1993 …2020

Research output per year

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Research Output

Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress

Taylor, R. C., Acquaah-Mensah, G., Singhal, M., Malhotra, D. & Biswal, S., Aug 2008, In : PLoS computational biology. 4, 8, e1000166.

Research output: Contribution to journalArticle

Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion

Xu, Z., Cho, H., Hartsock, M. J., Mitchell, K. L., Gong, J., Wu, L., Wei, Y., Wang, S., Thimmulappa, R. K., Sporn, M. B., Biswal, S., Welsbie, D. S. & Duh, E. J., Apr 1 2015, In : Journal of Neurochemistry. 133, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease

Sandford, A. J., Malhotra, D., Marike Boezen, H., Siedlinski, M., Postma, D. S., Wong, V., Akhabir, L., He, J. Q., Connett, J. E., Anthonisen, N. R., Paré, P. D. & Biswal, S., Aug 1 2012, In : Physiological Genomics. 44, 15, p. 754-763 10 p.

Research output: Contribution to journalArticle

Notch-Nrf2 axis: Regulation of Nrf2 gene expression and cytoprotection by notch signaling

Wakabayashi, N., Skoko, J. J., Chartoumpekis, D. V., Kimura, S., Slocum, S. L., Noda, K., Palliyaguru, D. L., Fujimuro, M., Boley, P. A., Tanaka, Y., Shigemura, N., Biswal, S., Yamamoto, M. & Kensler, T. W., Feb 1 2014, In : Molecular and cellular biology. 34, 4, p. 653-663 11 p.

Research output: Contribution to journalArticle

Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells

Kumar, V., Kumar, S., Hassan, M., Wu, H., Thimmulappa, R. K., Kumar, A., Sharma, S. K., Parmar, V. S., Biswal, S. & Malhotra, S. V., Jun 23 2011, In : Journal of medicinal chemistry. 54, 12, p. 4147-4159 13 p.

Research output: Contribution to journalArticle

Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells

Kumar, S., Singh, B. K., Arya, P., Malhotra, S., Thimmulappa, R., Prasad, A. K., Van Der Eycken, E., Olsen, C. E., Depass, A. L., Biswal, S., Parmar, V. S. & Ghosh, B., Nov 1 2011, In : European Journal of Medicinal Chemistry. 46, 11, p. 5498-5511 14 p.

Research output: Contribution to journalArticle

Nrf2: A transcription factor that modifies susceptibility to cigarette smoke-induced pulmonary oxidative stress and emphysema

Biswal, S. & Kensler, T. W., Dec 1 2006, Cigarette Smoke and Oxidative Stress. Springer Berlin Heidelberg, p. 365-377 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nrf2 activation via Keap1 deletion or sulforaphane treatment reduces Ova-induced sinonasal inflammation

London, N. R., Tharakan, A., Mendiola, M., Chen, M., Dobzanski, A., Sussan, T. E., Zaykaner, M., Han, A. H., Lane, A. P., Sidhaye, V., Biswal, S. & Ramanathan, M., Jan 1 2019, In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalLetter

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching

Wei, Y., Gong, J., Thimmulappa, R. K., Kosmider, B., Biswal, S. & Duh, E. J., Oct 8 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. E3910-E3918

Research output: Contribution to journalArticle

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

Solis, L. M., Behrens, C., Dong, W., Suraokar, M., Ozburn, N. C., Moran, C. A., Corvalan, A. H., Biswal, S., Swisher, S. G., Bekele, B. N., Minna, J. D., Stewart, D. J. & Wistuba, I. I., Jul 15 2010, In : Clinical Cancer Research. 16, 14, p. 3743-3753 11 p.

Research output: Contribution to journalArticle

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

Thimmulappa, R. K., Scollick, C., Traore, K., Yates, M., Trush, M. A., Liby, K. T., Sporn, M. B., Yamamoto, M., Kensler, T. W. & Biswal, S., Dec 29 2006, In : Biochemical and Biophysical Research Communications. 351, 4, p. 883-889 7 p.

Research output: Contribution to journalArticle

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

Singh, A., Ling, G., Suhasini, A. N., Zhang, P., Yamamoto, M., Navas-Acien, A., Cosgrove, G., Tuder, R. M., Kensler, T. W., Watson, W. H. & Biswal, S., Feb 1 2009, In : Free Radical Biology and Medicine. 46, 3, p. 376-386 11 p.

Research output: Contribution to journalArticle

Nrf2 exerts cell-autonomous antifibrotic effects: Compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

Wei, J., Zhu, H., Lord, G., Bhattachayya, M., Jones, B. M., Allaway, G., Biswal, S., Korman, B., Marangoni, R. G., Tourtellotte, W. G. & Varga, J., Jul 30 2016, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia

McGrath-Morrow, S., Lauer, T., Yee, M., Neptune, E., Podowski, M., Thimmulappa, R. K., O'Reilly, M. & Biswal, S., Apr 1 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 4, p. L565-L573

Research output: Contribution to journalArticle

Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A

Wei, Y., Gong, J., Xu, Z., Thimmulappa, R. K., Mitchell, K. L., Welsbie, D. S., Biswal, S. & Duh, E. J., Dec 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. E6927-E6936

Research output: Contribution to journalArticle

Nrf2 is a critical modulator of the innate immune response in a model of uveitis

Nagai, N., Thimmulappa, R. K., Cano, M., Fujihara, M., Izumi-Nagai, K., Kong, X., Sporn, M. B., Kensler, T. W., Biswal, S. & Handa, J. T., Aug 1 2009, In : Free Radical Biology and Medicine. 47, 3, p. 300-306 7 p.

