Stephen Mathai

Associate Professor

20052019
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Research Output 2005 2019

2019
Open Access
Air Pollution
Pulmonary Hypertension
Lung

Clinical trial design and new therapies for pulmonary arterial hypertension

Sitbon, O., Gomberg-Maitland, M., Granton, J., Lewis, M. I., Mathai, S., Rainisio, M., Stockbridge, N. L., Wilkins, M. R., Zamanian, R. T. & Rubin, L. J., Jan 1 2019, In : The European respiratory journal. 53, 1

Research output: Contribution to journalArticle

Pulmonary Hypertension
Clinical Trials
Advisory Committees
Epidemiologic Studies
Industry

Disconnect between fibrotic response and right ventricular dysfunction

Crnkovic, S., Egemnazarov, B., Damico, R., Marsh, L. M., Nagy, B. M., Douschan, P., Atsina, K., Kolb, T. M., Mathai, S. C., Hooper, J. E., Ghanim, B., Klepetko, W., Fruhwald, F., Lassner, D., Olschewski, A., Olschewski, H., Hassoun, P. M. & Kwapiszewska, G., Jun 15 2019, In : American journal of respiratory and critical care medicine. 199, 12, p. 1550-1560 11 p.

Research output: Contribution to journalArticle

Right Ventricular Dysfunction
Heart Ventricles
Galectin 3
Fibrosis
Pulmonary Hypertension

Identifying patients with pulmonary arterial hypertension using administrative claims algorithms

Mathai, S., Hemnes, A. R., Manaker, S., Anguiano, R. H., Dean, B. B., Saundankar, V., Classi, P., Nelsen, A. C., Gordon, K. & Ventetuolo, C. E., Jan 1 2019, In : Annals of the American Thoracic Society. 16, 7, p. 797-806 10 p.

Research output: Contribution to journalArticle

Open Access
Pulmonary Hypertension
Databases
Delivery of Health Care
Formularies
Costs and Cost Analysis

Oxygen use in chronic heart failure to relieve breathlessness: A systematic review

Asano, R., Mathai, S., Macdonald, P. S., Newton, P. J., Currow, D. C., Phillips, J., Yeung, W. F. & Davidson, P. M., Jan 1 2019, In : Heart Failure Reviews.

Research output: Contribution to journalReview article

Dyspnea
Heart Failure
Oxygen
PubMed
Sample Size

Pulmonary Embolism

Essien, E. O., Rali, P. & Mathai, S., May 1 2019, In : Medical Clinics of North America. 103, 3, p. 549-564 16 p.

Research output: Contribution to journalReview article

Pulmonary Embolism
Venous Thromboembolism
Embolectomy
Equipment and Supplies
Aftercare
Open Access
Systemic Scleroderma
Uric Acid
Pulmonary Hypertension
Survival
Serum

Validation of the REVEAL Prognostic Equation and Risk Score Calculator in Incident Systemic Sclerosis–Associated Pulmonary Arterial Hypertension

on behalf of the PHAROS Investigators, Jan 1 2019, (Accepted/In press) In : Arthritis and Rheumatology.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Systemic Scleroderma
Calibration
Survival
Brain Natriuretic Peptide

Ventricular mass as a prognostic imaging biomarker in incident pulmonary arterial hypertension

Simpson, C. E., Damico, R. L., Kolb, T. M., Mathai, S., Khair, R. M., Sato, T., Bourji, K., Tedford, R. J., Zimmerman, S. & Hassoun, P. M., Apr 1 2019, In : The European respiratory journal. 53, 4

Research output: Contribution to journalLetter

Open Access
Pulmonary Hypertension
Biomarkers
2018

Assessment of right ventricular function in the research setting: Knowledge gaps and pathways forward an official American thoracic society research statement

