Stephen J Gould

Professor

1986 …2019
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Research Output 1986 2019

2019

Exosomes

Pegtel, D. M. & Gould, S. J., Jun 20 2019, In : Annual review of biochemistry. 88, p. 487-514 28 p.

Research output: Contribution to journalArticle

Exosomes
Membranes
Tissue homeostasis
Neurodegenerative diseases
Proteins

The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

The Extracellular RNA Communication Consortium, Apr 4 2019, In : Cell. 177, 2, p. 231-242 12 p.

Research output: Contribution to journalReview article

RNA
Technology
Communication
Research
Biomarkers
2018

Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop

Li, K., Rodosthenous, R. S., Kashanchi, F., Gingeras, T., Gould, S. J., Kuo, L. S., Kurre, P., Lee, H., Leonard, J. N., Liu, H., Lombo, T. B., Momma, S., Nolan, J. P., Ochocinska, M. J., Pegtel, D. M., Sadovsky, Y., Sánchez-Madrid, F., Valdes, K. M., Vickers, K. C., Weaver, A. M. & 5 others, Witwer, K. W., Zeng, Y., Das, S., Raffai, R. L. & Howcroft, T. K., Apr 5 2018, In : JCI insight. 3, 7

Research output: Contribution to journalReview article

Open Access
RNA
Education
Research
RNA Transport
Transducers
2017

Cell biology: Organelle formation from scratch

Hettema, E. H. & Gould, S. J., Feb 9 2017, In : Nature. 542, 7640, p. 174-175 2 p.

Research output: Contribution to journalShort survey

cells and cell components
mitochondrion
Organelles
gene expression
enzyme activity
2016

Extending gene ontology in the context of extracellular RNA and vesicle communication

Cheung, K. H., Keerthikumar, S., Roncaglia, P., Subramanian, S. L., Roth, M. E., Samuel, M., Anand, S., Gangoda, L., Gould, S. J., Alexander, R., Galas, D., Gerstein, M. B., Hill, A. F., Kitchen, R. R., Lötvall, J., Patel, T., Procaccini, D. C., Quesenberry, P., Rozowsky, J., Raffai, R. L. & 8 others, Shypitsyna, A., Su, A. I., Théry, C., Vickers, K., Wauben, M. H. M., Mathivanan, S., Milosavljevic, A. & Laurent, L. C., Apr 12 2016, In : Journal of Biomedical Semantics. 7, 1, 19.

Research output: Contribution to journalArticle

Gene Ontology
RNA
Ontology
Genes
Communication

Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model

Li, L., Piontek, K., Ishida, M., Fausther, M., Dranoff, J. A., Fu, R., Mezey, E., Gould, S. J., Fordjour, F. K., Meltzer, S., Sirica, A. E. & Selaru, F., 2016, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Cholangiocarcinoma
MicroRNAs
Survival
Neoplasms
Fibroblasts
2015

Meeting report: Discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium

Laurent, L. C., Abdel-Mageed, A. B., David Adelson, P., Arango, J., Balaj, L., Breakefield, X., Carlson, E., Carter, B. S., Majem, B., Chen, C. C., Cocucci, E., Danielson, K., Courtright, A., Das, S., Elmageed, Z. Y. A., Enderle, D., Ezrin, A., Ferrer, M., Freedman, J., Galas, D. & 30 others, Gandhi, R., Huentelman, M. J., Van Keuren-Jensen, K., Kalani, Y., Kim, Y., Krichevsky, A. M., Lai, C., Lal-Nag, M., Laurent, C. D., Leonardo, T., Li, F., Malenica, I., Mondal, D., Nejad, P., Patel, T., Raffai, R. L., Rubio, R., Skog, J., Spetzler, R., Sun, J., Tanriverdi, K., Vickers, K., Wang, L., Wang, Y., Wei, Z., Weiner, H. L., Wong, D., Yan, I. K., Yeri, A. & Gould, S. J., 2015, In : Journal of Extracellular Vesicles. 4, 1, 26533.

Research output: Contribution to journalArticle

RNA
Ribonucleoproteins
National Institutes of Health (U.S.)
Lipoproteins
Biomarkers
2013

As we wait: Coping with an imperfect nomenclature for extracellular vesicles

Gould, S. J. & Raposo, G., 2013, In : Journal of Extracellular Vesicles. 2, 1, 20389.

