Research Output 1978 2017

2017
VDJ Recombinases
Genetic Recombination
Catalytic Domain
DNA
Genes
2016

Pumping the breaks on B cell development

Desiderio, S. 2016 In : Journal of Experimental Medicine. 213, 2, p. 140 1 p.

Research output: Contribution to journalArticle

B-Lymphocytes
2015

An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation

Lu, C., Ward, A., Bettridge, J., Liu, Y. & Desiderio, S. Jan 6 2015 In : Cell Reports. 10, 1, p. 29-38 10 p.

Research output: Contribution to journalArticle

VDJ Recombinases
Histones
Methylation
Genetic Recombination
Chromatin
2013

53BP1 is limiting for NHEJ repair in ATM-deficient model systems that are subjected to oncogenic stress or radiation

Rybanska-Spaeder, I., Reynolds, T. L., Chou, J., Prakash, M., Jefferson, T., Huso, D. L., Desiderio, S. & Franco, S. 2013 In : Molecular Cancer Research. 11, 10, p. 1223-1234 12 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Radiation
Thymocytes
VDJ Recombinases
Chromosome Breakage

Construction of human activity-based phosphorylation networks

Newman, R. H. , Hu, J. , Rho, H. S. , Xie, Z. , Woodard, C. , Neiswinger, J. , Cooper, C. , Shirley, M. , Clark, H. M. , Hu, S. , Hwang, W. , Seop Jeong, J. , Wu, G. , Lin, J. , Gao, X. , Ni, Q. , Goel, R. , Xia, S. , Ji, H. , Dalby, K. N. & 14 others Birnbaum, M. J., Cole, P. A., Knapp, S., Ryazanov, A. G., Zack, D. J., Blackshaw, S., Pawson, T., Gingras, A. C., Desiderio, S., Pandey, A., Turk, B. E., Zhang, J., Zhu, H. & Qian, J. 2013 In : Molecular Systems Biology. 9, 655

Research output: Contribution to journalArticle

Phosphorylation
Phosphotransferases
kinases
Paranasal Sinus Neoplasms
phosphorylation

Fine mapping of V(D)J recombinase mediated rearrangements in human lymphoid malignancies

Halper-Stromberg, E., Steranka, J., Giraldo-Castillo, N., Fuller, T., Desiderio, S. & Burns, K. H. Aug 19 2013 In : BMC Genomics. 14, 1, 565

Research output: Contribution to journalArticle

VDJ Recombinases
Genetic Recombination
Neoplasms
V(D)J Recombination
Chromosomes

Stat3β mitigates development of atherosclerosis in apolipoprotein E-deficient mice

Lee, J., Baldwin, W. M., Lee, C. Y. & Desiderio, S. Aug 2013 In : Journal of Molecular Medicine. 91, 8, p. 965-976 12 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Atherosclerosis
Inflammation
Protein Isoforms
Genes

The transcriptional repressor NKAP is required for the development of iNKT cells

Thapa, P., Das, J., McWilliams, D., Shapiro, M., Sundsbak, R., Nelson-Holte, M., Tangen, S., Anderson, J., Desiderio, S., Hiebert, S., Sant'Angelo, D. B. & Shapiro, V. S. 2013 In : Nature Communications. 4, 1582

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-cells
Histone Deacetylases
T-Lymphocytes
cells
2012

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model

Greenblatt, S., Li, L., Slape, C., Nguyen, B., Novak, R., Duffield, A., Huso, D., Desiderio, S., Borowitz, M. J., Aplan, P. & Small, D. Mar 22 2012 In : Blood. 119, 12, p. 2883-2894 12 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Mutation
Anthralin
Methacholine Compounds
Cyclic AMP Receptor Protein

Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors

Cooper, C. L., Hardy, R. R., Reth, M. & Desiderio, S. Jun 7 2012 In : Blood. 119, 23, p. 5438-5448 11 p.

Research output: Contribution to journalArticle

Lymphopoiesis
Hedgehogs
Castration
Stromal Cells
Cyclic AMP Receptor Protein
2011

Coupling of V(D)J Recombination to the Cell Cycle Suppresses Genomic Instability and Lymphoid Tumorigenesis

Zhang, L., Reynolds, T. L., Shan, X. & Desiderio, S. Feb 25 2011 In : Immunity. 34, 2, p. 163-174 12 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Genomic Instability
Genetic Recombination
Cell Cycle
Carcinogenesis

Defective nonhomologous end joining blocks B-cell development in FLT3/ITD mice

Li, L., Zhang, L., Fan, J., Greenberg, K., Desiderio, S., Rassool, F. V. & Small, D. Mar 17 2011 In : Blood. 117, 11, p. 3131-3139 9 p.

