Srinivasa Naga Raja

Professor

1980 …2020

Research output per year

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Article

Comparisons of motor and sensory abnormalities after lumbar and thoracic contusion spinal cord injury in male rats

Duan, W., Huang, Q., Chen, Z., Raja, S. N., Yang, F. & Guan, Y., Aug 24 2019, In : Neuroscience Letters. 708, 134358.

Research output: Contribution to journalArticle

Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury

Liu, S., Huang, Q., He, S., Chen, Z., Gao, X., Ma, D., Duan, W., Ford, N., Yang, F., Chen, X., Raja, S. N., Hao, D. & Guan, Y., Dec 1 2019, In : Pain. 160, 12, p. 2710-2723 14 p.

Research output: Contribution to journalArticle

Designing and conducting proof-of-concept chronic pain analgesic clinical trials

Campbell, C., Gilron, I., Doshi, T. & Raja, S. N., May 1 2019, In : Pain Reports. 4, 3, e697.

Research output: Contribution to journalArticle

Open Access

Modulation of Spinal Nociceptive Transmission by Sub-Sensory Threshold Spinal Cord Stimulation in Rats After Nerve Injury

Yang, F., Duan, W., Huang, Q., Chen, Z., Ford, N., Gao, X., Sivanesan, E., Sarma, S. V., Vera-Portocarrero, L. P., Linderoth, B., Raja, S. N. & Guan, Y., Jan 1 2019, In : Neuromodulation.

Research output: Contribution to journalArticle

Spinal cord stimulation prevents paclitaxel-induced mechanical and cold hypersensitivity and modulates spinal gene expression in rats

Sivanesan, E., Stephens, K. E., Huang, Q., Chen, Z., Ford, N. C., Duan, W., He, S. Q., Gao, X., Linderoth, B., Raja, S. N. & Guan, Y., Sep 1 2019, In : Pain Reports. 4, 5, e785.

Research output: Contribution to journalArticle

Open Access

The Impact of Electrical Charge Delivery on Inhibition of Mechanical Hypersensitivity in Nerve-Injured Rats by Sub-Sensory Threshold Spinal Cord Stimulation

Chen, Z., Huang, Q., Yang, F., Shi, C., Sivanesan, E., Liu, S., Chen, X., Sarma, S. V., Vera-Portocarrero, L. P., Linderoth, B., Raja, S. N. & Guan, Y., Feb 1 2019, In : Neuromodulation. 22, 2, p. 163-171 9 p.

Research output: Contribution to journalArticle

2018

Aspiring pain practitioners in India: Assessing challenges and building opportunities

Bhatnagar, S., Patel, A. & Raja, S. N., Jan 1 2018, In : Indian Journal of Palliative Care. 24, 1, p. 93-97 5 p.

Research output: Contribution to journalArticle

Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current

Yang, F., Anderson, M., He, S-Q., Stephens, K., Zheng, Y., Chen, Z., Raja, S. N., Aplin, F., Guan, Y. & Fridman, G. Y., Apr 11 2018, In : Science advances. 4, 4, eaaq1438.

Research output: Contribution to journalArticle

Neuropathic pain clinical trials: Factors associated with decreases in estimated drug efficacy

Finnerup, N. B., Haroutounian, S., Baron, R., Dworkin, R. H., Gilron, I., Haanpaa, M., Jensen, T. S., Kamerman, P. R., McNicol, E., Moore, A., Raja, S. N., Andersen, N. T., Sena, E. S., Smith, B. H., Rice, A. S. C. & Attal, N., Jan 1 2018, In : Pain. 159, 11, p. 2339-2346 8 p.

Research output: Contribution to journalArticle

Oligomerization of MrgC11 and μ-opioid receptors in sensory neurons enhances morphine analgesia

He, S-Q., Xu, Q., Tiwari, V., Yang, F., Anderson, M., Chen, Z., Grenald, S. A., Raja, S. N., Dong, X. & Guan, Y., Jun 19 2018, In : Science Signaling. 11, 535, eaao3134.

Research output: Contribution to journalArticle

Overexpression of μ-opioid receptors in peripheral afferents, but not in combination with enkephalin, decreases neuropathic pain behavior and enhances opioid analgesia in mouse

Klein, A. H., Mohammad, H. K., Ali, R., Peper, B., Wilson, S. P., Raja, S. N., Ringkamp, M. & Sweitzer, S., Jan 1 2018, In : Anesthesiology. 128, 5, p. 967-983 17 p.

