19972019

Research output per year

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Research Output

2019

A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm

Kilic, O., Yoon, A., Shah, S. R., Yong, H. M., Ruiz-Valls, A., Chang, H., Panettieri, R. A., Liggett, S. B., Quiñones-Hinojosa, A., An, S. & Levchenko, A., Jan 1 2019, In : Nature Biomedical Engineering.

Research output: Contribution to journalArticle

A nonapoptotic endothelial barrier-protective role for caspase-3

Suresh, K., Carino, K., Johnston, L., Servinsky, L., Machamer, C. E., Kolb, T. M., Lam, H., Dudek, S. M., An, S., Rane, M. J., Shimoda, L. & Damarla, M., Jun 1 2019, In : American journal of physiology. Lung cellular and molecular physiology. 316, 6, p. L1118-L1126

Research output: Contribution to journalArticle

Asporin restricts mesenchymal stromal cell differentiation, alters the tumor microenvironment, and drives metastatic progression

Hughes, R. M., Simons, B. W., Khan, H., Miller, R., Kugler, V., Torquato, S., Theodros, D., Haffner, M. C., Lotan, T., Huang, J., Davicioni, E., An, S. S., Riddle, R. C., Thorek, D. L. J., Garraway, I. P., Fertig, E. J., Isaacs, J. T., Nathaniel Brennen, W., Park, B. H. & Hurley, P. J., Jan 1 2019, In : Cancer Research. 79, 14, p. 3636-3650 15 p.

Research output: Contribution to journalArticle

Open Access

Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness

Tuday, E., Nomura, Y., Ruhela, D., Nakano, M., Fu, X., Shah, A., Roman, B., Yamaguchi, A., An, S. S., Steenbergen, C., Baraban, J. M., Berkowitz, D. E. & Das, S., Jan 1 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 317, 5, p. H1116-H1124

Research output: Contribution to journalArticle

Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening

Steppan, J., Wang, H., Bergman, Y., Rauer, M. J., Tan, S., Jandu, S., Nandakumar, K., Barreto-Ortiz, S., Cole, R. N., Boronina, T. N., Zhu, W., Halushka, M. K., An, S., Berkowitz, D. E. & Santhanam, L., Jul 1 2019, In : American journal of physiology. Heart and circulatory physiology. 317, 1, p. H49-H59

Research output: Contribution to journalArticle

Transforming Growth Factor-b1 Decreases b2-Agonist–induced Relaxation in Human Airway Smooth Muscle

Ojiaku, C. A., Chung, E., Parikh, V., Williams, J. K., Schwab, A., Fuentes, A. L., Corpuz, M. L., Lui, V., Paek, S., Bexiga, N. M., Narayan, S., Nunez, F. J., Ahn, K., Ostrom, R. S., An, S. S. & Panettieri, R. A., Aug 1 2019, In : American journal of respiratory cell and molecular biology. 61, 2, p. 209-218 10 p.

Research output: Contribution to journalArticle

YAP and TAZ regulate cell volume

Perez-Gonzalez, N. A., Rochman, N. D., Yao, K., Tao, J., Le, M. T. T., Flanary, S., Sablich, L., Toler, B., Crentsil, E., Takaesu, F., Lambrus, B., Huang, J., Fu, V., Chengappa, P., Jones, T. M., Holland, A. J., An, S., Wirtz, D., Petrie, R. J., Guan, K. L. & 1 others, Sun, S. X., Oct 7 2019, In : The Journal of cell biology. 218, 10, p. 3472-3488 17 p.

Research output: Contribution to journalArticle

Open Access
2018

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines

Pera, T., Deshpande, D. A., Ippolito, M., Wang, B., Gavrila, A., Michael, J. V., Nayak, A. P., Tompkins, E., Farrell, E., Kroeze, W. K., Roth, B. L., Panettieri, R. A., Benovic, J. L., An, S., Dulin, N. O. & Penn, R. B., Feb 1 2018, In : FASEB Journal. 32, 2, p. 862-874 13 p.

Research output: Contribution to journalArticle

Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread

Kim, D. H., Ewald, A., Park, J. S., Kshitiz, Kwak, M., Gray, R. S., Su, C. Y., Seo, J., An, S. & Levchenko, A., Dec 1 2018, In : Scientific Reports. 8, 1, 14210.