Research output: Contribution to journalArticle

Color Vision Defects
Castration
B-Lymphocytes
B-Lymphoid Precursor Cells
Repair
2010

NetPath: A public resource of curated signal transduction pathways

Kandasamy, K. , Sujatha Mohan, S. , Raju, R. , Keerthikumar, S. , Sameer Kumar, G. S. , Venugopal, A. K. , Telikicherla, D. , Navarro, D. J. , Mathivanan, S. , Pecquet, C. , Gollapudi, S. K. , Tattikota, S. G. , Mohan, S. , Padhukasahasram, H. , Subbannayya, Y. , Goel, R. , Jacob, H. K. C. , Zhong, J. , Sekhar, R. , Nanjappa, V. & 20 others Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Abdul Rahiman, B., Keshava Prasad, T. S., Lin, J. X., Houtman, J. C. D., Desiderio, S., Renauld, J. C., Constantinescu, S., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. & Pandey, A. Jan 12 2010 In : Genome Biology. 11, 1, r3

Research output: Contribution to journalArticle

human resources
Signal Transduction
resource
signal transduction
Biological Sciences

Temporal and spatial regulatory functions of the V(D)J recombinase

Desiderio, S. Dec 2010 In : Seminars in Immunology. 22, 6, p. 362-369 8 p.

Research output: Contribution to journalArticle

VDJ Recombinases
Recombinases
Chromatin
Cell Cycle
V(D)J Recombination
2009

Phospholipase C-γ binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity

Zachos, N. C., van Rossum, D. B., Li, X., Caraveo, G., Sarker, R., Cha, B., Mohan, S., Desiderio, S., Patterson, R. L. & Donowitz, M. Jul 17 2009 In : Journal of Biological Chemistry. 284, 29, p. 19437-19444 8 p.

Research output: Contribution to journalArticle

Phospholipase C gamma
Sodium-Hydrogen Antiporter
Calcium
Peptides
Transient Receptor Potential Channels

Temporal and spatial regulation of V(D)J recombination: Interactions of extrinsic factors with the RAG complex

Liu, Y., Zhang, L. & Desiderio, S. 2009 Advances in Experimental Medicine and Biology. Vol. 650, p. 157-165 9 p. (Advances in Experimental Medicine and Biology; vol. 650)

Research output: Chapter in Book/Report/Conference proceedingChapter

VDJ Recombinases
V(D)J Recombination
Recombinases
Antigen Receptors
Internal-External Control
2008

Along Came a Spider: AID Escapes a MicroRNA Web

Desiderio, S. May 16 2008 In : Immunity. 28, 5, p. 596-598 3 p.

Research output: Contribution to journalArticle

Cytidine Deaminase
Spiders
MicroRNAs
Immunity
B-Lymphocytes
RNA Polymerase II
Histones
Learned Helplessness
Transcription
Removal
2007

A Plant Homeodomain in Rag-2 that Binds Hypermethylated Lysine 4 of Histone H3 Is Necessary for Efficient Antigen-Receptor-Gene Rearrangement

Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. & Desiderio, S. Oct 26 2007 In : Immunity. 27, 4, p. 561-571 11 p.

Research output: Contribution to journalArticle

Antigen Receptors
Gene Rearrangement
Histones
Genetic Recombination
Lysine

hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions

Youn, M. Y., Yoo, H. S., Kim, M. J., Hwang, S. Y., Choi, Y., Desiderio, S. V. & Yoo, J. Y. Nov 30 2007 In : Journal of Biological Chemistry. 282, 48, p. 34727-34734 8 p.

Research output: Contribution to journalArticle

Interleukin-6
DNA
Genes
Transcription
Cyclic AMP Receptor Protein
2006

Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry

Caraveo, G., Van Rossum, D. B., Patterson, R. L., Snyder, S. H. & Desiderio, S. Oct 6 2006 In : Science. 314, 5796, p. 122-125 4 p.

