Sujatha Kannan

Associate Professor

20012019
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Research Output 2001 2019

2019

Administration of a 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor Improves Outcome in a Rat Model of Pediatric Traumatic Brain Injury

Shu, S., Zhang, Z., Spicer, D., Kulikowicz, E., Hu, K., Babapoor-Farrokhran, S., Kannan, S., Koehler, R. C. & Robertson, C., Jan 1 2019, (Accepted/In press) In : Developmental Neuroscience.

Research output: Contribution to journalArticle

Open Access
Pediatrics
Brain
Tumor Necrosis Factor-alpha
Cytokines
Contusions

Design of a dendrimeric nanomedicine pl atform for the treatment of a neuro-degenerati ve disease, x-ald

GoK, O., Nemeth, C. L., Turk, B., Kambhampati, S. P., Zhang, F., Sharma, A., Kannan, S., Fatemi, A. & Rangaramanujam, K., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanomedicine
Medical nanotechnology
Dendrimers
Brain
Cerebral Palsy

Neuroimmune responses in the developing brain following traumatic brain injury

Nasr, I., Chun, Y. & Kannan, S., Oct 1 2019, In : Experimental Neurology. 320, 112957.

Research output: Contribution to journalReview article

Immune System
Brain
Wounds and Injuries
Pediatrics
Neutrophil Activation

Neuronanotechnology for brain regeneration

Liaw, K., Zhang, Z. & Kannan, S., Jan 1 2019, In : Advanced Drug Delivery Reviews.

Research output: Contribution to journalArticle

Regeneration
Central Nervous System
Nervous System Trauma
Nanotechnology
Regenerative Medicine

Traumatic Injury Leads to Inflammation and Altered Tryptophan Metabolism in the Juvenile Rabbit Brain

Zhang, Z., Rasmussen, L., Saraswati, M., Koehler, R. C., Robertson, C. & Kannan, S., Jan 1 2019, In : Journal of Neurotrauma. 36, 1, p. 74-86 13 p.

Research output: Contribution to journalArticle

Tryptophan
Rabbits
Inflammation
Wounds and Injuries
Brain
2018

Altered trajectories of neurodevelopment and behavior in mouse models of Rett syndrome

Smith, E. S., Smith, D. R., Eyring, C., Braileanu, M., Smith-Connor, K. S., Ei Tan, Y., Fowler, A. Y., Hoffman, G. E., Johnston, M. V., Kannan, S. & Blue, M. E., Jan 1 2018, (Accepted/In press) In : Neurobiology of Learning and Memory.

Research output: Contribution to journalArticle

Rett Syndrome
Neuroglia
Phenotype
Inborn Genetic Diseases
Genetic Models

Cerebellar injury and impaired function in a rabbit model of maternal inflammation induced neonatal brain injury

Zhang, Z., Narayan, S., Su, L., Al-Alawyat, H., Liu, J. & Kannan, S., Jan 1 2018, (Accepted/In press) In : Neurobiology of Learning and Memory.

Research output: Contribution to journalArticle

Brain Injuries
Endotoxins
Mothers
Lipopolysaccharides
Rabbits

Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain

Nino, D., Zhou, Q., Yamaguchi, Y., Martin, L. Y., Wang, S., Fulton, W. B., Jia, H., Lu, P., Jr, T. P., Zhang, F., Crawford, J., Hou, Z., Mori, S., Chen, L. L., Guajardo, A., Fatemi, A., Pletnikov, M., Rangaramanujam, K., Kannan, S., Sodhi, C. & 1 others, Hackam, D., Dec 12 2018, In : Science Translational Medicine. 10, 471, eaan0237.

Research output: Contribution to journalArticle

Necrotizing Enterocolitis
Brain
Toll-Like Receptor 4
Intestines
CD14 Antigens
Rett Syndrome
Dendrimers
Microglia
Names
Cysteine

Dendrimer–N-acetyl-L-cysteine modulates monophagocytic response in adrenoleukodystrophy

Turk, B. R., Nemeth, C. L., Marx, J. S., Tiffany, C. W., Jones, R., Theisen, B., Kambhampati, S., Ramireddy, R., Singh, S., Rosen, M., Kaufman, M. L., Murray, C. F., Watkins, P. A., Kannan, S., Kannan, R. & Fatemi, A., Sep 1 2018, In : Annals of Neurology. 84, 3, p. 452-462 11 p.

