Susan M Aja – Research Output — Johns Hopkins University

2018

DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders

Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V., Dawson, T. M., Aja, S. M., Sesaki, H. & Pletnikov, M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 76.

Research output: Contribution to journal › Article

Astrocytes

Psychiatry

Lactic Acid

Schizophrenia

Glucose

2017

Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance

Lopez, P., Aja, S. M., Aoki, K., Seldin, M. M., Lei, X., V Ronnett, G., Wong, G. W. & Schnaar, R. L., 2017, In : Glycobiology. 27, 1, p. 129-139 11 p.

Research output: Contribution to journal › Article

beta-galactoside alpha-2,3-sialyltransferase

Sialyltransferases

Insulin Resistance

Obesity

Gangliosides

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

Kim, S. P., Frey, J. L., Li, Z., Kushwaha, P., Zoch, M. L., Tomlinson, R. E., Da, H., Aja, S. M., Noh, H. L., Kim, J. K., Hussain, M., Thorek, D. L. J., Wolfgang, M. J. & Riddle, R., Dec 26 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11238-E11247

Research output: Contribution to journal › Article

Body Composition

Adipocytes

Adipose Tissue

Bone and Bones

White Adipose Tissue

2016

D-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway

Jeon, Y., Aja, S. M., Ronnett, G. V. & Kim, E. K., Feb 19 2016, In : Biochemical and Biophysical Research Communications. 470, 4, p. 818-823 6 p.

Research output: Contribution to journal › Article

Neuropeptides

Eating

Insulin

Pro-Opiomelanocortin

Neuropeptide Y

Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet

Slocum, S. L., Skoko, J. J., Wakabayashi, N., Aja, S. M., Yamamoto, M., Kensler, T. W. & Chartoumpekis, D. V., Feb 1 2016, In : Archives of Biochemistry and Biophysics. 591, p. 57-65 9 p.

Research output: Contribution to journal › Article

High Fat Diet

Nutrition

Liver

Chemical activation

Fats

Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality

Lee, J., Choi, J., Aja, S. M., Scafidi, S. & Wolfgang, M. J., Feb 16 2016, In : Cell Reports. 14, 6, p. 1308-1316 9 p.

Research output: Contribution to journal › Article

Brown Adipose Tissue

Fatty Acids

Obesity

Tissue

Oxidation

2015

Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast

Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S. M., Wolfgang, M. J., Clemens, T. & Riddle, R., 2015, In : Molecular and Cellular Biology. 35, 11, p. 1979-1991 13 p.

Research output: Contribution to journal › Article

Osteoblasts

Fatty Acids

Bone and Bones

Osteocytes

Osteocalcin

2014

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice

Park, M. J., Aja, S. M., Li, Q., Degano, A. L., Penati, J., Zhuo, J., Roe, C. R. & Ronnett, G. V., 2014, In : PLoS One. 9, 10, e0109527.

Research output: Contribution to journal › Article

Methyl-CpG-Binding Protein 2

Rett Syndrome

metabolome

Metabolome

Nutrition

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice

Lee, D. A., Yoo, S., Pak, T., Salvatierra, J., Velarde, E., Aja, S. M. & Blackshaw, S., 2014, In : Frontiers in Neuroscience. 8 JUN, Article 157.

Research output: Contribution to journal › Article

Sex Factors

Neurogenesis

Young Adult

Median Eminence

Hypothalamus

Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation

McFadden, J. W., Aja, S. M., Li, Q., Bandaru, V. V. R., Kim, E. K., Haughey, N., Kuhajda, F. P. & Ronnett, G. V., Dec 26 2014, In : PLoS One. 9, 12, e115642.

