1993 …2020

Research output per year

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Research Output

2010

NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice

Kong, X., Thimmulappa, R., Kombairaju, P. & Biswal, S., Jul 1 2010, In : Journal of Immunology. 185, 1, p. 569-577 9 p.

Research output: Contribution to journalArticle

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

Solis, L. M., Behrens, C., Dong, W., Suraokar, M., Ozburn, N. C., Moran, C. A., Corvalan, A. H., Biswal, S., Swisher, S. G., Bekele, B. N., Minna, J. D., Stewart, D. J. & Wistuba, I. I., Jul 15 2010, In : Clinical Cancer Research. 16, 14, p. 3743-3753 11 p.

Research output: Contribution to journalArticle

Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract

Rangasamy, T., Williams, M. A., Bauer, S., Trush, M. A., Emo, J., Georas, S. N. & Biswal, S., Sep 1 2010, In : American journal of respiratory cell and molecular biology. 43, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

Regulation of Notch1 signaling by Nrf2: Implications for tissue regeneration

Wakabayashi, N., Shin, S., Slocum, S. L., Agoston, E. S., Wakabayashi, J., Kwak, M. K., Misra, V., Biswal, S., Yamamoto, M. & Kensler, T. W., Jul 13 2010, In : Science signaling. 3, 130, p. ra52

Research output: Contribution to journalArticle

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema

Yoshida, T., Mett, I., Bhunia, A. K., Bowman, J., Perez, M., Zhang, L., Gandjeva, A., Zhen, L., Chukwueke, U., Mao, T., Richter, A., Brown, E., Ashush, H., Notkin, N., Gelfand, A., Thimmulappa, R. K., Rangasamy, T., Sussan, T., Cosgrove, G., Mouded, M. & 5 others, Shapiro, S. D., Petrache, I., Biswal, S., Feinstein, E. & Tuder, R. M., Jul 1 2010, In : Nature medicine. 16, 7, p. 767-773 7 p.

Research output: Contribution to journalArticle

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway

Shah, Z. A., Li, R. C., Ahmad, A. S., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Dec 1 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 12, p. 1951-1961 11 p.

Research output: Contribution to journalArticle

2009

Cell stiffness, contractile stress and the role of extracellular matrix

An, S. S., Kim, J., Ahn, K., Trepat, X., Drake, K. J., Kumar, S., Ling, G., Purington, C., Rangasamy, T., Kensler, T. W., Mitzner, W., Fredberg, J. J. & Biswal, S., May 15 2009, In : Biochemical and Biophysical Research Communications. 382, 4, p. 697-703 7 p.

Research output: Contribution to journalArticle

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

Rangasamy, T., Misra, V., Zhen, L., Tankersley, C. G., Tuder, R. M. & Biswal, S., Jun 1 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 6, p. L888-L900

Research output: Contribution to journalArticle

Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: The role of Nrf2-regulated proteasomal activity

Malhotra, D., Thimmulappa, R., Vij, N., Navas-Acien, A., Sussan, T., Merali, S., Zhang, L., Kelsen, S. G., Myers, A., Wise, R., Tuder, R. & Biswal, S., Dec 15 2009, In : American journal of respiratory and critical care medicine. 180, 12, p. 1197-1207 11 p.

Research output: Contribution to journalArticle

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

Singh, A., Ling, G., Suhasini, A. N., Zhang, P., Yamamoto, M., Navas-Acien, A., Cosgrove, G., Tuder, R. M., Kensler, T. W., Watson, W. H. & Biswal, S., Feb 1 2009, In : Free Radical Biology and Medicine. 46, 3, p. 376-386 11 p.

Research output: Contribution to journalArticle

Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia

McGrath-Morrow, S., Lauer, T., Yee, M., Neptune, E., Podowski, M., Thimmulappa, R. K., O'Reilly, M. & Biswal, S., Apr 1 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 4, p. L565-L573

Research output: Contribution to journalArticle

Nrf2 is a critical modulator of the innate immune response in a model of uveitis

Nagai, N., Thimmulappa, R. K., Cano, M., Fujihara, M., Izumi-Nagai, K., Kong, X., Sporn, M. B., Kensler, T. W., Biswal, S. & Handa, J. T., Aug 1 2009, In : Free Radical Biology and Medicine. 47, 3, p. 300-306 7 p.