Research output: Contribution to journalArticle

Adrenoleukodystrophy
Dendrimers
Cysteine
Glutamic Acid
Acyl Coenzyme A

Design of a novel PAMAM-Based nanomedicine with sustained NAC release for treatment of neuroinflammation

Gok, O., Kambhampati, S. P., Smith, E., Kannan, S. & Rangaramanujam, K., Oct 1 2018, 2017 21st National Biomedical Engineering Meeting, BIYOMUT 2017. Institute of Electrical and Electronics Engineers Inc., 8479287

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Acetylcysteine
Medical nanotechnology
cysteine
Dendrimers
dendrimers

Early detection of hypothermic neuroprotection using T2-weighted magnetic resonance imaging in a mouse model of hypoxic ischemic encephalopathy

Doman, S. E., Girish, A., Nemeth, C. L., Drummond, G. T., Carr, P., Garcia, M. S., Johnston, M. V., Kannan, S., Fatemi, A., Zhang, J. & Wilson, M. A. A., May 8 2018, In : Frontiers in Neurology. 9, MAY, 304.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Ischemia
Magnetic Resonance Imaging
Hypothermia
Wounds and Injuries

Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model

Sharma, A., Porterfield, J. E., Smith, E., Sharma, R., Kannan, S. & Rangaramanujam, K., Aug 10 2018, In : Journal of Controlled Release. 283, p. 175-189 15 p.

Research output: Contribution to journalArticle

Dendrimers
Mannose
Hydroxyl Radical
Brain Injuries
Neuroglia

Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis

Tucker, E., Guglieri-Lopez, B., Ordonez Suarez, A., Ritchie, B., Klunk, M. H., Sharma, R., Chang, Y. S., Sanchez-Bautista, J., Frey, S., Lodge, M., Rowe, S., Holt, D., Gobburu, J. V. S., Peloquin, C. A., Mathews, W. B., Dannals, R. F., Pardo-Villamizar, C. A., Kannan, S., Ivaturi, V. D. & Jain, S., Dec 5 2018, In : Science Translational Medicine. 10, 470, aau0965.

Research output: Contribution to journalArticle

Meningeal Tuberculosis
Rifampin
Positron-Emission Tomography
Pharmaceutical Preparations
Brain

Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture

Alnasser, Y., Kambhampati, S. P., Nance, E., Rajbhandari, L., Shrestha, S., Venkatesan, A., Rangaramanujam, K. & Kannan, S., Jan 1 2018, In : Molecules. 23, 5, Y.

Research output: Contribution to journalArticle

Dendrimers
rabbits
dendrimers
Microglia
Neuroglia

Quantitative assessment of surface functionality effects on microglial uptake and retention of PAMAM dendrimers

Liaw, K., Gök, O., DeRidder, L. B., Kannan, S. & Rangaramanujam, K., Apr 1 2018, In : Journal of Nanoparticle Research. 20, 4, 111.

Research output: Contribution to journalArticle

Dendrimers
Surface Effects
dendrimers
Nucleus
Therapy

Targeting mitochondrial dysfunction and oxidative stress in activated microglia using dendrimer-based therapeutics

Sharma, A., Liaw, K., Sharma, R., Zhang, Z., Kannan, S. & Rangaramanujam, K., Jan 1 2018, In : Theranostics. 8, 20, p. 5529-5547 19 p.

Research output: Contribution to journalArticle

Dendrimers
Microglia
Cysteine
Oxidative Stress
Mitochondria

Trajectory of inflammatory and microglial activation markers in the postnatal rabbit brain following intrauterine endotoxin exposure

Zhang, Z., Jyoti, A., Balakrishnan, B., Williams, M., Singh, S., Chugani, D. C. & Kannan, S., Mar 1 2018, In : Neurobiology of Disease. 111, p. 153-162 10 p.

Research output: Contribution to journalArticle

Endotoxins
Rabbits
Brain
Mothers
Microglia
2017

Activated Microglia Targeting Dendrimer-Minocycline Conjugate as Therapeutics for Neuroinflammation

Sharma, R., Kim, S. Y., Sharma, A., Zhang, Z., Kambhampati, S. P., Kannan, S. & Rangaramanujam, K., Nov 15 2017, In : Bioconjugate Chemistry. 28, 11, p. 2874-2886 13 p.

