Stephen Desiderio

Professor

1978 …2019

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Research Output

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53BP1 is limiting for NHEJ repair in ATM-deficient model systems that are subjected to oncogenic stress or radiation

Rybanska-Spaeder, I., Reynolds, T. L., Chou, J., Prakash, M., Jefferson, T., Huso, D. L., Desiderio, S. & Franco, S., Oct 2013, In : Molecular Cancer Research. 11, 10, p. 1223-1234 12 p.

Research output: Contribution to journalArticle

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

Li, Z., Dordai, D. I., Lee, J. & Desiderio, S., Dec 1996, In : Immunity. 5, 6, p. 575-589 15 p.

Research output: Contribution to journalArticle

Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry

Caraveo, G., Van Rossum, D. B., Patterson, R. L., Snyder, S. H. & Desiderio, S., Oct 6 2006, In : Science. 314, 5796, p. 122-125 4 p.

Research output: Contribution to journalArticle

A cyclin-dependent kinase homologue, p130(PITSLRE), is a phosphotyrosine- independent SH2 ligand

Malek, S. N. & Desiderio, S., Dec 1 1994, In : Journal of Biological Chemistry. 269, 52, p. 33009-33020 12 p.

Research output: Contribution to journalArticle

A genome-wide analysis of the acute-phase response and its regulation by Stat3β

Desiderio, S. & Yoo, J. Y., Jan 1 2003, In : Annals of the New York Academy of Sciences. 987, p. 280-284 5 p.

Research output: Contribution to journalArticle

An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation

Lu, C., Ward, A., Bettridge, J., Liu, Y. & Desiderio, S., Jan 6 2015, In : Cell Reports. 10, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

A Plant Homeodomain in Rag-2 that Binds Hypermethylated Lysine 4 of Histone H3 Is Necessary for Efficient Antigen-Receptor-Gene Rearrangement

Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. & Desiderio, S., Oct 26 2007, In : Immunity. 27, 4, p. 561-571 11 p.

Research output: Contribution to journalArticle

A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen

Ahmed, R., Omidian, Z., Giwa, A., Cornwell, B., Majety, N., Bell, D. R., Lee, S., Zhang, H., Michels, A., Desiderio, S., Sadegh-Nasseri, S., Rabb, H., Gritsch, S., Suva, M. L., Cahan, P., Zhou, R., Jie, C., Donner, T. & Hamad, A. R. A., May 30 2019, In : Cell. 177, 6, p. 1583-1599.e16

Research output: Contribution to journalArticle

A V(D)J recombinase-inducible B-cell line: Role of transcriptional enhancer elements in directing V(D)J recombination

Oltz, E. M., Alt, F. W., Lin, W. C., Chen, J., Taccioli, G., Desiderio, S. & Rathbun, G., Jan 1 1993, In : Molecular and cellular biology. 13, 10, p. 6223-6230 8 p.

Research output: Contribution to journalArticle

Open Access

B-cell activation

Desiderio, S. V., Jun 1992, In : Current Opinion in Immunology. 4, 3, p. 252-256 5 p.

Research output: Contribution to journalArticle

Cell cycle regulation of V(D)J recombination-activating protein RAG-2

Lin, W. C. & Desiderio, S., Mar 29 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 7, p. 2733-2737 5 p.

Research output: Contribution to journalArticle

Open Access

cGMP-dependent protein kinase Iβ physically and functionally interacts with the transcriptional regulator TFII-I

Casteel, D. E., Zhuang, S., Gudi, T., Tang, J., Vuica, M., Desiderio, S. & Pilz, R. B., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 32003-32014 12 p.

Research output: Contribution to journalArticle

Construction of human activity-based phosphorylation networks

Newman, R. H., Hu, J., Rho, H. S., Xie, Z., Woodard, C., Neiswinger, J., Cooper, C., Shirley, M., Clark, H. M., Hu, S., Hwang, W., Seop Jeong, J., Wu, G., Lin, J., Gao, X., Ni, Q., Goel, R., Xia, S., Ji, H., Dalby, K. N. & 14 others, Birnbaum, M. J., Cole, P. A., Knapp, S., Ryazanov, A. G., Zack, D. J., Blackshaw, S., Pawson, T., Gingras, A. C., Desiderio, S., Pandey, A., Turk, B. E., Zhang, J., Zhu, H. & Qian, J., Jan 1 2013, In : Molecular systems biology. 9, 655.