Research output: Contribution to journalLetter

Terminology
Extracellular Vesicles

Exosomes and Microvesicles

Gould, S. J., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 262-264 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Exosomes
Cell membranes
Proteins
Cell Membrane
Multivesicular Bodies

Peroxisomal Metabolism

Gould, S. J., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 413-417 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolism
Peroxisomes
Fatty Acids
Oxidation
Ether

The cis-acting signals that target proteins to exosomes and microvesicles

Yang, J-M. & Gould, S. J., Feb 2013, In : Biochemical Society Transactions. 41, 1, p. 277-282 6 p.

Research output: Contribution to journalArticle

Exosomes
Proteins
Cell Polarity
Quality Control
Organelles
2012

HIV Pol inhibits HIV budding and mediates the severe budding defect of Gag-Pol

Gan, X. & Gould, S. J., Jan 3 2012, In : PLoS One. 7, 1, e29421.

Research output: Contribution to journalArticle

gag Gene Products
HIV
exosomes
Viruses
viruses
2011

Biogenesis of the posterior pole is mediated by the exosome/microvesicle protein-sorting pathway

Shen, B., Fang, Y., Wu, N. & Gould, S. J., Dec 23 2011, In : Journal of Biological Chemistry. 286, 51, p. 44162-44176 15 p.

Research output: Contribution to journalArticle

Exosomes
Protein Transport
Sorting
Poles
Proteins
Exosomes
Virion
HIV
Endosomal Sorting Complexes Required for Transport
Virus Release

Protein targeting to exosomes/microvesicles by plasma membrane anchors

Shen, B., Wu, N., Yang, J-M. & Gould, S. J., Apr 22 2011, In : Journal of Biological Chemistry. 286, 16, p. 14383-14395 13 p.

Research output: Contribution to journalArticle

Exosomes
Protein Transport
Cell membranes
Anchors
Cell Membrane
2009

Oleate β-oxidation in yeast involves thioesterase but not Yor180c protein that is not a dienoyl-CoA isomerase

Ntamack, A. G., Karpichev, I. V., Gould, S. J., Small, G. M. & Schulz, H., May 2009, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1791, 5, p. 371-378 8 p.

Research output: Contribution to journalArticle

Isomerases
Coenzyme A
Oleic Acid
Yeasts
Palmitic Acid
2007

Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes.

Fang, Y., Wu, N., Gan, X., Yan, W., Morrell, J. C. & Gould, S. J., Jun 2007, In : PLoS Biology. 5, 6

Research output: Contribution to journalArticle

exosomes
Exosomes
Oligomerization
Cell membranes
Sorting
2006

Assay and functional analysis of dynamin-like protein 1 in peroxisome division

Schrader, M. & Gould, S. J., 2006, In : Methods in Enzymology. 404, p. 586-597 12 p., 51.

Research output: Contribution to journalArticle

Dynamins
Functional analysis
Peroxisomes
Assays
Yeast

Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane

Booth, A. M., Fang, Y., Fallon, J. K., Yang, J-M., Hildreth, J. E. K., Gould, S. J., Sandefur, S. & Varthakavi, V., Mar 13 2006, In : Journal of Cell Biology. 172, 6, p. 923-935 13 p.

Research output: Contribution to journalArticle

Exosomes
Endosomes
Cell Membrane
HIV
T-Lymphocytes
2005

Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis

Weller, S., Cajigas, I., Morrell, J., Obie, C., Steel, G., Gould, S. J. & Valle, D., Jun 2005, In : American Journal of Human Genetics. 76, 6, p. 987-1007 21 p.

Research output: Contribution to journalArticle

Peroxisomes
Alternative Splicing
Membrane Proteins
Proteins
Mitochondria

Detecting patterns of protein distribution and gene expression in silico.

Bassett, D., Morrell, J. C., Gatto, G. J., Bai, J., Geisbrecht, B. V., Hieter, P. & Gould, S. J., Jan 11 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 2, p. 516 1 p.

Research output: Contribution to journalArticle

Computer Simulation
Gene Expression
Proteins

Erratum: Molecular characterization of Saccharomyces cerevisiae Δ3,Δ2-enoyl-CoA isomerase (The Journal of Biological Chemistry (1998) 273 (33184-33191))

Geisbrecht, B. V., Zhu, D., Schulz, K., Nau, K., Morrell, J. C., Geraghty, M., Schulz, H., Erdmann, R. & Gould, S. J., Apr 1 2005, In : Journal of Biological Chemistry. 280, 13, p. 13203 1 p.

