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2009

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

Singh, A., Ling, G., Suhasini, A. N., Zhang, P., Yamamoto, M., Navas-Acien, A., Cosgrove, G., Tuder, R. M., Kensler, T. W., Watson, W. H. & Biswal, S., Feb 1 2009, In : Free Radical Biology and Medicine. 46, 3, p. 376-386 11 p.

Research output: Contribution to journalArticle

Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia

McGrath-Morrow, S., Lauer, T., Yee, M., Neptune, E., Podowski, M., Thimmulappa, R. K., O'Reilly, M. & Biswal, S., Apr 1 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 4, p. L565-L573

Research output: Contribution to journalArticle

Nrf2 is a critical modulator of the innate immune response in a model of uveitis

Nagai, N., Thimmulappa, R. K., Cano, M., Fujihara, M., Izumi-Nagai, K., Kong, X., Sporn, M. B., Kensler, T. W., Biswal, S. & Handa, J. T., Aug 1 2009, In : Free Radical Biology and Medicine. 47, 3, p. 300-306 7 p.

Research output: Contribution to journalArticle

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Harvey, C. J., Thimmulappa, R. K., Singh, A., Blake, D. J., Ling, G., Wakabayashi, N., Fujii, J., Myers, A. & Biswal, S., Feb 15 2009, In : Free Radical Biology and Medicine. 46, 4, p. 443-453 11 p.

Research output: Contribution to journalArticle

Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema

Le, A., Zielinski, R., He, C., Crow, M. T., Biswal, S., Tuder, R. M. & Becker, P. M., Sep 1 2009, In : American journal of respiratory and critical care medicine. 180, 5, p. 396-406 11 p.

Research output: Contribution to journalArticle

Sildenafil Inhibits Superoxide Formation and Prevents Endothelial Dysfunction in a Mouse Model of Secondhand Smoke Induced Erectile Dysfunction

Bivalacqua, T. J., Sussan, T. E., Gebska, M. A., Strong, T. D., Berkowitz, D. E., Biswal, S., Burnett, A. L. & Champion, H. C., Feb 1 2009, In : Journal of Urology. 181, 2, p. 899-906 8 p.

Research output: Contribution to journalArticle

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., Sporn, M. B., Gabrielson, K. L., Champion, H. C., Tuder, R. M., Kensler, T. W. & Biswal, S., Jan 6 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 1, p. 250-255 6 p.

Research output: Contribution to journalArticle

2008

Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice

Fujihara, M., Nagai, N., Sussan, T. E., Biswal, S. & Handa, J. T., Sep 1 2008, In : PloS one. 3, 9, e3119.

Research output: Contribution to journalArticle

Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

Malhotra, D., Thimmulappa, R., Navas-Acien, A., Sandford, A., Elliott, M., Singh, A., Chen, L., Zhuang, X., Hogg, J., Pare, P., Tuder, R. M. & Biswal, S., Sep 15 2008, In : American journal of respiratory and critical care medicine. 178, 6, p. 592-604 13 p.

Research output: Contribution to journalArticle

Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs

Thimmulappa, R. K., Rangasamy, T., Alam, J. & Biswal, S., Sep 1 2008, In : Medicinal Chemistry. 4, 5, p. 473-481 9 p.

Research output: Contribution to journalArticle

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice

Sussan, T. E., Jun, J., Thimmulappa, R., Bedja, D., Antero, M., Gabrielson, K. L., Polotsky, V. Y. & Biswal, S., Nov 21 2008, In : PloS one. 3, 11, e3791.

Research output: Contribution to journalArticle

Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter

Williams, M. A., Rangasamy, T., Bauer, S. M., Killedar, S., Karp, M., Kensler, T. W., Yamamoto, M., Breysse, P., Biswal, S. & Georas, S. N., Oct 1 2008, In : Journal of Immunology. 181, 7, p. 4545-4559 15 p.

Research output: Contribution to journalArticle

Open Access

Effects of leptin deficiency on postnatal lung development in mice

Huang, K., Rabold, R., Abston, E., Schofield, B., Misra, V., Galdzicka, E., Lee, H., Biswal, S., Mitzner, W. & Tankersley, C. G., Jul 1 2008, In : Journal of applied physiology. 105, 1, p. 249-259 11 p.