Research output: Contribution to journalArticle

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

Thimmulappa, R. K., Lee, H., Rangasamy, T., Reddy, S. P., Yamamoto, M., Kensler, T. W. & Biswal, S., Apr 1 2006, In : Journal of Clinical Investigation. 116, 4, p. 984-995 12 p.

Research output: Contribution to journalArticle

Nrf2 is required for normal postnatal bone acquisition in mice

Kim, J. H., Singhal, V., Biswal, S., Thimmulappa, R. K. & DiGirolamo, D. J., Jan 1 2015, In : Bone Research. 2, 14033.

Research output: Contribution to journalArticle

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

Kim, J. H., Thimmulappa, R. K., Kumar, V., Cui, W., Kumar, S., Kombairaju, P., Zhang, H., Margolick, J., Matsui, W., Macvittie, T., Malhotra, S. V. & Biswal, S., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 730-741 12 p.

Research output: Contribution to journalArticle

Nrf2-mediated regulation of skeletal muscle glycogen metabolism

Uruno, A., Yagishita, Y., Katsuoka, F., Kitajima, Y., Nunomiya, A., Nagatomi, R., Pi, J., Biswal, S. & Yamamoto, M., 2016, In : Molecular and Cellular Biology. 36, 11, p. 1655-1672 18 p.

Research output: Contribution to journalArticle

NRF2 modulates aryl hydrocarbon receptor signaling: Influence on adipogenesis

Shin, S., Wakabayashi, N., Misra, V., Biswal, S., Gum, H. L., Agoston, E. S., Yamamoto, M. & Kensler, T. W., Oct 2007, In : Molecular and cellular biology. 27, 20, p. 7188-7197 10 p.

Research output: Contribution to journalArticle

NRF2 plays a protective role in diabetic retinopathy in mice

Xu, Z., Wei, Y., Gong, J., Cho, H., Park, J. K., Sung, E. R., Huang, H., Wu, L., Eberhart, C., Handa, J. T., Du, Y., Kern, T. S., Thimmulappa, R., Barber, A. J., Biswal, S. & Duh, E. J., Jan 1 2014, In : Diabetologia. 57, 1, p. 204-213 10 p.

Research output: Contribution to journalArticle

Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function

Sussan, T. E., Gajghate, S., Chatterjee, S., Mandke, P., McCormick, S., Sudini, K., Kumar, S., Breysse, P. N., Diette, G. B., Sidhaye, V. K. & Biswal, S., Jul 6 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 1, p. L27-L36

Research output: Contribution to journalArticle

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Harvey, C. J., Thimmulappa, R. K., Singh, A., Blake, D. J., Ling, G., Wakabayashi, N., Fujii, J., Myers, A. & Biswal, S., Feb 15 2009, In : Free Radical Biology and Medicine. 46, 4, p. 443-453 11 p.

Research output: Contribution to journalArticle

Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion

Osburn, W. O., Wakabayashi, N., Misra, V., Nilles, T., Biswal, S., Trush, M. A. & Kensler, T. W., Oct 1 2006, In : Archives of Biochemistry and Biophysics. 454, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation

Walker, A., Singh, A., Tully, E., Woo, J., Le Thi, Q. H., Nguyen, T., Biswal, S., Sharma, D. & Gabrielson, E., May 20 2018, In : Free Radical Biology and Medicine. 120, p. 407-413 7 p.

Research output: Contribution to journalArticle

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells

Wang, L., Kondo, N., Cano, M., Ebrahimi, K., Yoshida, T., Barnett, B. P., Biswal, S. & Handa, J. T., May 2014, In : Free Radical Biology and Medicine. 70, p. 155-166 12 p.

Research output: Contribution to journalArticle

Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract

Rangasamy, T., Williams, M. A., Bauer, S., Trush, M. A., Emo, J., Georas, S. N. & Biswal, S., Sep 1 2010, In : American journal of respiratory cell and molecular biology. 43, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

Oral administration of the flavanol (-)-epicatechin bolsters endogenous protection against focal ischemia through the Nrf2 cytoprotective pathway

Leonardo, C. C., Agrawal, M., Singh, N., Moore, J. R., Biswal, S. & Doré, S., Dec 2013, In : European Journal of Neuroscience. 38, 11, p. 3659-3668 10 p.

Research output: Contribution to journalArticle

Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke

Thimmulappa, R. K., Gang, X., Kim, J. H., Sussan, T. E., Witztum, J. L. & Biswal, S., Sep 21 2012, In : Biochemical and Biophysical Research Communications. 426, 2, p. 253-259 7 p.