Research output: Contribution to journalArticle

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure

Rainer, P. P., Dong, P., Sorge, M., Fert-Bober, J., Holewinski, R. J., Wang, Y., Foss, C. A., An, S. S., Baracca, A., Solaini, G., Glabe, C. G., Pomper, M. G., Van Eyk, J. E., Tomaselli, G. F., Paolocci, N. & Agnetti, G., May 11 2018, In : Circulation research. 122, 10, p. e75-e83

Research output: Contribution to journalArticle

Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition

Barreto Ortiz, S., Hori, D., Nomura, Y., Yun, X., Jiang, H., Yong, H., Chen, J., Paek, S., Pandey, D., Sikka, G., Bhatta, A., Gillard, A., Steppan, J., Kim, J. H., Adachi, H., Barodka, V., Romer, L., An, S., Shimoda, L., Santhanam, L. & 1 others, Berkowitz, D. E., Jan 1 2018, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 314, 1, p. L93-L106

Research output: Contribution to journalArticle

TGF-b1 evokes human airway smooth muscle cell shortening and hyperresponsiveness via Smad3

Ojiaku, C. A., Cao, G., Zhu, W., Yoo, E. J., Shumyatcher, M., Himes, B. E., An, S. & Panettieri, R. A., May 1 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 5, p. 575-584 10 p.

Research output: Contribution to journalArticle

TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness

Zhu, W., Kim, B. C., Wang, M., Huang, J., Isak, A., Bexiga, N. M., Monticone, R., Ha, T., Lakatta, E. & An, S., Dec 1 2018, In : Scientific Reports. 8, 1, 2668.

Research output: Contribution to journalArticle

2017

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination

Haffner, M. C., Esopi, D. M., Chaux, A., Gürel, M., Ghosh, S., Vaghasia, A. M., Tsai, H., Kim, K., Castagna, N., Lam, H., Hicks, J., Wyhs, N., Biswal Shinohara, D., Hurley, P., Simons, B. W., Schaeffer, E. M., Lotan, T., Isaacs, W. B., Netto, G. J., Demarzo, A. M. & 3 others, Nelson, W. G., An, S. & Yegnasubramanian, S., Dec 1 2017, In : Nature Communications. 8, 1, 142.

Research output: Contribution to journalArticle

Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension

Nishida, K., Brune, K. A., Putcha, N., Mandke, P., O’Neal, W. K., Shade, D., Srivastava, V., Wang, M., Lam, H., An, S., Drummond, M. B., Hansel, N., Robinson, D. & Sidhaye, V., Sep 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L581-L591

Research output: Contribution to journalArticle

Coupling of airway smooth muscle bitter taste receptors to intracellular signaling and relaxation is via Gαi1,2,3

Kim, D., Woo, J. A., Geffken, E., An, S. & Liggett, S. B., Jun 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 6, p. 762-771 10 p.

Research output: Contribution to journalArticle

12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner

Yoo, E. J., Cao, G., Koziol-White, C. J., Ojiaku, C. A., Sunder, K., Jude, J. A., Michael, J. V., Lam, H., Pushkarsky, I., Damoiseaux, R., Di Carlo, D., Ahn, K., An, S. S., Penn, R. B. & Panettieri, R. A., Dec 2017, In : British Journal of Pharmacology. 174, 23, p. 4383-4395 13 p.

Research output: Contribution to journalArticle

Impaired relaxation of airway smooth muscle in mice lacking the actin-binding protein gelsolin

Mikami, M., Zhang, Y., Danielsson, J., Joell, T., Yong, H. M., Townsend, E., Khurana, S., An, S. & Emala, C. W., May 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 5, p. 628-636 9 p.

Research output: Contribution to journalArticle

Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone

Singh, J., Mohanty, I., Addya, S., Phillips, B., Mee Yong, H., An, S., Penn, R. B. & Rattan, S., Dec 1 2017, In : Scientific Reports. 7, 1, 1477.

Research output: Contribution to journalArticle

Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system

An, S. & Liggett, S. B., Jan 26 2017, (Accepted/In press) In : Cellular Signalling.