Research output: Contribution to journalArticle

Dodecenoyl-CoA Isomerase
Saccharomyces cerevisiae
Computer Simulation
Gene Expression
Proteins

PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins

Jones, J. M., Morrell, J. C. & Gould, S. J., Jan 2004, In : Journal of Cell Biology. 164, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

Membrane Proteins
Protein Transport
Cytosol
Cytoplasm
Proteins

PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins

Fang, Y., Morrell, J. C., Jones, J. M. & Gould, S. J., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 863-875 13 p.

Research output: Contribution to journalArticle

Peroxisomes
Membrane Proteins
Membranes
Organelles
Cytoplasm

The evolution of alloimmunity and the genesis of adaptive immunity

Gould, S. J., Hildreth, J. E. K. & Booth, A. M., Dec 2004, In : Quarterly Review of Biology. 79, 4, p. 359-382 24 p.

Research output: Contribution to journalArticle

Histocompatibility
Adaptive Immunity
Retroviridae
pathogens
antigens
2003

Correlating structure and affinity for PEX5: PTS1 complexes

Gatto, G. J., Maynard, E. L., Guerrerio, A. L., Geisbrecht, B. V., Gould, S. J. & Berg, J. M., Feb 18 2003, In : Biochemistry®. 42, 6, p. 1660-1666 7 p.

Research output: Contribution to journalArticle

seryl-lysyl-leucine
Peroxisomes
Assays
Peptides
Consensus Sequence

Evidence That HIV Budding in Primary Macrophages Occurs through the Exosome Release Pathway

Nguyen, D. G., Booth, A., Gould, S. J. & Hildreth, J. E. K., Dec 26 2003, In : Journal of Biological Chemistry. 278, 52, p. 52347-52354 8 p.

Research output: Contribution to journalArticle

Exosomes
Virus Release
Macrophages
Viruses
HIV

Peroxisome Biogenesis Disorders

Weller, S., Gould, S. J. & Valle, D., 2003, In : Annual Review of Genomics and Human Genetics. 4, p. 165-211 47 p.

Research output: Contribution to journalArticle

Genes
Availability
Phenotype
Peroxisomes
Homeostasis

PEX5 binds the PTS1 independently of Hsp70 and the peroxin PEX12

Harper, C. C., Berg, J. M. & Gould, S. J., Mar 7 2003, In : Journal of Biological Chemistry. 278, 10, p. 7897-7901 5 p.

Research output: Contribution to journalArticle

Peroxisomes
Proteins
Enzymes
Peptides
Kinetics

The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11

Li, X. & Gould, S. J., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 17012-17020 9 p.

Research output: Contribution to journalArticle

Dynamins
Peroxisomes
GTP Phosphohydrolases
Yeast
Membranes

The Trojan exosome hypothesis

Gould, S. J., Booth, A. M. & Hildreth, J. E. K., Sep 16 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 19, p. 10592-10597 6 p.

Research output: Contribution to journalArticle

Exosomes
Retroviridae
Vaccines
Histocompatibility Antigens Class II
Adaptive Immunity
2002

Erratum: Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5 (Nature Structural Biology (2002) 7 (1091-1095))

Gatto, G. J., Geisbrecht, B. V., Gould, S. J. & Berg, J. M., Oct 2002, In : Nature Structural Biology. 9, 10, p. 788 1 p.

Research output: Contribution to journalArticle

Functional characterization of Δ3,Δ2-enoyl-CoA isomerases from rat liver

Zhang, D., Yu, W., Geisbrecht, B. V., Gould, S. J., Sprecher, H. & Schulz, H., Mar 15 2002, In : Journal of Biological Chemistry. 277, 11, p. 9127-9132 6 p.

Research output: Contribution to journalArticle

Dodecenoyl-CoA Isomerase
Liver
Rats
Isomerization
Multifunctional Enzymes

Peroxisomal membrane protein import does not require Pex17p

Harper, C. C., South, S. T., Michael McCaffery, J. & Gould, S. J., May 10 2002, In : Journal of Biological Chemistry. 277, 19, p. 16498-16504 7 p.

Research output: Contribution to journalArticle

Membrane Proteins
Defects
Peroxisomes
Pichia
Protein Stability

Peroxisomal-protein import: Is it really that complex?

Gould, S. J. & Collins, C. S., 2002, In : Nature Reviews Molecular Cell Biology. 3, 5, p. 382-389 8 p.

