Subhra Chakraborty

Associate Scientist

1993 …2019
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Research Output 1993 2019

2019
Open Access
Escherichia coli Vaccines
Enterotoxigenic Escherichia coli
Immunoassay
Antigens
Vaccines

Diagnostic techniques for rapid detection of Vibrio cholerae O1/O139

Ramamurthy, T., Das, B., Chakraborty, S., Mukhopadhyay, A. K. & Sack, D. A., Jan 1 2019, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Open Access
Vibrio cholerae O139
Vibrio cholerae O1
cholera
Routine Diagnostic Tests
Cholera

How genomics can be used to understand host susceptibility to enteric infection, aiding in the development of vaccines and immunotherapeutic interventions

Mottram, L., Chakraborty, S., Cox, E. & Fleckenstein, J., Jan 1 2019, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

vaccine development
Genomics
Enterotoxigenic Escherichia coli
Shigella Vaccines
Vaccines

Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection

Chakraborty, S., Randall, A., Vickers, T. J., Molina, D., Harro, C. D., DeNearing, B., Brubaker, J., Sack, D. A., Bourgeois, L., Felgner, P. L., Liang, X., Mani, S., Wenzel, H., Townsend, R. R., Gilmore, P. E., Darsley, M. J., Rasko, D. A. & Fleckenstein, J. M., Dec 1 2019, In : npj Vaccines. 4, 1, 37.

Research output: Contribution to journalArticle

Open Access
Escherichia coli Vaccines
Enterotoxigenic Escherichia coli
Antigens
Infection
Vaccines

Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge

Harro, C., Louis Bourgeois, A., Sack, D. A., Walker, R., DeNearing, B., Brubaker, J., Maier, N., Fix, A., Dally, L., Chakraborty, S., Clements, J. D., Saunders, I. & Darsley, M. J., Jan 1 2019, In : Vaccine.

Research output: Contribution to journalArticle

Open Access
Escherichia coli Vaccines
Enterotoxigenic Escherichia coli
enterotoxigenic Escherichia coli
adjuvants
volunteers

Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes

Sarkar, P., Saha, T., Sheikh, I. A., Chakraborty, S., Aoun, J., Chakrabarti, M. K., Rajendran, V. M., Ameen, N. A., Dutta, S. & Hoque, K. M., Feb 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 316, 2, p. G229-G246

Research output: Contribution to journalArticle

Claudin-2
Claudin-4
Bacillary Dysentery
Shigella
Zinc
2018

A Novel Shigella Proteome Microarray Discriminates Targets of Human Antibody Reactivity following Oral Vaccination and Experimental Challenge

Ndungo, E., Randall, A., Hazen, T. H., Kania, D. A., Trappl-Kimmons, K., Liang, X., Barry, E. M., Kotloff, K. L., Chakraborty, S., Mani, S., Rasko, D. A. & Pasetti, M. F., Aug 1 2018, In : mSphere. 3, 4

Research output: Contribution to journalArticle

Shigella
Proteome
Vaccination
Vaccines
Antigens

Enterotoxigenic E. Coli virulence gene regulation in human infections

Crofts, A. A., Giovanetti, S. M., Rubin, E. J., Poly, F. M., Gutiérrez, R. L., Talaat, K. R., Porter, C. K., Riddle, M. S., DeNearing, B., Brubaker, J., Maciel, M., Alcala, A. N., Chakraborty, S., Prouty, M. G., Savarino, S. J., Davies, B. W. & Trent, M. S., Sep 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. E8968-E8976

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli
Virulence
Infection
Genes
Fumarates

Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity

Kumar, P., Kuhlmann, F. M., Chakraborty, S., Bourgeois, L., Foulke-Abel, J., Tumala, B., Vickers, T. J., Sack, D. A., DeNearing, B., Harro, C. D., Wright, W. S., Gildersleeve, J. C., Ciorba, M. A., Santhanam, S., Porter, C. K., Gutierrez, R. L., Prouty, M. G., Riddle, M. S., Polino, A., Sheikh, A. & 2 others, Donowitz, M. & Fleckenstein, J. M., Aug 1 2018, In : Journal of Clinical Investigation. 128, 8, p. 3298-3311 14 p.