Research output: Contribution to journal › Article

beta oxidation

palmitates

Fatty Acids

inflammation

neurons

Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice

Wei, Z., Lei, X., Petersen, P. S., Aja, S. M. & Wong, G. W., Apr 1 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 7

Research output: Contribution to journal › Article

Knockout Mice

Insulin Resistance

Eating

Insulin

Energy Intake

2013

CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism

Peterson, J. M., Seldin, M. M., Wei, Z., Aja, S. M. & Wong, G. W., Aug 1 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 3

Research output: Contribution to journal › Article

Triglycerides

Diet

Liver

Transgenic Mice

High Fat Diet

CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction

Peterson, J. M., Wei, Z., Seldin, M. M., Byerly, M. S., Aja, S. M. & Wong, G. W., Sep 1 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 305, 5

Research output: Contribution to journal › Article

Transgenic Mice

Obesity

Diet

Skeletal Muscle

AMP-Activated Protein Kinases

Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression

Byerly, M. S., Al Salayta, M., Swanson, R. D., Kwon, K., Peterson, J. M., Wei, Z., Aja, S. M., Moran, T. H., Blackshaw, S. & Wong, G. W., Apr 2013, In : European Journal of Neuroscience. 37, 7, p. 1033-1047 15 p.

Research output: Contribution to journal › Article

Estrogen Receptor beta

Neuropeptide Y

Meals

Gene Expression

Nestin

Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite

Byerly, M. S., Swanson, R. D., Semsarzadeh, N. N., McCulloh, P. S., Kwon, K., Aja, S. M., Moran, T. H., Wong, G. W. & Blackshaw, S., Jun 15 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 12

Research output: Contribution to journal › Article

Nerve Growth Factors

Appetite

Neurons

Eating

Brain-Derived Neurotrophic Factor

2012

A novel obesity model: Synphilin-1-induced hyperphagia and obesity in mice

Li, X., Tamashiro, K., Liu, Z., Bello, N. T., Wang, X., Aja, S. M., Bi, S., Ladenheim, E. E., Ross, C. A., Moran, T. H. & Smith, W., Sep 2012, In : International Journal of Obesity. 36, 9, p. 1215-1221 7 p.

Research output: Contribution to journal › Article

Hyperphagia

Obesity

Eating

Body Weight

Hyperinsulinism

CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition

Peterson, J. M., Aja, S. M., Wei, Z. & Wong, G. W., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 1576-1587 12 p.

Research output: Contribution to journal › Article

Acetyl-CoA Carboxylase

AMP-Activated Protein Kinases

Fatty Acids

Chemical activation

Oxidation

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

Shin, M-K., Drager, L. F., Yao, Q., Bevans-Fonti, S., Yoo, D. Y., Jun, J., Aja, S. M., Bhanot, S. & Polotsky, V., Oct 1 2012, In : PLoS One. 7, 10, e46562.

Research output: Contribution to journal › Article

Antisense Oligonucleotides

High Fat Diet

high fat diet

Nutrition

oligonucleotides

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H., West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., Seredenina, T., Arbez, N., Zhu, S., Sommers, K., Qian, J., Zhang, J., Mori, S., Yang, X. W., Tamashiro, K., Aja, S. M. & 10 othersMoran, T. H., Luthi-Carter, R., Martin, B., Maudsley, S., Mattson, M. P., Cichewicz, R. H., Ross, C. A., Holtzman, D. M., Krainc, D. & Duan, W., Jan 2012, In : Nature Medicine. 18, 1, p. 153-158 6 p.

Research output: Contribution to journal › Article

Sirtuin 1

Huntington Disease

Chemical activation

Toxicity

Dopamine and cAMP-Regulated Phosphoprotein 32

Physiological oxygen level is critical for modeling neuronal metabolism in vitro

Zhu, J., Aja, S. M., Kim, E. K., Park, M. J., Ramamurthy, S., Jia, J., Hu, X., Geng, P. & Ronnett, G. V., Feb 2012, In : Journal of Neuroscience Research. 90, 2, p. 422-434 13 p.

Research output: Contribution to journal › Article

Oxygen

Adenosine Monophosphate

Glucose

Protein Kinases

Neurons

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., Aja, S. M., Ford, E., Fishell, G. & Blackshaw, S., May 2012, In : Nature Neuroscience. 15, 5, p. 700-702 3 p.

Research output: Contribution to journal › Article

Ependymoglial Cells

Median Eminence

Neurogenesis

Diet

Neurons

The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal

Gietzen, D. W. & Aja, S. M., Oct 2012, In : Molecular Neurobiology. 46, 2, p. 332-348 17 p.