Lahm, T., Douglas, I. S., Archer, S. L., Bogaard, H. J., Chesler, N. C., Haddad, F., Hemnes, A. R., Kawut, S. M., Kline, J. A., Kolb, T. M., Mathai, S. C., Mercier, O., Michelakis, E. D., Naeije, R., Tuder, R. M., Ventetuolo, C. E., Vieillard-Baron, A., Voelkel, N. F., Vonk-Noordegraaf, A. & Hassoun, P. M., Aug 15 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 4, p. e15-e43

Research output: Contribution to journalReview article

Right Ventricular Function
Thorax
Research
Pulmonary Circulation
Patient Rights

Breathing (and Coding?) a Bit Easier: Changes to International Classification of Disease Coding for Pulmonary Hypertension

Mathai, S. & Mathew, S., Jul 1 2018, In : Chest. 154, 1, p. 207-218 12 p.

Research output: Contribution to journalReview article

International Classification of Diseases
Pulmonary Hypertension
Respiration
Health Personnel
Delivery of Health Care

Challenges in pulmonary hypertension: Controversies in treating the tip of the iceberg a joint national institutes of health clinical center and pulmonary hypertension association symposium report

Elinoff, J. M., Agarwal, R., Barnett, C. F., Benza, R. L., Cuttica, M. J., Gharib, A. M., Gray, M. P., Hassoun, P. M., Hemnes, A. R., Humbert, M., Kolb, T. M., Lahm, T., Leopold, J. A., Mathai, S., McLaughlin, V. V., Preston, I. R., Rosenzweig, E. B., Shlobin, O. A., Steen, V. D., Zamanian, R. T. & 1 others, Solomon, M. A., Jul 15 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 2, p. 166-174 9 p.

Research output: Contribution to journalReview article

National Institutes of Health (U.S.)
Pulmonary Hypertension
Joints

Clinical phenotypes and survival of precapillary pulmonary hypertension in systemic sclerosis

Launay, D., Montani, D., Hassoun, P. M., Cottin, V., Le Pavec, J., Clerson, P., Sitbon, O., Jaïs, X., Savale, L., Weatherald, J., Sobanski, V., Mathai, S., Shafiq, M., Cordier, J. F., Hachulla, E., Simonneau, G. & Humbert, M., May 1 2018, In : PLoS One. 13, 5, e0197112.

Research output: Contribution to journalArticle

Systemic Scleroderma
Cluster analysis
sclerosis
Pulmonary Hypertension
hypertension

Improvement in right ventricular strain with ambrisentan and tadalafil upfront therapy in scleroderma-associated pulmonary arterial hypertension

Mercurio, V., Mukherjee, M., Tedford, R. J., Zamanian, R. T., Khair, R. M., Sato, T., Minai, O. A., Torres, F., Girgis, R. E., Chin, K., Damico, R. L., Kolb, T. M., Mathai, S. & Hassoun, P. M., Feb 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 3, p. 388-391 4 p.

Research output: Contribution to journalLetter

Pulmonary Hypertension
Therapeutics
ambrisentan
Tadalafil

Precision medicine in pulmonary hypertension: Start with the end (point)

Mathai, S., Apr 15 2018, In : International Journal of Cardiology. 257, p. 339-340 2 p.

Research output: Contribution to journalEditorial

Precision Medicine
Pulmonary Hypertension
Clinical Trials

Pulmonary arterial hypertension and atrial arrhythmias: incidence, risk factors, and clinical impact

Mercurio, V., Peloquin, G., Bourji, K. I., Diab, N., Sato, T., Enobun, B., Housten-Harris, T., Damico, R. L., Kolb, T. M., Mathai, S., Tedford, R. J., Tocchetti, C. G. & Hassoun, P. M., Apr 1 2018, In : Pulmonary Circulation. 8, 2

Research output: Contribution to journalArticle

Pulmonary Hypertension
Cardiac Arrhythmias
Systemic Scleroderma
Incidence
Mortality

Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease

Tampakakis, E., Shah, S. J., Borlaug, B. A., Leary, P. J., Patel, H. H., Miller, W. L., Kelemen, B. W., Houston, B. A., Kolb, T. M., Damico, R. L., Mathai, S., Kasper, E. K., Hassoun, P. M., Kass, D. A. & Tedford, R. J., Apr 1 2018, In : Circulation: Heart Failure. 11, 4, e004436.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Heart Diseases
Lung
Lung Compliance
Vascular Resistance

Rare loss of function variants in candidate genes and risk of colorectal cancer

NHLBI GO Exome Sequencing Project, Pulmonary Arterial Hypertension (PAH), Severe Asthma Research Program (SARP), Women’s Health Initiative (WHI), Anthropometry Project Team, Blood Count/Hematology Project Team, Blood Pressure Project Team, Data Flow Working Group, Early MI Project Team, ELSI Working Group, Executive Committee, Family Study Project Team, Lipids Project Team, Lung Project Team, Personal Genomics Project Team, Phenotype and Harmonization Working Group, Population Genetics and Statistical Analysis Working Group, Publications and Presentations Working Group, Quantitative Analysis Ad Hoc Task Group, Sequencing and Genotyping Working Group & 15 others, Steering Committee, Stroke Project Team, Structural Variation Working Group, Subclinical/Quantitative Project Team, Acute Lung Injury (ALI), Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Chronic Obstructive Pulmonary Disease (COPDGene), Coronary Artery Risk Development in Young Adults (CARDIA), Cystic Fibrosis (CF), Early Pseudomonas Infection Control (EPIC), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Lung Health Study (LHS) & Multi-Ethnic Study of Atherosclerosis (MESA), Oct 1 2018, In : Human Genetics. 137, 10, p. 795-806 12 p.

Research output: Contribution to journalArticle

Polyps
Colorectal Neoplasms
Genes
Penetrance
Genetic Testing

Right ventricular myofilament functional differences in humans with systemic sclerosis-associated versus idiopathic pulmonary arterial hypertension

Hsu, S., Kokkonen-Simon, K. M., Kirk, J. A., Kolb, T. M., Damico, R. L., Mathai, S., Mukherjee, M., Shah, A., Wigley, F., Margulies, K. B., Hassoun, P. M., Halushka, M. K., Tedford, R. J. & Kass, D. A., Jan 1 2018, In : Circulation. 137, 22, p. 2360-2370 11 p.

Research output: Contribution to journalArticle

Myofibrils
Systemic Scleroderma
Pulmonary Hypertension
Muscle Cells
Calcium
Pulmonary Hypertension

The Growing Burden of Pulmonary Hypertension in the Modern Era: A Zebra No More?

Mathai, S. & Ryan, J. J., Feb 1 2018, In : Circulation: Cardiovascular Quality and Outcomes. 11, 2, e004536.

Research output: Contribution to journalEditorial

Equidae
Pulmonary Hypertension

The impact of ambrisentan and tadalafil upfront combination therapy on cardiac function in scleroderma associated pulmonary arterial hypertension patients: cardiac magnetic resonance feature tracking study

Sato, T., Ambale Venkatesh, B., Lima, J., Zimmerman, S., Tedford, R. J., Fujii, T., Hulme, O. L., Pullins, E. H., Corona Villalobos, C., Zamanian, R. T., Minai, O. A., Girgis, R. E., Chin, K., Khair, R., Damico, R. L., Kolb, T. M., Mathai, S. & Hassoun, P. M., Feb 1 2018, In : Pulmonary Circulation. 8, 1

Research output: Contribution to journalArticle

Pulmonary Hypertension
Right Ventricular Function
Magnetic Resonance Spectroscopy
Left Ventricular Function
Systemic Scleroderma
2017

A multi-center study to improve understanding of pulmonary vascular disease through phenomics

Hemnes, A. R., Beck, G. J., Newman, J. H., Abidov, A., Aldred, M. A., Barnard, J., Rosenzweig, E. B., Borlaug, B. A., Chung, W. K., Comhair, S. A. A., Erzurum, S. C., Frantz, R. P., Gray, M. P., Grunig, G., Hassoun, P. M., Hill, N. S., Horn, E. M., Hu, B., Lempel, J. K., Maron, B. A. & 9 others, Mathai, S., Olman, M. A., Rischard, F. P., Systrom, D. M., Tang, W. H. W., Waxman, A. B., Xiao, L., Yuan, J. X. J. & Leopold, J. A., Jan 1 2017, In : Circulation Research. 121, 10, p. 1136-1139 4 p.

