Research Output 1999 2017

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2017

Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance

Lopez, P. H. H., Aja, S., Aoki, K., Seldin, M. M., Lei, X., V Ronnett, G., Wong, G. W. & Schnaar, R. L. 2017 In : Glycobiology. 27, 1, p. 129-139 11 p.

Research output: Contribution to journalArticle

beta-galactoside alpha-2,3-sialyltransferase
Sialyltransferases
Insulin Resistance
Obesity
Gangliosides

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

Kim, S. P., Frey, J. L., Li, Z., Kushwaha, P., Zoch, M. L., Tomlinson, R. E., Da, H., Aja, S., Noh, H. L., Kim, J. K., Hussain, M. A., Thorek, D. L. J., Wolfgang, M. J. & Riddle, R. C. Dec 26 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11238-E11247

Research output: Contribution to journalArticle

Body Composition
Adipocytes
Adipose Tissue
Bone and Bones
White Adipose Tissue
2016

D-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway

Jeon, Y., Aja, S., Ronnett, G. V. & Kim, E. K. Feb 19 2016 In : Biochemical and Biophysical Research Communications. 470, 4, p. 818-823 6 p.

Research output: Contribution to journalArticle

Neuropeptides
Eating
Insulin
Pro-Opiomelanocortin
Neuropeptide Y

Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet

Slocum, S. L., Skoko, J. J., Wakabayashi, N., Aja, S., Yamamoto, M., Kensler, T. W. & Chartoumpekis, D. V. Feb 1 2016 In : Archives of Biochemistry and Biophysics. 591, p. 57-65 9 p.

Research output: Contribution to journalArticle

High Fat Diet
Nutrition
Liver
Chemical activation
Fats

Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality

Lee, J., Choi, J., Aja, S., Scafidi, S. & Wolfgang, M. J. Feb 16 2016 In : Cell Reports. 14, 6, p. 1308-1316 9 p.

Research output: Contribution to journalArticle

Brown Adipose Tissue
Fatty Acids
Obesity
Tissue
Oxidation
2015

Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast

Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S., Wolfgang, M. J., Clemens, T. L. & Riddle, R. C. 2015 In : Molecular and Cellular Biology. 35, 11, p. 1979-1991 13 p.

Research output: Contribution to journalArticle

Osteoblasts
Fatty Acids
Bone and Bones
Osteocytes
Osteocalcin
2014

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

Park, M. J., Aja, S., Li, Q., Degano, A. L., Penati, J., Zhuo, J., Roe, C. R. & Ronnett, G. V. 2014 In : PLoS One. 9, 10, e0109527

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Rett Syndrome
metabolome
Metabolome
Nutrition

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice

Lee, D. A., Yoo, S., Pak, T., Salvatierra, J., Velarde, E., Aja, S. & Blackshaw, S. 2014 In : Frontiers in Neuroscience. 8 JUN, Article 157

Research output: Contribution to journalArticle

Sex Factors
Neurogenesis
Young Adult
Median Eminence
Hypothalamus

Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation

McFadden, J. W., Aja, S., Li, Q., Bandaru, V. V. R., Kim, E. K., Haughey, N. J., Kuhajda, F. P. & Ronnett, G. V. Dec 26 2014 In : PLoS One. 9, 12, e115642

Research output: Contribution to journalArticle

beta oxidation
palmitates
Fatty Acids
inflammation
neurons
Knockout Mice
Insulin Resistance
Eating
Insulin
Energy Intake
2013

CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism

Peterson, J. M., Seldin, M. M., Wei, Z., Aja, S. & Wong, G. W. Aug 1 2013 In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 3

Research output: Contribution to journalArticle

Triglycerides
Diet
Liver
Transgenic Mice
High Fat Diet

CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction

Peterson, J. M., Wei, Z., Seldin, M. M., Byerly, M. S., Aja, S. & Wong, G. W. Sep 1 2013 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 305, 5

Research output: Contribution to journalArticle

Transgenic Mice
Obesity
Diet
Skeletal Muscle
AMP-Activated Protein Kinases

Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression

Byerly, M. S., Al Salayta, M., Swanson, R. D., Kwon, K., Peterson, J. M., Wei, Z., Aja, S., Moran, T. H., Blackshaw, S. & Wong, G. W. Apr 2013 In : European Journal of Neuroscience. 37, 7, p. 1033-1047 15 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Neuropeptide Y
Meals
Gene Expression
Nestin

Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite

Byerly, M. S., Swanson, R. D., Semsarzadeh, N. N., McCulloh, P. S., Kwon, K., Aja, S., Moran, T. H., William Wong, G. & Blackshaw, S. Jun 15 2013 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 12

Research output: Contribution to journalArticle

Nerve Growth Factors
Appetite
Neurons
Eating
Brain-Derived Neurotrophic Factor
2012

A novel obesity model: Synphilin-1-induced hyperphagia and obesity in mice

Li, X., Tamashiro, K. L. K., Liu, Z., Bello, N. T., Wang, X., Aja, S., Bi, S., Ladenheim, E. E., Ross, C. A., Moran, T. H. & Smith, W. W. Sep 2012 In : International Journal of Obesity. 36, 9, p. 1215-1221 7 p.

Research output: Contribution to journalArticle

Hyperphagia
Obesity
Eating
Body Weight
Hyperinsulinism
Acetyl-CoA Carboxylase
AMP-Activated Protein Kinases
Fatty Acids
Chemical activation
Oxidation

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

Shin, M. K., Drager, L. F., Yao, Q., Bevans-Fonti, S., Yoo, D. Y., Jun, J. C., Aja, S., Bhanot, S. & Polotsky, V. Y. Oct 1 2012 In : PLoS One. 7, 10, e46562

Research output: Contribution to journalArticle

Antisense Oligonucleotides
High Fat Diet
high fat diet
Nutrition
oligonucleotides

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Jiang, M. , Wang, J. , Fu, J. , Du, L. , Jeong, H. , West, T. , Xiang, L. , Peng, Q. , Hou, Z. , Cai, H. , Seredenina, T. , Arbez, N. , Zhu, S. , Sommers, K. , Qian, J. , Zhang, J. , Mori, S. , Yang, X. W. , Tamashiro, K. L. K. , Aja, S. & 10 others Moran, T. H., Luthi-Carter, R., Martin, B., Maudsley, S., Mattson, M. P., Cichewicz, R. H., Ross, C. A., Holtzman, D. M., Krainc, D. & Duan, W. Jan 2012 In : Nature Medicine. 18, 1, p. 153-158 6 p.

Research output: Contribution to journalArticle

Sirtuin 1
Huntington Disease
Chemical activation
Toxicity
Dopamine and cAMP-Regulated Phosphoprotein 32

Physiological oxygen level is critical for modeling neuronal metabolism in vitro

Zhu, J., Aja, S., Kim, E. K., Park, M. J., Ramamurthy, S., Jia, J., Hu, X., Geng, P. & Ronnett, G. V. Feb 2012 In : Journal of Neuroscience Research. 90, 2, p. 422-434 13 p.

Research output: Contribution to journalArticle

Oxygen
Adenosine Monophosphate
Glucose
Protein Kinases
Neurons

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., Aja, S., Ford, E., Fishell, G. & Blackshaw, S. May 2012 In : Nature Neuroscience. 15, 5, p. 700-702 3 p.

Research output: Contribution to journalArticle

Ependymoglial Cells
Median Eminence
Neurogenesis
Diet
Neurons

The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal

Gietzen, D. W. & Aja, S. M. Oct 2012 In : Molecular Neurobiology. 46, 2, p. 332-348 17 p.

Research output: Contribution to journalArticle

Essential Amino Acids
Meals
Diet
Amino Acids
Brain
2011

Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity

Chao, P. T., Yang, L., Aja, S., Moran, T. H. & Bi, S. May 4 2011 In : Cell Metabolism. 13, 5, p. 573-583 11 p.