Research output: Contribution to journalArticle

Open Access

Coordination of immunoglobulin DJ(H) transcription and D-to-J(H) rearrangement by promoter-enhancer approximation

Alessandrini, A. & Desiderio, S. V., Jan 1 1991, In : Molecular and cellular biology. 11, 4, p. 2096-2107 12 p.

Research output: Contribution to journalArticle

Open Access

Coupling of V(D)J Recombination to the Cell Cycle Suppresses Genomic Instability and Lymphoid Tumorigenesis

Zhang, L., Reynolds, T. L., Shan, X. & Desiderio, S., Feb 25 2011, In : Immunity. 34, 2, p. 163-174 12 p.

Research output: Contribution to journalArticle

Cycle-dependent Accumulation in Vivo of Transposition-competent Complexes between Recombination Signal Ends and Full-length RAG Proiteins

Jiang, H., Ross, A. E. & Desiderio, S., Feb 27 2004, In : Journal of Biological Chemistry. 279, 9, p. 8478-8486 9 p.

Research output: Contribution to journalArticle

Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

Lee, J. & Desiderio, S., Dec 1999, In : Immunity. 11, 6, p. 771-781 11 p.

Research output: Contribution to journalArticle

Open Access

Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice

Li, L., Zhang, L., Fan, J., Greenberg, K., Desiderio, S., Rassool, F. V. & Small, D., Mar 17 2011, In : Blood. 117, 11, p. 3131-3139 9 p.

Research output: Contribution to journalArticle

Do antiidiotypic antibodies mimic antigen?

Amzel, L. M., Garcia, K. C. & Desiderio, S., 1994, In : Research in Immunology. 145, 1, p. 53-55 3 p.

Research output: Contribution to journalArticle

Double-stranded cleavage by cell extracts near recombinational signal sequences of immunoglobulin genes

Desiderio, S. & Baltimore, D., Dec 1 1984, In : Nature. 308, 5962, p. 860-862 3 p.

Research output: Contribution to journalArticle

Fine mapping of V(D)J recombinase mediated rearrangements in human lymphoid malignancies

Halper-Stromberg, E., Steranka, J., Giraldo-Castillo, N., Fuller, T., Desiderio, S. & Burns, K. H., Aug 19 2013, In : BMC genomics. 14, 1, 565.

Research output: Contribution to journalArticle

Genetic mapping of the gene for a novel tyrosine kinase, Blk, to mouse chromosome 14

Kozak, C. A., Dymecki, S. M., Niederhuber, J. E. & Desiderio, S. V., Apr 1991, In : Genomics. 9, 4, p. 762-764 3 p.

Research output: Contribution to journalArticle

hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions

Youn, M. Y., Yoo, H. S., Kim, M. J., Hwang, S. Y., Choi, Y., Desiderio, S. V. & Yoo, J. Y., Nov 30 2007, In : Journal of Biological Chemistry. 282, 48, p. 34727-34734 8 p.

Research output: Contribution to journalArticle

Open Access

Identification of Phosphorylation Sites for Bruton's Tyrosine Kinase within the Transcriptional Regulator BAP/TFII-I

Egloff, A. M. & Desiderio, S., Jul 27 2001, In : Journal of Biological Chemistry. 276, 30, p. 27806-27815 10 p.

Research output: Contribution to journalArticle

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

Desiderio, S. V., Yancopoulos, G. D., Paskind, M., Thomas, E., Boss, M. A., Landau, N., Alt, F. W. & Baltimore, D., Dec 1 1984, In : Nature. 311, 5988, p. 752-755 4 p.

Research output: Contribution to journalArticle

Open Access

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model

Greenblatt, S., Li, L., Slape, C., Nguyen, B., Novak, R., Duffield, A., Huso, D., Desiderio, S., Borowitz, M. J., Aplan, P. & Small, D., Mar 22 2012, In : Blood. 119, 12, p. 2883-2894 12 p.

Research output: Contribution to journalArticle

Lymphopoiesis: Transcription factors controlling B-cell development

Desiderio, S., Jun 1995, In : Current Biology. 5, 6, p. 605-608 4 p.