Research output: Contribution to journalArticle

Peripherally Acting μ-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats

Tiwari, V., Anderson, M., Yang, F., Tiwari, V., Zheng, Q., He, S-Q., Zhang, T., Shu, B., Chen, X., Grenald, S. A., Stephens, K. E., Chen, Z., Dong, X., Raja, S. N. & Guan, Y., Jun 1 2018, In : Anesthesiology. 128, 6, p. 1220-1236 17 p.

Research output: Contribution to journalArticle

RNA-seq of spinal cord from nerve-injured rats after spinal cord stimulation

Stephens, K. E., Chen, Z., Sivanesan, E., Raja, S. N., Linderoth, B., Taverna, S. D. & Guan, Y., Dec 1 2018, In : Molecular Pain. 14

Research output: Contribution to journalArticle

2017

Improving pain management and long-term outcomes following high-energy orthopaedic trauma (pain study)

Castillo, R. C., Raja, S. N., Frey, K. P., Vallier, H. A., Tornetta, P., Jaeblon, T., Goff, B. J., Gottschalk, A., Scharfstein, D. O., O'Toole, R. V., Allen, L. E., Carlini, A. R., De Lissovoy, G., MacKenzie, E. J., Taylor, T. J. & Weng, Y., 2017, In : Journal of Orthopaedic Trauma. 31, p. S71-S77

Research output: Contribution to journalArticle

Neuropathic pain

Colloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A. H., Yarnitsky, D., Freeman, R., Truini, A., Attal, N., Finnerup, N. B., Eccleston, C., Kalso, E., Bennett, D. L., Dworkin, R. H. & Raja, S. N., Feb 16 2017, In : Nature Reviews Disease Primers. 3, 17002.

Research output: Contribution to journalArticle

Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain

Li, Z., Tseng, P. Y., Tiwari, V., Xu, Q., He, S. Q., Wang, Y., Zheng, Q., Han, L., Wu, Z., Blobaum, A. L., Cui, Y., Tiwari, V., Sun, S., Cheng, Y., Huang-Lionnet, J. H. Y., Geng, Y., Xiao, B., Peng, J., Hopkins, C., Raja, S. N. & 2 others, Guan, Y. & Dong, X., Mar 7 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 10, p. E1996-E2005

Research output: Contribution to journalArticle

The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions

Kent, M. L., Tighe, P. J., Belfer, I., Brennan, T. J., Bruehl, S., Brummett, C. M., Buckenmaier, C. C., Buvanendran, A., Cohen, R. I., Desjardins, P., Edwards, D., Fillingim, R., Gewandter, J., Gordon, D. B., Hurley, R. W., Kehlet, H., Loeser, J. D., Mackey, S., McLean, S. A., Polomano, R. & 16 others, Rahman, S., Raja, S. N., Rowbotham, M., Suresh, S., Schachtel, B., Schreiber, K., Schumacher, M., Stacey, B., Stanos, S., Todd, K., Turk, D. C., Weisman, S. J., Wu, C., Carr, D. B., Dworkin, R. H. & Terman, G., May 1 2017, In : Pain medicine (Malden, Mass.). 18, 5, p. 947-958 12 p.

Research output: Contribution to journalArticle

The ACTTION–APS–AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions

Kent, M. L., Tighe, P. J., Belfer, I., Brennan, T. J., Bruehl, S., Brummett, C. M., Buckenmaier, C. C., Buvanendran, A., Cohen, R. I., Desjardins, P., Edwards, D., Fillingim, R., Gewandter, J., Gordon, D. B., Hurley, R. W., Kehlet, H., Loeser, J. D., Mackey, S., McLean, S. A., Polomano, R. & 16 others, Rahman, S., Raja, S. N., Rowbotham, M., Suresh, S., Schachtel, B., Schreiber, K., Schumacher, M., Stacey, B., Stanos, S., Todd, K., Turk, D. C., Weisman, S. J., Wu, C., Carr, D. B., Dworkin, R. H. & Terman, G., May 1 2017, In : Journal of Pain. 18, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations

Smith, S. M., Dworkin, R. H., Turk, D. C., Baron, R., Polydefkis, M. J., Tracey, I., Borsook, D., Edwards, R. R., Harris, R. E., Wager, T. D., Arendt-Nielsen, L., Burke, L. B., Carr, D. B., Chappell, A., Farrar, J. T., Freeman, R., Gilron, I., Goli, V., Haeussler, J., Jensen, T. & 16 others, Katz, N. P., Kent, J., Kopecky, E. A., Lee, D. A., Maixner, W., Markman, J. D., McArthur, J. C., McDermott, M. P., Parvathenani, L., Raja, S. N., Rappaport, B. A., Rice, A. S. C., Rowbotham, M. C., Tobias, J. K., Wasan, A. D. & Witter, J., 2017, (Accepted/In press) In : Journal of Pain.