Research output: Contribution to journalArticle

PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression

Zhou, W., Dowell, D. R., Geraci, M. W., Blackwell, T. S., Collins, R. D., Polosukhin, V. V., Lawson, W. E., Wu, P., Sussan, T., Biswal, S., Goleniewska, K., O'Neal, J., Newcomb, D. C., Toki, S., Morrow, J. D. & Stokes Peebles, J., Oct 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 4, p. L615-L622

Research output: Contribution to journalArticle

Plasma miRNA as biomarkers for assessment of total-body radiation exposure dosimetry

Cui, W., Ma, J., Wang, Y. & Biswal, S., 2011, In : PloS one. 6, 8, e22988.

Research output: Contribution to journalArticle

Plausible involvement of a diabetic serum factor in neutrophil membrane pathology.

Nath, N., Biswas, S., Bhelwa, A., Ittoop, A. & Biswal, S., Aug 1993, In : Indian journal of biochemistry & biophysics. 30, 4, p. 244-246 3 p.

Research output: Contribution to journalArticle

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils

Thimmulappa, R. K., Fuchs, R. J., Malhotra, D., Scollick, C., Traore, K., Bream, J. H., Trush, M. A., Liby, K. T., Sporn, M. B., Kensler, T. W. & Biswal, S., Oct 1 2007, In : Antioxidants and Redox Signaling. 9, 11, p. 1963-1970 8 p.

Research output: Contribution to journalArticle

Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer

Kombairaju, P., Ma, J., Thimmulappa, R., Yan, G., Gabrielson, E., Singh, A. & Biswal, S., Dec 1 2012, In : Journal of Carcinogenesis. 11, 8.

Research output: Contribution to journalArticle

Proteolytic loss of bcl-xL in FL5.12 cells undergoing apoptosis induced by MK886

Datta, K., Kern, J. C., Biswal, S. S. & Kehrer, J. P., Aug 1 2001, In : Toxicology and Applied Pharmacology. 174, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema

Le, A., Zielinski, R., He, C., Crow, M. T., Biswal, S., Tuder, R. M. & Becker, P. M., Sep 1 2009, In : American journal of respiratory and critical care medicine. 180, 5, p. 396-406 11 p.

Research output: Contribution to journalArticle

Redox-regulation of ERK 1/2-directed phosphatase by reactive oxygen species: Role in signaling TPA-induced growth arrest in ML-1 cells

Traore, K., Sharma, R., Thimmulappa, R. K., Watson, W. H., Biswal, S. & Trush, M. A., Jul 1 2008, In : Journal of Cellular Physiology. 216, 1, p. 276-285 10 p.

Research output: Contribution to journalArticle

Regulation of Notch1 signaling by Nrf2: Implications for tissue regeneration

Wakabayashi, N., Shin, S., Slocum, S. L., Agoston, E. S., Wakabayashi, J., Kwak, M. K., Misra, V., Biswal, S., Yamamoto, M. & Kensler, T. W., Jul 13 2010, In : Science signaling. 3, 130, p. ra52

Research output: Contribution to journalArticle

Retraction: Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

Malhotra, D., Thimmulappa, R. K., Mercado, N., Ito, K., Kombairaju, P., Kumar, S., Ma, J., Feller-Kopman, D., Wise, R., Barnes, P. & Biswal, S., Dec 1 2014, In : Journal of Clinical Investigation. 124, 12, 1 p.

Research output: Contribution to journalComment/debate

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin efficacy of recoupling nitric oxide synthase as a therapeutic strategy

Moens, A. L., Takimoto, E., Tocchetti, C. G., Chakir, K., Bedja, D., Cormaci, G., Ketner, E. A., Majmudar, M., Gabrielson, K., Halushka, M. K., Mitchell, J. B., Biswal, S., Channon, K. M., Wolin, M. S., Alp, N. J., Paolocci, N., Champion, H. C. & Kass, D. A., May 20 2008, In : Circulation. 117, 20, p. 2626-2636 11 p.

Research output: Contribution to journalArticle

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

Singh, A., Boldin-Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J., Blackford, A., Goodman, S. N., Bunz, F., Watson, W. H., Gabrielson, E., Feinstein, E. & Biswal, S., Oct 1 2008, In : Cancer Research. 68, 19, p. 7975-7984 10 p.

Research output: Contribution to journalArticle

Role of lung maintenance program in the heterogeneity of lung destruction in emphysema

Tuder, R. M., Yoshida, T., Fijalkowka, I., Biswal, S. & Petrache, I., Nov 1 2006, In : Proceedings of the American Thoracic Society. 3, 8, p. 673-679 7 p.

Research output: Contribution to journalArticle

Role of Nrf2 in protection against intracerebral hemorrhage injury in mice

Wang, J., Fields, J., Zhao, C., Langer, J., Thimmulappa, R. K., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Aug 1 2007, In : Free Radical Biology and Medicine. 43, 3, p. 408-414 7 p.

Research output: Contribution to journalArticle

Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury

Shah, Z. A., Li, R. C., Thimmulappa, R. K., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Jun 15 2007, In : Neuroscience. 147, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle