1993 …2020

Research output per year

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Research Output

2008

Antioxidant, antiinflammatory and antiinvasive activities of biopolyphenolics

Malhotra, S., Shakya, G., Kumar, A., Vanhoecke, B. W., Cholli, A. L., Raj, H. G., Saso, L., Ghosh, B., Bracke, M. E., Prasad, A. K., Biswal, S. & Parmar, V. S., Jun 15 2008, In : Arkivoc. 2008, 6, p. 119-139 21 p.

Research output: Contribution to journalReview article

Open Access

Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice

Fujihara, M., Nagai, N., Sussan, T. E., Biswal, S. & Handa, J. T., Sep 1 2008, In : PloS one. 3, 9, e3119.

Research output: Contribution to journalArticle

Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1

Malhotra, D., Thimmulappa, R., Navas-Acien, A., Sandford, A., Elliott, M., Singh, A., Chen, L., Zhuang, X., Hogg, J., Pare, P., Tuder, R. M. & Biswal, S., Sep 15 2008, In : American journal of respiratory and critical care medicine. 178, 6, p. 592-604 13 p.

Research output: Contribution to journalArticle

Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs

Thimmulappa, R. K., Rangasamy, T., Alam, J. & Biswal, S., Sep 1 2008, In : Medicinal Chemistry. 4, 5, p. 473-481 9 p.

Research output: Contribution to journalArticle

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice

Sussan, T. E., Jun, J., Thimmulappa, R., Bedja, D., Antero, M., Gabrielson, K. L., Polotsky, V. Y. & Biswal, S., Nov 21 2008, In : PloS one. 3, 11, e3791.

Research output: Contribution to journalArticle

Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter

Williams, M. A., Rangasamy, T., Bauer, S. M., Killedar, S., Karp, M., Kensler, T. W., Yamamoto, M., Breysse, P., Biswal, S. & Georas, S. N., Oct 1 2008, In : Journal of Immunology. 181, 7, p. 4545-4559 15 p.

Research output: Contribution to journalArticle

Open Access

Effects of leptin deficiency on postnatal lung development in mice

Huang, K., Rabold, R., Abston, E., Schofield, B., Misra, V., Galdzicka, E., Lee, H., Biswal, S., Mitzner, W. & Tankersley, C. G., Jul 2008, In : Journal of applied physiology. 105, 1, p. 249-259 11 p.

Research output: Contribution to journalArticle

Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury

Saleem, S., Zhuang, H., Biswal, S., Christen, Y. & Doré, S., Dec 1 2008, In : Stroke. 39, 12, p. 3389-3396 8 p.

Research output: Contribution to journalArticle

Impaired lung homeostasis in neonatal mice exposed to cigarette smoke

McGrath-Morrow, S., Rangasamy, T., Cho, C., Sussan, T., Neptune, E., Wise, R., Tuder, R. M. & Biswal, S., Apr 1 2008, In : American journal of respiratory cell and molecular biology. 38, 4, p. 393-400 8 p.

Research output: Contribution to journalArticle

Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress

Taylor, R. C., Acquaah-Mensah, G., Singhal, M., Malhotra, D. & Biswal, S., Aug 2008, In : PLoS computational biology. 4, 8, e1000166.

Research output: Contribution to journalArticle

Redox-regulation of ERK 1/2-directed phosphatase by reactive oxygen species: Role in signaling TPA-induced growth arrest in ML-1 cells

Traore, K., Sharma, R., Thimmulappa, R. K., Watson, W. H., Biswal, S. & Trush, M. A., Jul 1 2008, In : Journal of Cellular Physiology. 216, 1, p. 276-285 10 p.