Research output: Contribution to journalArticle

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Harvey, C. J., Thimmulappa, R. K., Singh, A., Blake, D. J., Ling, G., Wakabayashi, N., Fujii, J., Myers, A. & Biswal, S., Feb 15 2009, In : Free Radical Biology and Medicine. 46, 4, p. 443-453 11 p.

Research output: Contribution to journalArticle

Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema

Le, A., Zielinski, R., He, C., Crow, M. T., Biswal, S., Tuder, R. M. & Becker, P. M., Sep 1 2009, In : American journal of respiratory and critical care medicine. 180, 5, p. 396-406 11 p.

Research output: Contribution to journalArticle

Sildenafil Inhibits Superoxide Formation and Prevents Endothelial Dysfunction in a Mouse Model of Secondhand Smoke Induced Erectile Dysfunction

Bivalacqua, T. J., Sussan, T. E., Gebska, M. A., Strong, T. D., Berkowitz, D. E., Biswal, S., Burnett, A. L. & Champion, H. C., Feb 1 2009, In : Journal of Urology. 181, 2, p. 899-906 8 p.

Research output: Contribution to journalArticle

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., Sporn, M. B., Gabrielson, K. L., Champion, H. C., Tuder, R. M., Kensler, T. W. & Biswal, S., Jan 6 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 1, p. 250-255 6 p.

Research output: Contribution to journalArticle

2008

Antioxidant, antiinflammatory and antiinvasive activities of biopolyphenolics

Malhotra, S., Shakya, G., Kumar, A., Vanhoecke, B. W., Cholli, A. L., Raj, H. G., Saso, L., Ghosh, B., Bracke, M. E., Prasad, A. K., Biswal, S. & Parmar, V. S., Jun 15 2008, In : Arkivoc. 2008, 6, p. 119-139 21 p.

Research output: Contribution to journalReview article

Open Access

Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice

Fujihara, M., Nagai, N., Sussan, T. E., Biswal, S. & Handa, J. T., Sep 1 2008, In : PloS one. 3, 9, e3119.

Research output: Contribution to journalArticle

Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

Malhotra, D., Thimmulappa, R., Navas-Acien, A., Sandford, A., Elliott, M., Singh, A., Chen, L., Zhuang, X., Hogg, J., Pare, P., Tuder, R. M. & Biswal, S., Sep 15 2008, In : American journal of respiratory and critical care medicine. 178, 6, p. 592-604 13 p.

Research output: Contribution to journalArticle

Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs

Thimmulappa, R. K., Rangasamy, T., Alam, J. & Biswal, S., Sep 1 2008, In : Medicinal Chemistry. 4, 5, p. 473-481 9 p.

Research output: Contribution to journalArticle

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice

Sussan, T. E., Jun, J., Thimmulappa, R., Bedja, D., Antero, M., Gabrielson, K. L., Polotsky, V. Y. & Biswal, S., Nov 21 2008, In : PloS one. 3, 11, e3791.

Research output: Contribution to journalArticle

Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter

Williams, M. A., Rangasamy, T., Bauer, S. M., Killedar, S., Karp, M., Kensler, T. W., Yamamoto, M., Breysse, P., Biswal, S. & Georas, S. N., Oct 1 2008, In : Journal of Immunology. 181, 7, p. 4545-4559 15 p.

Research output: Contribution to journalArticle

Open Access

Effects of leptin deficiency on postnatal lung development in mice

Huang, K., Rabold, R., Abston, E., Schofield, B., Misra, V., Galdzicka, E., Lee, H., Biswal, S., Mitzner, W. & Tankersley, C. G., Jul 1 2008, In : Journal of applied physiology. 105, 1, p. 249-259 11 p.

Research output: Contribution to journalArticle

Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury

Saleem, S., Zhuang, H., Biswal, S., Christen, Y. & Doré, S., Dec 1 2008, In : Stroke. 39, 12, p. 3389-3396 8 p.