Research output: Contribution to journalArticle

Brown Adipocytes
Neuropeptide Y
Hypothalamus
Obesity
Diet

Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

Kuhajda, F. P., Aja, S., Tu, Y., Han, W. F., Medghalchi, S. M., El Meskini, R., Landree, L. E., Peterson, J. M., Daniels, K., Wong, K., Wydysh, E. A., Townsend, C. A. & Ronnett, G. V. Jul 2011 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 301, 1

Research output: Contribution to journalArticle

Acyltransferases
Adiposity
Obese Mice
Insulin Resistance
Obesity

The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W. J., Sereda, S., Clerc, P., Polster, B. M., Aja, S. M., Pletnikov, M. V., Kensler, T. W., Shirihai, O. S., Iijima, M., Hussain, M. A. & Sesaki, H. Jul 1 2011 In : Molecular Biology of the Cell. 22, 13, p. 2235-2245 11 p.

Research output: Contribution to journalArticle

Dynamins
GTP Phosphohydrolases
Insulin-Secreting Cells
Adenosine Triphosphate
Mitochondrial DNA
2010

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

Chiang, P. M., Ling, J., Jeong, Y. H., Price, D. L., Aja, S. M. & Wong, P. C. Sep 14 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16320-16324 5 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Adipose Tissue
Down-Regulation
Obesity
DNA-Binding Proteins

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

Fulzele, K., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S., Hussain, M. A., Brüning, J. C. & Clemens, T. L. Jul 2010 In : Cell. 142, 2, p. 309-319 11 p.

Research output: Contribution to journalArticle

Osteoblasts
Insulin Receptor
Body Composition
Osteocalcin
Bone
2009

AMPK in the brain: Its roles in energy balance and neuroprotection

Ronnett, G. V., Ramamurthy, S., Kleman, A. M., Landree, L. E. & Aja, S. May 2009 In : Journal of Neurochemistry. 109, SUPPL. 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

Adenosine Monophosphate
Energy balance
Protein Kinases
Brain
Physiological Stress

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity

Davis, L. M., Michaelides, M., Cheskin, L. J., Moran, T. H., Aja, S., Watkins, P. A., Pei, Z., Contoreggi, C., McCullough, K., Hope, B., Wang, G. J., Volkow, N. D. & Thanos, P. K. Feb 2009 In : Neuroendocrinology. 89, 2, p. 152-162 11 p.

Research output: Contribution to journalArticle

Zucker Rats
Leptin Receptors
Hyperphagia
Dopamine Plasma Membrane Transport Proteins
Bromocriptine

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

Shin, S., Wakabayashi, J., Yates, M. S., Wakabayashi, N., Dolan, P. M., Aja, S., Liby, K. T., Sporn, M. B., Yamamoto, M. & Kensler, T. W. Oct 12 2009 In : European Journal of Pharmacology. 620, 1-3, p. 138-144 7 p.

Research output: Contribution to journalArticle

High Fat Diet
Obesity
1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole
Liver
Body Weight
2008

AMP-activated protein kinase in the brain

Ronnett, G. V. & Aja, S. Sep 2008 In : International Journal of Obesity. 32, SUPPL.4

Research output: Contribution to journalArticle

AMP-activated protein kinase
AMP-Activated Protein Kinases
brain
energy balance
Brain

Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats

Mansouri, A., Aja, S., Moran, T. H., Ronnett, G., Kuhajda, F. P., Arnold, M., Geary, N., Langhans, W. & Leonhardt, M. Sep 2008 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 295, 3

Research output: Contribution to journalArticle

Intraperitoneal Injections
Eating
Meals
Inhibition (Psychology)
Fatty Acid Synthases

Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight

Aja, S., Landree, L. E., Kleman, A. M., Medghalchi, S. M., Vadlamudi, A., McFadden, J. M., Aplasca, A., Hyun, J., Plummer, E., Daniels, K., Kemm, M., Townsend, C. A., Thupari, J. N., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V. Feb 2008 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 2

Research output: Contribution to journalArticle

Carnitine
Transferases
Eating
Body Weight
Pharmacology

Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro

Kleman, A. M., Yuan, J. Y., Aja, S., Ronnett, G. V. & Landree, L. E. Jan 30 2008 In : Journal of Neuroscience Methods. 167, 2, p. 292-301 10 p.

