Stephen Desiderio

Professor

1978 …2019

Research output per year

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Research Output

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Article
2019

A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen

Ahmed, R., Omidian, Z., Giwa, A., Cornwell, B., Majety, N., Bell, D. R., Lee, S., Zhang, H., Michels, A., Desiderio, S., Sadegh-Nasseri, S., Rabb, H., Gritsch, S., Suva, M. L., Cahan, P., Zhou, R., Jie, C., Donner, T. & Hamad, A. R. A., May 30 2019, In : Cell. 177, 6, p. 1583-1599.e16

Research output: Contribution to journalArticle

Open Access
2018

Short telomere syndromes cause a primary T cell immunodeficiency

Wagner, C. L., Hanumanthu, V. S., Conover Talbot, C., Abraham, R. S., Hamm, D., Gable, D. L., Kanakry, C. G., Applegate, C. D., Siliciano, J., Brooks Jackson, J., Desiderio, S., Alder, J. K., Luznik, L. & Armanios, M., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5222-5234 13 p.

Research output: Contribution to journalArticle

Smoothened signaling in the mouse osteoblastoid lineage is required for efficient b lymphopoiesis

Lu, W., Dordai, D., Huso, D. L. & Desiderio, S., Jan 18 2018, In : Blood. 131, 3, p. 323-327 5 p.

Research output: Contribution to journalArticle

The RAG-2 Inhibitory Domain Gates Accessibility of the V(D)J Recombinase to Chromatin

Ward, A., Kumari, G., Sen, R. & Desiderio, S., Aug 1 2018, In : Molecular and cellular biology. 38, 15

Research output: Contribution to journalArticle

Open Access
2017
2016

Pumping the breaks on B cell development

Desiderio, S., Feb 8 2016, In : Journal of Experimental Medicine. 213, 2, 1 p.

Research output: Contribution to journalArticle

2015

An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation

Lu, C., Ward, A., Bettridge, J., Liu, Y. & Desiderio, S., Jan 6 2015, In : Cell Reports. 10, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

2013

53BP1 is limiting for NHEJ repair in ATM-deficient model systems that are subjected to oncogenic stress or radiation

Rybanska-Spaeder, I., Reynolds, T. L., Chou, J., Prakash, M., Jefferson, T., Huso, D. L., Desiderio, S. & Franco, S., Oct 2013, In : Molecular Cancer Research. 11, 10, p. 1223-1234 12 p.

Research output: Contribution to journalArticle

Construction of human activity-based phosphorylation networks

Newman, R. H., Hu, J., Rho, H. S., Xie, Z., Woodard, C., Neiswinger, J., Cooper, C., Shirley, M., Clark, H. M., Hu, S., Hwang, W., Seop Jeong, J., Wu, G., Lin, J., Gao, X., Ni, Q., Goel, R., Xia, S., Ji, H., Dalby, K. N. & 14 others, Birnbaum, M. J., Cole, P. A., Knapp, S., Ryazanov, A. G., Zack, D. J., Blackshaw, S., Pawson, T., Gingras, A. C., Desiderio, S., Pandey, A., Turk, B. E., Zhang, J., Zhu, H. & Qian, J., Jan 1 2013, In : Molecular systems biology. 9, 655.

Research output: Contribution to journalArticle

Fine mapping of V(D)J recombinase mediated rearrangements in human lymphoid malignancies

Halper-Stromberg, E., Steranka, J., Giraldo-Castillo, N., Fuller, T., Desiderio, S. & Burns, K. H., Aug 19 2013, In : BMC genomics. 14, 1, 565.

Research output: Contribution to journalArticle

Stat3β mitigates development of atherosclerosis in apolipoprotein E-deficient mice

Lee, J., Baldwin, W. M., Lee, C. Y. & Desiderio, S., Aug 1 2013, In : Journal of Molecular Medicine. 91, 8, p. 965-976 12 p.

Research output: Contribution to journalArticle

The transcriptional repressor NKAP is required for the development of iNKT cells

Thapa, P., Das, J., McWilliams, D., Shapiro, M., Sundsbak, R., Nelson-Holte, M., Tangen, S., Anderson, J., Desiderio, S., Hiebert, S., Sant'Angelo, D. B. & Shapiro, V. S., Apr 10 2013, In : Nature communications. 4, 1582.

Research output: Contribution to journalArticle

2012

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model

Greenblatt, S., Li, L., Slape, C., Nguyen, B., Novak, R., Duffield, A., Huso, D., Desiderio, S., Borowitz, M. J., Aplan, P. & Small, D., Mar 22 2012, In : Blood. 119, 12, p. 2883-2894 12 p.

