1993 …2020

Research output per year

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Research Output

2011

Plasma miRNA as biomarkers for assessment of total-body radiation exposure dosimetry

Cui, W., Ma, J., Wang, Y. & Biswal, S., 2011, In : PloS one. 6, 8, e22988.

Research output: Contribution to journalArticle

Smoking and COPD and Other Respiratory Diseases

Sussan, T. E. & Biswal, S., Feb 24 2011, Cigarette Smoke Toxicity: Linking Individual Chemicals to Human Diseases. Wiley-VCH, p. 167-190 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Synthesis and biological activity evaluation of N-protected isatin derivatives as inhibitors of ICAM-1 expression on human endothelial cells

Malhotra, S., Balwani, S., Dhawan, A., Singh, B. K., Kumar, S., Thimmulappa, R., Biswal, S., Olsen, C. E., Van Der Eycken, E., Prasad, A. K., Ghosh, B. & Parmar, V. S., Aug 1 2011, In : MedChemComm. 2, 8, p. 743-751 9 p.

Research output: Contribution to journalArticle

Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model

Harvey, C. J., Thimmulappa, R. K., Sethi, S., Kong, X., Yarmus, L., Brown, R. H., Feller-Kopman, D., Wise, R. & Biswal, S., Apr 13 2011, In : Science translational medicine. 3, 78, 78ra32.

Research output: Contribution to journalArticle

Telomere length is a determinant of emphysema susceptibility

Alder, J. K., Guo, N., Kembou, F., Parry, E. M., Anderson, C. J., Gorgy, A. I., Walsh, M. F., Sussan, T., Biswal, S., Mitzner, W., Tuder, R. M. & Armanios, M., Oct 15 2011, In : American journal of respiratory and critical care medicine. 184, 8, p. 904-912 9 p.

Research output: Contribution to journalArticle

The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels

Merchant, A. A., Singh, A., Matsui, W. & Biswal, S., Dec 15 2011, In : Blood. 118, 25, p. 6572-6579 8 p.

Research output: Contribution to journalArticle

2012

Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: Structure-activity analysis

Kumar, S., Reddy L, C. S., Kumar, Y., Kumar, A., Singh, B. K., Kumar, V., Malhotra, S., Pandey, M. K., Jain, R., Thimmulappa, R., Sharma, S. K., Prasad, A. K., Biswal, S., Van Der Eycken, E., Depass, A. L., Malhotra, S. V., Ghosh, B. & Parmar, V. S., May 2012, In : Archiv der Pharmazie. 345, 5, p. 368-377 10 p.

Research output: Contribution to journalArticle

Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD

Biswal, S., Thimmulappa, R. K. & Harvey, C. J., May 1 2012, In : Proceedings of the American Thoracic Society. 9, 2, p. 47-51 5 p.

Research output: Contribution to journalArticle

Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis

Bhalla, K., Hwang, B. J., Dewi, R. E., Twaddel, W., Goloubeva, O. G., Wong, K. K., Saxena, N. K., Biswal, S. & Girnun, G. D., Apr 2012, In : Cancer Prevention Research. 5, 4, p. 544-552 9 p.

Research output: Contribution to journalArticle

NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease

Sandford, A. J., Malhotra, D., Marike Boezen, H., Siedlinski, M., Postma, D. S., Wong, V., Akhabir, L., He, J. Q., Connett, J. E., Anthonisen, N. R., Paré, P. D. & Biswal, S., Aug 1 2012, In : Physiological Genomics. 44, 15, p. 754-763 10 p.

Research output: Contribution to journalArticle

Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke

Thimmulappa, R. K., Gang, X., Kim, J. H., Sussan, T. E., Witztum, J. L. & Biswal, S., Sep 21 2012, In : Biochemical and Biophysical Research Communications. 426, 2, p. 253-259 7 p.

Research output: Contribution to journalArticle

Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer

Kombairaju, P., Ma, J., Thimmulappa, R., Yan, G., Gabrielson, E., Singh, A. & Biswal, S., Dec 1 2012, In : Journal of Carcinogenesis. 11, 8.

Research output: Contribution to journalArticle

Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease

Acquaah-Mensah, G. K., Malhotra, D., Vulimiri, M., McDermott, J. E. & Biswal, S., Jul 2012, In : PLoS computational biology. 8, 7, e1002597.

