Subhra Chakraborty

Associate Scientist

1993 …2019

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2019
Open Access

Diagnostic techniques for rapid detection of Vibrio cholerae O1/O139

Ramamurthy, T., Das, B., Chakraborty, S., Mukhopadhyay, A. K. & Sack, D. A., Jan 1 2019, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Open Access

How genomics can be used to understand host susceptibility to enteric infection, aiding in the development of vaccines and immunotherapeutic interventions

Mottram, L., Chakraborty, S., Cox, E. & Fleckenstein, J., Jan 1 2019, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection

Chakraborty, S., Randall, A., Vickers, T. J., Molina, D., Harro, C. D., DeNearing, B., Brubaker, J., Sack, D. A., Bourgeois, L., Felgner, P. L., Liang, X., Mani, S., Wenzel, H., Townsend, R. R., Gilmore, P. E., Darsley, M. J., Rasko, D. A. & Fleckenstein, J. M., Dec 1 2019, In : npj Vaccines. 4, 1, 37.

Research output: Contribution to journalArticle

Open Access

Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge

Harro, C., Louis Bourgeois, A., Sack, D. A., Walker, R., DeNearing, B., Brubaker, J., Maier, N., Fix, A., Dally, L., Chakraborty, S., Clements, J. D., Saunders, I. & Darsley, M. J., Jan 1 2019, In : Vaccine.

Research output: Contribution to journalArticle

Open Access

Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes

Sarkar, P., Saha, T., Sheikh, I. A., Chakraborty, S., Aoun, J., Chakrabarti, M. K., Rajendran, V. M., Ameen, N. A., Dutta, S. & Hoque, K. M., Feb 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 316, 2, p. G229-G246

Research output: Contribution to journalArticle

2018

A Novel Shigella Proteome Microarray Discriminates Targets of Human Antibody Reactivity following Oral Vaccination and Experimental Challenge

Ndungo, E., Randall, A., Hazen, T. H., Kania, D. A., Trappl-Kimmons, K., Liang, X., Barry, E. M., Kotloff, K. L., Chakraborty, S., Mani, S., Rasko, D. A. & Pasetti, M. F., Aug 1 2018, In : mSphere. 3, 4

Research output: Contribution to journalArticle

Enterotoxigenic E. Coli virulence gene regulation in human infections

Crofts, A. A., Giovanetti, S. M., Rubin, E. J., Poly, F. M., Gutiérrez, R. L., Talaat, K. R., Porter, C. K., Riddle, M. S., DeNearing, B., Brubaker, J., Maciel, M., Alcala, A. N., Chakraborty, S., Prouty, M. G., Savarino, S. J., Davies, B. W. & Trent, M. S., Sep 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. E8968-E8976

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity

Kumar, P., Kuhlmann, F. M., Chakraborty, S., Bourgeois, L., Foulke-Abel, J., Tumala, B., Vickers, T. J., Sack, D. A., DeNearing, B., Harro, C. D., Wright, W. S., Gildersleeve, J. C., Ciorba, M. A., Santhanam, S., Porter, C. K., Gutierrez, R. L., Prouty, M. G., Riddle, M. S., Polino, A., Sheikh, A. & 2 others, Donowitz, M. & Fleckenstein, J. M., Aug 1 2018, In : Journal of Clinical Investigation. 128, 8, p. 3298-3311 14 p.

Research output: Contribution to journalArticle

Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development

Chakraborty, S., Randall, A., Vickers, T. J., Molina, D., Harro, C. D., DeNearing, B., Brubaker, J., Sack, D. A., Bourgeois, L., Felgner, P. L., Liang, X., Mani, S., Wenzel, H., Townsend, R. R., Gilmore, P. E., Darsley, M. J., Rasko, D. A. & Fleckenstein, J. M., Sep 22 2018, In : The Journal of infectious diseases. 218, 9, p. 1436-1446 11 p.

Research output: Contribution to journalArticle

Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers

Chakraborty, S., Harro, C., DeNearing, B., Brubaker, J., Connor, S., Maier, N., Dally, L., Flores, J., Bourgeois, L., Walker, R. & Sack, D. A., Apr 27 2018, In : PLoS Neglected Tropical Diseases. 12, 4, e0006442.

Research output: Contribution to journalArticle

Rifaximin Fails to Prevent Campylobacteriosis in the Human Challenge Model: A Randomized, Double-Blind, Placebo-Controlled Trial

Rimmer, J. E., Harro, C., Sack, D. A., Talaat, K. R., Gutierrez, R. L., DeNearing, B., Brubaker, J., Laird, R. M., Poly, F., Maue, A. C., Jaep, K., Alcala, A., Mochalova, Y., Gariepy, C. L., Chakraborty, S., Guerry, P., Tribble, D. R., Porter, C. K. & Riddle, M. S., Apr 17 2018, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 66, 9, p. 1435-1441 7 p.