Research output: Contribution to journalArticle

Impaired lung homeostasis in neonatal mice exposed to cigarette smoke

McGrath-Morrow, S., Rangasamy, T., Cho, C., Sussan, T., Neptune, E., Wise, R., Tuder, R. M. & Biswal, S., Apr 1 2008, In : American journal of respiratory cell and molecular biology. 38, 4, p. 393-400 8 p.

Research output: Contribution to journalArticle

Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress

Taylor, R. C., Acquaah-Mensah, G., Singhal, M., Malhotra, D. & Biswal, S., Aug 1 2008, In : PLoS computational biology. 4, 8, e1000166.

Research output: Contribution to journalArticle

Redox-regulation of ERK 1/2-directed phosphatase by reactive oxygen species: Role in signaling TPA-induced growth arrest in ML-1 cells

Traore, K., Sharma, R., Thimmulappa, R. K., Watson, W. H., Biswal, S. & Trush, M. A., Jul 1 2008, In : Journal of Cellular Physiology. 216, 1, p. 276-285 10 p.

Research output: Contribution to journalArticle

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin efficacy of recoupling nitric oxide synthase as a therapeutic strategy

Moens, A. L., Takimoto, E., Tocchetti, C. G., Chakir, K., Bedja, D., Cormaci, G., Ketner, E. A., Majmudar, M., Gabrielson, K., Halushka, M. K., Mitchell, J. B., Biswal, S., Channon, K. M., Wolin, M. S., Alp, N. J., Paolocci, N., Champion, H. C. & Kass, D. A., May 20 2008, In : Circulation. 117, 20, p. 2626-2636 11 p.

Research output: Contribution to journalArticle

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

Singh, A., Boldin-Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J., Blackford, A., Goodman, S. N., Bunz, F., Watson, W. H., Gabrielson, E., Feinstein, E. & Biswal, S., Oct 1 2008, In : Cancer Research. 68, 19, p. 7975-7984 10 p.

Research output: Contribution to journalArticle

2007

A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice

Balbir, A., Lee, H., Okumura, M., Biswal, S., Fitzgerald, R. S. & Shirahata, M., Mar 1 2007, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 3, p. L704-L715

Research output: Contribution to journalArticle

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

Kensler, T. W., Wakabayashi, N. & Biswal, S., Feb 23 2007, Annual Review of Pharmacology and Toxicology. Cho, A. (ed.). p. 89-116 28 p. (Annual Review of Pharmacology and Toxicology; vol. 47).

Research output: Chapter in Book/Report/Conference proceedingChapter

Correspondence

Biswal, S., May 2007, In : American journal of respiratory cell and molecular biology. 36, 5, 1 p.

Research output: Contribution to journalLetter

Deficiency in Nrf2 GSH signaling impairs type II cell growth and enhances sensitivity to oxidants

Reddy, N. M., Kleeberger, S. R., Cho, H. Y., Yamamoto, M., Kensler, T. W., Biswal, S. & Reddy, S. P., Jul 2007, In : American journal of respiratory cell and molecular biology. 37, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice

Papaiahgari, S., Yerrapureddy, A., Reddy, S. R., Reddy, N. M., Dodd-O, J. M., Crow, M. T., Grigoryev, D. N., Barnes, K., Tuder, R. M., Yamamoto, M., Kensler, T. W., Biswal, S., Mitzner, W., Hassoun, P. M. & Reddy, S. P., Dec 15 2007, In : American journal of respiratory and critical care medicine. 176, 12, p. 1222-1235 14 p.

Research output: Contribution to journalArticle

Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection

Reddy, N. M., Kleeberger, S. R., Yamamoto, M., Kensler, T. W., Scollick, C., Biswal, S. & Reddy, S. P., Dec 19 2007, In : Physiological Genomics. 32, 1, p. 74-81 8 p.

Research output: Contribution to journalArticle

Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes

Misra, V., Lee, H., Singh, A., Huang, K., Thimmulappa, R. K., Mitzner, W., Biswal, S. & Tankersley, C. G., Nov 14 2007, In : Physiological Genomics. 31, 3, p. 429-440 12 p.