Research output: Contribution to journalArticle

Tissue transglutaminase modulates vascular stiffness and function through crosslinking-dependent and crosslinking-independent functions

Steppan, J., Bergman, Y., Viegas, K., Armstrong, D., Tan, S., Wang, H., Melucci, S., Hori, D., Park, S. Y., Barreto, S. F., Isak, A., Jandu, S., Flavahan, N., Butlin, M., An, S., Avolio, A., Berkowitz, D. E., Halushka, M. K. & Santhanam, L., 2017, In : Journal of the American Heart Association. 6, 2, e004161.

Research output: Contribution to journalArticle

TWIST1-WDR5-hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis

Malek, R., Gajula, R. P., Williams, R. D., Nghiem, B., Simons, B. W., Nugent, K., Wang, H., Taparra, K., Lemtiri-Chlieh, G., Yoon, A. R., True, L., An, S., DeWeese, T., Ross, A. E., Schaeffer, E. M., Pienta, K., Hurley, P., Morrissey, C. & Tran, P. T., Jun 15 2017, In : Cancer Research. 77, 12, p. 3181-3193 13 p.

Research output: Contribution to journalArticle

2016

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma

An, S. S., Mitzner, W., Tang, W. Y., Ahn, K., Yoon, A. R., Huang, J., Kilic, O., Yong, H. M., Fahey, J. W., Kumar, S., Biswal, S., Holgate, S. T., Panettieri, R. A., Solway, J. & Liggett, S. B., Jul 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 294-297.e4

Research output: Contribution to journalArticle

Common polygenic variation and risk for childhood-onset schizophrenia

Ahn, K., An, S. S., Shugart, Y. Y. & Rapoport, J. L., Jan 1 2016, In : Molecular psychiatry. 21, 1, p. 94-96 3 p.

Research output: Contribution to journalArticle

Defining an olfactory receptor function in airway smooth muscle cells

Aisenberg, W. H., Huang, J., Zhu, W., Rajkumar, P., Cruz, R., Santhanam, L., Natarajan, N., Yong, H. M., De Santiago, B., Oh, J. J., Yoon, A. R., Panettieri, R. A., Homann, O., Sullivan, J. K., Liggett, S. B., Pluznick, J. L. & An, S. S., Dec 1 2016, In : Scientific reports. 6, 38231.

Research output: Contribution to journalArticle

Directed migration of cancer cells guided by the graded texture of the underlying matrix

Park, J. S., Kim, D. H., Kim, H. N., Wang, C. J., Kwak, M. K., Hur, E., Suh, K. Y., An, S. & Levchenko, A., Jul 1 2016, In : Nature Materials. 15, 7, p. 792-801 10 p.

Research output: Contribution to journalArticle

Germline variants in asporin vary by race, modulate the tumor microenvironment, and are differentially associated with metastatic prostate cancer

Hurley, P. J., Sundi, D., Shinder, B., Simons, B. W., Hughes, R. M., Miller, R. M., Benzon, B., Faraj, S. F., Netto, G. J., Vergara, I. A., Erho, N., Davicioni, E., Karnes, R. J., Yan, G., Ewing, C., Isaacs, S. D., Berman, D. M., Rider, J. R., Jordahl, K. M., Mucci, L. A. & 7 others, Huang, J., An, S. S., Park, B. H., Isaacs, W. B., Marchionni, L., Ross, A. E. & Schaeffer, E. M., Jan 15 2016, In : Clinical Cancer Research. 22, 2, p. 448-458 11 p.

Research output: Contribution to journalArticle

Interdicting Gq activation in airway disease by receptor-dependent and receptor-independent mechanisms

Carr, R., Koziol-White, C., Zhang, J., Lam, H., An, S. S., Tall, G. G., Panettieri, R. A. & Benovic, J. L., Jan 1 2016, In : Molecular Pharmacology. 89, 1, p. 94-104 11 p.

Research output: Contribution to journalArticle

β2-adrenergic receptors chaperone trapped bitter taste receptor 14 to the cell surface as a heterodimer and exert unidirectional desensitization of taste receptor function

Kim, D., Pauer, S. H., Yong, H. M., An, S. & Liggett, S. B., Aug 19 2016, In : Journal of Biological Chemistry. 291, 34, p. 17616-17628 13 p.