Research output: Contribution to journalArticle

Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase

Malek, S. N., Dordai, D. I., Reim, J., Dintzis, H. & Desiderio, S., Jun 23 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 13, p. 7351-7356 6 p.

Research output: Contribution to journalArticle

Mapping of the gene for the tyrosine kinase itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q

Janis, E. M., Slliciano, J. D., Isaac, D. D., Griffin, C. A., Hawkins, A. L., Kozak, C. A. & Desiderio, S., Sep 1 1994, In : Genomics. 23, 1, p. 269-271 3 p.

Research output: Contribution to journalArticle

Mimicry of Pre-B Cell Receptor Signaling by Activation of the Tyrosine Kinase Blk

Tretter, T., Ross, A. E., Dordai, D. I. & Desiderio, S., Dec 15 2003, In : Journal of Experimental Medicine. 198, 12, p. 1863-1873 11 p.

Research output: Contribution to journalArticle

Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase

Klages, S., Adam, D., Eiseman, E., Fargnoli, J., Dymecki, S. M., Desiderio, S. V. & Bolen, J. B., Jan 1 1993, In : Oncogene. 8, 3, p. 713-719 7 p.

Research output: Contribution to journalArticle

NBP, a protein that specifically binds an enhancer of immunoglobulin gene rearrangement: purification and characterization.

Li, M., Morzycka-Wroblewska, E. & Desiderio, S. V., Nov 1989, In : Genes & development. 3, 11, p. 1801-1813 13 p.

Research output: Contribution to journalArticle

Open Access

NetPath: A public resource of curated signal transduction pathways

Kandasamy, K., Sujatha Mohan, S., Raju, R., Keerthikumar, S., Sameer Kumar, G. S., Venugopal, A. K., Telikicherla, D., Navarro, D. J., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V. & 20 others, Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Abdul Rahiman, B., Keshava Prasad, T. S., Lin, J. X., Houtman, J. C. D., Desiderio, S., Renauld, J. C., Constantinescu, S., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. & Pandey, A., Jan 12 2010, In : Genome biology. 11, 1, r3.

Research output: Contribution to journalArticle

Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors

Cooper, C. L., Hardy, R. R., Reth, M. & Desiderio, S., Jun 7 2012, In : Blood. 119, 23, p. 5438-5448 11 p.

Research output: Contribution to journalArticle

Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells

Ross, A. E., Vuica, M. & Desiderio, S., Aug 1 2003, In : Molecular and cellular biology. 23, 15, p. 5308-5319 12 p.

Research output: Contribution to journalArticle

P150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains

Malek, S. N., Yang, C. H., Earnshaw, W. C., Kozak, C. A. & Desiderio, S., Mar 22 1996, In : Journal of Biological Chemistry. 271, 12, p. 6952-6962 11 p.

Research output: Contribution to journalArticle

Open Access

Phospholipase C-γ binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity

Zachos, N. C., van Rossum, D. B., Li, X., Caraveo, G., Sarker, R., Cha, B., Mohan, S., Desiderio, S., Patterson, R. L. & Donowitz, M., Jul 17 2009, In : Journal of Biological Chemistry. 284, 29, p. 19437-19444 8 p.

Research output: Contribution to journalArticle

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

Yancopoulos, G. D., Desiderio, S. V., Paskind, M., Kearney, J. F., Baltimore, D. & Alt, F. W., Dec 1 1984, In : Nature. 311, 5988, p. 727-733 7 p.

Research output: Contribution to journalArticle

Pumping the breaks on B cell development

Desiderio, S., Feb 8 2016, In : Journal of Experimental Medicine. 213, 2, 1 p.

Research output: Contribution to journalArticle

RAG-1- and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution

Li, W., Swanson, P. & Desiderio, S., Dec 1997, In : Molecular and cellular biology. 17, 12, p. 6932-6939 8 p.

Research output: Contribution to journalArticle

Open Access

RAG-1 mutations associated with B-Cell-negative SCID dissociate the nicking and transesterification steps of V(D)J recombination

Li, W., Chang, F. C. & Desiderio, S., Jun 1 2001, In : Molecular and cellular biology. 21, 12, p. 3935-3946 12 p.

Research output: Contribution to journalArticle