1993 …2020

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2013

Linoleic acid metabolite drives severe asthma by causing airway epithelial injury

Mabalirajan, U., Rehman, R., Ahmad, T., Kumar, S., Singh, S., Leishangthem, G. D., Aich, J., Kumar, M., Khanna, K., Singh, V. P., Dinda, A. K., Biswal, S., Agrawal, A. & Ghosh, B., Mar 11 2013, In : Scientific reports. 3, 1349.

Research output: Contribution to journalArticle

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching

Wei, Y., Gong, J., Thimmulappa, R. K., Kosmider, B., Biswal, S. & Duh, E. J., Oct 8 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. E3910-E3918

Research output: Contribution to journalArticle

Oral administration of the flavanol (-)-epicatechin bolsters endogenous protection against focal ischemia through the Nrf2 cytoprotective pathway

Leonardo, C. C., Agrawal, M., Singh, N., Moore, J. R., Biswal, S. & Doré, S., Dec 2013, In : European Journal of Neuroscience. 38, 11, p. 3659-3668 10 p.

Research output: Contribution to journalArticle

The Twist box domain is required for Twist1-induced prostate cancer metastasis

Gajula, R. P., Chettiar, S. T., Williams, R. D., Thiyagarajan, S., Kato, Y., Aziz, K., Wang, R., Gandhi, N., Wild, A. T., Vesuna, F., Ma, J., Salih, T., Cades, J., Fertig, E., Biswal, S., Burns, T. F., Chung, C. H., Rudin, C. M., Herman, J. M., Hales, R. K. & 3 others, Raman, V., An, S. S. & Tran, P. T., Nov 1 2013, In : Molecular Cancer Research. 11, 11, p. 1387-1400 14 p.

Research output: Contribution to journalArticle

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis

Singh, A., Happel, C., Manna, S. K., Acquaah-Mensah, G., Carrerero, J., Kumar, S., Nasipuri, P., Krausz, K. W., Wakabayashi, N., Dewi, R., Boros, L. G., Gonzalez, F. J., Gabrielson, E., Wong, K. K., Girnun, G. & Biswal, S., Jul 1 2013, In : Journal of Clinical Investigation. 123, 7, p. 2921-2934 14 p.

Research output: Contribution to journalArticle

2012

Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: Structure-activity analysis

Kumar, S., Reddy L, C. S., Kumar, Y., Kumar, A., Singh, B. K., Kumar, V., Malhotra, S., Pandey, M. K., Jain, R., Thimmulappa, R., Sharma, S. K., Prasad, A. K., Biswal, S., Van Der Eycken, E., Depass, A. L., Malhotra, S. V., Ghosh, B. & Parmar, V. S., May 1 2012, In : Archiv der Pharmazie. 345, 5, p. 368-377 10 p.

Research output: Contribution to journalArticle

Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD

Biswal, S., Thimmulappa, R. K. & Harvey, C. J., May 1 2012, In : Proceedings of the American Thoracic Society. 9, 2, p. 47-51 5 p.

Research output: Contribution to journalArticle

Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis

Bhalla, K., Hwang, B. J., Dewi, R. E., Twaddel, W., Goloubeva, O. G., Wong, K. K., Saxena, N. K., Biswal, S. & Girnun, G. D., Apr 1 2012, In : Cancer Prevention Research. 5, 4, p. 544-552 9 p.

Research output: Contribution to journalArticle

NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease

Sandford, A. J., Malhotra, D., Marike Boezen, H., Siedlinski, M., Postma, D. S., Wong, V., Akhabir, L., He, J. Q., Connett, J. E., Anthonisen, N. R., Paré, P. D. & Biswal, S., Aug 1 2012, In : Physiological Genomics. 44, 15, p. 754-763 10 p.

Research output: Contribution to journalArticle

Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke

Thimmulappa, R. K., Gang, X., Kim, J. H., Sussan, T. E., Witztum, J. L. & Biswal, S., Sep 21 2012, In : Biochemical and Biophysical Research Communications. 426, 2, p. 253-259 7 p.

Research output: Contribution to journalArticle

Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer

Kombairaju, P., Ma, J., Thimmulappa, R., Yan, G., Gabrielson, E., Singh, A. & Biswal, S., Dec 1 2012, In : Journal of Carcinogenesis. 11, 8.

Research output: Contribution to journalArticle

Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease

Acquaah-Mensah, G. K., Malhotra, D., Vulimiri, M., McDermott, J. E. & Biswal, S., Jul 2012, In : PLoS computational biology. 8, 7, e1002597.