Research output: Contribution to journalArticle

Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smokeinduced lung inflammation

Reddy, N. M., Vegiraju, S., Irving, A., Paun, B. C., Luzina, I. G., Atamas, S. P., Biswal, S., Ana, N. A., Mitzner, W. & Reddy, S. P., Feb 2012, In : American Journal of Pathology. 180, 2, p. 562-574 13 p.

Research output: Contribution to journalArticle

The transcription factor encyclopedia.

Yusuf, D., Butland, S. L., Swanson, M. I., Bolotin, E., Ticoll, A., Cheung, W. A., Zhang, X. Y. C., Dickman, C. T. D., Fulton, D. L., Lim, J. S., Schnabl, J. M., Ramos, O. H. P., Vasseur-Cognet, M., de Leeuw, C. N., Simpson, E. M., Ryffel, G. U., Lam, E. W. F., Kist, R., Wilson, M. S. C., Marco-Ferreres, R. & 79 others, Brosens, J. J., Beccari, L. L., Bovolenta, P., Benayoun, B. A., Monteiro, L. J., Schwenen, H. D. C., Grontved, L., Wederell, E., Mandrup, S., Veitia, R. A., Chakravarthy, H., Hoodless, P. A., Mancarelli, M. M., Torbett, B. E., Banham, A. H., Reddy, S. P., Cullum, R. L., Liedtke, M., Tschan, M. P., Vaz, M., Rizzino, A., Zannini, M., Frietze, S., Farnham, P. J., Eijkelenboom, A., Brown, P. J., Laperrière, D., Leprince, D., de Cristofaro, T., Prince, K. L., Putker, M., del Peso, L., Camenisch, G., Wenger, R. H., Mikula, M., Rozendaal, M., Mader, S., Ostrowski, J., Rhodes, S. J., Van Rechem, C., Boulay, G., Olechnowicz, S. W. Z., Breslin, M. B., Lan, M. S., Nanan, K. K., Wegner, M., Hou, J., Mullen, R. D., Colvin, S. C., Noy, P. J., Webb, C. F., Witek, M. E., Ferrell, S., Daniel, J. M., Park, J., Waldman, S. A., Peet, D. J., Taggart, M., Jayaraman, P. S., Karrich, J. J., Blom, B., Vesuna, F., O'Geen, H., Sun, Y., Gronostajski, R. M., Woodcroft, M. W., Hough, M. R., Chen, E., Europe-Finner, G. N., Karolczak-Bayatti, M., Bailey, J., Hankinson, O., Raman, V., LeBrun, D. P., Biswal, S., Harvey, C. J., DeBruyne, J. P., Hogenesch, J. B. & Hevner, R. F., 2012, In : Genome biology. 13, 3, p. R24

Research output: Contribution to journalArticle

Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus

Jachak, A., Lai, S. K., Hida, K., Suk, J. S., Markovic, N., Biswal, S., Breysse, P. N. & Hanes, J., Sep 1 2012, In : Nanotoxicology. 6, 6, p. 614-622 9 p.

Research output: Contribution to journalArticle

2013

12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma

Mabalirajan, U., Rehman, R., Ahmad, T., Kumar, S., Leishangthem, G. D., Singh, S., Dinda, A. K., Biswal, S., Agrawal, A. & Ghosh, B., Apr 9 2013, In : Scientific reports. 3, 1540.

Research output: Contribution to journalArticle

A novel cinnamate derivative attenuates asthma features and reduces bronchial epithelial injury in mouse model

Kumar, S., Mabalirajan, U., Rehman, R., Singh, B. K., Parmar, V. S., Prasad, A. K., Biswal, S. & Ghosh, B., Jan 1 2013, In : International Immunopharmacology. 15, 1, p. 150-159 10 p.

Research output: Contribution to journalArticle

Ethyl 3′,4′,5′-trimethoxythionocinnamate modulates NF-κB and Nrf2 transcription factors

Kumar, S., Singh, B. K., Prasad, A. K., Parmar, V. S., Biswal, S. & Ghosh, B., Jan 30 2013, In : European Journal of Pharmacology. 700, 1-3, p. 32-41 10 p.

Research output: Contribution to journalArticle

Histone deacetylase 6-mediated selective autophagy regulates copd-associated cilia dysfunction

Lam, H. C., Cloonan, S. M., Bhashyam, A. R., Haspel, J. A., Singh, A., Sathirapongsasuti, J. F., Cervo, M., Yao, H., Chung, A. L., Mizumura, K., An, C. H., Shan, B., Franks, J. M., Haley, K. J., Owen, C. A., Tesfaigzi, Y., Washko, G. R., Quackenbush, J., Silverman, E. K., Rahman, I. & 5 others, Kim, H. P., Mahmood, A., Biswal, S. S., Ryter, S. W. & Choi, A. M. K., Dec 2 2013, In : Journal of Clinical Investigation. 123, 12, p. 5212-5230 19 p.

