Stephen Desiderio

Professor

1978 …2019

Research output per year

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Research Output

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1980
1981
1984

Double-stranded cleavage by cell extracts near recombinational signal sequences of immunoglobulin genes

Desiderio, S. & Baltimore, D., Dec 1 1984, In : Nature. 308, 5962, p. 860-862 3 p.

Research output: Contribution to journalArticle

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

Desiderio, S. V., Yancopoulos, G. D., Paskind, M., Thomas, E., Boss, M. A., Landau, N., Alt, F. W. & Baltimore, D., Dec 1 1984, In : Nature. 311, 5988, p. 752-755 4 p.

Research output: Contribution to journalArticle

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

Yancopoulos, G. D., Desiderio, S. V., Paskind, M., Kearney, J. F., Baltimore, D. & Alt, F. W., Dec 1 1984, In : Nature. 311, 5988, p. 727-733 7 p.

Research output: Contribution to journalArticle

1987
Open Access
Open Access
1988
Open Access

Unusual immunoglobulin gene rearrangement leads to replacement of recombinational signal sequences

Morzycka-Wroblewska, E., Lee, F. E. H. & Desiderio, S. V., Jan 1 1988, In : Science. 242, 4876, p. 261-263 3 p.

Research output: Contribution to journalArticle

1989

NBP, a protein that specifically binds an enhancer of immunoglobulin gene rearrangement: purification and characterization.

Li, M., Morzycka-Wroblewska, E. & Desiderio, S. V., Nov 1989, In : Genes & development. 3, 11, p. 1801-1813 13 p.

Research output: Contribution to journalArticle

Open Access
1990

Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells

Dymecki, S. M., Niederhuber, J. E. & Desiderio, S. V., Jan 1 1990, In : Science. 247, 4940, p. 332-336 5 p.

Research output: Contribution to journalArticle

1991

Coordination of immunoglobulin DJ(H) transcription and D-to-J(H) rearrangement by promoter-enhancer approximation

Alessandrini, A. & Desiderio, S. V., Jan 1 1991, In : Molecular and cellular biology. 11, 4, p. 2096-2107 12 p.

Research output: Contribution to journalArticle

Open Access

Genetic mapping of the gene for a novel tyrosine kinase, Blk, to mouse chromosome 14

Kozak, C. A., Dymecki, S. M., Niederhuber, J. E. & Desiderio, S. V., Apr 1991, In : Genomics. 9, 4, p. 762-764 3 p.

Research output: Contribution to journalArticle

Repression of Immunoglobulin Enhancers by the Helix-Loop-Helix Protein Id: Implications for B-Lymphoid-Cell Development

Wilson, R. B., Kiledjian, M., Shen, C. P., Benezra, R., Zwollo, P., Dymecki, S. M., Desiderio, S. V. & Kadesch, T., Dec 1991, In : Molecular and cellular biology. 11, 12, p. 6185-6191 7 p.

Research output: Contribution to journalArticle

Open Access
1992

B-cell activation

Desiderio, S. V., Jun 1992, In : Current Opinion in Immunology. 4, 3, p. 252-256 5 p.

Research output: Contribution to journalArticle

Open Access

Recognition of angiotensin II: Antibodies at different levels of an idiotypic network are superimposable

Garcia, K. C., Desiderio, S. V., Ronco, P. M., Verroust, P. J. & Amzel, L. M., Jan 1 1992, In : Science. 257, 5069, p. 528-531 4 p.

Research output: Contribution to journalArticle

Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk

Dymecki, S. M., Zwollo, P., Zeller, K., Kuhajda, F. P. & Desiderio, S. V., Jan 1 1992, In : Journal of Biological Chemistry. 267, 7, p. 4815-4823 9 p.

Research output: Contribution to journalArticle

1993

A V(D)J recombinase-inducible B-cell line: Role of transcriptional enhancer elements in directing V(D)J recombination

Oltz, E. M., Alt, F. W., Lin, W. C., Chen, J., Taccioli, G., Desiderio, S. & Rathbun, G., Jan 1 1993, In : Molecular and cellular biology. 13, 10, p. 6223-6230 8 p.

Research output: Contribution to journalArticle

Open Access

Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase

Klages, S., Adam, D., Eiseman, E., Fargnoli, J., Dymecki, S. M., Desiderio, S. V. & Bolen, J. B., Jan 1 1993, In : Oncogene. 8, 3, p. 713-719 7 p.

Research output: Contribution to journalArticle

Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation

Lin, W. C. & Desiderio, S., Jan 1 1993, In : Science. 260, 5110, p. 953-959 7 p.

Research output: Contribution to journalArticle

SH2 domains of the protein-tyrosine kinases Blk, Lyn, and Fyn(T) bind distinct sets of phosphoproteins from B lymphocytes

Malek, S. N. & Desiderio, S., Jan 1 1993, In : Journal of Biological Chemistry. 268, 30, p. 22557-22565 9 p.

Research output: Contribution to journalArticle

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor ζ and CD3ε from activated Jurkat T cells

Wange, R. L., Malek, S. N., Desiderio, S. & Samelson, L. E., Jan 1 1993, In : Journal of Biological Chemistry. 268, 26, p. 19797-19801 5 p.

Research output: Contribution to journalArticle

1994

A cyclin-dependent kinase homologue, p130(PITSLRE), is a phosphotyrosine- independent SH2 ligand

Malek, S. N. & Desiderio, S., Dec 1 1994, In : Journal of Biological Chemistry. 269, 52, p. 33009-33020 12 p.

Research output: Contribution to journalArticle

Cell cycle regulation of V(D)J recombination-activating protein RAG-2

Lin, W. C. & Desiderio, S., Mar 29 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 7, p. 2733-2737 5 p.