Research output: Contribution to journalArticle

Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury

Saleem, S., Zhuang, H., Biswal, S., Christen, Y. & Doré, S., Dec 1 2008, In : Stroke. 39, 12, p. 3389-3396 8 p.

Research output: Contribution to journalArticle

Impaired lung homeostasis in neonatal mice exposed to cigarette smoke

McGrath-Morrow, S., Rangasamy, T., Cho, C., Sussan, T., Neptune, E., Wise, R., Tuder, R. M. & Biswal, S., Apr 1 2008, In : American journal of respiratory cell and molecular biology. 38, 4, p. 393-400 8 p.

Research output: Contribution to journalArticle

Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress

Taylor, R. C., Acquaah-Mensah, G., Singhal, M., Malhotra, D. & Biswal, S., Aug 1 2008, In : PLoS computational biology. 4, 8, e1000166.

Research output: Contribution to journalArticle

Redox-regulation of ERK 1/2-directed phosphatase by reactive oxygen species: Role in signaling TPA-induced growth arrest in ML-1 cells

Traore, K., Sharma, R., Thimmulappa, R. K., Watson, W. H., Biswal, S. & Trush, M. A., Jul 1 2008, In : Journal of Cellular Physiology. 216, 1, p. 276-285 10 p.

Research output: Contribution to journalArticle

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin efficacy of recoupling nitric oxide synthase as a therapeutic strategy

Moens, A. L., Takimoto, E., Tocchetti, C. G., Chakir, K., Bedja, D., Cormaci, G., Ketner, E. A., Majmudar, M., Gabrielson, K., Halushka, M. K., Mitchell, J. B., Biswal, S., Channon, K. M., Wolin, M. S., Alp, N. J., Paolocci, N., Champion, H. C. & Kass, D. A., May 20 2008, In : Circulation. 117, 20, p. 2626-2636 11 p.

Research output: Contribution to journalArticle

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

Singh, A., Boldin-Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J., Blackford, A., Goodman, S. N., Bunz, F., Watson, W. H., Gabrielson, E., Feinstein, E. & Biswal, S., Oct 1 2008, In : Cancer Research. 68, 19, p. 7975-7984 10 p.

Research output: Contribution to journalArticle

2007

A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice

Balbir, A., Lee, H., Okumura, M., Biswal, S., Fitzgerald, R. S. & Shirahata, M., Mar 1 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 3, p. L704-L715

Research output: Contribution to journalArticle

Deficiency in Nrf2 GSH signaling impairs type II cell growth and enhances sensitivity to oxidants

Reddy, N. M., Kleeberger, S. R., Cho, H. Y., Yamamoto, M., Kensler, T. W., Biswal, S. & Reddy, S. P., Jul 2007, In : American journal of respiratory cell and molecular biology. 37, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice

Papaiahgari, S., Yerrapureddy, A., Reddy, S. R., Reddy, N. M., Dodd-O, J. M., Crow, M. T., Grigoryev, D. N., Barnes, K., Tuder, R. M., Yamamoto, M., Kensler, T. W., Biswal, S., Mitzner, W., Hassoun, P. M. & Reddy, S. P., Dec 15 2007, In : American journal of respiratory and critical care medicine. 176, 12, p. 1222-1235 14 p.

Research output: Contribution to journalArticle

Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection

Reddy, N. M., Kleeberger, S. R., Yamamoto, M., Kensler, T. W., Scollick, C., Biswal, S. & Reddy, S. P., Dec 19 2007, In : Physiological Genomics. 32, 1, p. 74-81 8 p.

Research output: Contribution to journalArticle

Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes

Misra, V., Lee, H., Singh, A., Huang, K., Thimmulappa, R. K., Mitzner, W., Biswal, S. & Tankersley, C. G., Nov 14 2007, In : Physiological Genomics. 31, 3, p. 429-440 12 p.

