Sudipto Ganguly

Assistant Professor

20062019
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Research Output 2006 2019

  • 38 Article
  • 1 Conference contribution
  • 1 Comment/debate
2019

A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

Wolf, M. T., Ganguly, S., Wang, T. L., Anderson, C. W., Sadtler, K., Narain, R., Cherry, C., Parrillo, A. J., Park, B. V., Wang, G., Pan, F., Sukumar, S., Pardoll, D. M. & Elisseeff, J. H., Jan 30 2019, In : Science Translational Medicine. 11, 477, aat7973.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunotherapy
Wound Healing
Neoplasms
Urinary Bladder

Divergent immune responses to synthetic and biological scaffolds

Sadtler, K., Wolf, M. T., Ganguly, S., Moad, C. A., Chung, L., Majumdar, S., Housseau, F., Pardoll, D. M. & Elisseeff, J. H., Feb 1 2019, In : Biomaterials. 192, p. 405-415 11 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Scaffolds (biology)
Biomaterials
Scaffolds
Immune system

ExCYT: A Graphical User Interface for Streamlining Analysis of High-Dimensional Cytometry Data

Sidhom, J. W., Theodros, D., Murter, B., Zarif, J., Ganguly, S., Pardoll, A. M. & Baras, A., Jan 16 2019, In : Journal of visualized experiments : JoVE. 143

Research output: Contribution to journalArticle

Flow cytometry
Graphical user interfaces
Flow Cytometry
Cluster Analysis
Directories

Interleukin-36γ-producing macrophages drive IL-17-mediated fibrosis

Sommerfeld, S. D., Cherry, C., Schwab, R. M., Chung, L., Maestas, D. R., Laffont, P., Stein, J. E., Tam, A., Ganguly, S., Housseau, F., Taube, J. M., Pardoll, A. M., Cahan, P. & Elisseeff, J. H., Oct 11 2019, In : Science Immunology. 4, 40, eaax4783.

Research output: Contribution to journalArticle

Interleukin-17
Interleukins
Fibrosis
Macrophages
Urinary Bladder

Mouse PVRIg has CD8+ T cell-specific coinhibitory functions and dampens antitumor immunity

Murter, B., Pan, X., Ophir, E., Alteber, Z., Azulay, M., Sen, R., Levy, O., Dassa, L., Vaknin, I., Fridman-Kfir, T., Salomon, R., Ravet, A., Tam, A., Levin, D., Vaknin, Y., Tatirovsky, E., Machlenkin, A., Pardoll, A. M. & Ganguly, S., Feb 1 2019, In : Cancer immunology research. 7, 2, p. 244-256 13 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
Proteins
Tumor Microenvironment
poliovirus receptor

PVRIG and PVRL2 are induced in cancer and inhibit CD8+ T-cell function

Whelan, S., Ophir, E., Kotturi, M. F., Levy, O., Ganguly, S., Leung, L., Vaknin, I., Kumar, S., Dassa, L., Hansen, K., Bernados, D., Murter, B., Soni, A., Taube, J. M., Nickles Fader, A. N., Wang, T-L., Shih, I. M., White, M., Pardoll, A. M. & Liang, S. C., Feb 1 2019, In : Cancer immunology research. 7, 2, p. 257-268 12 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasms
Immunotherapy
Tumor-Infiltrating Lymphocytes
Endometrial Neoplasms

The biologic scaffold immune microenvironment inhibits tumor formation and synergizes with immunotherapy

Wolf, M. T., Ganguly, S., Narain, R., Sadtler, K., Pardoll, D. M. & Elisseeff, J. H., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumor Microenvironment
Scaffolds
Immunotherapy
Tumors
Neoplasms
2018

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

Chung, L., Orberg, E. T., Geis, A., Chan, J. L., Fu, K., Shields, C. E. D. S., Dejea, C. M., Fathi, P., Chen, J., Finard, B. B., Tam, A. J., McAllister, F. M., Fan, H., Wu, X., Ganguly, S., Lebid, A., Metz, P., Van Meerbeke, S. W., Huso, D. L., Wick, E. C. & 5 others, Pardoll, A. M., Wan, F., Wu, S., Sears, C. L. & Housseau, F., Jan 1 2018, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Colon
Epithelial Cells
Carcinogenesis
Bacteroides fragilis
Myeloid Cells

Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma

Garzon-Muvdi, T., Theodros, D., Luksik, A. S., Maxwell, R., Kim, E., Jackson, C. M., Belcaid, Z., Ganguly, S., Tyler, B. M., Brem, H., Pardoll, A. M. & Lim, M., Apr 17 2018, In : Oncotarget. 9, 29, p. 20681-20697 17 p.

Research output: Contribution to journalArticle

Glioblastoma
Immunotherapy
Dendritic Cells
Antigen Presentation
Neoplasms

Erratum: Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells (Cell Host & Microbe (2018) 23(2) (203–214.e5) (S1931312818300428) (10.1016/j.chom.2018.01.007))

Chung, L., Orberg, E. T., Geis, A., Chan, J. L., Fu, K., DeStefano Shields, C. E., Dejea, C. M., Fathi, P., Chen, J., Finard, B. B., Tam, A. J., McAllister, F., Fan, H., Wu, X., Ganguly, S., Lebid, A., Metz, P., Van Meerbeke, S. W., Huso, D. L., Wick, E. C. & 5 others, Pardoll, D. M., Wan, F., Wu, S., Sears, C. L. & Housseau, F., Mar 14 2018, In : Cell Host and Microbe. 23, 3, 1 p.

Research output: Contribution to journalComment/debate

Names
Epithelial Cells
Bacteroides fragilis toxin

Systemic depletion of lymphocytes following focal radiation to the brain in a murine model

Piotrowski, A. F., Nirschl, T. R., Velarde, E., Blosser, L., Ganguly, S., Burns, K., Luznik, L., Wong, J., Drake, C. G. & Grossman, S. A., May 4 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Lymphocyte Depletion
Lymphocyte Count
Lymphopenia
Radiation
Lymph Nodes
2017

Cyclin-dependent kinase 5 activity is required for allogeneic T-cell responses after hematopoietic cell transplantation in mice

Askew, D., Pareek, T. K., Eid, S., Ganguly, S., Tyler, M., Huang, A. Y., Letterio, J. J. & Cooke, K. R., Jan 12 2017, In : Blood. 129, 2, p. 246-256 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
T-cells
Cell Transplantation
T-Lymphocytes
Graft vs Host Disease

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

Thiele Orberg, E., Fan, H., Tam, A. J., Dejea, C. M., Destefano Shields, C. E., Wu, S., Chung, L., Finard, B. B., Wu, X., Fathi, P., Ganguly, S., Fu, J., Pardoll, A. M., Sears, C. L. & Housseau, F., Mar 1 2017, In : Mucosal Immunology. 10, 2, p. 421-433 13 p.

Research output: Contribution to journalArticle

Bacteroides fragilis
Colon
Carcinogenesis
Interleukin-17
Myeloid Cells
2016

Induction of MHC-mismatched Mouse Lung Allograft Acceptance with Combined Donor Bone Marrow: Lung Transplant using a 12-Hour Nonmyeloablative Conditioning Regimen

Dodd-o, J. M., Ganguly, S., Vulic, A., Panoskaltsis-Mortari, A., McDyer, J. F. & Luznik, L., Sep 21 2016, (Accepted/In press) In : Transplantation.

Research output: Contribution to journalArticle

Allografts
Bone Marrow
Tissue Donors
Transplants
Lung

Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis

Housseau, F., Wu, S., Wick, E. C., Fan, H., Wu, X., Llosa, N., Smith, K., Tam, A., Ganguly, S., Wanyiri, J. W., Iyadorai, T., Malik, A. A., Roslani, A. C., Vadivelu, J. S., Van Meerbeke, S., Huso, D. L., Pardoll, A. M. & Sears, C. L., Apr 15 2016, In : Cancer Research. 76, 8, p. 2115-2124 10 p.