Research output: Contribution to journalArticle

2015

Androgen-regulated SPARCL1 in the tumor microenvironment inhibits metastatic progression

Hurley, P. J., Hughes, R. M., Simons, B. W., Huang, J., Miller, R. M., Shinder, B., Haffner, M. C., Esopi, D., Kimura, Y., Jabbari, J., Ross, A. E., Erho, N., Vergara, I. A., Faraj, S. F., Davicioni, E., Netto, G. J., Yegnasubramanian, S., An, S. S. & Schaeffer, E. M., Oct 15 2015, In : Cancer Research. 75, 20, p. 4322-4334 13 p.

Research output: Contribution to journalArticle

COX-2 dependent regulation of mechanotransduction in human breast cancer cells

Yoon, A. R., Stasinopoulos, I., Kim, J. H., Yong, H. M., Kilic, O., Wirtz, D., Bhujwalla, Z. M. & An, S. S., Mar 1 2015, In : Cancer Biology and Therapy. 16, 3, p. 430-437 8 p.

Research output: Contribution to journalArticle

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells

Shiraishi, T., Verdone, J. E., Huang, J., Kahlert, U. D., Hernandez, J. R., Torga, G., Zarif, J. C., Epstein, T., Gatenby, R., McCartney, A., Elisseeff, J. H., Mooney, S. M., An, S. S. & Pienta, K. J., Jan 1 2015, In : Oncotarget. 6, 1, p. 130-143 14 p.

Research output: Contribution to journalArticle

Open Access

Hydrogen Sulfide Signaling in Oxidative Stress and Aging Development

Yang, G., An, S. S., Ji, Y., Zhang, W. & Pei, Y., Jan 1 2015, In : Oxidative medicine and cellular longevity. 2015, 357824.

Research output: Contribution to journalEditorial

LAMC2 enhances the metastatic potential of lung adenocarcinoma

Moon, Y. W., Rao, G., Kim, J. J., Shim, H. S., Park, K. S., An, S. S., Kim, B., Steeg, P. S., Sarfaraz, S., Changwoo Lee, L., Voeller, D., Choi, E. Y., Luo, J., Palmieri, D., Chung, H. C., Kim, J. H., Wang, Y. & Giaccone, G., Aug 7 2015, In : Cell death and differentiation. 22, 8, p. 1341-1352 12 p.

Research output: Contribution to journalArticle

Pleiotropic effects of bitter taste receptors on [Ca2+]i mobilization, hyperpolarization, and relaxation of human airway smooth muscle cells

Camoretti-Mercado, B., Pauer, S. H., Yong, H. M., Smith, D. C., Deshpande, D. A., An, S. S. & Liggett, S. B., Jun 29 2015, In : PloS one. 10, 6, e0131582.

Research output: Contribution to journalArticle

Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility

Aifuwa, I., Giri, A., Longe, N., Lee, S. H., An, S. S. & Wirtz, D., Jan 1 2015, In : Oncotarget. 6, 31, p. 30516-30531 16 p.

Research output: Contribution to journalArticle

Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells

Gajula, R. P., Chettiar, S. T., Williams, R. D., Nugent, K., Kato, Y., Wang, H., Malek, R., Taparra, K., Cades, J., Annadanam, A., Yoon, A. R., Fertig, E., Firulli, B. A., Mazzacurati, L., Burns, T. F., Firulli, A. B., An, S. S. & Tran, P. T., Jan 1 2015, In : Neoplasia. 17, 1, p. 16-31 16 p.

Research output: Contribution to journalArticle

2014

Bitter taste receptor function in asthmatic and nonasthmatic human airway smooth muscle cells

Robinett, K. S., Koziol-White, C. J., Akoluk, A., An, S. S., Panettieri, R. A. & Liggett, S. B., Apr 2014, In : American journal of respiratory cell and molecular biology. 50, 4, p. 678-683 6 p.

Research output: Contribution to journalArticle

H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal KATP channel

Fitzgerald, R., DeSantiago, B., Lee, D. Y., Yang, G., Kim, J. Y., Brian Foster, D., Chan-Li, Y., Horton, M. R., Panettieri, R. A., Wang, R. & An, S. S., Mar 28 2014, In : Biochemical and Biophysical Research Communications. 446, 1, p. 393-398 6 p.