Research output: Contribution to journal › Article

Essential Amino Acids

Meals

Diet

Amino Acids

Brain

2011

Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity

Chao, P. T., Yang, L., Aja, S. M., Moran, T. H. & Bi, S., May 4 2011, In : Cell Metabolism. 13, 5, p. 573-583 11 p.

Research output: Contribution to journal › Article

Brown Adipocytes

Neuropeptide Y

Hypothalamus

Obesity

Diet

Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity

Kuhajda, F. P., Aja, S. M., Tu, Y., Han, W. F., Medghalchi, S. M., El Meskini, R., Landree, L. E., Peterson, J. M., Daniels, K., Wong, K., Wydysh, E. A., Townsend, C. A. & Ronnett, G. V., Jul 2011, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 301, 1

Research output: Contribution to journal › Article

Acyltransferases

Adiposity

Obese Mice

Insulin Resistance

Obesity

The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W. J., Sereda, S., Clerc, P., Polster, B. M., Aja, S. M., Pletnikov, M., Kensler, T. W., Shirihai, O. S., Iijima, M., Hussain, M. & Sesaki, H., Jul 1 2011, In : Molecular Biology of the Cell. 22, 13, p. 2235-2245 11 p.

Research output: Contribution to journal › Article

Dynamins

GTP Phosphohydrolases

Insulin-Secreting Cells

Adenosine Triphosphate

Mitochondrial DNA

2010

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

Chiang, P. M., Ling, J., Jeong, Y. H., Price, D. L., Aja, S. M. & Wong, P. C., Sep 14 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16320-16324 5 p.

Research output: Contribution to journal › Article

Embryonic Stem Cells

Adipose Tissue

Down-Regulation

Obesity

DNA-Binding Proteins

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

Fulzele, K., Riddle, R., DiGirolamo, D., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S. M., Hussain, M., Brüning, J. C. & Clemens, T., Jul 2010, In : Cell. 142, 2, p. 309-319 11 p.

Research output: Contribution to journal › Article

Osteoblasts

Insulin Receptor

Body Composition

Osteocalcin

Bone

2009

AMPK in the brain: Its roles in energy balance and neuroprotection

Ronnett, G. V., Ramamurthy, S., Kleman, A. M., Landree, L. E. & Aja, S. M., May 2009, In : Journal of Neurochemistry. 109, SUPPL. 1, p. 17-23 7 p.

Research output: Contribution to journal › Article

Adenosine Monophosphate

Energy balance

Protein Kinases

Brain

Physiological Stress

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity

Davis, L. M., Michaelides, M., Cheskin, L. J., Moran, T. H., Aja, S. M., Watkins, P. A., Pei, Z., Contoreggi, C., McCullough, K., Hope, B., Wang, G. J., Volkow, N. D. & Thanos, P. K., Feb 2009, In : Neuroendocrinology. 89, 2, p. 152-162 11 p.

Research output: Contribution to journal › Article

Zucker Rats

Leptin Receptors

Hyperphagia

Dopamine Plasma Membrane Transport Proteins

Bromocriptine

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

Shin, S., Wakabayashi, J., Yates, M. S., Wakabayashi, N., Dolan, P. M., Aja, S. M., Liby, K. T., Sporn, M. B., Yamamoto, M. & Kensler, T. W., Oct 12 2009, In : European Journal of Pharmacology. 620, 1-3, p. 138-144 7 p.

Research output: Contribution to journal › Article

High Fat Diet

Obesity

1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole

Liver

Body Weight

2008

AMP-activated protein kinase in the brain

Ronnett, G. V. & Aja, S. M., Sep 2008, In : International Journal of Obesity. 32, SUPPL.4

Research output: Contribution to journal › Article

AMP-activated protein kinase

AMP-Activated Protein Kinases

brain

energy balance

Brain

Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats

Mansouri, A., Aja, S. M., Moran, T. H., Ronnett, G., Kuhajda, F. P., Arnold, M., Geary, N., Langhans, W. & Leonhardt, M., Sep 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 295, 3