Research output: Contribution to journalArticle

Vascular Diseases
Lung Diseases
Pulmonary Hypertension
National Heart, Lung, and Blood Institute (U.S.)
National Institutes of Health (U.S.)
Health care
Pulmonary Hypertension
Drug therapy
Clinical Trials
Standardization

Enhancing insights into pulmonary vascular disease through a precision medicine approach: A joint nhlbi-cardiovascular medical research and education fund workshop report

Newman, J. H., Rich, S., Abman, S. H., Alexander, J. H., Barnard, J., Beck, G. J., Benza, R. L., Bull, T. M., Chan, S. Y., Chun, H. J., Doogan, D., Dupuis, J., Erzurum, S. C., Frantz, R. P., Geraci, M., Gillies, H., Gladwin, M., Gray, M. P., Hemnes, A. R., Herbst, R. S. & 27 others, Hernandez, A. F., Hill, N. S., Horn, E. M., Hunter, K., Jing, Z. C., Johns, R. A., Kaul, S., Kawut, S. M., Lahm, T., Leopold, J. A., Lewis, G. D., Mathai, S., McLaughlin, V. V., Michelakis, E. D., Nathan, S. D., Nichols, W., Page, G., Rabinovitch, M., Rich, J., Rischard, F., Rounds, S., Shah, S. J., Tapson, V. F., Lowy, N., Stockbridge, N., Weinmann, G. & Xiao, L., Jun 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 12, p. 1661-1670 10 p.

Research output: Contribution to journalArticle

Precision Medicine
Financial Management
Medical Education
Vascular Diseases
Lung Diseases

Evaluation of criteria for exerciseinduced pulmonary hypertension in patients with resting pulmonary hypertension

Mullin, C. J., Hsu, S., Amancherla, K., Wand, A., Rhodes, P., Leary, P. J., Mukherjee, M., Damico, R. L., Kolb, T. M., Mathai, S., Hassoun, P. M. & Tedford, R. J., Sep 1 2017, In : European Respiratory Journal. 50, 3, 00784.

Research output: Contribution to journalLetter

Pulmonary Hypertension

Follow-up tricuspid annular plane systolic excursion predicts survival in pulmonary arterial hypertension

Mazurek, J. A., Vaidya, A., Mathai, S., Roberts, J. D. & Forfia, P. R., 2017, In : Pulmonary Circulation. 7, 2, p. 361-371 11 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Survival
Cardiac Catheterization
Proportional Hazards Models
Echocardiography

Health disparities in patients with pulmonary arterial hypertension: A blueprint for action: An official American thoracic society statement

Talwar, A., Garcia, J. G. N., Tsai, H., Moreno, M., Lahm, T., Zamanian, R. T., Machado, R., Kawut, S. M., Selej, M., Mathai, S., D'Anna, L. H., Sahni, S., Rodriquez, E. J., Channick, R., Fagan, K., Gray, M., Armstrong, J., Lopez, J. R. & De Jesus Perez, V., Oct 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 8, p. e32-e47

Research output: Contribution to journalArticle

Pulmonary Hypertension
Thorax
Health
Research
Medical Subject Headings

Magnetic resonance imaging in pulmonary arterial hypertension

Mathai, S. & Kawut, S. M., Jul 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 2, p. 129-131 3 p.

Research output: Contribution to journalEditorial

Pulmonary Hypertension
Magnetic Resonance Imaging

New insights into the recognition, classification and management of systemic sclerosis-associated pulmonary hypertension

Mullin, C. J. & Mathai, S., Nov 1 2017, In : Current Opinion in Rheumatology. 29, 6, p. 561-567 7 p.