Research output: Contribution to journalArticle

Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smokeinduced lung inflammation

Reddy, N. M., Vegiraju, S., Irving, A., Paun, B. C., Luzina, I. G., Atamas, S. P., Biswal, S., Ana, N. A., Mitzner, W. & Reddy, S. P., Feb 2012, In : American Journal of Pathology. 180, 2, p. 562-574 13 p.

Research output: Contribution to journalArticle

The transcription factor encyclopedia.

Yusuf, D., Butland, S. L., Swanson, M. I., Bolotin, E., Ticoll, A., Cheung, W. A., Zhang, X. Y. C., Dickman, C. T. D., Fulton, D. L., Lim, J. S., Schnabl, J. M., Ramos, O. H. P., Vasseur-Cognet, M., de Leeuw, C. N., Simpson, E. M., Ryffel, G. U., Lam, E. W. F., Kist, R., Wilson, M. S. C., Marco-Ferreres, R. & 79 others, Brosens, J. J., Beccari, L. L., Bovolenta, P., Benayoun, B. A., Monteiro, L. J., Schwenen, H. D. C., Grontved, L., Wederell, E., Mandrup, S., Veitia, R. A., Chakravarthy, H., Hoodless, P. A., Mancarelli, M. M., Torbett, B. E., Banham, A. H., Reddy, S. P., Cullum, R. L., Liedtke, M., Tschan, M. P., Vaz, M., Rizzino, A., Zannini, M., Frietze, S., Farnham, P. J., Eijkelenboom, A., Brown, P. J., Laperrière, D., Leprince, D., de Cristofaro, T., Prince, K. L., Putker, M., del Peso, L., Camenisch, G., Wenger, R. H., Mikula, M., Rozendaal, M., Mader, S., Ostrowski, J., Rhodes, S. J., Van Rechem, C., Boulay, G., Olechnowicz, S. W. Z., Breslin, M. B., Lan, M. S., Nanan, K. K., Wegner, M., Hou, J., Mullen, R. D., Colvin, S. C., Noy, P. J., Webb, C. F., Witek, M. E., Ferrell, S., Daniel, J. M., Park, J., Waldman, S. A., Peet, D. J., Taggart, M., Jayaraman, P. S., Karrich, J. J., Blom, B., Vesuna, F., O'Geen, H., Sun, Y., Gronostajski, R. M., Woodcroft, M. W., Hough, M. R., Chen, E., Europe-Finner, G. N., Karolczak-Bayatti, M., Bailey, J., Hankinson, O., Raman, V., LeBrun, D. P., Biswal, S., Harvey, C. J., DeBruyne, J. P., Hogenesch, J. B. & Hevner, R. F., 2012, In : Genome biology. 13, 3, p. R24

Research output: Contribution to journalArticle

Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus

Jachak, A., Lai, S. K., Hida, K., Suk, J. S., Markovic, N., Biswal, S., Breysse, P. N. & Hanes, J., Sep 1 2012, In : Nanotoxicology. 6, 6, p. 614-622 9 p.

Research output: Contribution to journalArticle

2011

Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia

Wang, B., Cao, W., Biswal, S. & Doré, S., Sep 1 2011, In : Stroke. 42, 9, p. 2605-2610 6 p.

Research output: Contribution to journalArticle

Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation

Reddy, N. M., Potteti, H. R., Mariani, T. J., Biswall, S. & Reddy, S. P., Dec 1 2011, In : American journal of respiratory cell and molecular biology. 45, 6, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

Mercado, N., Thimmulappa, R., Thomas, C. M. R., Fenwick, P. S., Chana, K. K., Donnelly, L. E., Biswal, S., Ito, K. & Barnes, P. J., Mar 11 2011, In : Biochemical and Biophysical Research Communications. 406, 2, p. 292-298 7 p.

Research output: Contribution to journalArticle

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

Malhotra, D., Thimmulappa, R. K., Mercado, N., Ito, K., Kombairaju, P., Kumar, S., Ma, J., Feller-Kopman, D., Wise, R., Barnes, P. & Biswal, S., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4289-4302 14 p.

Research output: Contribution to journalArticle

Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells

Pandey, M. K., Kumar, S., Thimmulappa, R. K., Parmar, V. S., Biswal, S. & Watterson, A. C., May 18 2011, In : European Journal of Pharmaceutical Sciences. 43, 1-2, p. 16-24 9 p.