Research output: Contribution to journalArticle

Linoleic acid metabolite drives severe asthma by causing airway epithelial injury

Mabalirajan, U., Rehman, R., Ahmad, T., Kumar, S., Singh, S., Leishangthem, G. D., Aich, J., Kumar, M., Khanna, K., Singh, V. P., Dinda, A. K., Biswal, S., Agrawal, A. & Ghosh, B., 2013, In : Scientific reports. 3, 1349.

Research output: Contribution to journalArticle

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching

Wei, Y., Gong, J., Thimmulappa, R. K., Kosmider, B., Biswal, S. & Duh, E. J., Oct 8 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 41, p. E3910-E3918

Research output: Contribution to journalArticle

Oral administration of the flavanol (-)-epicatechin bolsters endogenous protection against focal ischemia through the Nrf2 cytoprotective pathway

Leonardo, C. C., Agrawal, M., Singh, N., Moore, J. R., Biswal, S. & Doré, S., Dec 2013, In : European Journal of Neuroscience. 38, 11, p. 3659-3668 10 p.

Research output: Contribution to journalArticle

The Twist box domain is required for Twist1-induced prostate cancer metastasis

Gajula, R. P., Chettiar, S. T., Williams, R. D., Thiyagarajan, S., Kato, Y., Aziz, K., Wang, R., Gandhi, N., Wild, A. T., Vesuna, F., Ma, J., Salih, T., Cades, J., Fertig, E., Biswal, S., Burns, T. F., Chung, C. H., Rudin, C. M., Herman, J. M., Hales, R. K. & 3 others, Raman, V., An, S. S. & Tran, P. T., Nov 2013, In : Molecular Cancer Research. 11, 11, p. 1387-1400 14 p.

Research output: Contribution to journalArticle

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis

Singh, A., Happel, C., Manna, S. K., Acquaah-Mensah, G., Carrerero, J., Kumar, S., Nasipuri, P., Krausz, K. W., Wakabayashi, N., Dewi, R., Boros, L. G., Gonzalez, F. J., Gabrielson, E., Wong, K. K., Girnun, G. & Biswal, S., Jul 1 2013, In : Journal of Clinical Investigation. 123, 7, p. 2921-2934 14 p.

Research output: Contribution to journalArticle

Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle

Kombairaju, P., Kerr, J. P., Roche, J. A., Pratt, S. J. P., Lovering, R. M., Sussan, T. E., Kim, J. H., Shi, G., Biswal, S. & Ward, C. W., 2014, In : Frontiers in Physiology. 5 FEB, Article 57.

Research output: Contribution to journalArticle

Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1

Page, A., Volchkova, V. A., Reid, S. P., Mateo, M., Bagnaud-Baule, A., Nemirov, K., Shurtleff, A. C., Lawrence, P., Reynard, O., Ottmann, M., Lotteau, V., Biswal, S. S., Thimmulappa, R. K., Bavari, S. & Volchkov, V. E., Mar 27 2014, In : Cell Reports. 6, 6, p. 1026-1036 11 p.

Research output: Contribution to journalArticle

Notch-Nrf2 axis: Regulation of Nrf2 gene expression and cytoprotection by notch signaling

Wakabayashi, N., Skoko, J. J., Chartoumpekis, D. V., Kimura, S., Slocum, S. L., Noda, K., Palliyaguru, D. L., Fujimuro, M., Boley, P. A., Tanaka, Y., Shigemura, N., Biswal, S., Yamamoto, M. & Kensler, T. W., Feb 1 2014, In : Molecular and cellular biology. 34, 4, p. 653-663 11 p.

Research output: Contribution to journalArticle

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

Kim, J. H., Thimmulappa, R. K., Kumar, V., Cui, W., Kumar, S., Kombairaju, P., Zhang, H., Margolick, J., Matsui, W., Macvittie, T., Malhotra, S. V. & Biswal, S., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 730-741 12 p.