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli
Blood Group Antigens
Cholera
Polysaccharides
Hot Temperature

Erratum: Enterotoxigenic Escherichia coli-blood group a interactions intensify diarrheal severity (Journal of Clinical Investigation (2018)128(8)(3298-3311)Doi:10.1172/JCI97659)

Kumar, P., Kuhlmann, F. M., Chakraborty, S., Bourgeois, A. L., Foulke-Abel, J., Tumala, B., Vickers, T. J., Sack, D. A., DeNearing, B., Harro, C. D., Wright, W. S., Gildersleeve, J. C., Ciorba, M. A., Santhanam, S., Porter, C. K., Gutierrez, R. L., Prouty, M. G., Riddle, M. S., Polino, A., Sheikh, A. & 2 others, Donowitz, M. & Fleckenstein, J. M., Aug 1 2018, In : Journal of Clinical Investigation. 129, 7, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Tropical Medicine
Enterotoxigenic Escherichia coli
HT29 Cells
Blood Group Antigens
Hygiene

Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development

Chakraborty, S., Randall, A., Vickers, T. J., Molina, D., Harro, C. D., DeNearing, B., Brubaker, J., Sack, D. A., Bourgeois, L., Felgner, P. L., Liang, X., Mani, S., Wenzel, H., Townsend, R. R., Gilmore, P. E., Darsley, M. J., Rasko, D. A. & Fleckenstein, J. M., Sep 22 2018, In : The Journal of infectious diseases. 218, 9, p. 1436-1446 11 p.

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli
Vaccines
Antigens
Escherichia coli Infections
Volunteers

Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers

Chakraborty, S., Harro, C., DeNearing, B., Brubaker, J., Connor, S., Maier, N., Dally, L., Flores, J., Bourgeois, L., Walker, R. & Sack, D. A., Apr 27 2018, In : PLoS Neglected Tropical Diseases. 12, 4, e0006442.

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli
Volunteers
Diarrhea
Vaccines
Mucosal Immunity

Rifaximin Fails to Prevent Campylobacteriosis in the Human Challenge Model: A Randomized, Double-Blind, Placebo-Controlled Trial

Rimmer, J. E., Harro, C., Sack, D. A., Talaat, K. R., Gutierrez, R. L., DeNearing, B., Brubaker, J., Laird, R. M., Poly, F., Maue, A. C., Jaep, K., Alcala, A., Mochalova, Y., Gariepy, C. L., Chakraborty, S., Guerry, P., Tribble, D. R., Porter, C. K. & Riddle, M. S., Apr 17 2018, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 66, 9, p. 1435-1441 7 p.

Research output: Contribution to journalArticle

Open Access
rifaximin
Placebos
Campylobacter jejuni
Campylobacter Infections
Primary Prevention
2017

Occurrence of hybrid Escherichia coli strains carrying Shiga toxin and heat-stable toxin in livestock of Bangladesh

Johura, F. T., Parveen, R., Islam, A., Sadique, A., Rahim, M. N., Monira, S., Khan, A. R., Ahsan, S., Ohnishi, M., Watanabe, H., Chakraborty, S., George, C. M., Cravioto, A., Navarro, A., Hasan, B. & Alam, M., Jan 9 2017, In : Frontiers in Public Health. 4, JAN, 287.

Research output: Contribution to journalArticle

Shiga Toxin
Enterotoxigenic Escherichia coli
Bangladesh
Shiga-Toxigenic Escherichia coli
Livestock
2016

An evidenced-based scale of disease severity following human challenge with enteroxigenic Escherichia coli

Porter, C. K., Riddle, M. S., Alcala, A. N., Sack, D. A., Harro, C., Chakraborty, S., Gutierrez, R. L., Savarino, S. J., Darsley, M., McKenzie, R., DeNearing, B., Steinsland, H., Tribble, D. R. & Bourgeois, L., Mar 1 2016, In : PLoS One. 11, 3, e0149358.