Research output: Contribution to journalArticle

Dendrimers
Minocycline
Microglia
Blood-Brain Barrier
Therapeutics

Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome

Nance, E., Kambhampati, S. P., Smith, E. S., Zhang, Z., Zhang, F., Singh, S., Johnston, M. V., Rangaramanujam, K., Blue, M. E. & Kannan, S., Dec 19 2017, In : Journal of Neuroinflammation. 14, 1, 252.

Research output: Contribution to journalArticle

Rett Syndrome
Dendrimers
Microglia
Cysteine
Neuroglia

Emerging nanomedicine approaches in obstetrics

Rangaramanujam, K. & Kannan, S., Mar 1 2017, In : American Journal of Obstetrics and Gynecology. 216, 3, p. 201-203 3 p.

Research output: Contribution to journalEditorial

Nanomedicine
Obstetrics

Generation-6 hydroxyl PAMAM dendrimers improve CNS penetration from intravenous administration in a large animal brain injury model

Zhang, F., Trent Magruder, J., Lin, Y. A., Crawford, T. C., Grimm, J. C., Sciortino, C. M., Wilson, M. A. A., Blue, M. E., Kannan, S., Johnston, M. V., Baumgartner, W. A. & Rangaramanujam, K., Mar 10 2017, In : Journal of Controlled Release. 249, p. 173-182 10 p.

Research output: Contribution to journalArticle

Dendrimers
Intravenous Administration
Hydroxyl Radical
Brain Injuries
Brain

Immunomodulation in Critical Illness: The Quest Continues∗

Tucker, E. & Kannan, S., Feb 1 2017, In : Pediatric Critical Care Medicine. 18, 2, p. 190-191 2 p.

Research output: Contribution to journalEditorial

Mannose-Binding Lectin
Immunomodulation
Critical Illness
Sepsis
Pediatrics

Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury

Lei, J., Rosenzweig, J. M., Mishra, M. K., Alshehri, W., Brancusi, F., McLane, M., Almalki, A., Bahabry, R., Arif, H., Rozzah, R., Alyousif, G., Shabi, Y., Alhehaily, N., Zhong, W., Facciabene, A., Kannan, S., Rangaramanujam, K. & Burd, I., Dec 1 2017, In : Scientific Reports. 7, 1, 6106.

Research output: Contribution to journalArticle

Dendrimers
Premature Birth
Nanoparticles
Brain Injuries
Mothers

Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain

Williams, M., Zhang, Z., Nance, E., Drewes, J., Lesniak, W., Singh, S., Chugani, D. C., Rangaramanujam, K., Graham, D. & Kannan, S., Sep 1 2017, In : Developmental Neuroscience. 39, 5, p. 399-412 14 p.

Research output: Contribution to journalArticle

Kynurenine
Tryptophan
Placenta
Serotonin
Mothers

Selective Localization of a Novel Dendrimer Nanoparticle in Myocardial Ischemia-Reperfusion Injury

Magruder, J. T., Crawford, T. C., Lin, Y. A., Zhang, F., Grimm, J. C., Rangaramanujam, K., Kannan, S. & Sciortino, C. M., 2017, (Accepted/In press) In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Dendrimers
Reperfusion Injury
Nanoparticles
Myocardial Ischemia

Uptake of dendrimer-drug by different cell types in the hippocampus after hypoxic–ischemic insult in neonatal mice: Effects of injury, microglial activation and hypothermia

Nemeth, C. L., Drummond, G. T., Mishra, M. K., Zhang, F., Carr, P., Garcia, M. S., Doman, S., Fatemi, A., Johnston, M. V., Rangaramanujam, K., Kannan, S. & Wilson, M. A. A., Oct 1 2017, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 7, p. 2359-2369 11 p.

Research output: Contribution to journalArticle

Hypothermia
Dendrimers
Microglia
Brain Diseases
Hippocampus
2016

Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain

Zhang, Z., Bassam, B., Thomas, A. G., Williams, M., Liu, J., Nance, E., Rojas, C., Slusher, B. & Kannan, S., Oct 1 2016, In : Neurobiology of Disease. 94, p. 116-128 13 p.