Research output: Contribution to journalArticle

Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis

Kong, X., Thimmulappa, R., Craciun, F., Harvey, C., Singh, A., Kombairaju, P., Reddy, S. P., Remick, D. & Biswal, S., Oct 15 2011, In : American journal of respiratory and critical care medicine. 184, 8, p. 928-938 11 p.

Research output: Contribution to journalArticle

Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells

Kumar, V., Kumar, S., Hassan, M., Wu, H., Thimmulappa, R. K., Kumar, A., Sharma, S. K., Parmar, V. S., Biswal, S. & Malhotra, S. V., Jun 23 2011, In : Journal of medicinal chemistry. 54, 12, p. 4147-4159 13 p.

Research output: Contribution to journalArticle

Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells

Kumar, S., Singh, B. K., Arya, P., Malhotra, S., Thimmulappa, R., Prasad, A. K., Van Der Eycken, E., Olsen, C. E., Depass, A. L., Biswal, S., Parmar, V. S. & Ghosh, B., Nov 1 2011, In : European Journal of Medicinal Chemistry. 46, 11, p. 5498-5511 14 p.

Research output: Contribution to journalArticle

PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression

Zhou, W., Dowell, D. R., Geraci, M. W., Blackwell, T. S., Collins, R. D., Polosukhin, V. V., Lawson, W. E., Wu, P., Sussan, T., Biswal, S., Goleniewska, K., O'Neal, J., Newcomb, D. C., Toki, S., Morrow, J. D. & Stokes Peebles, J., Oct 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 4, p. L615-L622

Research output: Contribution to journalArticle

Plasma miRNA as biomarkers for assessment of total-body radiation exposure dosimetry

Cui, W., Ma, J., Wang, Y. & Biswal, S., Aug 22 2011, In : PloS one. 6, 8, e22988.

Research output: Contribution to journalArticle

Synthesis and biological activity evaluation of N-protected isatin derivatives as inhibitors of ICAM-1 expression on human endothelial cells

Malhotra, S., Balwani, S., Dhawan, A., Singh, B. K., Kumar, S., Thimmulappa, R., Biswal, S., Olsen, C. E., Van Der Eycken, E., Prasad, A. K., Ghosh, B. & Parmar, V. S., Aug 1 2011, In : MedChemComm. 2, 8, p. 743-751 9 p.

Research output: Contribution to journalArticle

Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model

Harvey, C. J., Thimmulappa, R. K., Sethi, S., Kong, X., Yarmus, L., Brown, R. H., Feller-Kopman, D., Wise, R. & Biswal, S., Apr 13 2011, In : Science translational medicine. 3, 78, 78ra32.

Research output: Contribution to journalArticle

Telomere length is a determinant of emphysema susceptibility

Alder, J. K., Guo, N., Kembou, F., Parry, E. M., Anderson, C. J., Gorgy, A. I., Walsh, M. F., Sussan, T., Biswal, S., Mitzner, W., Tuder, R. M. & Armanios, M., Oct 15 2011, In : American journal of respiratory and critical care medicine. 184, 8, p. 904-912 9 p.

Research output: Contribution to journalArticle

The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels

Merchant, A. A., Singh, A., Matsui, W. & Biswal, S., Dec 15 2011, In : Blood. 118, 25, p. 6572-6579 8 p.

Research output: Contribution to journalArticle

2010

Calreticulin transacetylase catalyzed modification of the TNF-α mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates

Singh, U., Kumar, A., Sinha, R., Manral, S., Arora, S., Ram, S., Mishra, R. K., Gupta, P., Bansal, S. K., Prasad, A. K., Biswal, S., Parmar, V. S. & Raj, H. G., May 1 2010, In : Chemico-Biological Interactions. 185, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

Cano, M., Thimmalappula, R., Fujihara, M., Nagai, N., Sporn, M., Wang, A. L., Neufeld, A. H., Biswal, S. & Handa, J. T., Mar 1 2010, In : Vision Research. 50, 7, p. 652-664 13 p.

Research output: Contribution to journalArticle

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation

Blake, D. J., Singh, A., Kombairaju, P., Malhotra, D., Mariani, T. J., Tuder, R. M., Gabrielson, E. & Biswal, S., May 1 2010, In : American journal of respiratory cell and molecular biology. 42, 5, p. 524-536 13 p.