Research output: Contribution to journalArticle

enterotoxigenic Escherichia coli
disease severity
Escherichia coli
Enterotoxigenic Escherichia coli
Signs and Symptoms
Escherichia coli Vaccines
Enterotoxigenic Escherichia coli
Mucosal Immunity
Escherichia coli
Antigens

Evaluation of the safety, tolerability, and immunogenicity of an oral, inactivated whole-cell shigella flexneri 2a vaccine in healthy adult subjects

Chakraborty, S., Harro, C., DeNearing, B., Bream, J., Bauers, N., Dally, L., Flores, J., Van De Verg, L., Sack, D. A. & Walker, R., Apr 1 2016, In : Clinical and Vaccine Immunology. 23, 4, p. 315-325 11 p.

Research output: Contribution to journalArticle

Shigella flexneri
Healthy Volunteers
Vaccines
Safety
Lymphocytes

Individual-specific changes in the human gut microbiota after challenge with enterotoxigenic Escherichia coli and subsequent ciprofloxacin treatment

Pop, M., Paulson, J. N., Chakraborty, S., Astrovskaya, I., Lindsay, B. R., Li, S., Bravo, H. C., Harro, C., Parkhill, J., Walker, A. W., Walker, R. I., Sack, D. A. & Stine, O. C., Jun 8 2016, In : BMC Genomics. 17, 1, 440.

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli
Ciprofloxacin
Diarrhea
Microbiota
16S Ribosomal RNA

Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans

Yang, W., Suchindran, S., Nicholson, B. P., McClain, M. T., Burke, T., Ginsburg, G. S., Harro, C. D., Chakraborty, S., Sack, D. A., Woods, C. W. & Tsalik, E. L., May 1 2016, In : Journal of Infectious Diseases. 213, 9, p. 1495-1504 10 p.

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli
Escherichia coli Infections
Gene Expression
Drug Repositioning
Infection
2015

Shigella infections in household contacts of pediatric shigellosis patients in rural Bangladesh

George, C. M., Ahmed, S., Talukder, K. A., Azmi, I. J., Perin, J. L., Sack, R. B., Sack, D. A., Stine, O. C., Oldja, L., Shahnaij, M., Chakraborty, S., Parvin, T., Bhuyian, S. I., Bouwer, E., Zhang, X., Hasan, T. N., Luna, S. J., Akter, F. & Faruque, A. S. G., Nov 1 2015, In : Emerging Infectious Diseases. 21, 11, p. 2006-2013 8 p.

Research output: Contribution to journalArticle

Bacillary Dysentery
Shigella
Bangladesh
Pediatrics
Infection
2014

Quantitative PCR and culture evaluation for enterotoxigenic Escherichia coli (ETEC) associated diarrhea in volunteers

Lindsay, B. R., Chakraborty, S., Harro, C., Li, S., Nataro, J. P., Sommerfelt, H., Sack, D. A. & Colin Stine, O., Mar 2014, In : FEMS Microbiology Letters. 352, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli
Volunteers
Diarrhea
Polymerase Chain Reaction
Sensitivity and Specificity
2013
Vibrio cholerae O139
Vibrio cholerae O1
Vibrio cholerae
Bangladesh
Cholera
2012

New advances in the pathophysiology of intestinal ion transport and barrier function in diarrhea and the impact on therapy

Hoque, K. M., Chakraborty, S., Sheikh, I. A. & Woodward, O. M., Jun 2012, In : Expert Review of Anti-Infective Therapy. 10, 6, p. 687-699 13 p.