Research output: Contribution to journalArticle

Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors

Cooper, C. L., Hardy, R. R., Reth, M. & Desiderio, S., Jun 7 2012, In : Blood. 119, 23, p. 5438-5448 11 p.

Research output: Contribution to journalArticle

2011

Coupling of V(D)J Recombination to the Cell Cycle Suppresses Genomic Instability and Lymphoid Tumorigenesis

Zhang, L., Reynolds, T. L., Shan, X. & Desiderio, S., Feb 25 2011, In : Immunity. 34, 2, p. 163-174 12 p.

Research output: Contribution to journalArticle

Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice

Li, L., Zhang, L., Fan, J., Greenberg, K., Desiderio, S., Rassool, F. V. & Small, D., Mar 17 2011, In : Blood. 117, 11, p. 3131-3139 9 p.

Research output: Contribution to journalArticle

2010

NetPath: A public resource of curated signal transduction pathways

Kandasamy, K., Sujatha Mohan, S., Raju, R., Keerthikumar, S., Sameer Kumar, G. S., Venugopal, A. K., Telikicherla, D., Navarro, D. J., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V. & 20 others, Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Abdul Rahiman, B., Keshava Prasad, T. S., Lin, J. X., Houtman, J. C. D., Desiderio, S., Renauld, J. C., Constantinescu, S., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. & Pandey, A., Jan 12 2010, In : Genome biology. 11, 1, r3.

Research output: Contribution to journalArticle

2009

Phospholipase C-γ binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity

Zachos, N. C., van Rossum, D. B., Li, X., Caraveo, G., Sarker, R., Cha, B., Mohan, S., Desiderio, S., Patterson, R. L. & Donowitz, M., Jul 17 2009, In : Journal of Biological Chemistry. 284, 29, p. 19437-19444 8 p.

Research output: Contribution to journalArticle

2008
2007

A Plant Homeodomain in Rag-2 that Binds Hypermethylated Lysine 4 of Histone H3 Is Necessary for Efficient Antigen-Receptor-Gene Rearrangement

Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. & Desiderio, S., Oct 26 2007, In : Immunity. 27, 4, p. 561-571 11 p.

Research output: Contribution to journalArticle

hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions

Youn, M. Y., Yoo, H. S., Kim, M. J., Hwang, S. Y., Choi, Y., Desiderio, S. V. & Yoo, J. Y., Nov 30 2007, In : Journal of Biological Chemistry. 282, 48, p. 34727-34734 8 p.

Research output: Contribution to journalArticle

2006

Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry

Caraveo, G., Van Rossum, D. B., Patterson, R. L., Snyder, S. H. & Desiderio, S., Oct 6 2006, In : Science. 314, 5796, p. 122-125 4 p.

Research output: Contribution to journalArticle

2005

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle

Jiang, H., Chang, F. C., Ross, A. E., Lee, J., Nakayama, K., Nakayama, K. & Desiderio, S., Jun 10 2005, In : Molecular cell. 18, 6, p. 699-709 11 p.

Research output: Contribution to journalArticle

Vascular endothelial growth factor receptor-2: Counter-regulation by the transcription factors, TFII-I and TFII-IRD1

Jackson, T. A., Taylor, H. E., Sharma, D., Desiderio, S. & Danoff, S. K., Aug 19 2005, In : Journal of Biological Chemistry. 280, 33, p. 29856-29863 8 p.

Research output: Contribution to journalArticle

2004

Cycle-dependent Accumulation in Vivo of Transposition-competent Complexes between Recombination Signal Ends and Full-length RAG Proiteins

Jiang, H., Ross, A. E. & Desiderio, S., Feb 27 2004, In : Journal of Biological Chemistry. 279, 9, p. 8478-8486 9 p.

Research output: Contribution to journalArticle

2003

A genome-wide analysis of the acute-phase response and its regulation by Stat3β

Desiderio, S. & Yoo, J. Y., Jan 1 2003, In : Annals of the New York Academy of Sciences. 987, p. 280-284 5 p.

Research output: Contribution to journalArticle

Mimicry of Pre-B Cell Receptor Signaling by Activation of the Tyrosine Kinase Blk

Tretter, T., Ross, A. E., Dordai, D. I. & Desiderio, S., Dec 15 2003, In : Journal of Experimental Medicine. 198, 12, p. 1863-1873 11 p.

Research output: Contribution to journalArticle

Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells

Ross, A. E., Vuica, M. & Desiderio, S., Aug 1 2003, In : Molecular and cellular biology. 23, 15, p. 5308-5319 12 p.

