19972019
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Research Output 1997 2019

2019

A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm

Kilic, O., Yoon, A., Shah, S. R., Yong, H. M., Ruiz-Valls, A., Chang, H., Panettieri, R. A., Liggett, S. B., Quiñones-Hinojosa, A., An, S. & Levchenko, A., Jan 1 2019, In : Nature Biomedical Engineering.

Research output: Contribution to journalArticle

Bronchial Spasm
Asthma
Smooth Muscle
Epithelial Cells
Molecular Models

A nonapoptotic endothelial barrier-protective role for caspase-3

Suresh, K., Carino, K., Johnston, L., Servinsky, L., Machamer, C. E., Kolb, T. M., Lam, H., Dudek, S. M., An, S., Rane, M. J., Shimoda, L. & Damarla, M., Jun 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 6, p. L1118-L1126

Research output: Contribution to journalArticle

Caspase 3
Thrombin
Caspases
Electric Impedance
Endothelial Cells

Asporin restricts mesenchymal stromal cell differentiation, alters the tumor microenvironment, and drives metastatic progression

Hughes, R. M., Simons, B. W., Khan, H., Miller, R., Kugler, V., Torquato, S., Theodros, D., Haffner, M. C., Lotan, T., Huang, J., Davicioni, E., An, S., Riddle, R., Thorek, D. L. J., Garraway, I. P., Fertig, E., Isaacs, J. T., Nathaniel Brennen, W., Park, B. H. & Hurley, P., Jan 1 2019, In : Cancer Research. 79, 14, p. 3636-3650 15 p.

Research output: Contribution to journalArticle

Open Access
Tumor Microenvironment
Mesenchymal Stromal Cells
Cell Differentiation
Neoplasms
Neoplasm Metastasis

Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening

Steppan, J., Wang, H., Bergman, Y., Rauer, M. J., Tan, S., Jandu, S., Nandakumar, K., Barreto-Ortiz, S., Cole, R. N., Boronina, T. N., Zhu, W., Halushka, M. K., An, S., Berkowitz, D. E. & Santhanam, L., Jul 1 2019, In : American journal of physiology. Heart and circulatory physiology. 317, 1, p. H49-H59

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Blood Vessels
Smooth Muscle Myocytes
Pulse Wave Analysis
Vascular Stiffness

Transforming Growth Factor-β1 Decreases β2-Agonist-induced Relaxation in Human Airway Smooth Muscle

Ojiaku, C. A., Chung, E., Parikh, V., Williams, J. K., Schwab, A., Fuentes, A. L., Corpuz, M. L., Lui, V., Paek, S., Bexiga, N. M., Narayan, S., Nunez, F. J., Ahn, K., Ostrom, R. S., An, S. & Panettieri, R. A., Aug 1 2019, In : American journal of respiratory cell and molecular biology. 61, 2, p. 209-218 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Smooth Muscle Myocytes
Smooth Muscle
Muscle
Asthma
2018

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines

Pera, T., Deshpande, D. A., Ippolito, M., Wang, B., Gavrila, A., Michael, J. V., Nayak, A. P., Tompkins, E., Farrell, E., Kroeze, W. K., Roth, B. L., Panettieri, R. A., Benovic, J. L., An, S., Dulin, N. O. & Penn, R. B., Feb 1 2018, In : FASEB Journal. 32, 2, p. 862-874 13 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Benzodiazepines
Protons
GTP-Binding Proteins
Ligands

Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread

Kim, D. H., Ewald, A., Park, J. S., Kshitiz, Kwak, M., Gray, R. S., Su, C. Y., Seo, J., An, S. & Levchenko, A., Dec 1 2018, In : Scientific Reports. 8, 1, 14210.