Research output: Contribution to journalReview article

Systemic Scleroderma
Pulmonary Hypertension
Therapeutics
Vasodilator Agents
Vascular Diseases

Poor survival in patients with scleroderma and pulmonary hypertension due to heart failure with preserved ejection fraction

Bourji, K. I., Kelemen, B. W., Mathai, S., Damico, R. L., Kolb, T. M., Mercurio, V., Cozzi, F., Tedford, R. J. & Hassoun, P. M., 2017, In : Pulmonary Circulation. 7, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Pulmonary Hypertension
Heart Failure
Survival
Cardiac Catheterization
Systemic Scleroderma
Familial Primary Pulmonary Hypertension

The authors reply

Metkus, T., Mathai, S. & Tedford, R. J., Aug 1 2017, In : Critical Care Medicine. 45, 8, p. e874-e875

Research output: Contribution to journalLetter

Use of thermodilution cardiac output overestimates diagnoses of exercise-induced pulmonary hypertension

Hsu, S., Brusca, S. B., Rhodes, P. S., Kolb, T. M., Mathai, S. & Tedford, R. J., Jan 1 2017, In : Pulmonary Circulation. 7, 1, p. 253-255 3 p.

Research output: Contribution to journalLetter

Thermodilution
Pulmonary Hypertension
Cardiac Output
Exercise
2016

An observational study of inhaled-treprostinil respiratory-related safety in patients with pulmonary arterial hypertension

Zamanian, R. T., Levine, D. J., Bourge, R. C., De Souza, S. A., Rosenzweig, E. B., Alnuaimat, H., Burger, C., Mathai, S., Leedom, N., DeAngelis, K., Lim, A. & De Marco, T., Sep 1 2016, In : Pulmonary Circulation. 6, 3, p. 329-337 9 p.

Research output: Contribution to journalArticle

Patient Safety
Pulmonary Hypertension
Observational Studies
United States Food and Drug Administration
Therapeutics

Association between Initial Oral Therapy and Outcomes in Systemic Sclerosis-Related Pulmonary Arterial Hypertension

Lammi, M. R., Mathai, S., Saketkoo, L. A., Domsic, R. T., Bojanowski, C., Furst, D. E. & Steen, V. D., Mar 1 2016, In : Arthritis and Rheumatology. 68, 3, p. 740-748 9 p.

Research output: Contribution to journalArticle

Phosphodiesterase 5 Inhibitors
Systemic Scleroderma
Pulmonary Hypertension
Therapeutics
Endothelin Receptor Antagonists

Beast of pulmonary arterial hypertension burden

Mathai, S. & McLaughlin, V. V., Dec 1 2016, In : JAMA Cardiology. 1, 9, p. 1030-1031 2 p.

Research output: Contribution to journalComment/debate

Pulmonary Hypertension

Exhaled nitric oxide in pulmonary arterial hypertension associated with systemic sclerosis

Cao, Z., Mathai, S., Hummers, L., Shah, A., Wigley, F., Lechtzin, N., Hassoun, P. M. & Girgis, R. E., Dec 1 2016, In : Pulmonary Circulation. 6, 4, p. 545-550 6 p.

Research output: Contribution to journalArticle

Systemic Scleroderma
Pulmonary Hypertension
Nitric Oxide
Healthy Volunteers
Lung

Health-related quality of life and survival in pulmonary arterial hypertension

Mathai, S., Suber, T., Khair, R. M., Kolb, T. M., Damico, R. L. & Hassoun, P. M., Jan 1 2016, In : Annals of the American Thoracic Society. 13, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Quality of Life
Survival
Proportional Hazards Models
Hemodynamics

Heart rate dependence of the pulmonary resistance x compliance (rc) time and impact on right ventricular load

Metkus, T., Mullin, C. J., Grandin, E. W., Rame, J. E., Tampakakis, E., Hsu, S., Kolb, T. M., Damico, R. L., Hassoun, P. M., Kass, D. A., Mathai, S. & Tedford, R. J., Nov 1 2016, In : PLoS One. 11, 11, e0166463.