Research output: Contribution to journalArticle

Phospholipase C gamma
Calcium
Transient Receptor Potential Channels
Phosphotyrosine
src Homology Domains
2005

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle

Jiang, H., Chang, F. C., Ross, A. E., Lee, J., Nakayama, K., Nakayama, K. & Desiderio, S. Jun 10 2005 In : Molecular Cell. 18, 6, p. 699-709 11 p.

Research output: Contribution to journalArticle

VDJ Recombinases
Ubiquitination
Cell Cycle
S Phase
SKP Cullin F-Box Protein Ligases

Vascular endothelial growth factor receptor-2: Counter-regulation by the transcription factors, TFII-I and TFII-IRD1

Jackson, T. A., Taylor, H. E., Sharma, D., Desiderio, S. & Danoff, S. K. Aug 19 2005 In : Journal of Biological Chemistry. 280, 33, p. 29856-29863 8 p.

Research output: Contribution to journalArticle

TFII Transcription Factors
Vascular Endothelial Growth Factor Receptor-2
E-Box Elements
Cape Verde
Vascular Endothelial Growth Factor A
2004
Genetic Recombination
Proteins
Castration
V(D)J Recombination
Cell Cycle
Williams Syndrome
Phenotype
Brain
Genes
Human Chromosomes
2003

A genome-wide analysis of the acute-phase response and its regulation by Stat3β

Desiderio, S. & Yoo, J. Y. 2003 In : Annals of the New York Academy of Sciences. 987, p. 280-284 5 p.

Research output: Contribution to journalArticle

Acute-Phase Reaction
Genome
Genes
Cyclic AMP Receptor Protein
Gene
Acute-Phase Reaction
Adaptive Immunity
Innate Immunity
Histocompatibility Antigens Class I
Antigen Presentation

Mimicry of Pre-B Cell Receptor Signaling by Activation of the Tyrosine Kinase Blk

Tretter, T., Ross, A. E., Dordai, D. I. & Desiderio, S. Dec 15 2003 In : Journal of Experimental Medicine. 198, 12, p. 1863-1873 11 p.

Research output: Contribution to journalArticle

Pre-B Cell Receptors
Protein-Tyrosine Kinases
B-Lymphoid Precursor Cells
src-Family Kinases
Interleukin-7
Nuclear Localization Signals
Genetic Recombination
Proteolysis
Karyopherins
Nuclear Proteins
2002

cGMP-dependent protein kinase Iβ physically and functionally interacts with the transcriptional regulator TFII-I

Casteel, D. E., Zhuang, S., Gudi, T., Tang, J., Vuica, M., Desiderio, S. & Pilz, R. B. Aug 30 2002 In : Journal of Biological Chemistry. 277, 35, p. 32003-32014 12 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Cricetinae
Transcriptional Activation
Kidney
Amino Acids

Specific ablation of Stat3β distorts the pattern of stat3-responsive gene expression and impairs recovery from endotoxic shock

Yoo, J. Y., Huso, D. L., Nathans, D. & Desiderio, S. 2002 In : Cell. 108, 3, p. 331-344 14 p.

Research output: Contribution to journalArticle

Septic Shock
Gene Expression
Cyclic AMP Receptor Protein
Endotoxins
Liver
2001

Identification of Phosphorylation Sites for Bruton's Tyrosine Kinase within the Transcriptional Regulator BAP/TFII-I

Egloff, A. M. & Desiderio, S. Jul 27 2001 In : Journal of Biological Chemistry. 276, 30, p. 27806-27815 10 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Phosphorylation
Paranasal Sinus Neoplasms
Castration
B-Lymphocytes

RAG-1 mutations associated with B-Cell-negative SCID dissociate the nicking and transesterification steps of V(D)J recombination

Li, W., Chang, F. C. & Desiderio, S. Jun 2001 In : Molecular and Cellular Biology. 21, 12, p. 3935-3946 12 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Severe Combined Immunodeficiency
B-Lymphocytes
Mutation
DNA

Synergistic Activity of STAT3 and c-Jun at a Specific Array of DNA Elements in the α2-Macroglobulin Promoter

Yoo, J. Y., Wang, W., Desiderio, S. & Nathans, D. Jul 13 2001 In : Journal of Biological Chemistry. 276, 28, p. 26421-26429 9 p.

Research output: Contribution to journalArticle

Macroglobulins
Oligonucleotide Array Sequence Analysis
Mutation
DNA
AT Rich Sequence
2000

Somatic evolution of antibody specificity: Setting the clock forward

Desiderio, S. Dec 2000 In : Nature Immunology. 1, 6, p. 463-464 2 p.