Research output: Contribution to journalArticle

Melanoma
Neoplasms
Traction
Cell Movement
Cues

Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition

Barreto Ortiz, S., Hori, D., Nomura, Y., Yun, X., Jiang, H., Yong, H., Chen, J., Paek, S., Pandey, D., Sikka, G., Bhatta, A., Gillard, A., Steppan, J., Kim, J. H., Adachi, H., Barodka, V., Romer, L., An, S., Shimoda, L., Santhanam, L. & 1 others, Berkowitz, D. E., Jan 1 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 1, p. L93-L106

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 2
Opsins
Vasodilation
Pulmonary Artery
Light

TGF-b1 evokes human airway smooth muscle cell shortening and hyperresponsiveness via Smad3

Ojiaku, C. A., Cao, G., Zhu, W., Yoo, E. J., Shumyatcher, M., Himes, B. E., An, S. & Panettieri, R. A., May 1 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 5, p. 575-584 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Smooth Muscle Myocytes
Muscle
Cells
Asthma

TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness

Zhu, W., Kim, B. C., Wang, M., Huang, J., Isak, A., Bexiga, N. M., Monticone, R., Ha, T., Lakatta, E. & An, S., Dec 1 2018, In : Scientific Reports. 8, 1, 2668.

Research output: Contribution to journalArticle

Transforming Growth Factors
Vascular Smooth Muscle
Smooth Muscle Myocytes
Thoracic Aorta
Actin Cytoskeleton
2017

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination

Haffner, M. C., Esopi, D. M., Chaux, A., Gürel, M., Ghosh, S., Vaghasia, A. M., Tsai, H., Kim, K., Castagna, N., Lam, H., Hicks, J., Wyhs, N., Biswal Shinohara, D., Hurley, P., Simons, B. W., Schaeffer, E. M., Lotan, T., Isaacs, W. B., Netto, G. J., Demarzo, A. M. & 3 others, Nelson, W. G., An, S. & Yegnasubramanian, S., Dec 1 2017, In : Nature Communications. 8, 1, 142.

Research output: Contribution to journalArticle

Microfilament Proteins
Cell Movement
Actins
Melanoma
cancer

Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension

Nishida, K., Brune, K. A., Putcha, N., Mandke, P., O’Neal, W. K., Shade, D., Srivastava, V., Wang, M., Lam, H., An, S., Drummond, M. B., Hansel, N., Robinson, D. & Sidhaye, V., Sep 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L581-L591

Research output: Contribution to journalArticle

Cell Adhesion
Smoke
Tobacco Products
Epithelial Cells
Chronic Obstructive Pulmonary Disease

Coupling of airway smooth muscle bitter taste receptors to intracellular signaling and relaxation is via Gαi1,2,3

Kim, D., Woo, J. A., Geffken, E., An, S. & Liggett, S. B., Jun 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 6, p. 762-771 10 p.

Research output: Contribution to journalArticle

Smooth Muscle
Muscle
GTP-Binding Proteins
Type C Phospholipases
Phosphorylation

12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner

Yoo, E. J., Cao, G., Koziol-White, C. J., Ojiaku, C. A., Sunder, K., Jude, J. A., Michael, J. V., Lam, H., Pushkarsky, I., Damoiseaux, R., Di Carlo, D., Ahn, K., An, S., Penn, R. B. & Panettieri, R. A., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Smooth Muscle
Phosphatidylinositol 3-Kinases
Muscle Contraction
Serum Response Element

Impaired relaxation of airway smooth muscle in mice lacking the actin-binding protein gelsolin

Mikami, M., Zhang, Y., Danielsson, J., Joell, T., Yong, H. M., Townsend, E., Khurana, S., An, S. & Emala, C. W., May 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 5, p. 628-636 9 p.

Research output: Contribution to journalArticle

Gelsolin
Microfilament Proteins
Smooth Muscle
Muscle
Knockout Mice

Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone

Singh, J., Mohanty, I., Addya, S., Phillips, B., Mee Yong, H., An, S., Penn, R. B. & Rattan, S., Dec 1 2017, In : Scientific Reports. 7, 1, 1477.

Research output: Contribution to journalArticle

Anal Canal
MicroRNAs
Smooth Muscle
Immunoblotting
Smooth Muscle Myocytes

Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system

An, S. & Liggett, S. B., Jan 26 2017, (Accepted/In press) In : Cellular Signalling.