Research output: Contribution to journalArticle

2002

cGMP-dependent protein kinase Iβ physically and functionally interacts with the transcriptional regulator TFII-I

Casteel, D. E., Zhuang, S., Gudi, T., Tang, J., Vuica, M., Desiderio, S. & Pilz, R. B., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 32003-32014 12 p.

Research output: Contribution to journalArticle

Specific ablation of Stat3β distorts the pattern of stat3-responsive gene expression and impairs recovery from endotoxic shock

Yoo, J. Y., Huso, D. L., Nathans, D. & Desiderio, S., Jan 1 2002, In : Cell. 108, 3, p. 331-344 14 p.

Research output: Contribution to journalArticle

2001

Identification of Phosphorylation Sites for Bruton's Tyrosine Kinase within the Transcriptional Regulator BAP/TFII-I

Egloff, A. M. & Desiderio, S., Jul 27 2001, In : Journal of Biological Chemistry. 276, 30, p. 27806-27815 10 p.

Research output: Contribution to journalArticle

RAG-1 mutations associated with B-Cell-negative SCID dissociate the nicking and transesterification steps of V(D)J recombination

Li, W., Chang, F. C. & Desiderio, S., Jun 1 2001, In : Molecular and cellular biology. 21, 12, p. 3935-3946 12 p.

Research output: Contribution to journalArticle

Synergistic Activity of STAT3 and c-Jun at a Specific Array of DNA Elements in the α2-Macroglobulin Promoter

Yoo, J. Y., Wang, W., Desiderio, S. & Nathans, D., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26421-26429 9 p.

Research output: Contribution to journalArticle

2000

The B-cell-specific src-family kinase Blk is dispensable for B-cell development and activation

Texido, G., Su, I. H., Mecklenbräuker, I., Saijo, K., Malek, S. N., Desiderio, S., Rajewsky, K. & Tarakhovsky, A., Feb 1 2000, In : Molecular and cellular biology. 20, 4, p. 1227-1233 7 p.

Research output: Contribution to journalArticle

1999

Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

Lee, J. & Desiderio, S., Dec 1999, In : Immunity. 11, 6, p. 771-781 11 p.

Research output: Contribution to journalArticle

Open Access

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

Swanson, P. C. & Desiderio, S., May 1999, In : Molecular and cellular biology. 19, 5, p. 3674-3683 10 p.

Research output: Contribution to journalArticle

Open Access

Signaling pathways that control V(D)J recombination

Desiderio, S. & Lee, J., Dec 1 1999, In : Current topics in microbiology and immunology. 245 II, p. 31-56 26 p.

Research output: Contribution to journalArticle

1998

Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase

Malek, S. N., Dordai, D. I., Reim, J., Dintzis, H. & Desiderio, S., Jun 23 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 13, p. 7351-7356 6 p.

Research output: Contribution to journalArticle

V(D)J recombination signal recognition: Distinct, overlapping DNA- protein contacts in complexes containing RAG1 with and without RAG2

Swanson, P. C. & Desiderio, S., Jul 1998, In : Immunity. 9, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

1997

RAG-1- and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution

Li, W., Swanson, P. & Desiderio, S., Dec 1997, In : Molecular and cellular biology. 17, 12, p. 6932-6939 8 p.

Research output: Contribution to journalArticle

Open Access

Role of Btk in B cell development and signaling

Desiderio, S., Aug 1997, In : Current Opinion in Immunology. 9, 4, p. 534-540 7 p.

Research output: Contribution to journalArticle

The Pax-5 gene is alternatively spliced during B-cell development

Zwollo, P., Arrieta, H., Ede, K., Molinder, K., Desiderio, S. & Pollock, R., Apr 11 1997, In : Journal of Biological Chemistry. 272, 15, p. 10160-10168 9 p.

Research output: Contribution to journalArticle

1996

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

Li, Z., Dordai, D. I., Lee, J. & Desiderio, S., Dec 1996, In : Immunity. 5, 6, p. 575-589 15 p.

Research output: Contribution to journalArticle

P150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains

Malek, S. N., Yang, C. H., Earnshaw, W. C., Kozak, C. A. & Desiderio, S., Mar 22 1996, In : Journal of Biological Chemistry. 271, 12, p. 6952-6962 11 p.

Research output: Contribution to journalArticle

Open Access

RAG mutations in human B cell-negative SCID

Schwarz, K., Gauss, G. H., Ludwig, L., Pannicke, U., Li, Z., Lindner, D., Friedrich, W., Seger, R. A., Hansen-Hagge, T. E., Desiderio, S., Lieber, M. R. & Bartram, C. R., Oct 15 1996, In : Science. 274, 5284, p. 97-99 3 p.

Research output: Contribution to journalArticle