Research output: Contribution to journalArticle

Ion Transport
Diarrhea
Intestinal Absorption
Virulence Factors
Practice Guidelines

The oral, live attenuated enterotoxigenic Escherichia coli vaccine ACE527 reduces the incidence and severity of diarrhea in a human challenge model of diarrheal disease

Darsley, M. J., Chakraborty, S., DeNearing, B., Sack, D. A., Feller, A., Buchwaldt, C., Bourgeois, L., Walker, R. & Harro, C. D., Dec 2012, In : Clinical and Vaccine Immunology. 19, 12, p. 1921-1931 11 p.

Research output: Contribution to journalArticle

Escherichia coli Vaccines
Enterotoxigenic Escherichia coli
Diarrhea
Vaccines
Escherichia coli
2011
Combined Vaccines
Enterotoxigenic Escherichia coli
Escherichia coli
Hot Temperature
Placebos

QRDR mutations, efflux system & antimicrobial resistance genes in enterotoxigenic Escherichia coli isolated from an outbreak of diarrhoea in Ahmedabad, India

Pazhani, G. P., Chakraborty, S., Fujihara, K., Yamasaki, S., Ghosh, A., Nair, G. B. & Ramamurthy, T., Aug 2011, In : Indian Journal of Medical Research. 134, 8, p. 214-223 10 p.

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli
Quinolones
Escherichia coli
Disease Outbreaks
India

Refinement of a human challenge model for evaluation of enterotoxigenic Escherichia coli vaccines

Harro, C., Chakraborty, S., Feller, A., DeNearing, B., Cage, A., Ram, M., Lundgren, A., Svennerholm, A. M., Bourgeois, L., Walker, R. I. & Sack, D. A., Oct 2011, In : Clinical and Vaccine Immunology. 18, 10, p. 1719-1727 9 p.

Research output: Contribution to journalArticle

Escherichia coli Vaccines
Enterotoxigenic Escherichia coli
Escherichia coli
Bicarbonates
Volunteers
2010

Isolation of a bacteriophage specific for CS7-expressing strains of enterotoxigenic Escherichia coli

Begum, Y. A., Chakraborty, S., Chowdhury, A., Ghosh, A. N., Nair, G. B., Sack, R. B., Svennerholm, A. M. & Qadri, F., Mar 2010, In : Journal of Medical Microbiology. 59, 3, p. 266-272 7 p.

Research output: Contribution to journalArticle

Enterotoxigenic Escherichia coli
Bacteriophages
Coliphages
Virulence Factors
Blocking Antibodies
2008

Characterization of the Francisella tularensis subsp. novicida type IV pilus

Zogaj, X., Chakraborty, S., Liu, J., Thanassi, D. G. & Klose, K. E., 2008, In : Microbiology. 154, 7, p. 2139-2150 12 p.

Research output: Contribution to journalArticle

Francisella tularensis
Mutation
Genes
Virulence
Fimbriae Proteins

Type IV pili in Francisella tularensis: Roles of pilF and pilT in fiber assembly, host cell adherence, and virulence

Chakraborty, S., Monfett, M., Maier, T. M., Benach, J. L., Frank, D. W. & Thanassi, D. G., Jul 2008, In : Infection and Immunity. 76, 7, p. 2852-2861 10 p.

Research output: Contribution to journalArticle

Francisella tularensis
Virulence
Vaccines
Tularemia
Adenosine Triphosphatases
2006

Identification of a family of BspA like surface proteins of Entamoeba histolytica with novel leucine rich repeats

Davis, P. H., Zhang, Z., Chen, M., Zhang, X., Chakraborty, S. & Stanley, S. L., Jan 2006, In : Molecular and Biochemical Parasitology. 145, 1, p. 111-116 6 p.

Research output: Contribution to journalArticle

Protozoan Proteins
Molecular Sequence Data
Minisatellite Repeats
Entamoeba histolytica
Bacterial Proteins
2005

Cytotoxic and cell vacuolating activity of Vibrio fluvialis isolated from paediatric patients with diarrhoea

Chakraborty, R., Chakraborty, S., De, K., Sinha, S., Mukhopadhyay, A. K., Khanam, J., Ramamurthy, T., Takeda, Y., Bhattacharya, S. K. & Nair, G. B., Aug 2005, In : Journal of Medical Microbiology. 54, 8, p. 707-716 10 p.