Research output: Contribution to journalArticle

Odorant Receptors
Smell
Smooth Muscle
Lung
Asthma

Tissue transglutaminase modulates vascular stiffness and function through crosslinking-dependent and crosslinking-independent functions

Steppan, J., Bergman, Y., Viegas, K., Armstrong, D., Tan, S., Wang, H., Melucci, S., Hori, D., Park, S. Y., Barreto, S. F., Isak, A., Jandu, S., Flavahan, N., Butlin, M., An, S., Avolio, A., Berkowitz, D. E., Halushka, M. K. & Santhanam, L., 2017, In : Journal of the American Heart Association. 6, 2, e004161.

Research output: Contribution to journalArticle

Vascular Stiffness
Smooth Muscle Myocytes
Electric Impedance
Blood Vessels
Myography

TWIST1-WDR5-hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis

Malek, R., Gajula, R. P., Williams, R. D., Nghiem, B., Simons, B. W., Nugent, K., Wang, H., Taparra, K., Lemtiri-Chlieh, G., Yoon, A. R., True, L., An, S., DeWeese, T., Ross, A. E., Schaeffer, E. M., Pienta, K., Hurley, P., Morrissey, C. & Tran, P. T., Jun 15 2017, In : Cancer Research. 77, 12, p. 3181-3193 13 p.

Research output: Contribution to journalArticle

Chromatin
Prostatic Neoplasms
Neoplasm Metastasis
Prostate
Long Noncoding RNA
2016

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma

An, S., Mitzner, W. A., Tang, W-Y., Ahn, K., Yoon, A. R., Huang, J., Kilic, O., Yong, H. M., Fahey, J. W., Kumar, S., Biswal, S., Holgate, S. T., Panettieri, R. A., Solway, J. & Liggett, S. B., 2016, (Accepted/In press) In : The Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Common polygenic variation and risk for childhood-onset schizophrenia

Ahn, K., An, S., Shugart, Y. Y. & Rapoport, J. L., Jan 1 2016, In : Molecular Psychiatry. 21, 1, p. 94-96 3 p.

Research output: Contribution to journalArticle

Childhood Schizophrenia
Schizophrenia
Siblings
Autistic Disorder
Genome-Wide Association Study

Defining an olfactory receptor function in airway smooth muscle cells

Aisenberg, W. H., Huang, J., Zhu, W., Rajkumar, P., Cruz, R., Santhanam, L., Natarajan, N., Yong, H. M., De Santiago, B., Oh, J. J., Yoon, A. R., Panettieri, R. A., Homann, O., Sullivan, J. K., Liggett, S. B., Pluznick, J. & An, S., Dec 1 2016, In : Scientific Reports. 6, 38231.

Research output: Contribution to journalArticle

Odorant Receptors
Smooth Muscle Myocytes
Smooth Muscle
Asthma
Lung

Directed migration of cancer cells guided by the graded texture of the underlying matrix

Park, J. S., Kim, D. H., Kim, H. N., Wang, C. J., Kwak, M. K., Hur, E., Suh, K. Y., An, S. & Levchenko, A., Jul 1 2016, In : Nature Materials. 15, 7, p. 792-801 10 p.

Research output: Contribution to journalArticle

textures
Textures
cancer
Cells
matrices

Germline variants in asporin vary by race, modulate the tumor microenvironment, and are differentially associated with metastatic prostate cancer

Hurley, P., Sundi, D., Shinder, B., Simons, B. W., Hughes, R. M., Miller, R. M., Benzon, B., Faraj, S. F., Netto, G. J., Vergara, I. A., Erho, N., Davicioni, E., Karnes, R. J., Yan, G., Ewing, C., Isaacs, S. D., Berman, D. M., Rider, J. R., Jordahl, K. M., Mucci, L. A. & 7 others, Huang, J., An, S., Park, B. H., Isaacs, W. B., Marchionni, L., Ross, A. E. & Schaeffer, E. M., Jan 15 2016, In : Clinical Cancer Research. 22, 2, p. 448-458 11 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Prostatic Neoplasms
Confidence Intervals
Heterografts
Neoplasm Metastasis

Interdicting Gq activation in airway disease by receptor-dependent and receptor-independent mechanisms

Carr, R., Koziol-White, C., Zhang, J., Lam, H., An, S., Tall, G. G., Panettieri, R. A. & Benovic, J. L., Jan 1 2016, In : Molecular Pharmacology. 89, 1, p. 94-104 11 p.