Research output: Contribution to journalArticle

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates

Mattison, J. A., Wang, M., Bernier, M., Zhang, J., Park, S. S., Maudsley, S., An, S. S., Santhanam, L., Martin, B., Faulkner, S., Morrell, C., Baur, J. A., Peshkin, L., Sosnowska, D., Csiszar, A., Herbert, R. L., Tilmont, E. M., Ungvari, Z., Pearson, K. J., Lakatta, E. G. & 1 others, De Cabo, R., Jul 1 2014, In : Cell Metabolism. 20, 1, p. 183-190 8 p.

Research output: Contribution to journalArticle

Spatial control of adult stem cell fate using nanotopographic cues

Ahn, E. H., Kim, Y., Kshitiz, An, S. S., Afzal, J., Lee, S., Kwak, M., Suh, K. Y., Kim, D. H. & Levchenko, A., Mar 1 2014, In : Biomaterials. 35, 8, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle

Wang, W. C. H., Pauer, S. H., Smith, D. C., Dixon, M. A., Disimile, D. J., Panebra, A., An, S. S., Camoretti-Mercado, B. & Liggett, S. B., Nov 15 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 307, 10, p. L775-L780

Research output: Contribution to journalArticle

β-agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent

Morgan, S. J., Deshpande, D. A., Tiegs, B. C., Misior, A. M., Yan, H., Hershfeld, A. V., Rich, T. C., Panettieri, R. A., An, S. S. & Penn, R. B., Aug 15 2014, In : Journal of Biological Chemistry. 289, 33, p. 23065-23074 10 p.

Research output: Contribution to journalArticle

2013

Acquisition of paclitaxel resistance is associated with a more aggressive and invasive phenotype in prostate cancer

Kim, J. J., Yin, B., Christudass, C. S., Terada, N., Rajagopalan, K., Fabry, B., Lee, D. Y., Shiraishi, T., Getzenberg, R. H., Veltri, R. W., An, S. S. & Mooney, S. M., Jun 1 2013, In : Journal of cellular biochemistry. 114, 6, p. 1286-1293 8 p.

Research output: Contribution to journalArticle

Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice

Jung, S. M., Jandu, S., Steppan, J., Belkin, A., An, S. S., Pak, A., Choi, E. Y., Nyhan, D., Butlin, M., Viegas, K., Avolio, A., Berkowitz, D. E. & Santhanam, L., Sep 15 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 6, p. H803-H810

Research output: Contribution to journalArticle

The Twist box domain is required for Twist1-induced prostate cancer metastasis

Gajula, R. P., Chettiar, S. T., Williams, R. D., Thiyagarajan, S., Kato, Y., Aziz, K., Wang, R., Gandhi, N., Wild, A. T., Vesuna, F., Ma, J., Salih, T., Cades, J., Fertig, E., Biswal, S., Burns, T. F., Chung, C. H., Rudin, C. M., Herman, J. M., Hales, R. K. & 3 others, Raman, V., An, S. S. & Tran, P. T., Nov 1 2013, In : Molecular Cancer Research. 11, 11, p. 1387-1400 14 p.

Research output: Contribution to journalArticle

2012

Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation

Garzon-Muvdi, T., Schiapparelli, P., ap Rhys, C., Guerrero-Cazares, H., Smith, C., Kim, D. H., Kone, L., Farber, H., Lee, D. Y., An, S. S., Levchenko, A. & Quiñones-Hinojosa, A., May 1 2012, In : PLoS biology. 10, 5, e1001320.

Research output: Contribution to journalArticle

Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation

An, S. S., Robinett, K. S., Deshpande, D. A., Wang, W. C. H. & Liggett, S. B., May 1 2012, In : Nature medicine. 18, 5, p. 650-651 2 p.

Research output: Contribution to journalLetter

TAS2R activation promotes airway smooth muscle relaxation despite β 2-adrenergic receptor tachyphylaxis

An, S. S., Wang, W. C. H., Koziol-White, C. J., Ahn, K., Lee, D. Y., Kurten, R. C., Panettieri, R. A. & Liggett, S. B., Aug 15 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 303, 4, p. L304-L311

Research output: Contribution to journalArticle

The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH

Saxena, H., Deshpande, D. A., Tiegs, B. C., Yan, H., Battafarano, R. J., Burrows, W. M., Damera, G., Panettieri, R. A., Dubose, T. D., An, S. S. & Penn, R. B., Jun 1 2012, In : British Journal of Pharmacology. 166, 3, p. 981-990 10 p.

Research output: Contribution to journalArticle