Research output: Contribution to journalArticle

Open Access
2017

Occurrence of hybrid Escherichia coli strains carrying Shiga toxin and heat-stable toxin in livestock of Bangladesh

Johura, F. T., Parveen, R., Islam, A., Sadique, A., Rahim, M. N., Monira, S., Khan, A. R., Ahsan, S., Ohnishi, M., Watanabe, H., Chakraborty, S., George, C. M., Cravioto, A., Navarro, A., Hasan, B. & Alam, M., Jan 9 2017, In : Frontiers in Public Health. 4, JAN, 287.

Research output: Contribution to journalArticle

2016

An evidenced-based scale of disease severity following human challenge with enteroxigenic Escherichia coli

Porter, C. K., Riddle, M. S., Alcala, A. N., Sack, D. A., Harro, C., Chakraborty, S., Gutierrez, R. L., Savarino, S. J., Darsley, M., McKenzie, R., DeNearing, B., Steinsland, H., Tribble, D. R. & Bourgeois, L., Mar 1 2016, In : PLoS One. 11, 3, e0149358.

Research output: Contribution to journalArticle

Evaluation of the safety, tolerability, and immunogenicity of an oral, inactivated whole-cell shigella flexneri 2a vaccine in healthy adult subjects

Chakraborty, S., Harro, C., DeNearing, B., Bream, J., Bauers, N., Dally, L., Flores, J., Van De Verg, L., Sack, D. A. & Walker, R., Apr 1 2016, In : Clinical and Vaccine Immunology. 23, 4, p. 315-325 11 p.

Research output: Contribution to journalArticle

Individual-specific changes in the human gut microbiota after challenge with enterotoxigenic Escherichia coli and subsequent ciprofloxacin treatment

Pop, M., Paulson, J. N., Chakraborty, S., Astrovskaya, I., Lindsay, B. R., Li, S., Bravo, H. C., Harro, C., Parkhill, J., Walker, A. W., Walker, R. I., Sack, D. A. & Stine, O. C., Jun 8 2016, In : BMC Genomics. 17, 1, 440.

Research output: Contribution to journalArticle

Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans

Yang, W., Suchindran, S., Nicholson, B. P., McClain, M. T., Burke, T., Ginsburg, G. S., Harro, C. D., Chakraborty, S., Sack, D. A., Woods, C. W. & Tsalik, E. L., May 1 2016, In : Journal of Infectious Diseases. 213, 9, p. 1495-1504 10 p.

Research output: Contribution to journalArticle

2015

Shigella infections in household contacts of pediatric shigellosis patients in rural Bangladesh

George, C. M., Ahmed, S., Talukder, K. A., Azmi, I. J., Perin, J., Sack, R. B., Sack, D. A., Stine, O. C., Oldja, L., Shahnaij, M., Chakraborty, S., Parvin, T., Bhuyian, S. I., Bouwer, E., Zhang, X., Hasan, T. N., Luna, S. J., Akter, F. & Faruque, A. S. G., Nov 2015, In : Emerging infectious diseases. 21, 11, p. 2006-2013 8 p.

Research output: Contribution to journalArticle

2012

New advances in the pathophysiology of intestinal ion transport and barrier function in diarrhea and the impact on therapy

Hoque, K. M., Chakraborty, S., Sheikh, I. A. & Woodward, O. M., Jun 2012, In : Expert Review of Anti-Infective Therapy. 10, 6, p. 687-699 13 p.

Research output: Contribution to journalArticle

The oral, live attenuated enterotoxigenic Escherichia coli vaccine ACE527 reduces the incidence and severity of diarrhea in a human challenge model of diarrheal disease

Darsley, M. J., Chakraborty, S., DeNearing, B., Sack, D. A., Feller, A., Buchwaldt, C., Bourgeois, L., Walker, R. & Harro, C. D., Dec 2012, In : Clinical and Vaccine Immunology. 19, 12, p. 1921-1931 11 p.

Research output: Contribution to journalArticle

2011

QRDR mutations, efflux system & antimicrobial resistance genes in enterotoxigenic Escherichia coli isolated from an outbreak of diarrhoea in Ahmedabad, India

Pazhani, G. P., Chakraborty, S., Fujihara, K., Yamasaki, S., Ghosh, A., Nair, G. B. & Ramamurthy, T., Aug 2011, In : Indian Journal of Medical Research. 134, 8, p. 214-223 10 p.

Research output: Contribution to journalArticle

Refinement of a human challenge model for evaluation of enterotoxigenic Escherichia coli vaccines

Harro, C., Chakraborty, S., Feller, A., DeNearing, B., Cage, A., Ram, M., Lundgren, A., Svennerholm, A. M., Bourgeois, A. L., Walker, R. I. & Sack, D. A., Oct 1 2011, In : Clinical and Vaccine Immunology. 18, 10, p. 1719-1727 9 p.