Research output: Contribution to journalArticle

NRF2 modulates aryl hydrocarbon receptor signaling: Influence on adipogenesis

Shin, S., Wakabayashi, N., Misra, V., Biswal, S., Gum, H. L., Agoston, E. S., Yamamoto, M. & Kensler, T. W., Oct 1 2007, In : Molecular and cellular biology. 27, 20, p. 7188-7197 10 p.

Research output: Contribution to journalArticle

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils

Thimmulappa, R. K., Fuchs, R. J., Malhotra, D., Scollick, C., Traore, K., Bream, J. H., Trush, M. A., Liby, K. T., Sporn, M. B., Kensler, T. W. & Biswal, S., Oct 1 2007, In : Antioxidants and Redox Signaling. 9, 11, p. 1963-1970 8 p.

Research output: Contribution to journalArticle

Role of Nrf2 in protection against intracerebral hemorrhage injury in mice

Wang, J., Fields, J., Zhao, C., Langer, J., Thimmulappa, R. K., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Aug 1 2007, In : Free Radical Biology and Medicine. 43, 3, p. 408-414 7 p.

Research output: Contribution to journalArticle

Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury

Shah, Z. A., Li, R. C., Thimmulappa, R. K., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Jun 15 2007, In : Neuroscience. 147, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

Selective and nonselective packaging of cellular RNAs in retrovirus particles

Rulli, S. J., Hibbert, C. S., Mirro, J., Pederson, T., Biswal, S. & Rein, A., Jun 1 2007, In : Journal of virology. 81, 12, p. 6623-6631 9 p.

Research output: Contribution to journalArticle

Variation in senescent-dependent lung changes in inbred mouse strains

Huang, K., Mitzner, W., Rabold, R., Schofield, B., Lee, H., Biswal, S. & Tankersley, C. G., Apr 1 2007, In : Journal of applied physiology. 102, 4, p. 1632-1639 8 p.

Research output: Contribution to journalArticle

2006

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., Brock, M. V. & Biswal, S., Oct 1 2006, In : PLoS medicine. 3, 10, p. 1865-1876 12 p.

Research output: Contribution to journalArticle

Ethanol sensitivity: A central role for CREB transcription regulation in the cerebellum

Acquaah-Mensah, G. K., Misra, V. & Biswal, S., Dec 5 2006, In : BMC genomics. 7, 308.

Research output: Contribution to journalArticle

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

Singh, A., Rangasamy, T., Thimmulappa, R. K., Lee, H., Osburn, W. O., Brigelius-Flohé, R., Kensler, T. W., Yamamoto, M. & Biswal, S., Dec 1 2006, In : American journal of respiratory cell and molecular biology. 35, 6, p. 639-650 12 p.

Research output: Contribution to journalArticle

Long term environmental tobacco smoke activates nuclear transcription factor-kappa B, activator protein-1, and stress responsive kinases in mouse brain

Manna, S. K., Rangasamy, T., Wise, K., Sarkar, S., Shishodia, S., Biswal, S. & Ramesh, G. T., May 28 2006, In : Biochemical Pharmacology. 71, 11, p. 1602-1609 8 p.

Research output: Contribution to journalArticle

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

Thimmulappa, R. K., Scollick, C., Traore, K., Yates, M., Trush, M. A., Liby, K. T., Sporn, M. B., Yamamoto, M., Kensler, T. W. & Biswal, S., Dec 29 2006, In : Biochemical and Biophysical Research Communications. 351, 4, p. 883-889 7 p.

Research output: Contribution to journalArticle

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

Thimmulappa, R. K., Lee, H., Rangasamy, T., Reddy, S. P., Yamamoto, M., Kensler, T. W. & Biswal, S., Apr 1 2006, In : Journal of Clinical Investigation. 116, 4, p. 984-995 12 p.

Research output: Contribution to journalArticle

Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion

Osburn, W. O., Wakabayashi, N., Misra, V., Nilles, T., Biswal, S., Trush, M. A. & Kensler, T. W., Oct 1 2006, In : Archives of Biochemistry and Biophysics. 454, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Role of lung maintenance program in the heterogeneity of lung destruction in emphysema

Tuder, R. M., Yoshida, T., Fijalkowka, I., Biswal, S. & Petrache, I., Nov 1 2006, In : Proceedings of the American Thoracic Society. 3, 8, p. 673-679 7 p.