Research output: Contribution to journalArticle

Physiological Stress
AMP-Activated Protein Kinases
Glucose
Hyperglycemia
Energy Metabolism
2007

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Gao, S., Kinzig, K. P., Aja, S., Scott, K. A., Keung, W., Kelly, S., Strynadka, K., Chohnan, S., Smith, W. W., Tamashiro, K. L. K., Ladenheim, E. E., Ronnett, G. V., Tu, Y., Birnbaum, M. J., Lopaschuk, G. D. & Moran, T. H. Oct 30 2007 In : Proceedings of the National Academy of Sciences of the United States of America. 104, 44, p. 17358-17363 6 p.

Research output: Contribution to journalArticle

Acetyl-CoA Carboxylase
Leptin
Eating
Malonyl Coenzyme A
AMP-Activated Protein Kinases
2006

Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression

Aja, S., Ewing, C., Lin, J., Hyun, J. & Moran, T. H. Jan 2006 In : Peptides. 27, 1, p. 157-164 8 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Brain
Rhombencephalon
Chemical activation
Eating

Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats

Aja, S., Bi, S., Knipp, S. B., McFadden, J. M., Ronnett, G. V., Kuhajda, F. P. & Moran, T. H. 2006 In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291, 1

Research output: Contribution to journalArticle

Meals
Gene Expression
Weight Loss
Body Weight
Melanocortins

Leptin modulation of peripheral controls of meal size

Moran, T. H., Aja, S. & Ladenheim, E. E. Nov 30 2006 In : Physiology and Behavior. 89, 4, p. 511-516 6 p.

Research output: Contribution to journalArticle

Leptin
Meals
Melanocortins
Rhombencephalon
Solitary Nucleus
Adiposity
Energy Metabolism
Homeostasis
Obesity
Fats
Satiety Response
Cholagogues and Choleretics
Receptors, Serotonin, 5-HT3
Ondansetron
Serotonin Antagonists
2004

Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei

Miller, I., Ronnett, G. V., Moran, T. H. & Aja, S. Apr 9 2004 In : NeuroReport. 15, 5, p. 925-929 5 p.

Research output: Contribution to journalArticle

Rhombencephalon
Paraventricular Hypothalamic Nucleus
Arcuate Nucleus of Hypothalamus
Fasting
Lateral Hypothalamic Area

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

Kim, E. K., Miller, I., Aja, S., Landree, L. E., Pinn, M., McFadden, J., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V. May 7 2004 In : Journal of Biological Chemistry. 279, 19, p. 19970-19976 7 p.

Research output: Contribution to journalArticle

Fatty Acid Synthases
AMP-Activated Protein Kinases
Eating
Aminoimidazole Carboxamide
Hypothalamus
2002

Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats

Aja, S., Robinson, B. M., Mills, K. J., Ladenheim, E. E. & Moran, T. H. Oct 2002 In : Behavioral Neuroscience. 116, 5, p. 918-921 4 p.

Research output: Contribution to journalArticle

Fourth Ventricle
Amphetamine
Cocaine
Drinking
Eating
Rhombencephalon
Amphetamine
Cocaine
Eating
Peptides
Rhombencephalon
Amphetamine
Cocaine
Eating
Peptides
Amphetamine
Cocaine
Peptides
Meals
Eating
2000

Basolateral and central amygdaloid lesions leave aversion to dietary amino acid imbalance intact

Aja, S., Sisouvong, S., Barrett, J. A. & Gietzen, D. W. 2000 In : Physiology and Behavior. 71, 5, p. 533-541 9 p.

Research output: Contribution to journalArticle

Amino Acids
Saccharin
Essential Amino Acids
Anorexia
Amygdala
1999

CCK(A) and 5-HT3 receptors interact in anorectic responses to amino acid deficiency

Aja, S. M., Barrett, J. A. & Gietzen, D. W. Mar 1999 In : Pharmacology Biochemistry and Behavior. 62, 3, p. 487-491 5 p.

Research output: Contribution to journalArticle

tropisetron
Receptors, Serotonin, 5-HT3
Appetite Depressants
Cholecystokinin
Nutrition

DA1 receptor activity opposes anorectic responses to amino acid-imbalanced diets

Aja, S. M., Chan, P., Barrett, J. A. & Gietzen, D. W. Mar 1999 In : Pharmacology Biochemistry and Behavior. 62, 3, p. 493-498 6 p.

Research output: Contribution to journalArticle

Appetite Depressants
Nutrition
Dopamine
tropisetron
Diet