Research output: Contribution to journalArticle

Hemolysin Proteins
Vibrio
Diarrhea
Pediatrics
Ribotyping
2004

Molecular epidemiology of diarrhoeagenic Escherichia coli associated with sporadic cases and outbreaks of diarrhoea between 2000 and 2001 in India

Kahali, S., Sarkar, B., Chakraborty, S., Macaden, R., Deokule, J. S., Ballal, M., Nandy, R. K., Bhattacharya, S. K., Takeda, Y. & Ramamurthy, T., May 2004, In : European Journal of Epidemiology. 19, 5, p. 473-479 7 p.

Research output: Contribution to journalArticle

Molecular Epidemiology
Disease Outbreaks
India
Diarrhea
Escherichia coli
2003

Association of Cytolethal Distending Toxin Locus cdtB with Enteropathogenic Escherichia coli Isolated from Patients with Acute Diarrhea in Calcutta, India

Pandey, M., Khan, A., Das, S. C., Sarkar, B., Kahali, S., Chakraborty, S., Chattopadhyay, S., Yamasaki, S., Takeda, Y., Nair, G. B. & Ramamurthy, T., Nov 2003, In : Journal of Clinical Microbiology. 41, 11, p. 5277-5281 5 p.

Research output: Contribution to journalArticle

Enteropathogenic Escherichia coli
India
Diarrhea
Pulsed Field Gel Electrophoresis
Retrospective Studies

Infantile diarrhoea associated with sorbitol-fermenting, non-shiga toxin-producing Escherichia coli O157: H-

Chakraborty, S., Khan, A., Kahali, S., Faruque, S. M., Yamasaki, S. & Ramamurthy, T., May 1 2003, In : European Journal of Clinical Microbiology and Infectious Diseases. 22, 5, p. 324-326 3 p.

Research output: Contribution to journalArticle

Severity of Illness Index
Infantile Diarrhea
Microbial Colony Count
Bacterial Toxins
Escherichia coli Infections

Rapid spread of hepatitis C and needle exchange programme in Kolkata, India [6]

Sarkar, K., Mitra, S., Bal, B., Chakraborty, S. & Bhattacharya, S. K., Apr 12 2003, In : The Lancet. 361, 9365, p. 1301-1302 2 p.

Research output: Contribution to journalArticle

Needle-Exchange Programs
Hepatitis C
India
1994

Clostridium difficile in antibiotic associated pediatric diarrhea

Dutta, P., Niyogi, S. K., Mitra, U., Rasaily, R., Bhattacharya, M. K., Chakraborty, S. & Mitra, A., 1994, In : Indian Pediatrics. 31, 2, p. 121-126 6 p.

Research output: Contribution to journalArticle

Clostridium difficile
Diarrhea
Pediatrics
Anti-Bacterial Agents
Hospitalized Child
1993

Randomized clinical trial of furazolidone for typhoid fever in children

Dutta, P., Rasaily, R., Saha, M. R., Mitra, U., Manna, B., Chakraborty, S. & Mukherjee, A., 1993, In : Scandinavian Journal of Gastroenterology. 28, 2, p. 168-172 5 p.

Research output: Contribution to journalArticle

Furazolidone
Typhoid Fever
Chloramphenicol
Salmonella typhi
Randomized Controlled Trials

Role of viruses as causal agents of sporadic infantile diarrhea in calcutta.

Dutta, P., Ghosh, A. N., Bhattacharya, S. S., Mitra, U., Rasaily, R., Bhattacharya, M. K., Chakraborty, S. & Lahiri, M., Jul 1993, In : Indian Pediatrics. 30, 7, p. 941-942 2 p.

Research output: Contribution to journalArticle

Infantile Diarrhea
Virus Diseases
Viruses