Research output: Contribution to journalArticle

2010

Isolation of a bacteriophage specific for CS7-expressing strains of enterotoxigenic Escherichia coli

Begum, Y. A., Chakraborty, S., Chowdhury, A., Ghosh, A. N., Nair, G. B., Sack, R. B., Svennerholm, A. M. & Qadri, F., Mar 1 2010, In : Journal of Medical Microbiology. 59, 3, p. 266-272 7 p.

Research output: Contribution to journalArticle

2008

Characterization of the Francisella tularensis subsp. novicida type IV pilus

Zogaj, X., Chakraborty, S., Liu, J., Thanassi, D. G. & Klose, K. E., Sep 11 2008, In : Microbiology. 154, 7, p. 2139-2150 12 p.

Research output: Contribution to journalArticle

Type IV pili in Francisella tularensis: Roles of pilF and pilT in fiber assembly, host cell adherence, and virulence

Chakraborty, S., Monfett, M., Maier, T. M., Benach, J. L., Frank, D. W. & Thanassi, D. G., Jul 1 2008, In : Infection and immunity. 76, 7, p. 2852-2861 10 p.

Research output: Contribution to journalArticle

2006

Identification of a family of BspA like surface proteins of Entamoeba histolytica with novel leucine rich repeats

Davis, P. H., Zhang, Z., Chen, M., Zhang, X., Chakraborty, S. & Stanley, S. L., Jan 1 2006, In : Molecular and Biochemical Parasitology. 145, 1, p. 111-116 6 p.

Research output: Contribution to journalArticle

2005

Cytotoxic and cell vacuolating activity of Vibrio fluvialis isolated from paediatric patients with diarrhoea

Chakraborty, R., Chakraborty, S., De, K., Sinha, S., Mukhopadhyay, A. K., Khanam, J., Ramamurthy, T., Takeda, Y., Bhattacharya, S. K. & Nair, G. B., Aug 1 2005, In : Journal of Medical Microbiology. 54, 8, p. 707-716 10 p.

Research output: Contribution to journalArticle

2004

Molecular epidemiology of diarrhoeagenic Escherichia coli associated with sporadic cases and outbreaks of diarrhoea between 2000 and 2001 in India

Kahali, S., Sarkar, B., Chakraborty, S., Macaden, R., Deokule, J. S., Ballal, M., Nandy, R. K., Bhattacharya, S. K., Takeda, Y. & Ramamurthy, T., May 2004, In : European Journal of Epidemiology. 19, 5, p. 473-479 7 p.

Research output: Contribution to journalArticle

2003

Association of Cytolethal Distending Toxin Locus cdtB with Enteropathogenic Escherichia coli Isolated from Patients with Acute Diarrhea in Calcutta, India

Pandey, M., Khan, A., Das, S. C., Sarkar, B., Kahali, S., Chakraborty, S., Chattopadhyay, S., Yamasaki, S., Takeda, Y., Nair, G. B. & Ramamurthy, T., Nov 1 2003, In : Journal of clinical microbiology. 41, 11, p. 5277-5281 5 p.

Research output: Contribution to journalArticle

Infantile diarrhoea associated with sorbitol-fermenting, non-shiga toxin-producing Escherichia coli O157: H-

Chakraborty, S., Khan, A., Kahali, S., Faruque, S. M., Yamasaki, S. & Ramamurthy, T., May 1 2003, In : European Journal of Clinical Microbiology and Infectious Diseases. 22, 5, p. 324-326 3 p.

Research output: Contribution to journalArticle

Rapid spread of hepatitis C and needle exchange programme in Kolkata, India [6]

Sarkar, K., Mitra, S., Bal, B., Chakraborty, S. & Bhattacharya, S. K., Apr 12 2003, In : The Lancet. 361, 9365, p. 1301-1302 2 p.

Research output: Contribution to journalArticle

1994

Clostridium difficile in antibiotic associated pediatric diarrhea

Dutta, P., Niyogi, S. K., Mitra, U., Rasaily, R., Bhattacharya, M. K., Chakraborty, S. & Mitra, A., 1994, In : Indian Pediatrics. 31, 2, p. 121-126 6 p.

Research output: Contribution to journalArticle

1993

Randomized clinical trial of furazolidone for typhoid fever in children

Dutta, P., Rasaily, R., Saha, M. R., Mitra, U., Manna, B., Chakraborty, S. & Mukherjee, A., 1993, In : Scandinavian Journal of Gastroenterology. 28, 2, p. 168-172 5 p.

Research output: Contribution to journalArticle