Research output: Contribution to journalArticle

Pathology
Smooth Muscle
PAR-1 Receptor
Airway Remodeling
Leukotriene Antagonists

β2-adrenergic receptors chaperone trapped bitter taste receptor 14 to the cell surface as a heterodimer and exert unidirectional desensitization of taste receptor function

Kim, D., Pauer, S. H., Yong, H. M., An, S. & Liggett, S. B., Aug 19 2016, In : Journal of Biological Chemistry. 291, 34, p. 17616-17628 13 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Smooth Muscle
Muscle
Muscle Relaxation
Recycling
2015

Androgen-regulated SPARCL1 in the tumor microenvironment inhibits metastatic progression

Hurley, P., Hughes, R. M., Simons, B. W., Huang, J., Miller, R. M., Shinder, B., Haffner, M. C., Esopi, D., Kimura, Y., Jabbari, J., Ross, A. E., Erho, N., Vergara, I. A., Faraj, S. F., Davicioni, E., Netto, G. J., Yegnasubramanian, S., An, S. & Schaeffer, E. M., Oct 15 2015, In : Cancer Research. 75, 20, p. 4322-4334 13 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Androgens
Cysteine
Androgen Receptors
Prostatic Neoplasms

COX-2 dependent regulation of mechanotransduction in human breast cancer cells

Yoon, A. R., Stasinopoulos, I., Kim, J. H., Yong, H. M., Kilic, O., Wirtz, D., Bhujwalla, Z. M. & An, S., Mar 1 2015, In : Cancer Biology and Therapy. 16, 3, p. 430-437 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Dinoprostone
Traction
Mechanical Phenomena
Biological Phenomena

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells

Shiraishi, T., Verdone, J. E., Huang, J., Kahlert, U. D., Hernandez, J. R., Torga, G., Zarif, J., Epstein, T., Gatenby, R., McCartney, A., Elisseeff, J. H., Mooney, S. M., An, S. & Pienta, K., 2015, In : Oncotarget. 6, 1, p. 130-143 14 p.

Research output: Contribution to journalArticle

Glycolysis
Energy Metabolism
Cell Movement
Prostatic Neoplasms
Breast Neoplasms

Hydrogen Sulfide Signaling in Oxidative Stress and Aging Development

Yang, G., An, S., Ji, Y., Zhang, W. & Pei, Y., 2015, In : Oxidative Medicine and Cellular Longevity. 2015, 357824.

Research output: Contribution to journalArticle

Protective Agents
Signal transduction
Hydrogen Sulfide
Oxidative stress
Animals

LAMC2 enhances the metastatic potential of lung adenocarcinoma

Moon, Y. W., Rao, G., Kim, J. J., Shim, H. S., Park, K. S., An, S., Kim, B., Steeg, P. S., Sarfaraz, S., Changwoo Lee, L., Voeller, D., Choi, E. Y., Luo, J., Palmieri, D., Chung, H. C., Kim, J. H., Wang, Y. & Giaccone, G., Aug 7 2015, In : Cell Death and Differentiation. 22, 8, p. 1341-1352 12 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Neoplasm Metastasis
Lung Neoplasms
Traction
Laminin

Pleiotropic effects of bitter taste receptors on [Ca2+]i mobilization, hyperpolarization, and relaxation of human airway smooth muscle cells

Camoretti-Mercado, B., Pauer, S. H., Yong, H. M., Smith, D. C., Deshpande, D. A., An, S. & Liggett, S. B., Jun 29 2015, In : PLoS One. 10, 6, e0131582.

Research output: Contribution to journalArticle

smooth muscle
myocytes
Smooth Muscle Myocytes
Muscle
Cells

Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility

Aifuwa, I., Giri, A., Longe, N., Lee, S. H., An, S. & Wirtz, D., 2015, In : Oncotarget. 6, 31, p. 30516-30531 16 p.