Research output: Contribution to journalArticle

Peroxisomes
Enzymes
Proteins
Membranes
Organelles

PEX11 promotes peroxisome division independently of peroxisome metabolism

Li, X. & Gould, S. J., Feb 18 2002, In : Journal of Cell Biology. 156, 4, p. 643-651 9 p.

Research output: Contribution to journalArticle

Peroxisomes
Fatty Acids
Proteins
Metabolic Networks and Pathways
Ether

PEX11α is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation

Li, X., Baumgart, E., Dong, G. X., Morrell, J. C., Jimenez-Sanchez, G., Valle, D., Smith, K. D. & Gould, S. J., Dec 2002, In : Molecular and Cellular Biology. 22, 23, p. 8226-8240 15 p.

Research output: Contribution to journalArticle

PPAR alpha
Peroxisomes
4-phenylbutyric acid
Genes
Eukaryota

PEX11β deficiency is lethal and impairs neuronal migration but does not abrogate peroxisome function

Li, X., Baumgart, E., Morrell, J. C., Jimenez-Sanchez, G., Valle, D. & Gould, S. J., 2002, In : Molecular and Cellular Biology. 22, 12, p. 4358-4365 8 p.

Research output: Contribution to journalArticle

Zellweger Syndrome
Peroxisomes
Muscle Hypotonia
Phenotype
Nervous System Diseases

Visualization and purification of yeast peroxisomes

Erdmann, R. & Gould, S. J., 2002, In : Methods in Enzymology. 351, p. 365-381 17 p.

Research output: Contribution to journalArticle

Peroxisomes
Yeasts
2001

Domain Mapping of Human PEX5 Reveals Functional and Structural Similarities to Saccharomyces cerevisiae Pex18p and Pex21p

Dodt, G., Warren, D., Becker, E., Rehling, P. & Gould, S. J., Nov 9 2001, In : Journal of Biological Chemistry. 276, 45, p. 41769-41781 13 p.

Research output: Contribution to journalArticle

Yeast
Saccharomyces cerevisiae
Yeasts
Amino Acids
Cells

Identification of the α-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene

Praphanphoj, V., Sacksteder, K. A., Gould, S. J., Thomas, G. H. & Geraghty, M. T., 2001, In : Molecular Genetics and Metabolism. 72, 4, p. 336-342 7 p.

Research output: Contribution to journalArticle

Yeast
Oxidoreductases
Genes
Yeasts
Complementary DNA
Peroxisomes
Protein Transport
Endoplasmic Reticulum
Membrane Proteins
Organelles

Malonyl CoA decarboxylase deficiency: C to T transition in intron 2 of the MCD gene

Surendran, S., Sacksteder, K. A., Gould, S. J., Coldwell, J. G., Rady, P. L., Tyring, S. K. & Matalon, R., Sep 15 2001, In : Journal of Neuroscience Research. 65, 6, p. 591-594 4 p.

Research output: Contribution to journalArticle

malonyl-CoA decarboxylase
Introns
Exons
Genes
Cardiomyopathies

Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line

Habinowski, S. A., Hirshman, M., Sakamoto, K., Kemp, B. E., Gould, S. J., Goodyear, L. J. & Witters, L. A., Dec 1 2001, In : Archives of Biochemistry and Biophysics. 396, 1, p. 71-79 9 p.

Research output: Contribution to journalArticle

malonyl-CoA decarboxylase
AMP-Activated Protein Kinases
Islets of Langerhans
Muscle
Rats

Multiple distinct targeting signals in integral peroxisomal membrane proteins

Jones, J. M., Morrell, J. C. & Gould, S. J., Jun 11 2001, In : Journal of Cell Biology. 153, 6, p. 1141-1149 9 p.

Research output: Contribution to journalArticle

Membrane Proteins
Peroxisomes
Protein Transport
Membranes
Proteins
Peroxisomes
Genes
Proteins
Liver
Metabolic Diseases
2000

A proposed model for the PEX5-peroxisomal targeting signal-1 recognition complex

Gatto, G. J., Geisbrecht, B. V., Gould, S. J. & Berg, J. M., Feb 15 2000, In : Proteins. 38, 3, p. 241-246 6 p.

Research output: Contribution to journalArticle

Ligands
Peptides
Asparagine
Proteins
Atoms

Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases

Jones, J. M., Morrell, J. C. & Gould, S. J., Apr 28 2000, In : Journal of Biological Chemistry. 275, 17, p. 12590-12597 8 p.

Research output: Contribution to journalArticle

Hydroxy Acids
Oxidoreductases
Liver
Fatty Acids
glycolic acid