Research output: Contribution to journal › Article

Intraperitoneal Injections

Eating

Meals

Inhibition (Psychology)

Fatty Acid Synthases

Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight

Aja, S. M., Landree, L. E., Kleman, A. M., Medghalchi, S. M., Vadlamudi, A., McFadden, J. M., Aplasca, A., Hyun, J., Plummer, E., Daniels, K., Kemm, M., Townsend, C. A., Thupari, J. N., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V., Feb 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 2

Research output: Contribution to journal › Article

Carnitine

Transferases

Eating

Body Weight

Pharmacology

Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro

Kleman, A. M., Yuan, J. Y., Aja, S. M., Ronnett, G. V. & Landree, L. E., Jan 30 2008, In : Journal of Neuroscience Methods. 167, 2, p. 292-301 10 p.

Research output: Contribution to journal › Article

Physiological Stress

AMP-Activated Protein Kinases

Glucose

Hyperglycemia

Energy Metabolism

2007

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Gao, S., Kinzig, K. P., Aja, S. M., Scott, K. A., Keung, W., Kelly, S., Strynadka, K., Chohnan, S., Smith, W., Tamashiro, K., Ladenheim, E. E., Ronnett, G. V., Tu, Y., Birnbaum, M. J., Lopaschuk, G. D. & Moran, T. H., Oct 30 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 44, p. 17358-17363 6 p.

Research output: Contribution to journal › Article

Acetyl-CoA Carboxylase

Leptin

Eating

Malonyl Coenzyme A

AMP-Activated Protein Kinases

2006

Blockade of central GLP-1 receptors prevents CART-induced hypophagia and brain c-Fos expression

Aja, S. M., Ewing, C., Lin, J., Hyun, J. & Moran, T. H., Jan 2006, In : Peptides. 27, 1, p. 157-164 8 p.

Research output: Contribution to journal › Article

Glucagon-Like Peptide 1

Brain

Rhombencephalon

Chemical activation

Eating

Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats

Aja, S. M., Bi, S., Knipp, S. B., McFadden, J. M., Ronnett, G. V., Kuhajda, F. P. & Moran, T. H., 2006, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291, 1

Research output: Contribution to journal › Article

Meals

Gene Expression

Weight Loss

Body Weight

Melanocortins

Leptin modulation of peripheral controls of meal size

Moran, T. H., Aja, S. M. & Ladenheim, E. E., Nov 30 2006, In : Physiology and Behavior. 89, 4, p. 511-516 6 p.

Research output: Contribution to journal › Article

Leptin

Meals

Melanocortins

Rhombencephalon

Solitary Nucleus

Recent advances in obesity: Adiposity signaling and fat metabolism in energy homeostasis

Aja, S. M. & Moran, T. H., 2006, In : Advances in Psychosomatic Medicine. 27, p. 1-23 23 p.

Research output: Contribution to journal › Article

Adiposity

Energy Metabolism

Homeostasis

Obesity

Fats

Serotonin-3 receptors in gastric mechanisms of cholecystokinin-induced satiety

Aja, S. M., 2006, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291, 1

Research output: Contribution to journal › Article

Satiety Response

Cholagogues and Choleretics

Receptors, Serotonin, 5-HT3

Ondansetron

Serotonin Antagonists

2004

Anorexigenic C75 alters c-Fos in mouse hypothalamic and hindbrain subnuclei

Miller, I., Ronnett, G. V., Moran, T. H. & Aja, S. M., Apr 9 2004, In : NeuroReport. 15, 5, p. 925-929 5 p.

Research output: Contribution to journal › Article

Rhombencephalon

Paraventricular Hypothalamic Nucleus

Arcuate Nucleus of Hypothalamus

Fasting

Lateral Hypothalamic Area

C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein Kinase

Kim, E. K., Miller, I., Aja, S. M., Landree, L. E., Pinn, M., McFadden, J., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19970-19976 7 p.

Research output: Contribution to journal › Article

Fatty Acid Synthases

AMP-Activated Protein Kinases

Eating

Aminoimidazole Carboxamide

Hypothalamus

2002