Research output: Contribution to journalArticle

Th17 Cells
Colon
Carcinogenesis
Bacteroides fragilis
T-Lymphocytes
2015

CD8+IL-17+ T cells mediate neutrophilic airway obliteration in T-bet-deficient mouse lung allograft recipients

Lendermon, E. A., Dodd-o, J. M., Coon, T. A., Miller, H. L., Ganguly, S., Popescu, I., O'Donnell, C. P., Cardenes, N., Levine, M., Rojas, M., Weathington, N. M., Zhao, J., Zhao, Y. & McDyer, J. F., May 1 2015, In : American Journal of Respiratory Cell and Molecular Biology. 52, 5, p. 622-633 12 p.

Research output: Contribution to journalArticle

T-cells
Interleukin-17
Allografts
T-Lymphocytes
Pathology

Human bone marrow niche chemoprotection mediated by cytochrome p450 enzymes

Alonso, S., Su, M., Jones, J. W., Ganguly, S., Kane, M. A., Jones, R. J. & Ghiaur, G., 2015, In : Oncotarget. 6, 17, p. 14905-14912 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP3A
Bone Marrow
Multiple Myeloma
Drug Resistance

Human mesenchymal stromal cells attenuate graft-versus-host disease and maintain graft-versus-leukemia activity following experimental allogeneic bone marrow transplantation

Auletta, J. J., Eid, S. K., Wuttisarnwattana, P., Silva, I., Metheny, L., Keller, M. D., Guardia-Wolff, R., Liu, C., Wang, F., Bowen, T., Lee, Z., Solchaga, L. A., Ganguly, S., Tyler, M., Wilson, D. L. & Cooke, K. R., Feb 1 2015, In : Stem Cells. 33, 2, p. 601-614 14 p.

Research output: Contribution to journalArticle

Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Mesenchymal Stromal Cells
Leukemia
Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Cyclophosphamide
Anti-Inflammatory Agents

The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells

Chang, E., Ganguly, S., Rajkhowa, T., Gocke, C., Levis, M. J. & Konig, H., Dec 21 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Methyltransferases
Myeloid Cells
Acute Myeloid Leukemia
Protein-Tyrosine Kinases
DNA
2014

Donor CD4+Foxp3+regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice

Ganguly, S., Ross, D. B., Panoskaltsis-Mortari, A., Kanakry, C. G., Blazar, B. R., Levy, R. B. & Luznik, L., Sep 25 2014, In : Blood. 124, 13, p. 2131-2141 11 p.

Research output: Contribution to journalArticle

T-cells
Graft vs Host Disease
Regulatory T-Lymphocytes
Grafts
Cyclophosphamide
2013

Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide

Kanakry, C. G., Ganguly, S., Zahurak, M., Bolanos Meade, F. J., Thoburn, C., Perkins, B., Fuchs, E. J., Jones, R. J., Hess, A. D. & Luznik, L., Nov 13 2013, In : Science Translational Medicine. 5, 211, 211ra157.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Regulatory T-Lymphocytes
Cyclophosphamide
Graft vs Host Disease
T-Lymphocytes
2010

Efficacy of artemisinin in experimental visceral leishmaniasis

Sen, R., Ganguly, S., Saha, P. & Chatterjee, M., Jul 2010, In : International Journal of Antimicrobial Agents. 36, 1, p. 43-49 7 p.

Research output: Contribution to journalArticle

Visceral Leishmaniasis
Leishmania
Inhibitory Concentration 50
Leishmania donovani
Antimony

Enhanced lesional foxp3 expression and peripheral anergic lymphocytes indicate a role for regulatory T cells in indian post-kala-azar dermal leishmaniasis

Ganguly, S., Mukhopadhyay, D., Das, N. K., Chaduvula, M., Sadhu, S., Chatterjee, U., Rahman, M., Goswami, R. P., Guha, S. K., Modak, D., Mallik, S., Gonju, D., Pramanik, N., Barbhuiya, J. N., Saha, B. & Chatterjee, M., Apr 2010, In : Journal of Investigative Dermatology. 130, 4, p. 1013-1022 10 p.