Research output: Contribution to journalArticle

Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype

Singh, A., Wu, H., Zhang, P., Happel, C., Ma, J. & Biswal, S., Aug 1 2010, In : Molecular cancer therapeutics. 9, 8, p. 2365-2376 12 p.

Research output: Contribution to journalArticle

Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance

Singh, A., Bodas, M., Wakabayashi, N., Bunz, F. & Biswal, S., Dec 1 2010, In : Antioxidants and Redox Signaling. 13, 11, p. 1627-1637 11 p.

Research output: Contribution to journalArticle

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through chip-seq profiling and network analysis

Malhotra, D., Portales-Casamar, E., Singh, A., Srivastava, S., Arenillas, D., Happel, C., Shyr, C., Wakabayashi, N., Kensler, T. W., Wasserman, W. W. & Biswal, S., May 11 2010, In : Nucleic acids research. 38, 17, p. 5718-5734 17 p., gkq212.

Research output: Contribution to journalArticle

Loss of kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth

Zhang, P., Singh, A., Yegnasubramanian, S., Esopi, D., Kombairaju, P., Bodas, M., Wu, H., Bova, S. G. & Biswal, S., Feb 1 2010, In : Molecular cancer therapeutics. 9, 2, p. 336-346 11 p.

Research output: Contribution to journalArticle

NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice

Kong, X., Thimmulappa, R., Kombairaju, P. & Biswal, S., Jul 1 2010, In : Journal of Immunology. 185, 1, p. 569-577 9 p.

Research output: Contribution to journalArticle

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

Solis, L. M., Behrens, C., Dong, W., Suraokar, M., Ozburn, N. C., Moran, C. A., Corvalan, A. H., Biswal, S., Swisher, S. G., Bekele, B. N., Minna, J. D., Stewart, D. J. & Wistuba, I. I., Jul 15 2010, In : Clinical Cancer Research. 16, 14, p. 3743-3753 11 p.

Research output: Contribution to journalArticle

Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract

Rangasamy, T., Williams, M. A., Bauer, S., Trush, M. A., Emo, J., Georas, S. N. & Biswal, S., Sep 1 2010, In : American journal of respiratory cell and molecular biology. 43, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

Regulation of Notch1 signaling by Nrf2: Implications for tissue regeneration

Wakabayashi, N., Shin, S., Slocum, S. L., Agoston, E. S., Wakabayashi, J., Kwak, M. K., Misra, V., Biswal, S., Yamamoto, M. & Kensler, T. W., Jul 13 2010, In : Science signaling. 3, 130, p. ra52

Research output: Contribution to journalArticle

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema

Yoshida, T., Mett, I., Bhunia, A. K., Bowman, J., Perez, M., Zhang, L., Gandjeva, A., Zhen, L., Chukwueke, U., Mao, T., Richter, A., Brown, E., Ashush, H., Notkin, N., Gelfand, A., Thimmulappa, R. K., Rangasamy, T., Sussan, T., Cosgrove, G., Mouded, M. & 5 others, Shapiro, S. D., Petrache, I., Biswal, S., Feinstein, E. & Tuder, R. M., Jul 1 2010, In : Nature medicine. 16, 7, p. 767-773 7 p.

Research output: Contribution to journalArticle

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway

Shah, Z. A., Li, R. C., Ahmad, A. S., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Dec 1 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 12, p. 1951-1961 11 p.

Research output: Contribution to journalArticle

2009

Cell stiffness, contractile stress and the role of extracellular matrix

An, S. S., Kim, J., Ahn, K., Trepat, X., Drake, K. J., Kumar, S., Ling, G., Purington, C., Rangasamy, T., Kensler, T. W., Mitzner, W., Fredberg, J. J. & Biswal, S., May 15 2009, In : Biochemical and Biophysical Research Communications. 382, 4, p. 697-703 7 p.

Research output: Contribution to journalArticle

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

Rangasamy, T., Misra, V., Zhen, L., Tankersley, C. G., Tuder, R. M. & Biswal, S., Jun 1 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 6, p. L888-L900

Research output: Contribution to journalArticle

Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: The role of Nrf2-regulated proteasomal activity

Malhotra, D., Thimmulappa, R., Vij, N., Navas-Acien, A., Sussan, T., Merali, S., Zhang, L., Kelsen, S. G., Myers, A., Wise, R., Tuder, R. & Biswal, S., Dec 15 2009, In : American journal of respiratory and critical care medicine. 180, 12, p. 1197-1207 11 p.

Research output: Contribution to journalArticle