Research output: Contribution to journalArticle

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin efficacy of recoupling nitric oxide synthase as a therapeutic strategy

Moens, A. L., Takimoto, E., Tocchetti, C. G., Chakir, K., Bedja, D., Cormaci, G., Ketner, E. A., Majmudar, M., Gabrielson, K., Halushka, M. K., Mitchell, J. B., Biswal, S., Channon, K. M., Wolin, M. S., Alp, N. J., Paolocci, N., Champion, H. C. & Kass, D. A., May 20 2008, In : Circulation. 117, 20, p. 2626-2636 11 p.

Research output: Contribution to journalArticle

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

Singh, A., Boldin-Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J., Blackford, A., Goodman, S. N., Bunz, F., Watson, W. H., Gabrielson, E., Feinstein, E. & Biswal, S., Oct 1 2008, In : Cancer Research. 68, 19, p. 7975-7984 10 p.

Research output: Contribution to journalArticle

2009

Cell stiffness, contractile stress and the role of extracellular matrix

An, S. S., Kim, J., Ahn, K., Trepat, X., Drake, K. J., Kumar, S., Ling, G., Purington, C., Rangasamy, T., Kensler, T. W., Mitzner, W., Fredberg, J. J. & Biswal, S., May 15 2009, In : Biochemical and Biophysical Research Communications. 382, 4, p. 697-703 7 p.

Research output: Contribution to journalArticle

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

Rangasamy, T., Misra, V., Zhen, L., Tankersley, C. G., Tuder, R. M. & Biswal, S., Jun 1 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 6, p. L888-L900

Research output: Contribution to journalArticle

Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: The role of Nrf2-regulated proteasomal activity

Malhotra, D., Thimmulappa, R., Vij, N., Navas-Acien, A., Sussan, T., Merali, S., Zhang, L., Kelsen, S. G., Myers, A., Wise, R., Tuder, R. & Biswal, S., Dec 15 2009, In : American journal of respiratory and critical care medicine. 180, 12, p. 1197-1207 11 p.

Research output: Contribution to journalArticle

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

Singh, A., Ling, G., Suhasini, A. N., Zhang, P., Yamamoto, M., Navas-Acien, A., Cosgrove, G., Tuder, R. M., Kensler, T. W., Watson, W. H. & Biswal, S., Feb 1 2009, In : Free Radical Biology and Medicine. 46, 3, p. 376-386 11 p.

Research output: Contribution to journalArticle

Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia

McGrath-Morrow, S., Lauer, T., Yee, M., Neptune, E., Podowski, M., Thimmulappa, R. K., O'Reilly, M. & Biswal, S., Apr 1 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 4, p. L565-L573

Research output: Contribution to journalArticle

Nrf2 is a critical modulator of the innate immune response in a model of uveitis

Nagai, N., Thimmulappa, R. K., Cano, M., Fujihara, M., Izumi-Nagai, K., Kong, X., Sporn, M. B., Kensler, T. W., Biswal, S. & Handa, J. T., Aug 1 2009, In : Free Radical Biology and Medicine. 47, 3, p. 300-306 7 p.

Research output: Contribution to journalArticle

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Harvey, C. J., Thimmulappa, R. K., Singh, A., Blake, D. J., Ling, G., Wakabayashi, N., Fujii, J., Myers, A. & Biswal, S., Feb 15 2009, In : Free Radical Biology and Medicine. 46, 4, p. 443-453 11 p.

Research output: Contribution to journalArticle

Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema

Le, A., Zielinski, R., He, C., Crow, M. T., Biswal, S., Tuder, R. M. & Becker, P. M., Sep 1 2009, In : American journal of respiratory and critical care medicine. 180, 5, p. 396-406 11 p.

Research output: Contribution to journalArticle

Sildenafil Inhibits Superoxide Formation and Prevents Endothelial Dysfunction in a Mouse Model of Secondhand Smoke Induced Erectile Dysfunction

Bivalacqua, T. J., Sussan, T. E., Gebska, M. A., Strong, T. D., Berkowitz, D. E., Biswal, S., Burnett, A. L. & Champion, H. C., Feb 1 2009, In : Journal of Urology. 181, 2, p. 899-906 8 p.

Research output: Contribution to journalArticle

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., Sporn, M. B., Gabrielson, K. L., Champion, H. C., Tuder, R. M., Kensler, T. W. & Biswal, S., Jan 6 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 1, p. 250-255 6 p.

Research output: Contribution to journalArticle

2010

Calreticulin transacetylase catalyzed modification of the TNF-α mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates

Singh, U., Kumar, A., Sinha, R., Manral, S., Arora, S., Ram, S., Mishra, R. K., Gupta, P., Bansal, S. K., Prasad, A. K., Biswal, S., Parmar, V. S. & Raj, H. G., May 1 2010, In : Chemico-Biological Interactions. 185, 3, p. 263-270 8 p.

Research output: Contribution to journalArticle

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

Cano, M., Thimmalappula, R., Fujihara, M., Nagai, N., Sporn, M., Wang, A. L., Neufeld, A. H., Biswal, S. & Handa, J. T., Mar 1 2010, In : Vision Research. 50, 7, p. 652-664 13 p.

Research output: Contribution to journalArticle

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation

Blake, D. J., Singh, A., Kombairaju, P., Malhotra, D., Mariani, T. J., Tuder, R. M., Gabrielson, E. & Biswal, S., May 1 2010, In : American journal of respiratory cell and molecular biology. 42, 5, p. 524-536 13 p.

Research output: Contribution to journalArticle

Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype

Singh, A., Wu, H., Zhang, P., Happel, C., Ma, J. & Biswal, S., Aug 2010, In : Molecular cancer therapeutics. 9, 8, p. 2365-2376 12 p.

Research output: Contribution to journalArticle

Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance

Singh, A., Bodas, M., Wakabayashi, N., Bunz, F. & Biswal, S., Dec 1 2010, In : Antioxidants and Redox Signaling. 13, 11, p. 1627-1637 11 p.

Research output: Contribution to journalArticle

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through chip-seq profiling and network analysis

Malhotra, D., Portales-Casamar, E., Singh, A., Srivastava, S., Arenillas, D., Happel, C., Shyr, C., Wakabayashi, N., Kensler, T. W., Wasserman, W. W. & Biswal, S., May 11 2010, In : Nucleic acids research. 38, 17, p. 5718-5734 17 p., gkq212.

Research output: Contribution to journalArticle

Loss of kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth

Zhang, P., Singh, A., Yegnasubramanian, S., Esopi, D., Kombairaju, P., Bodas, M., Wu, H., Bova, S. G. & Biswal, S., Feb 2010, In : Molecular cancer therapeutics. 9, 2, p. 336-346 11 p.

Research output: Contribution to journalArticle

NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice

Kong, X., Thimmulappa, R., Kombairaju, P. & Biswal, S., Jul 1 2010, In : Journal of Immunology. 185, 1, p. 569-577 9 p.

Research output: Contribution to journalArticle

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

Solis, L. M., Behrens, C., Dong, W., Suraokar, M., Ozburn, N. C., Moran, C. A., Corvalan, A. H., Biswal, S., Swisher, S. G., Bekele, B. N., Minna, J. D., Stewart, D. J. & Wistuba, I. I., Jul 15 2010, In : Clinical Cancer Research. 16, 14, p. 3743-3753 11 p.