Research output: Contribution to journalArticle

NRF2 plays a protective role in diabetic retinopathy in mice

Xu, Z., Wei, Y., Gong, J., Cho, H., Park, J. K., Sung, E. R., Huang, H., Wu, L., Eberhart, C., Handa, J. T., Du, Y., Kern, T. S., Thimmulappa, R., Barber, A. J., Biswal, S. & Duh, E. J., Jan 1 2014, In : Diabetologia. 57, 1, p. 204-213 10 p.

Research output: Contribution to journalArticle

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells

Wang, L., Kondo, N., Cano, M., Ebrahimi, K., Yoshida, T., Barnett, B. P., Biswal, S. & Handa, J. T., May 2014, In : Free Radical Biology and Medicine. 70, p. 155-166 12 p.

Research output: Contribution to journalArticle

Retraction: Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

Malhotra, D., Thimmulappa, R. K., Mercado, N., Ito, K., Kombairaju, P., Kumar, S., Ma, J., Feller-Kopman, D., Wise, R., Barnes, P. & Biswal, S., Dec 1 2014, In : Journal of Clinical Investigation. 124, 12, 1 p.

Research output: Contribution to journalComment/debate

Source of biomass cooking fuel determines pulmonary response to household air pollution

Sussan, T. E., Ingole, V., Kim, J. H., McCormick, S., Negherbon, J., Fallica, J., Akulian, J., Yarmus, L., Feller-Kopman, D., Wills-Karp, M., Horton, M. R., Breysse, P. N., Agrawal, A., Juvekar, S., Salvi, S. & Biswal, S., Mar 2014, In : American journal of respiratory cell and molecular biology. 50, 3, p. 538-548 11 p.

Research output: Contribution to journalArticle

Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status

McGrath-Morrow, S. A., Lauer, T., Collaco, J. M., Lopez, A., Malhotra, D., Alekseyev, Y. O., Neptune, E., Wise, R. & Biswal, S., Jan 1 2014, In : Cytokine. 65, 1, p. 4-9 6 p.

Research output: Contribution to journalArticle

2015

Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model

Sussan, T. E., Gajghate, S., Thimmulappa, R. K., Ma, J., Kim, J. H., Sudini, K., Consolini, N., Cormier, S. A., Lomnicki, S., Hasan, F., Pekosz, A. & Biswal, S., Feb 4 2015, In : PloS one. 10, 2, 0116861.

Research output: Contribution to journalArticle

Field testing of alternative cookstove performance in a rural setting of Western India

Muralidharan, V., Sussan, T. E., Limaye, S., Koehler, K., Williams, DA. L., Rule, A. M., Juvekar, S., Breysse, P. N., Salvi, S. & Biswal, S., Feb 3 2015, In : International journal of environmental research and public health. 12, 2, p. 1773-1787 15 p.

Research output: Contribution to journalArticle

Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy

Lounsbury, N., Mateo, G., Jones, B., Papaiahgari, S., Thimmulappa, R. K., Teijaro, C., Gordon, J., Korzekwa, K., Ye, M., Allaway, G., Abou-Gharbia, M., Biswal, S. & Childers, W., Sep 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5352-5359 8 p.

Research output: Contribution to journalArticle

Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells

Chen, H., Jin, S., Guo, J., Kombairaju, P., Biswal, S. & Zirkin, B. R., Jul 5 2015, In : Molecular and Cellular Endocrinology. 409, p. 113-120 8 p.

Research output: Contribution to journalArticle

Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion

Xu, Z., Cho, H., Hartsock, M. J., Mitchell, K. L., Gong, J., Wu, L., Wei, Y., Wang, S., Thimmulappa, R. K., Sporn, M. B., Biswal, S., Welsbie, D. S. & Duh, E. J., Apr 1 2015, In : Journal of Neurochemistry. 133, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A

Wei, Y., Gong, J., Xu, Z., Thimmulappa, R. K., Mitchell, K. L., Welsbie, D. S., Biswal, S. & Duh, E. J., Dec 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. E6927-E6936

Research output: Contribution to journalArticle

Nrf2 is required for normal postnatal bone acquisition in mice

Kim, J. H., Singhal, V., Biswal, S., Thimmulappa, R. K. & DiGirolamo, D. J., Jan 1 2015, In : Bone Research. 2, 14033.