Research output: Contribution to journalArticle

Clonal Evolution
Antibody Specificity
Double-Stranded DNA Breaks

The B-cell-specific src-family kinase Blk is dispensable for B-cell development and activation

Texido, G., Su, I. H., Mecklenbräuker, I., Saijo, K., Malek, S. N., Desiderio, S., Rajewsky, K. & Tarakhovsky, A. Feb 2000 In : Molecular and Cellular Biology. 20, 4, p. 1227-1233 7 p.

Research output: Contribution to journalArticle

src-Family Kinases
B-Lymphocytes
Phosphotransferases
Lymphocytes
Cell Physiological Phenomena
1999

Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

Lee, J. & Desiderio, S. Dec 1999 In : Immunity. 11, 6, p. 771-781 11 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Cyclin A
DNA Repair
Genetic Recombination
VDJ Recombinases

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

Swanson, P. C. & Desiderio, S. May 1999 In : Molecular and Cellular Biology. 19, 5, p. 3674-3683 10 p.

Research output: Contribution to journalArticle

Genetic Recombination
Protein Sorting Signals
DNA
Proteins
V(D)J Recombination

Signaling pathways that control V(D)J recombination

Desiderio, S. & Lee, J. 1999 In : Current Topics in Microbiology and Immunology. 245 II, p. 31-56 26 p.

Research output: Contribution to journalArticle

V(D)J Recombination
1998
Protein-Tyrosine Kinases
B-Lymphocytes
B-Lymphoid Precursor Cells
T-Lymphocyte Subsets
Transgenic Mice

V(D)J recombination signal recognition: Distinct, overlapping DNA- protein contacts in complexes containing RAG1 with and without RAG2

Swanson, P. C. & Desiderio, S. Jul 1998 In : Immunity. 9, 1, p. 115-125 11 p.

Research output: Contribution to journalArticle

V(D)J Recombination
DNA
Proteins
Protein Sorting Signals
Genetic Recombination
1997
Protein-Tyrosine Kinases
B-Lymphocytes
B-Cell Antigen Receptors
Phosphorylation
Tyrosine
GTPase-Activating Proteins
Staphylococcal Protein A
B-Lymphocytes
Antigen Receptors
Proteins

RAG-1- and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution

Li, W., Swanson, P. & Desiderio, S. Dec 1997 In : Molecular and Cellular Biology. 17, 12, p. 6932-6939 8 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Protein Sorting Signals
Genetic Recombination
DNA
Mutation

Role of Btk in B cell development and signaling

Desiderio, S. Aug 1997 In : Current Opinion in Immunology. 9, 4, p. 534-540 7 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
B-Lymphocytes
X-Linked Combined Immunodeficiency Diseases
Mutation

The Pax-5 gene is alternatively spliced during B-cell development

Zwollo, P., Arrieta, H., Ede, K., Molinder, K., Desiderio, S. & Pollock, R. Apr 11 1997 In : Journal of Biological Chemistry. 272, 15, p. 10160-10168 9 p.

Research output: Contribution to journalArticle

Protein Isoforms
B-Lymphocytes
Cell Line
Genes
Castration
1996

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

Li, Z., Dordai, D. I., Lee, J. & Desiderio, S. Dec 1996 In : Immunity. 5, 6, p. 575-589 15 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Cell Division
Cell Cycle
Proteins
Alanine

P150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains

Malek, S. N., Yang, C. H., Earnshaw, W. C., Kozak, C. A. & Desiderio, S. Mar 22 1996 In : Journal of Biological Chemistry. 271, 12, p. 6952-6962 11 p.

Research output: Contribution to journalArticle

src Homology Domains
Phosphoproteins
Proteins
Serine
Complementary DNA

RAG mutations in human B cell-negative SCID

Schwarz, K., Gauss, G. H., Ludwig, L., Pannicke, U., Li, Z., Lindner, D., Friedrich, W., Seger, R. A., Hansen-Hagge, T. E., Desiderio, S., Lieber, M. R. & Bartram, C. R. 1996 In : Science. 274, 5284, p. 97-99 3 p.

Research output: Contribution to journalArticle

Severe Combined Immunodeficiency
B-Lymphocytes
Mutation
Genetic Recombination
RAG-1 Genes