Research output: Contribution to journalArticle

NRF2 modulates aryl hydrocarbon receptor signaling: Influence on adipogenesis

Shin, S., Wakabayashi, N., Misra, V., Biswal, S., Gum, H. L., Agoston, E. S., Yamamoto, M. & Kensler, T. W., Oct 1 2007, In : Molecular and cellular biology. 27, 20, p. 7188-7197 10 p.

Research output: Contribution to journalArticle

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils

Thimmulappa, R. K., Fuchs, R. J., Malhotra, D., Scollick, C., Traore, K., Bream, J. H., Trush, M. A., Liby, K. T., Sporn, M. B., Kensler, T. W. & Biswal, S., Oct 1 2007, In : Antioxidants and Redox Signaling. 9, 11, p. 1963-1970 8 p.

Research output: Contribution to journalArticle

Role of Nrf2 in protection against intracerebral hemorrhage injury in mice

Wang, J., Fields, J., Zhao, C., Langer, J., Thimmulappa, R. K., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Aug 1 2007, In : Free Radical Biology and Medicine. 43, 3, p. 408-414 7 p.

Research output: Contribution to journalArticle

Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury

Shah, Z. A., Li, R. C., Thimmulappa, R. K., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Jun 15 2007, In : Neuroscience. 147, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

Selective and nonselective packaging of cellular RNAs in retrovirus particles

Rulli, S. J., Hibbert, C. S., Mirro, J., Pederson, T., Biswal, S. & Rein, A., Jun 1 2007, In : Journal of virology. 81, 12, p. 6623-6631 9 p.

Research output: Contribution to journalArticle

Sepsis: Redox mechanisms and therapeutic opportunities

Biswal, S. & Remick, D. G., Oct 1 2007, In : Antioxidants and Redox Signaling. 9, 11, p. 1959-1961 3 p.

Research output: Contribution to journalEditorial

Variation in senescent-dependent lung changes in inbred mouse strains

Huang, K., Mitzner, W., Rabold, R., Schofield, B., Lee, H., Biswal, S. & Tankersley, C. G., Apr 1 2007, In : Journal of applied physiology. 102, 4, p. 1632-1639 8 p.

Research output: Contribution to journalArticle

2006

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., Brock, M. V. & Biswal, S., Oct 1 2006, In : PLoS medicine. 3, 10, p. 1865-1876 12 p.

Research output: Contribution to journalArticle

Ethanol sensitivity: A central role for CREB transcription regulation in the cerebellum

Acquaah-Mensah, G. K., Misra, V. & Biswal, S., Dec 5 2006, In : BMC genomics. 7, 308.

Research output: Contribution to journalArticle

Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

Singh, A., Rangasamy, T., Thimmulappa, R. K., Lee, H., Osburn, W. O., Brigelius-Flohé, R., Kensler, T. W., Yamamoto, M. & Biswal, S., Dec 1 2006, In : American journal of respiratory cell and molecular biology. 35, 6, p. 639-650 12 p.

Research output: Contribution to journalArticle

Long term environmental tobacco smoke activates nuclear transcription factor-kappa B, activator protein-1, and stress responsive kinases in mouse brain

Manna, S. K., Rangasamy, T., Wise, K., Sarkar, S., Shishodia, S., Biswal, S. & Ramesh, G. T., May 28 2006, In : Biochemical Pharmacology. 71, 11, p. 1602-1609 8 p.

Research output: Contribution to journalArticle

Nrf2: A transcription factor that modifies susceptibility to cigarette smoke-induced pulmonary oxidative stress and emphysema

Biswal, S. & Kensler, T. W., Dec 1 2006, Cigarette Smoke and Oxidative Stress. Springer Berlin Heidelberg, p. 365-377 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

Thimmulappa, R. K., Scollick, C., Traore, K., Yates, M., Trush, M. A., Liby, K. T., Sporn, M. B., Yamamoto, M., Kensler, T. W. & Biswal, S., Dec 29 2006, In : Biochemical and Biophysical Research Communications. 351, 4, p. 883-889 7 p.

Research output: Contribution to journalArticle