Research output: Contribution to journalArticle

2005

Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: A comprehensive transcriptional response

Tian, J., Ishibashi, K., Ishibashi, K., Reiser, K., Grebe, R., Biswal, S., Gehlbach, P. & Handa, J. T., Aug 16 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 33, p. 11846-11851 6 p.

Research output: Contribution to journalArticle

Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N. & Biswal, S., Jul 4 2005, In : Journal of Experimental Medicine. 202, 1, p. 47-59 13 p.

Research output: Contribution to journalArticle

Identification of transcriptional targets of HOXA5

Chen, H., Rubin, E., Zhang, H., Chung, S., Jie, C. C., Garrett, E., Biswal, S. & Sukumar, S., May 13 2005, In : Journal of Biological Chemistry. 280, 19, p. 19373-19380 8 p.

Research output: Contribution to journalArticle

Multiple-laboratory comparison of microarray platforms

Irizarry, R. A., Warren, D., Spencer, F., Kim, I. F., Biswal, S., Frank, B. C., Gabrielson, E., Garcia, J. G. N., Geoghegan, J., Germino, G., Griffin, C., Hilmer, S. C., Hoffman, E., Jedlicka, A. E., Kawasaki, E., Martínez-Murillo, F., Morsberger, L., Lee, H., Petersen, D., Quackenbush, J. & 5 others, Scott, A., Wilson, M., Yang, Y., Ye, S. Q. & Yu, W., May 1 2005, In : Nature Methods. 2, 5, p. 345-349 5 p.

Research output: Contribution to journalArticle

2004

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

Rangasamy, T., Cho, C. Y., Thimmulappa, R. K., Zhen, L., Srisuma, S. S., Kensler, T. W., Yamamoto, M., Petrache, I., Tuder, R. M. & Biswal, S., Nov 1 2004, In : Journal of Clinical Investigation. 114, 9, p. 1248-1259 12 p.

Research output: Contribution to journalArticle

2003

Identification of genes promoting angiogenesis in mouse lung by transcriptional profiling

Srisuma, S., Biswal, S. S., Mitzner, W. A., Gallagher, S. J., Mai, K. H. & Wagner, E. M., Aug 1 2003, In : American journal of respiratory cell and molecular biology. 29, 2, p. 172-179 8 p.

Research output: Contribution to journalArticle

Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein

Biswal, S., Maxwell, T., Rangasamy, T. & Kehrer, J. P., Aug 1 2003, In : Carcinogenesis. 24, 8, p. 1401-1406 6 p.

Research output: Contribution to journalArticle

Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis

Wu, X., Biswal, S. S. & Kehrer, J. P., Jun 1 2003, In : Cell Biology and Toxicology. 19, 3, p. 135-143 9 p.

Research output: Contribution to journalArticle

2002

Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells

Tirumalai, R., Rajesh Kumar, T., Mai, K. H. & Biswal, S., Jun 7 2002, In : Toxicology Letters. 132, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Thimmulappa, R. K., Mai, K. H., Srisuma, S., Kensler, T. W., Yamamoto, M. & Biswal, S., Sep 15 2002, In : Cancer Research. 62, 18, p. 5196-5203 8 p.

Research output: Contribution to journalArticle

Inhibition of cell proliferation and AP-1 activity by acrolein in human A549 lung adenocarcinoma cells due to thiol imbalance and covalent modifications

Biswal, S., Acquaah-Mensah, G., Datta, K., Wu, X. & Kehrer, J. P., Mar 4 2002, In : Chemical research in toxicology. 15, 2, p. 180-186 7 p.

Research output: Contribution to journalArticle

2001

Association between bcl-xL and 5-lipoxygenase activating protein (FLAP) levels in IL-3-dependent FL5.12 cells

Biswal, S. S., Datta, K. & Kehrer, J. P., Mar 7 2001, In : Toxicology. 160, 1-3, p. 97-103 7 p.

Research output: Contribution to journalArticle