Research output: Contribution to journalArticle

Glutamate Carboxypeptidase II
Microglia
Glutamic Acid
Homeostasis
Up-Regulation

Microglia activation in a pediatric rabbit model of tuberculous meningitis

Tucker, E., Pokkali, S., Zhang, Z., DeMarco, V. P., Klunk, M., Smith, E. S., Ordonez Suarez, A., Penet, M-F., Bhujwalla, Z. M., Jain, S. & Kannan, S., Dec 1 2016, In : DMM Disease Models and Mechanisms. 9, 12, p. 1497-1502 6 p.

Research output: Contribution to journalArticle

Meningeal Tuberculosis
Pediatrics
Microglia
Macrophages
Chemical activation

Microglial migration and interactions with dendrimer nanoparticles are altered in the presence of neuroinflammation

Zhang, F., Nance, E., Alnasser, Y., Rangaramanujam, K. & Kannan, S., Mar 22 2016, In : Journal of Neuroinflammation. 13, 1, 65.

Research output: Contribution to journalArticle

Dendrimers
Nanoparticles
Cerebral Palsy
Microglia
Inflammation

Nanoscale effects in dendrimer-mediated targeting of neuroinflammation

Nance, E., Zhang, F., Mishra, M. K., Zhang, Z., Kambhampati, S. P., Rangaramanujam, K. & Kannan, S., Sep 1 2016, In : Biomaterials. 101, p. 96-107 12 p.

Research output: Contribution to journalArticle

Dendrimers
Brain
Neuroglia
Rabbits
Microglia
Dendrimers
Nanotechnology
Brain Injuries
Canidae
Inflammation

Surface functionality affects the biodistribution and microglia-targeting of intra-amniotically delivered dendrimers

Zhang, F., Nance, E., Zhang, Z., Jasty, V., Kambhampati, S. P., Mishra, M. K., Burd, I., Romero, R., Kannan, S. & Rangaramanujam, K., Sep 10 2016, In : Journal of Controlled Release. 237, p. 61-70 10 p.

Research output: Contribution to journalArticle

Dendrimers
Microglia
Inflammation
Cerebral Palsy
Mothers
2015

A New Rabbit Model of Pediatric Traumatic Brain Injury

Zhang, Z., Saraswati, M., Koehler, R. C., Robertson, C. & Kannan, S., Sep 1 2015, In : Journal of Neurotrauma. 32, 17, p. 1369-1379 11 p.

Research output: Contribution to journalArticle

Pediatrics
Rabbits
Wounds and Injuries
Aptitude
Craniotomy

Neuroinflammation and neuroimmune dysregulation after acute hypoxic-ischemic injury of developing brain

Bhalala, U. S., Koehler, R. C. & Kannan, S., Jan 1 2015, In : Frontiers in Pediatrics. 2, JAN, 144.

Research output: Contribution to journalReview article

Open Access
Brain Injuries
Wounds and Injuries
Brain
Macrophages
Asphyxia

Systemic dendrimer-drug treatment of ischemia-induced neonatal white matter injury

Nance, E., Porambo, M., Zhang, F., Mishra, M. K., Buelow, M., Getzenberg, R., Johnston, M. V., Rangaramanujam, K., Fatemi, A. & Kannan, S., Jul 31 2015, In : Journal of Controlled Release. 214, p. 112-120 9 p.

Research output: Contribution to journalArticle

Dendrimers
Ischemia
Wounds and Injuries
Pharmaceutical Preparations
Oligodendroglia

Targeting specific cells in the brain with nanomedicines for CNS therapies

Zhang, F., Lin, Y. A., Kannan, S. & Rangaramanujam, K., Oct 22 2015, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Nanomedicine
Central Nervous System
Microglia
Brain
Central Nervous System Diseases
2014
brain damage
Dendrimers
animal models
dendrimers
brain

Emerging concepts in dendrimer-based nanomedicine: From design principles to clinical applications

Rangaramanujam, K., Nance, E., Kannan, S. & Tomalia, D. A., Dec 1 2014, In : Journal of Internal Medicine. 276, 6, p. 579-617 39 p.

Research output: Contribution to journalArticle

Nanomedicine
Dendrimers
Nanoparticles
Pharmaceutical Preparations
Nanostructures

Fetal uptake of intra-amniotically delivered dendrimers in a mouse model of intrauterine inflammation and preterm birth

Burd, I., Zhang, F., Dada, T., Mishra, M. K., Borbiev, T., Lesniak, W., Baghlaf, H., Kannan, S. & Rangaramanujam, K., 2014, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 10, 6, p. 1343-1351 9 p.