Research output: Contribution to journalArticle

2016

Activation of cannabinoid CB1 receptor contributes to suppression of spinal nociceptive transmission and inhibition of mechanical hypersensitivity by Aβ-fiber stimulation

Yang, F., Xu, Q., Shu, B., Tiwari, V., He, S-Q., Vera-Portocarrero, L. P., Dong, X., Linderoth, B., Raja, S. N., Wang, Y. & Guan, Y., Aug 19 2016, In : Pain. 157, 11, p. 2582-2593 12 p.

Research output: Contribution to journalArticle

Activation of Peripheral μ-opioid Receptors by Dermorphin [d-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain

Tiwari, V., Yang, F., He, S. Q., Shechter, R., Zhang, C., Shu, B., Zhang, T., Tiwari, V., Wang, Y., Dong, X., Guan, Y. & Raja, S. N., Mar 1 2016, In : Anesthesiology. 124, 3, p. 706-720 15 p.

Research output: Contribution to journalArticle

Deconstructing chronic low back pain in the older adult—step by step evidence and expertbased recommendations for evaluation and treatment. Part VI: Lumbar spinal stenosis

Fritz, J. M., Rundell, S. D., Dougherty, P., Gentili, A., Kochersberger, G., Morone, N. E., Raja, S. N., Rodriguez, E., Rossi, M. I., Shega, J., Sowa, G. & Weiner, D. K., 2016, In : Pain Medicine (United States). 17, 3, p. 501-510 10 p.

Research output: Contribution to journalArticle

Neuropathic pain: An updated grading system for research and clinical practice

Finnerup, N. B., Haroutounian, S., Kamerman, P., Baron, R., Bennett, D. L. H., Bouhassira, D., Cruccu, G., Freeman, R., Hansson, P., Nurmikko, T., Raja, S. N., Rice, A. S. C., Serra, J., Smith, B. H., Treede, R. D. & Jensen, T. S., Jun 8 2016, In : Pain. 157, 8, p. 1599-1606 8 p.

Research output: Contribution to journalArticle

Reporting of cross-over clinical trials of analgesic treatments for chronic pain: Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks systematic review and recommendations

Gewandter, J. S., McDermott, M. P., McKeown, A., Hoang, K., Iwan, K., Kralovic, S., Rothstein, D., Gilron, I., Katz, N. P., Raja, S. N., Senn, S., Smith, S. M., Turk, D. C. & Dworkin, R. H., Aug 19 2016, In : Pain. 157, 11, p. 2544-2551 8 p.

Research output: Contribution to journalArticle

2015

Effects of combined electrical stimulation of the dorsal column and dorsal roots on wide-dynamic-range neuronal activity in nerve-injured rats

Yang, F., Zhang, T., Tiwari, V., Shu, B., Zhang, C., Wang, Y., Vera-Portocarrero, L. P., Raja, S. N. & Guan, Y., Oct 2015, In : Neuromodulation. 18, 7, p. 592-597 6 p.

Research output: Contribution to journalArticle

Electrical stimulation of dorsal root entry zone attenuates wide-dynamic-range neuronal activity in rats

Yang, F., Zhang, C., Xu, Q., Tiwari, V., He, S. Q., Wang, Y., Dong, X., Vera-Portocarrero, L. P., Wacnik, P. W., Raja, S. N. & Guan, Y., Jan 1 2015, In : Neuromodulation. 18, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice

Sdrulla, A. D., Xu, Q., He, S-Q., Tiwari, V., Yang, F., Zhang, C., Shu, B., Shechter, R., Raja, S. N., Wang, Y., Dong, X. & Guan, Y., 2015, In : Pain. 156, 6, p. 1008-1017 10 p.

Research output: Contribution to journalArticle

Injury-specific promoters enhance herpes simplex virus-mediated gene therapy for treating neuropathic pain in rodents

Smith, S. N., Paige, C., Velazquez, K. T., Smith, T. P., Raja, S. N., Wilson, S. P. & Sweitzer, S. M., Mar 1 2015, In : Journal of Pain. 16, 3, p. 283-290 8 p.