Research output: Contribution to journalArticle

Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract

Rangasamy, T., Williams, M. A., Bauer, S., Trush, M. A., Emo, J., Georas, S. N. & Biswal, S., Sep 1 2010, In : American journal of respiratory cell and molecular biology. 43, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

Regulation of Notch1 signaling by Nrf2: Implications for tissue regeneration

Wakabayashi, N., Shin, S., Slocum, S. L., Agoston, E. S., Wakabayashi, J., Kwak, M. K., Misra, V., Biswal, S., Yamamoto, M. & Kensler, T. W., Jul 13 2010, In : Science signaling. 3, 130, p. ra52

Research output: Contribution to journalArticle

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema

Yoshida, T., Mett, I., Bhunia, A. K., Bowman, J., Perez, M., Zhang, L., Gandjeva, A., Zhen, L., Chukwueke, U., Mao, T., Richter, A., Brown, E., Ashush, H., Notkin, N., Gelfand, A., Thimmulappa, R. K., Rangasamy, T., Sussan, T., Cosgrove, G., Mouded, M. & 5 others, Shapiro, S. D., Petrache, I., Biswal, S., Feinstein, E. & Tuder, R. M., Jul 1 2010, In : Nature medicine. 16, 7, p. 767-773 7 p.

Research output: Contribution to journalArticle

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway

Shah, Z. A., Li, R. C., Ahmad, A. S., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Dec 1 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 12, p. 1951-1961 11 p.

Research output: Contribution to journalArticle

2011

Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia

Wang, B., Cao, W., Biswal, S. & Doré, S., Sep 1 2011, In : Stroke. 42, 9, p. 2605-2610 6 p.

Research output: Contribution to journalArticle

Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation

Reddy, N. M., Potteti, H. R., Mariani, T. J., Biswall, S. & Reddy, S. P., Dec 1 2011, In : American journal of respiratory cell and molecular biology. 45, 6, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

Mercado, N., Thimmulappa, R., Thomas, C. M. R., Fenwick, P. S., Chana, K. K., Donnelly, L. E., Biswal, S., Ito, K. & Barnes, P. J., Mar 11 2011, In : Biochemical and Biophysical Research Communications. 406, 2, p. 292-298 7 p.

Research output: Contribution to journalArticle

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

Malhotra, D., Thimmulappa, R. K., Mercado, N., Ito, K., Kombairaju, P., Kumar, S., Ma, J., Feller-Kopman, D., Wise, R., Barnes, P. & Biswal, S., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4289-4302 14 p.

Research output: Contribution to journalArticle

Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells

Pandey, M. K., Kumar, S., Thimmulappa, R. K., Parmar, V. S., Biswal, S. & Watterson, A. C., May 18 2011, In : European Journal of Pharmaceutical Sciences. 43, 1-2, p. 16-24 9 p.

Research output: Contribution to journalArticle

Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis

Kong, X., Thimmulappa, R., Craciun, F., Harvey, C., Singh, A., Kombairaju, P., Reddy, S. P., Remick, D. & Biswal, S., Oct 15 2011, In : American journal of respiratory and critical care medicine. 184, 8, p. 928-938 11 p.

Research output: Contribution to journalArticle

Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells

Kumar, V., Kumar, S., Hassan, M., Wu, H., Thimmulappa, R. K., Kumar, A., Sharma, S. K., Parmar, V. S., Biswal, S. & Malhotra, S. V., Jun 23 2011, In : Journal of medicinal chemistry. 54, 12, p. 4147-4159 13 p.

Research output: Contribution to journalArticle

Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells

Kumar, S., Singh, B. K., Arya, P., Malhotra, S., Thimmulappa, R., Prasad, A. K., Van Der Eycken, E., Olsen, C. E., Depass, A. L., Biswal, S., Parmar, V. S. & Ghosh, B., Nov 1 2011, In : European Journal of Medicinal Chemistry. 46, 11, p. 5498-5511 14 p.

Research output: Contribution to journalArticle

PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression

Zhou, W., Dowell, D. R., Geraci, M. W., Blackwell, T. S., Collins, R. D., Polosukhin, V. V., Lawson, W. E., Wu, P., Sussan, T., Biswal, S., Goleniewska, K., O'Neal, J., Newcomb, D. C., Toki, S., Morrow, J. D. & Stokes Peebles, J., Oct 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 4, p. L615-L622

Research output: Contribution to journalArticle