Research output: Contribution to journalArticle

Dendrimers
Premature Birth
Nanomedicine
Medical nanotechnology
Inflammation

Oropharyngeal dermoid cyst in an infant with intermittent airway obstruction a case report

Wagner, M. W., Haileselassie, B., Kannan, S., Chen, C., Poretti, A., Tunkel, D. E. & Huisman, T. A. G. M., Oct 1 2014, In : Neuroradiology Journal. 27, 5, p. 627-631 5 p.

Research output: Contribution to journalArticle

Dermoid Cyst
Airway Obstruction
Magnetic Resonance Imaging
Choristoma
Laryngoscopy
2013

Biodistribution of fluorescently labeled PAMAM dendrimers in neonatal rabbits: Effect of neuroinflammation

Lesniak, W., Mishra, M. K., Jyoti, A., Balakrishnan, B., Zhang, F., Nance, E., Romero, R., Kannan, S. & Rangaramanujam, K., Dec 2 2013, In : Molecular Pharmaceutics. 10, 12, p. 4560-4571 12 p.

Research output: Contribution to journalArticle

Dendrimers
Rabbits
ethylenediamine
Cerebral Palsy
Kidney

Chilled to the marrow: Neonatal brain injury, hypothermia, and the immune system

Kannan, S., Oct 2013, In : Pediatric Critical Care Medicine. 14, 8, p. 823-824 2 p.

Research output: Contribution to journalArticle

Brain Hypoxia-Ischemia
Induced Hypothermia
Hypothermia
Chemokines
Brain Injuries

Concurrent quantification of tryptophan and its major metabolites

Lesniak, W., Jyoti, A., Mishra, M. K., Louissaint, N., Romero, R., Chugani, D. C., Kannan, S. & Rangaramanujam, K., 2013, In : Analytical Biochemistry. 443, 2, p. 222-231 10 p.

Research output: Contribution to journalArticle

Metabolites
Tryptophan
High Pressure Liquid Chromatography
Kynurenic Acid
Kynurenine

Dendrimer-based therapeutic delivery for cerebral palsy: Mechanism of nanoparticle uptake

Rangaramanujam, K., Nance, E., Zhang, F., Mishra, M., Balakrishnan, B. & Kannan, S., 2013, Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. AIChE, p. 18 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

cerebral palsy
Dendrimers
nanoparticles
Cerebral Palsy
Nanoparticles

Maternal endotoxin exposure results in abnormal neuronal architecture in the newborn rabbit

Balakrishnan, B., Dai, H., Janisse, J., Romero, R. & Kannan, S., Oct 2013, In : Developmental Neuroscience. 35, 5, p. 396-405 10 p.

Research output: Contribution to journalArticle

Maternal Exposure
Cerebral Palsy
Endotoxins
Anterior Thalamic Nuclei
Rabbits

Nanomedicine in cerebral palsy

Balakrishnan, B., Nance, E., Johnston, M. V., Rangaramanujam, K. & Kannan, S., Nov 1 2013, In : International Journal of Nanomedicine. 8, p. 4183-4195 13 p.

Research output: Contribution to journalArticle

Nanomedicine
Medical nanotechnology
Cerebral Palsy
Brain
Brain Injuries
2012

Augmented annotation and orthologue analysis for Oryctolagus cuniculus: Better Bunny

Craig, D. B., Kannan, S. & Dombkowski, A. A., May 8 2012, In : BMC Bioinformatics. 13, 1, 84.

Research output: Contribution to journalArticle

Rabbit
Annotation
Genes
Rabbits
Gene

Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model

Kannan, S., Dai, H., Navath, R. S., Balakrishnan, B., Jyoti, A., Janisse, J., Romero, R. & Rangaramanujam, K., Apr 18 2012, In : Science Translational Medicine. 4, 130, 130ra46.

Research output: Contribution to journalArticle

Dendrimers
Cerebral Palsy
Rabbits
Acetylcysteine
Microglia

"Hot spots" in the brain: Tissue to be rescued?

Kannan, S. & Johnston, M. V., Jun 2012, In : Critical Care Medicine. 40, 6, p. 1996-1997 2 p.

Research output: Contribution to journalArticle

Organotechnetium Compounds
Brain Hypoxia-Ischemia
Oximes
Radiopharmaceuticals
Positron-Emission Tomography