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Leishmaniasis
Visceral Leishmaniasis
T-cells
Lymphocytes

Iron enhances generation of free radicals by Artemisinin causing a caspase-independent, apoptotic death in Leishmania donovani promastigotes

Sen, R., Saha, P., Sarkar, A., Ganguly, S. & Chatterjee, M., Nov 2010, In : Free Radical Research. 44, 11, p. 1289-1295 7 p.

Research output: Contribution to journalArticle

Leishmania donovani
Caspases
Free Radicals
Iron
Acetylcysteine

Post-kala-azar dermal leishmaniasis - an overview

Ganguly, S., Das, N. K., Barbhuiya, J. N. & Chatterjee, M., Aug 2010, In : International Journal of Dermatology. 49, 8, p. 921-931 11 p.

Research output: Contribution to journalArticle

Leishmaniasis
Visceral Leishmaniasis
Skin
Interleukin-10
Lymphocytes
2009

Antioxidant effect of ethanolic extract of Piper betle Linn. (paan) on erythrocytes from patients with HbE-beta thalassemia

Srimani, P., Mandal, G., Ganguly, S., Sana, P., Sen, R., De, R., Chatterjee, A., Bhattacharyya, M., Chaudhuri, U., Bandyopadhyay, S. K. & Chatterjee, M., Jun 2009, In : Indian journal of biochemistry & biophysics. 46, 3, p. 241-246 6 p.

Research output: Contribution to journalArticle

Piper betle
beta-Thalassemia
Antioxidants
Erythrocytes
Fluorescence

Antioxidant effect of ethanolic extract of Piper betle Linn. (Paan) on erythrocytes from patients with HbE-beta thalassemia

Srimani, P., Mandal, G., Ganguly, S., Saha, P., Sen, R., De, R., Chatterjee, A., Bhattacharyya, M., Chaudhuri, U., Bandyopadhyay, S. K. & Chatterjee, M., 2009, In : Indian Journal of Geo-Marine Sciences. 46, 3, p. 241-246 6 p.

Research output: Contribution to journalArticle

antioxidant
fluorescence
free radical
flow cytometry
blood

Cytotoxicity of Senecio in macrophages is mediated via its induction of oxidative stress

Bandyopadhyay, S., Ganguly, S., Mandal, G., Sen, R., Saha, P., Ghosh, M. K., Sarkar, M. & Chatterjee, M., Aug 2009, In : Research in Veterinary Science. 87, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

Senecio
cytotoxicity
Reactive Oxygen Species
Oxidative Stress
macrophages

High-throughput screening of amastigotes of Leishmania donovani clinical isolates against drugs using a colorimetric β-lactamase assay

Mandal, S., Maharjan, M., Ganguly, S., Chatterjee, M., Singh, S., Buckner, F. S. & Madhubala, R., Jun 2009, In : Indian Journal of Experimental Biology. 47, 6 SPEC. ISS., p. 475-479 5 p.

Research output: Contribution to journalArticle

Leishmania donovani
Visceral Leishmaniasis
Macrophages
High-Throughput Screening Assays
Leishmaniasis
2008

Analysis of T-cell proliferation and cytokine secretion in the individuals exposed to arsenic

Biswas, R., Ghosh, P., Banerjee, N., Das, J. K., Sau, T., Banerjee, A., Roy, S., Ganguly, S., Chatterjee, M., Mukherjee, A. & Giri, A. K., May 2008, In : Human and Experimental Toxicology. 27, 5, p. 381-386 6 p.

Research output: Contribution to journalArticle

T-cells
Cell proliferation
Arsenic
Cell Proliferation
Cytokines

An ethanolic extract of leaves of Piper betle (Paan) Linn mediates its antileishmanial activity via apoptosis

Sarkar, A., Sen, R., Saha, P., Ganguly, S., Mandal, G. & Chatterjee, M., May 2008, In : Parasitology Research. 102, 6, p. 1249-1255 7 p.