Research output: Contribution to journalArticle

Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function

Sussan, T. E., Gajghate, S., Chatterjee, S., Mandke, P., McCormick, S., Sudini, K., Kumar, S., Breysse, P. N., Diette, G. B., Sidhaye, V. K. & Biswal, S., Jul 6 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 1, p. L27-L36

Research output: Contribution to journalArticle

An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma

An, S. S., Mitzner, W., Tang, W. Y., Ahn, K., Yoon, A. R., Huang, J., Kilic, O., Yong, H. M., Fahey, J. W., Kumar, S., Biswal, S., Holgate, S. T., Panettieri, R. A., Solway, J. & Liggett, S. B., Jul 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 294-297.e4

Research output: Contribution to journalArticle

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (CTRIUMPH): Protocol for a multicentric prospective observational study

Gupte, A., Padmapriyadarsini, C., Mave, V., Kadam, D., Suryavanshi, N., Shivakumar, S. V. B. Y., Kohli, R., Gupte, N., Thiruvengadam, K., Kagal, A., Meshram, S., Bharadwaj, R., Khadse, S., Ramachandran, G., Hanna, L. E., Pradhan, N., Gomathy, N. S., DeLuca, A., Gupta, A., Swaminathan, S. & 73 others, Kinikar, A., Raja, A., Nagraj, A., Anand Kumar, B., More, A., Gaikwad, A., Nangude, A., Balaji, S., Thomas, B., Joseph, B., Bharath, T. K., Brindha, B., Dowdy, D., Pole, D., Devanathan, A., Devi Sangamithrai, M., Jain, D., Dolla, C. K., Smit, G., Gangadarsharma, R., Chaugule, H., Koli, H., Hemanthkumar, Jeeva, J., Elf, J., Golub, J., Chandane, J., Savita, K., Kannan, M., Karthikesh, M., Karunakaran, S., Dooley, K., Murali, L., Lavanya, M., Madasamy, S., Mageshkumar, M., Mangaiyarkarasi, S., Gujare, M., Manoharan, S., Michel Premkumar, M., Munivardhan, P., Murugesan, S., Gomathy, N. S., Nagaraj, Ponnuraja, C., Premkumar, N., Lokhande, R., Rajkumar, S., Ranganathan, K., Rani, S., Madewar, R., Bollinger, R., Warlick, R., Shivakoti, R., Javanjal, S., Sathyamurthi, P., Pawar, S., Hande, S., Muley, S., Sali, S., Shubhapriya, K., Biswal, S., Silambu Chelvi, K., Nimkar, S., Selvaraj, S., Salvi, S., Raskar, S., Devi, U., Kulkarni, V., Hulyalkar, V., Tayawade, V., Bansode, V. & Daware, Y., Jan 1 2016, In : BMJ open. 6, 2, e010542.

Research output: Contribution to journalArticle

Indoor particulate matter < 2.5 μm in mean aerodynamic diameter and carbon monoxide levels during the burning of mosquito coils and their association with respiratory health

Salvi, D., Limaye, S., Muralidharan, V., Londhe, J., Madas, S., Juvekar, S., Biswal, S. & Salvi, S., Feb 2016, In : CHEST. 149, 2, p. 459-466 8 p.

Research output: Contribution to journalArticle

Intrauterine inflammation and maternal exposure to ambient pm2.5 during preconception and specific periods of pregnancy: The boston birth cohort

Nachman, R. M., Mao, G., Zhang, X., Hong, X., Chen, Z., Soria, C. S., He, H., Wang, G., Caruso, D., Pearson, C., Biswal, S., Zuckerman, B., Wills-Karp, M. & Wang, X., Oct 1 2016, In : Environmental Health Perspectives. 124, 10, p. 1608-1615 8 p.

Research output: Contribution to journalArticle

Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: A randomized, double-blind, placebo controlled trial

Wise, R. A., Holbrook, J. T., Criner, G., Sethi, S., Rayapudi, S., Sudini, K. R., Sugar, E. A., Burke, A., Thimmulappa, R., Singh, A., Talalay, P., Fahey, J. W., Berenson, C. S., Jacobs, M. R., Biswal, S., Leatherman, G., Daniel, M., Thurman, A., Marchetti, N., Kim, V. & 25 others, Shenoy, K., Smith, H., Rosario, M., Bolla, S., Mandapati, C., Eberhardt, E., Kruzel, R., Kumar, S., Noel, S., Beselman, A., Amend-Libercci, D., Ewing, C., Hart, A., Lears, A., Nowakowski, D., Prusakowski, N., Shade, D., Yasin, R., Brown, E., Wang, L., O'Connor, G., Strange, C., Wendt, C., Punturieri, A. & Viviano, L. W., Nov 2016, In : PloS one. 11, 11, e0163716.

Research output: Contribution to journalArticle