, In : Physiology and Behavior. 89, 4, p. 511-516 6 p.Research output: Contribution to journal › Article
2004
Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei
Miller, I., Ronnett, G. V., Moran, T. H. & Aja, S., Apr 9 2004, In : Neuroreport. 15, 5, p. 925-929 5 p.Research output: Contribution to journal › Article
C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase
Kim, E. K., Miller, I., Aja, S., Landree, L. E., Pinn, M., McFadden, J., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19970-19976 7 p.Research output: Contribution to journal › Article
2002
Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats
Aja, S., Robinson, B. M., Mills, K. J., Ladenheim, E. E. & Moran, T. H., Oct 2002, In : Behavioral Neuroscience. 116, 5, p. 918-921 4 p.Research output: Contribution to journal › Article
2001
Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site
Susan, A. J. A., Sahandy, S., Ladenheim, E. E., Schwartz, G. J. & Moran, T. H., Dec 1 2001, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 281, 6 50-6, p. R1862-R1867Research output: Contribution to journal › Article
Intracerebroventricular CART peptide reduces rat ingestive behavior and alters licking microstructure
Aja, S., Schwartz, G. J., Kuhar, M. J. & Moran, T. H., Jul 3 2001, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 280, 6 49-6, p. R1613-R1619Research output: Contribution to journal › Article
2000
Basolateral and central amygdaloid lesions leave aversion to dietary amino acid imbalance intact
Aja, S., Sisouvong, S., Barrett, J. A. & Gietzen, D. W., Jan 1 2000, In : Physiology and Behavior. 71, 5, p. 533-541 9 p.Research output: Contribution to journal › Article
1999
CCK(A) and 5-HT3 receptors interact in anorectic responses to amino acid deficiency
Aja, S. M., Barrett, J. A. & Gietzen, D. W., Mar 1 1999, In : Pharmacology Biochemistry and Behavior. 62, 3, p. 487-491 5 p.Research output: Contribution to journal › Article
DA1 receptor activity opposes anorectic responses to amino acid-imbalanced diets
Aja, S. M., Chan, P., Barrett, J. A. & Gietzen, D. W., Mar 1 1999, In : Pharmacology Biochemistry and Behavior. 62, 3, p. 493-498 6 p.Research output: Contribution to journal › Article