Research output: Contribution to journalArticle

Cell Migration Inhibition
Myosins
Stromal Cells
Phenotype
Microtubules

Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells

Gajula, R. P., Chettiar, S. T., Williams, R. D., Nugent, K., Kato, Y., Wang, H., Malek, R., Taparra, K., Cades, J., Annadanam, A., Yoon, A. R., Fertig, E., Firulli, B. A., Mazzacurati, L., Burns, T. F., Firulli, A. B., An, S. & Tran, P. T., Jan 1 2015, In : Neoplasia. 17, 1, p. 16-31 16 p.

Research output: Contribution to journalArticle

Helix-Loop-Helix Motifs
Prostatic Neoplasms
Phosphorylation
Mutation
Neoplasm Metastasis
2014

Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells

Robinett, K. S., Koziol-White, C. J., Akoluk, A., An, S., Panettieri, R. A. & Liggett, S. B., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 50, 4, p. 678-683 6 p.

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Muscle
Cells
Asthma
Interleukin-13

H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal KATP channel

Fitzgerald, R. S., DeSantiago, B., Lee, D. Y., Yang, G., Kim, J. Y., Foster, D. B., Chan-Li, Y., Horton, M., Panettieri, R. A., Wang, R. & An, S., Mar 28 2014, In : Biochemical and Biophysical Research Communications. 446, 1, p. 393-398 6 p.

Research output: Contribution to journalArticle

KATP Channels
Smooth Muscle Myocytes
Muscle
Cells
Smooth Muscle

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates

Mattison, J. A., Wang, M., Bernier, M., Zhang, J., Park, S. S., Maudsley, S., An, S., Santhanam, L., Martin, B., Faulkner, S., Morrell, C., Baur, J. A., Peshkin, L., Sosnowska, D., Csiszar, A., Herbert, R. L., Tilmont, E. M., Ungvari, Z., Pearson, K. J., Lakatta, E. & 1 others, De Cabo, R., Jul 1 2014, In : Cell Metabolism. 20, 1, p. 183-190 8 p.

Research output: Contribution to journalArticle

Arteritis
Pulse Wave Analysis
High Fat Diet
Primates
Sucrose

Spatial control of adult stem cell fate using nanotopographic cues

Ahn, E. H., Kim, Y., Kshitiz, An, S., Afzal, J., Lee, S., Kwak, M., Suh, K. Y., Kim, D. H. & Levchenko, A., Mar 2014, In : Biomaterials. 35, 8, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Stem cells
Cues
Cell adhesion
Cell Engineering

Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle

Wang, W. C. H., Pauer, S. H., Smith, D. C., Dixon, M. A., Disimile, D. J., Panebra, A., An, S., Camoretti-Mercado, B. & Liggett, S. B., Nov 15 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 307, 10, p. L775-L780

Research output: Contribution to journalArticle

Gene Transfer Techniques
Adrenergic Receptors
Smooth Muscle
Transgenic Mice
Muscle Relaxation

β-agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent

Morgan, S. J., Deshpande, D. A., Tiegs, B. C., Misior, A. M., Yan, H., Hershfeld, A. V., Rich, T. C., Panettieri, R. A., An, S. & Penn, R. B., Aug 15 2014, In : Journal of Biological Chemistry. 289, 33, p. 23065-23074 10 p.

Research output: Contribution to journalArticle

Muscle Proteins
Cyclic AMP-Dependent Protein Kinases
Smooth Muscle
Muscle
Isoproterenol
2013

Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer

Kim, J. J., Yin, B., Christudass, C. S., Terada, N., Rajagopalan, K., Fabry, B., Lee, D. Y., Shiraishi, T., Getzenberg, R. H., Veltri, R. W., An, S. & Mooney, S. M., Jun 2013, In : Journal of Cellular Biochemistry. 114, 6, p. 1286-1293 8 p.