Research output: Contribution to journalArticle

Piper betle
leaf extracts
apoptosis
Apoptosis
amastigotes

Anti-inflammatory effect of allylpyrocatechol in LPS-induced macrophages is mediated by suppression of iNOS and COX-2 via the NF-κB pathway

Sarkar, D., Saha, P., Gamre, S., Bhattacharjee, S., Hariharan, C., Ganguly, S., Sen, R., Mandal, G., Chattopadhyay, S., Majumdar, S. & Chatterjee, M., Sep 2008, In : International Immunopharmacology. 8, 9, p. 1264-1271 8 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Macrophages
Dinoprostone
Piper betle
Interleukin-12 Subunit p40

Arsenic-induced mitochondrial instability leading to programmed cell death in the exposed individuals

Banerjee, N., Banerjee, M., Ganguly, S., Bandyopadhyay, S., Das, J. K., Bandyopadhay, A., Chatterjee, M. & Giri, A. K., Apr 18 2008, In : Toxicology. 246, 2-3, p. 101-111 11 p.

Research output: Contribution to journalArticle

Arsenic
Cell death
Cell Death
Skin
Cells

Increased levels of interleukin-10 and IgG3 are hallmarks of Indian Post-Kala-Azar Dermal Leishmaniasis

Ganguly, S., Das, N. K., Panja, M., Pal, S., Modak, D., Rahaman, M., Mallik, S., Guha, S. K., Pramanik, N., Goswami, R., Barbhuiya, J. N., Saha, B. & Chatterjee, M., Jun 15 2008, In : Journal of Infectious Diseases. 197, 12, p. 1762-1771 10 p.

Research output: Contribution to journalArticle

Leishmaniasis
Visceral Leishmaniasis
Interleukin-10
Immunoglobulin G
Skin

Resveratrol induces apoptosis in K562 (chronic myelogenous leukemia) cells by targeting a key survival protein, heat shock protein 70

Chakraborty, P. K., Mustafi, S. B., Ganguly, S., Chatterjee, M. & Raha, S., Jun 2008, In : Cancer Science. 99, 6, p. 1109-1116 8 p.

Research output: Contribution to journalArticle

HSP70 Heat-Shock Proteins
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Apoptosis
tanespimycin
Proteins
2007

An ethanol extract of Piper betle Linn. mediates its anti-inflammatory activity via down-regulation of nitric oxide

Ganguly, S., Mula, S., Chattopadhyay, S. & Chatterjee, M., May 2007, In : Journal of Pharmacy and Pharmacology. 59, 5, p. 711-718 8 p.

Research output: Contribution to journalArticle

Piper betle
Reactive Nitrogen Species
Aptitude
Nitric Oxide
Anti-Inflammatory Agents

Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes

Sen, R., Bandyopadhyay, S., Dutta, A., Mandal, G., Ganguly, S., Saha, P. & Chatterjee, M., Sep 2007, In : Journal of Medical Microbiology. 56, 9, p. 1213-1218 6 p.

Research output: Contribution to journalArticle

Leishmania donovani
Cell Cycle Checkpoints
Leishmaniasis
Apoptosis
Antimony Sodium Gluconate
2006

Antipromastigote activity of an ethanolic extract of leaves of Artemisia indica

Ganguly, S., Bandyopadhyay, S., Bera, A. & Chatterjee, M., Jan 2006, In : Indian Journal of Pharmacology. 38, 1, p. 64-65 2 p.

Research output: Contribution to journalArticle

Artemisia

Development of a semi-automated colorimetric assay for screening anti-leishmanial agents

Ganguly, S., Bandyopadhyay, S., Sarkar, A. & Chatterjee, M., Jul 2006, In : Journal of Microbiological Methods. 66, 1, p. 79-86 8 p.

Research output: Contribution to journalArticle

miltefosine
Cell Survival
Mucocutaneous Leishmaniasis
Growth
Tetrazolium Salts