Research output: Contribution to journalArticle

Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: A NeuPSIG systematic review, Delphi survey, and expert panel recommendations

Van Hecke, O., Kamerman, P. R., Attal, N., Baron, R., Bjornsdottir, G., Bennett, D. L. H., Bennett, M. I., Bouhassira, D., Diatchenko, L., Freeman, R., Freynhagen, R., Haanpää, M., Jensen, T. S., Raja, S. N., Rice, A. S. C., Seltzer, ZE., Thorgeirsson, T. E., Yarnitsky, D. & Smith, B. H., Nov 1 2015, In : Pain. 156, 11, p. 2337-2353 17 p.

Research output: Contribution to journalArticle

Pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis

Finnerup, N. B., Attal, N., Haroutounian, S., McNicol, E., Baron, R., Dworkin, R. H., Gilron, I., Haanpää, M., Hansson, P., Jensen, T. S., Kamerman, P. R., Lund, K., Moore, A., Raja, S. N., Rice, A. S. C., Rowbotham, M., Sena, E., Siddall, P., Smith, B. H. & Wallace, M., Jan 1 2015, In : The Lancet Neurology. 14, 2, p. 162-173 12 p.

Research output: Contribution to journalArticle

The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms

Li, Z., He, S. Q., Tseng, P. Y., Xu, Q., Tiwari, V., Yang, F., Shu, B., Zhang, T., Tang, Z., Raja, S. N., Wang, Y., Dong, X. & Guan, Y., Aug 6 2015, In : Neuroscience. 300, p. 393-403 11 p.

Research output: Contribution to journalArticle

World Health Organization essential medicines lists: Where are the drugs to treat neuropathic pain?

Kamerman, P. R., Wadley, A. L., Davis, K. D., Hietaharju, A., Jain, P., Kopf, A., Meyer, A. C., Raja, S. N., Rice, A. S. C., Smith, B. H., Treede, R. D. & Wiffen, P. J., May 1 2015, In : Pain. 156, 5, p. 793-797 5 p.

Research output: Contribution to journalArticle

2014

Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice

Li, Z., He, S. Q., Xu, Q., Yang, F., Tiwari, V., Liu, Q., Tang, Z., Han, L., Chu, Y. X., Wang, Y., Hin, N., Tsukamoto, T., Slusher, B., Guan, X., Wei, F., Raja, S. N., Dong, X. & Guan, Y., Aug 2014, In : Pain. 155, 8, p. 1613-1621 9 p.

Research output: Contribution to journalArticle

Antidepressant drugs for prevention of acute and chronic postsurgical pain early evidence and recommended future directions

Wong, K., Phelan, R., Kalso, E., Galvin, I., Goldstein, D., Raja, S. & Gilron, I., Jan 1 2014, In : Anesthesiology. 121, 3, p. 591-608 18 p.

Research output: Contribution to journalArticle

Comparison of intensity-dependent inhibition of spinal wide-dynamic range neurons by dorsal column and peripheral nerve stimulation in a rat model of neuropathic pain

Yang, F., Xu, Q., Cheong, Y. K., Shechter, R., Sdrulla, A., He, S. Q., Tiwari, V., Dong, X., Wacnik, P. W., Meyer, R., Raja, S. N. & Guan, Y., Aug 2014, In : European Journal of Pain (United Kingdom). 18, 7, p. 978-988 11 p.

Research output: Contribution to journalArticle

Intrathecal carbenoxolone inhibits neuropathic pain and spinal wide-dynamic range neuronal activity in rats after an L5 spinal nerve injury

Xu, Q., Cheong, Y. K., Yang, F., Tiwari, V., Li, J., Liu, J., Raja, S. N., Li, W. & Guan, Y., Mar 20 2014, In : Neuroscience Letters. 563, p. 45-50 6 p.

Research output: Contribution to journalArticle

Lenalidomide for complex regional pain syndrome type 1: Lack of efficacy in a phase II randomized study

Manning, D. C., Alexander, G., Arezzo, J. C., Cooper, A., Harden, R. N., Oaklander, A. L., Raja, S. N., Rauck, R. & Schwartzman, R., Dec 1 2014, In : Journal of Pain. 15, 12, p. 1366-1376 11 p.