Research output: Contribution to journalArticle

Paclitaxel
Prostatic Neoplasms
Phenotype
Castration
Drug Resistance

Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice

Jung, S. M., Jandu, S., Steppan, J., Belkin, A., An, S., Pak, A., Choi, E. Y., Nyhan, D., Butlin, M., Viegas, K., Avolio, A., Berkowitz, D. E. & Santhanam, L., Sep 15 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 6

Research output: Contribution to journalArticle

Vascular Stiffness
Knockout Mice
Nitric Oxide Synthase
Pulse Wave Analysis
Nitric Oxide

The Twist box domain is required for Twist1-induced prostate cancer metastasis

Gajula, R. P., Chettiar, S. T., Williams, R. D., Thiyagarajan, S., Kato, Y., Aziz, K., Wang, R., Gandhi, N., Wild, A. T., Vesuna, F., Ma, J., Salih, T., Cades, J., Fertig, E., Biswal, S., Burns, T. F., Chung, C. H., Rudin, C. M., Herman, J. M., Hales, R. & 3 others, Raman, V., An, S. & Tran, P. T., Nov 2013, In : Molecular Cancer Research. 11, 11, p. 1387-1400 14 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasm Metastasis
Phenotype
Neoplasms
Lung
2012

Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation

Garzon-Muvdi, T., Schiapparelli, P., ap Rhys, C., Guerrero-Cazares, H., Smith, C., Kim, D. H., Kone, L., Farber, H., Lee, D. Y., An, S., Levchenko, A. & Quiñones-Hinojosa, A., May 2012, In : PLoS Biology. 10, 5, e1001320.

Research output: Contribution to journalArticle

Sodium-Potassium-Chloride Symporters
Focal Adhesions
Brain Neoplasms
adhesion
Tumors

Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation

An, S., Robinett, K. S., Deshpande, D. A., Wang, W. C. H. & Liggett, S. B., May 2012, In : Nature Medicine. 18, 5, p. 650-651 2 p.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels

TAS2R activation promotes airway smooth muscle relaxation despite β 2-adrenergic receptor tachyphylaxis

An, S., Wang, W. C. H., Koziol-White, C. J., Ahn, K., Lee, D. Y., Kurten, R. C., Panettieri, R. A. & Liggett, S. B., Aug 15 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 303, 4

Research output: Contribution to journalArticle

Tachyphylaxis
Muscle Relaxation
Adrenergic Receptors
Smooth Muscle
Albuterol

The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH

Saxena, H., Deshpande, D. A., Tiegs, B. C., Yan, H., Battafarano, R. J., Burrows, W. M., Damera, G., Panettieri, R. A., Dubose, T. D., An, S. & Penn, R. B., Jun 2012, In : British Journal of Pharmacology. 166, 3, p. 981-990 10 p.

Research output: Contribution to journalArticle

Smooth Muscle Myocytes
Smooth Muscle
Muscle Contraction
Protons
Real-Time Polymerase Chain Reaction
2011

A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: A staged high-throughput biophysical screening

An, S., Askovich, P. S., Zarembinski, T. I., Ahn, K., Peltier, J. M., von Rechenberg, M., Sahasrabudhe, S. & Fredberg, J. J., Jan 13 2011, In : Respiratory Research. 12, 8.

Research output: Contribution to journalArticle

HSP20 Heat-Shock Proteins
14-3-3 Proteins
Obstructive Lung Diseases
Fluorescence Polarization
Smooth Muscle

Bronchodilator activity of bitter tastants in human tissue

Deshpande, D. A., Robinett, K. S., Wang, W. C. H., Sham, J., An, S. & Liggett, S. B., Jul 2011, In : Nature Medicine. 17, 7, p. 776-778 3 p.

Research output: Contribution to journalArticle

Papaverine
Bronchodilator Agents
Chloroquine
G-Protein-Coupled Receptors
Isoproterenol
2010

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction

Deshpande, D. A., Wang, W. C. H., McIlmoyle, E. L., Robinett, K. S., Schillinger, R. M., An, S., Sham, J. & Liggett, S. B., Nov 2010, In : Nature Medicine. 16, 11, p. 1299-1304 6 p.

Research output: Contribution to journalArticle

Calcium Signaling
Smooth Muscle
Muscle
Calcium
Obstructive Lung Diseases