Research output: Contribution to journalArticle

Open Access

Do antiidiotypic antibodies mimic antigen?

Amzel, L. M., Garcia, K. C. & Desiderio, S., 1994, In : Research in Immunology. 145, 1, p. 53-55 3 p.

Research output: Contribution to journalArticle

Mapping of the gene for the tyrosine kinase itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q

Janis, E. M., Slliciano, J. D., Isaac, D. D., Griffin, C. A., Hawkins, A. L., Kozak, C. A. & Desiderio, S., Sep 1 1994, In : Genomics. 23, 1, p. 269-271 3 p.

Research output: Contribution to journalArticle

Specific recognition of the blk promoter by the B-lymphoid transcription factor B-cell-specific activator protein

Zwollo, P. & Desiderio, S., May 27 1994, In : Journal of Biological Chemistry. 269, 21, p. 15310-15317 8 p.

Research output: Contribution to journalArticle

The B cell antigen receptor in B-cell development

Desiderio, S., Apr 1994, In : Current Opinion in Immunology. 6, 2, p. 248-256 9 p.

Research output: Contribution to journalArticle

1995

Lymphopoiesis: Transcription factors controlling B-cell development

Desiderio, S., Jun 1995, In : Current Biology. 5, 6, p. 605-608 4 p.

Research output: Contribution to journalArticle

V(D)J recombination and the cell cycle

Lin, W. C. & Desiderio, S., Jun 1995, In : Immunology Today. 16, 6, p. 279-289 11 p.

Research output: Contribution to journalArticle

1996

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

Li, Z., Dordai, D. I., Lee, J. & Desiderio, S., Dec 1996, In : Immunity. 5, 6, p. 575-589 15 p.

Research output: Contribution to journalArticle

P150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains

Malek, S. N., Yang, C. H., Earnshaw, W. C., Kozak, C. A. & Desiderio, S., Mar 22 1996, In : Journal of Biological Chemistry. 271, 12, p. 6952-6962 11 p.

Research output: Contribution to journalArticle

Open Access

RAG mutations in human B cell-negative SCID

Schwarz, K., Gauss, G. H., Ludwig, L., Pannicke, U., Li, Z., Lindner, D., Friedrich, W., Seger, R. A., Hansen-Hagge, T. E., Desiderio, S., Lieber, M. R. & Bartram, C. R., Oct 15 1996, In : Science. 274, 5284, p. 97-99 3 p.

Research output: Contribution to journalArticle

The cell cycle and V(D)J recombination

Desiderio, S., Lin, W. C. & Li, Z., Dec 1 1996, In : Current topics in microbiology and immunology. 217, p. 45-59 15 p.

Research output: Contribution to journalArticle

1997

RAG-1- and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution

Li, W., Swanson, P. & Desiderio, S., Dec 1997, In : Molecular and cellular biology. 17, 12, p. 6932-6939 8 p.

Research output: Contribution to journalArticle

Open Access

Role of Btk in B cell development and signaling

Desiderio, S., Aug 1997, In : Current Opinion in Immunology. 9, 4, p. 534-540 7 p.

Research output: Contribution to journalArticle

The Pax-5 gene is alternatively spliced during B-cell development

Zwollo, P., Arrieta, H., Ede, K., Molinder, K., Desiderio, S. & Pollock, R., Apr 11 1997, In : Journal of Biological Chemistry. 272, 15, p. 10160-10168 9 p.

Research output: Contribution to journalArticle

1998

Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase

Malek, S. N., Dordai, D. I., Reim, J., Dintzis, H. & Desiderio, S., Jun 23 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 13, p. 7351-7356 6 p.

Research output: Contribution to journalArticle

V(D)J recombination signal recognition: Distinct, overlapping DNA- protein contacts in complexes containing RAG1 with and without RAG2

Swanson, P. C. & Desiderio, S., Jul 1998, In : Immunity. 9, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

1999

Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

Lee, J. & Desiderio, S., Dec 1999, In : Immunity. 11, 6, p. 771-781 11 p.

Research output: Contribution to journalArticle

Open Access

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

Swanson, P. C. & Desiderio, S., May 1999, In : Molecular and cellular biology. 19, 5, p. 3674-3683 10 p.

Research output: Contribution to journalArticle

Open Access

Signaling pathways that control V(D)J recombination

Desiderio, S. & Lee, J., Dec 1 1999, In : Current topics in microbiology and immunology. 245 II, p. 31-56 26 p.

Research output: Contribution to journalArticle

2000

The B-cell-specific src-family kinase Blk is dispensable for B-cell development and activation

Texido, G., Su, I. H., Mecklenbräuker, I., Saijo, K., Malek, S. N., Desiderio, S., Rajewsky, K. & Tarakhovsky, A., Feb 1 2000, In : Molecular and cellular biology. 20, 4, p. 1227-1233 7 p.

Research output: Contribution to journalArticle

2001

Identification of Phosphorylation Sites for Bruton's Tyrosine Kinase within the Transcriptional Regulator BAP/TFII-I

Egloff, A. M. & Desiderio, S., Jul 27 2001, In : Journal of Biological Chemistry. 276, 30, p. 27806-27815 10 p.

Research output: Contribution to journalArticle

RAG-1 mutations associated with B-Cell-negative SCID dissociate the nicking and transesterification steps of V(D)J recombination

Li, W., Chang, F. C. & Desiderio, S., Jun 1 2001, In : Molecular and cellular biology. 21, 12, p. 3935-3946 12 p.

Research output: Contribution to journalArticle

Synergistic Activity of STAT3 and c-Jun at a Specific Array of DNA Elements in the α2-Macroglobulin Promoter

Yoo, J. Y., Wang, W., Desiderio, S. & Nathans, D., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26421-26429 9 p.

Research output: Contribution to journalArticle