Research output: Contribution to journalArticle

MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain

He, S. Q., Li, Z., Chu, Y. X., Han, L., Xu, Q., Li, M., Yang, F., Liu, Q., Tang, Z., Wang, Y., Hin, N., Tsukamoto, T., Slusher, B., Tiwari, V., Shechter, R., Wei, F., Raja, S. N., Dong, X. & Guan, Y., Mar 2014, In : Pain. 155, 3, p. 534-544 11 p.

Research output: Contribution to journalArticle

Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

Xu, J. T., Zhao, J. Y., Zhao, X., Ligons, D., Tiwari, V., Atianjoh, F. E., Lee, C. Y., Liang, L., Zang, W., Njoku, D., Raja, S. N., Yaster, M. & Tao, Y. X., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 592-603 12 p.

Research output: Contribution to journalArticle

Suppression of spinal connexin 43 expression attenuates mechanical hypersensitivity in rats after an L5 spinal nerve injury

Xu, Q., Cheong, Y. K., He, S. Q., Tiwari, V., Liu, J., Wang, Y., Raja, S. N., Li, J., Guan, Y. & Li, W., Apr 30 2014, In : Neuroscience Letters. 566, p. 194-199 6 p.

Research output: Contribution to journalArticle

Temporal changes in MrgC expression after spinal nerve injury

He, S. Q., Han, L., Li, Z., Xu, Q., Tiwari, V., Yang, F., Guan, X., Wang, Y., Raja, S. N., Dong, X. & Guan, Y., Mar 7 2014, In : Neuroscience. 261, p. 43-51 9 p.

Research output: Contribution to journalArticle

2013

Abuse liability measures for use in analgesic clinical trials in patients with pain: IMMPACT recommendations

O'Connor, A. B., Turk, D. C., Dworkin, R. H., Katz, N. P., Colucci, R., Haythornthwaite, J. A., Klein, M., O'Brien, C., Posner, K., Rappaport, B. A., Reisfield, G., Adams, E. H., Balster, R. L., Bigelow, G. E., Burke, L. B., Comer, S. D., Cone, E., Cowan, P., Denisco, R. A., Farrar, J. T. & 19 others, Foltin, R. W., Haddox, J. D., Hertz, S., Jay, G. W., Junor, R., Kopecky, E. A., Leiderman, D. B., McDermott, M. P., Palmer, P. P., Raja, S. N., Rauschkolb, C., Rowbotham, M. C., Sampaio, C., Setnik, B., Smith, S. M., Sokolowska, M., Stauffer, J. W., Walsh, S. L. & Zacny, J. P., Nov 2013, In : Pain. 154, 11, p. 2324-2334 11 p.

Research output: Contribution to journalArticle

Conventional and kilohertz-frequency spinal cord stimulation produces intensity-and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain

Shechter, R., Yang, F., Xu, Q., Cheong, Y. K., He, S. Q., Sdrulla, A., Carteret, A. F., Wacnik, P. W., Dong, X., Meyer, R. A., Raja, S. N. & Guan, Y., Aug 1 2013, In : Anesthesiology. 119, 2, p. 422-432 11 p.

Research output: Contribution to journalArticle

Neuropathic pain needs systematic classification

Finnerup, N. B., Scholz, J., Attal, N., Baron, R., Haanpää, M., Hansson, P., Raja, S. N., Rice, A. S. C., Rief, W., Rowbotham, M. C., Simpson, D. M. & Treede, R. D., Aug 1 2013, In : European Journal of Pain (United Kingdom). 17, 7, p. 953-956 4 p.

Research output: Contribution to journalArticle

Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats

He, S. Q., Yang, F., Perez, F. M., Xu, Q., Shechter, R., Cheong, Y. K., Carteret, A. F., Dong, X., Sweitzer, S. M., Raja, S. N. & Guan, Y., Nov 2013, In : Pain. 154, 11, p. 2477-2486 10 p.

Research output: Contribution to journalArticle

2012

Analgesic properties of loperamide differ following systemic and local administration to rats after spinal nerve injury

Chung, C., Carteret, A. F., McKelvy, A. D., Ringkamp, M., Yang, F., Hartke, T. V., Dong, X., Raja, S. N. & Guan, Y., Aug 1 2012, In : European Journal of Pain (United Kingdom). 16, 7, p. 1021-1032 12 p.

Research output: Contribution to journalArticle

Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers

Ringkamp, M., Tal, M., Hartke, T. V., Wooten, M., McKelvy, A., Turnquist, B. P., Guan, Y., Meyer, R. A. & Raja, S. N., Jul 25 2012, In : PloS one. 7, 7, e42105.

Research output: Contribution to journalArticle