Research output: Contribution to journalArticle

compliance
Compliance
heart rate
Heart Rate
lungs

Identification of Rare Variants in ATP8B4 as a Risk Factor for Systemic Sclerosis by Whole-Exome Sequencing

Gao, L., Emond, M. J., Louie, T., Cheadle, C., Berger, A. E., Rafaels, N., Vergara, C., Kim, Y., Taub, M. A., Ruczinski, I., Mathai, S., Rich, S. S., Nickerson, D. A., Hummers, L., Bamshad, M. J., Hassoun, P. M., Mathias, R. & Barnes, K. C., Jan 1 2016, In : Arthritis and Rheumatology. 68, 1, p. 191-200 10 p.

Research output: Contribution to journalArticle

Exome
Systemic Scleroderma
Pulmonary Hypertension
Odds Ratio
Ubiquitin-Protein Ligase Complexes

Lung transplantation in scleroderma time for the pendulum to swing?

Eberlein, M. & Mathai, S., Jun 1 2016, In : Annals of the American Thoracic Society. 13, 6, p. 767-769 3 p.

Research output: Contribution to journalEditorial

Management of interstitial lung disease associated with connective tissue disease

Mathai, S. & Danoff, S., Feb 24 2016, In : BMJ (Online). 352, h6819.

Research output: Contribution to journalArticle

Connective Tissue Diseases
Interstitial Lung Diseases
Pulmonary Hypertension
Lung
Therapeutics

Management of the scleroderma patient with pulmonary arterial hypertension failing initial therapy

Mullin, C. J. & Mathai, S., Jan 1 2016, Scleroderma: From Pathogenesis to Comprehensive Management. Springer International Publishing, p. 691-700 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pulmonary Hypertension
Systemic Scleroderma
Therapeutics
Proxy
Cause of Death

Prognostic significance of biomarkers in pulmonary arterial hypertension

Al-Naamani, N., Palevsky, H. I., Lederer, D. J., Horn, E. M., Mathai, S., Roberts, K. E., Tracy, R. P., Hassoun, P. M., Girgis, R. E., Shimbo, D., Post, W. S. & Kawut, S. M., Jan 1 2016, In : Annals of the American Thoracic Society. 13, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Biomarkers
Thromboxane B2
von Willebrand Factor
HDL Cholesterol
Lung Compliance
Adult Respiratory Distress Syndrome
Catheters
Vascular Resistance
Survivors

Quality of life in patients with chronic thromboembolic pulmonary hypertension

Mathai, S., Ghofrani, H. A., Mayer, E., Pepke-Zaba, J., Nikkho, S. & Simonneau, G., Aug 1 2016, In : European Respiratory Journal. 48, 2, p. 526-537 12 p.

Research output: Contribution to journalReview article

Pulmonary Hypertension
Quality of Life
Therapeutics
Randomized Controlled Trials
Psychology

Rationale and study design of MOTION: A phase 4, prospective, single-arm, open-label study to measure outcomes in patients with pulmonary arterial hypertension not on active treatment

Mathai, S., Minai, O., Sullivan, S. D., Lerner, D. & Levine, D., Jun 8 2016, (Accepted/In press) In : Respiratory Medicine.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Outcome Assessment (Health Care)
Walking
Quality of Life
Therapeutics

Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension

Hsu, S., Houston, B. A., Tampakakis, E., Bacher, A. C., Rhodes, P. S., Mathai, S., Damico, R. L., Kolb, T. M., Hummers, L., Shah, A., McMahan, Z., Corona Villalobos, C., Zimmerman, S., Wigley, F., Hassoun, P. M., Kass, D. A. & Tedford, R. J., May 12 2016, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Ergometry
Right Ventricular Function
Systemic Scleroderma
Recycling