1993 …2020

Research output per year

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Research Output

Article

Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs

Singh, A., Ling, G., Suhasini, A. N., Zhang, P., Yamamoto, M., Navas-Acien, A., Cosgrove, G., Tuder, R. M., Kensler, T. W., Watson, W. H. & Biswal, S., Feb 1 2009, In : Free Radical Biology and Medicine. 46, 3, p. 376-386 11 p.

Research output: Contribution to journalArticle

Nrf2 exerts cell-autonomous antifibrotic effects: Compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

Wei, J., Zhu, H., Lord, G., Bhattachayya, M., Jones, B. M., Allaway, G., Biswal, S., Korman, B., Marangoni, R. G., Tourtellotte, W. G. & Varga, J., Jul 30 2016, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia

McGrath-Morrow, S., Lauer, T., Yee, M., Neptune, E., Podowski, M., Thimmulappa, R. K., O'Reilly, M. & Biswal, S., Apr 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 4, p. L565-L573

Research output: Contribution to journalArticle

Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A

Wei, Y., Gong, J., Xu, Z., Thimmulappa, R. K., Mitchell, K. L., Welsbie, D. S., Biswal, S. & Duh, E. J., Dec 15 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. E6927-E6936

Research output: Contribution to journalArticle

Nrf2 is a critical modulator of the innate immune response in a model of uveitis

Nagai, N., Thimmulappa, R. K., Cano, M., Fujihara, M., Izumi-Nagai, K., Kong, X., Sporn, M. B., Kensler, T. W., Biswal, S. & Handa, J. T., Aug 1 2009, In : Free Radical Biology and Medicine. 47, 3, p. 300-306 7 p.

Research output: Contribution to journalArticle

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

Thimmulappa, R. K., Lee, H., Rangasamy, T., Reddy, S. P., Yamamoto, M., Kensler, T. W. & Biswal, S., Apr 1 2006, In : Journal of Clinical Investigation. 116, 4, p. 984-995 12 p.

Research output: Contribution to journalArticle

Nrf2 is required for normal postnatal bone acquisition in mice

Kim, J. H., Singhal, V., Biswal, S., Thimmulappa, R. K. & DiGirolamo, D. J., Jan 1 2015, In : Bone Research. 2, 14033.

Research output: Contribution to journalArticle

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

Kim, J. H., Thimmulappa, R. K., Kumar, V., Cui, W., Kumar, S., Kombairaju, P., Zhang, H., Margolick, J., Matsui, W., Macvittie, T., Malhotra, S. V. & Biswal, S., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 730-741 12 p.

Research output: Contribution to journalArticle

Nrf2-mediated regulation of skeletal muscle glycogen metabolism

Uruno, A., Yagishita, Y., Katsuoka, F., Kitajima, Y., Nunomiya, A., Nagatomi, R., Pi, J., Biswal, S. S. & Yamamoto, M., 2016, In : Molecular and cellular biology. 36, 11, p. 1655-1672 18 p.

Research output: Contribution to journalArticle

NRF2 modulates aryl hydrocarbon receptor signaling: Influence on adipogenesis

Shin, S., Wakabayashi, N., Misra, V., Biswal, S., Gum, H. L., Agoston, E. S., Yamamoto, M. & Kensler, T. W., Oct 2007, In : Molecular and cellular biology. 27, 20, p. 7188-7197 10 p.

Research output: Contribution to journalArticle

NRF2 plays a protective role in diabetic retinopathy in mice

Xu, Z., Wei, Y., Gong, J., Cho, H., Park, J. K., Sung, E. R., Huang, H., Wu, L., Eberhart, C., Handa, J. T., Du, Y., Kern, T. S., Thimmulappa, R., Barber, A. J., Biswal, S. & Duh, E. J., Jan 2014, In : Diabetologia. 57, 1, p. 204-213 10 p.

Research output: Contribution to journalArticle

Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function

Sussan, T. E., Gajghate, S., Chatterjee, S., Mandke, P., McCormick, S., Sudini, K., Kumar, S., Breysse, P. N., Diette, G. B., Sidhaye, V. K. & Biswal, S., Jul 6 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 1, p. L27-L36

Research output: Contribution to journalArticle

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Harvey, C. J., Thimmulappa, R. K., Singh, A., Blake, D. J., Ling, G., Wakabayashi, N., Fujii, J., Myers, A. & Biswal, S., Feb 15 2009, In : Free Radical Biology and Medicine. 46, 4, p. 443-453 11 p.

Research output: Contribution to journalArticle

Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion

Osburn, W. O., Wakabayashi, N., Misra, V., Nilles, T., Biswal, S., Trush, M. A. & Kensler, T. W., Oct 1 2006, In : Archives of Biochemistry and Biophysics. 454, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

Nrf2 signaling and autophagy are complementary in protecting breast cancer cells during glucose deprivation

Walker, A., Singh, A., Tully, E., Woo, J., Le Thi, Q. H., Nguyen, T., Biswal, S., Sharma, D. & Gabrielson, E., May 20 2018, In : Free Radical Biology and Medicine. 120, p. 407-413 7 p.

Research output: Contribution to journalArticle

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells

Wang, L., Kondo, N., Cano, M., Ebrahimi, K., Yoshida, T., Barnett, B. P., Biswal, S. & Handa, J. T., May 2014, In : Free Radical Biology and Medicine. 70, p. 155-166 12 p.

Research output: Contribution to journalArticle

Nuclear erythroid 2 p45-related factor 2 inhibits the maturation of murine dendritic cells by ragweed extract

Rangasamy, T., Williams, M. A., Bauer, S., Trush, M. A., Emo, J., Georas, S. N. & Biswal, S., Sep 1 2010, In : American journal of respiratory cell and molecular biology. 43, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

Oral administration of the flavanol (-)-epicatechin bolsters endogenous protection against focal ischemia through the Nrf2 cytoprotective pathway

Leonardo, C. C., Agrawal, M., Singh, N., Moore, J. R., Biswal, S. & Doré, S., Dec 2013, In : European Journal of Neuroscience. 38, 11, p. 3659-3668 10 p.

Research output: Contribution to journalArticle

Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke

Thimmulappa, R. K., Gang, X., Kim, J. H., Sussan, T. E., Witztum, J. L. & Biswal, S., Sep 21 2012, In : Biochemical and Biophysical Research Communications. 426, 2, p. 253-259 7 p.

Research output: Contribution to journalArticle

PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression

Zhou, W., Dowell, D. R., Geraci, M. W., Blackwell, T. S., Collins, R. D., Polosukhin, V. V., Lawson, W. E., Wu, P., Sussan, T., Biswal, S., Goleniewska, K., O'Neal, J., Newcomb, D. C., Toki, S., Morrow, J. D. & Stokes Peebles, J., Oct 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 4, p. L615-L622

Research output: Contribution to journalArticle

Plasma miRNA as biomarkers for assessment of total-body radiation exposure dosimetry

Cui, W., Ma, J., Wang, Y. & Biswal, S., 2011, In : PloS one. 6, 8, e22988.

Research output: Contribution to journalArticle

Plausible involvement of a diabetic serum factor in neutrophil membrane pathology.

Nath, N., Biswas, S., Bhelwa, A., Ittoop, A. & Biswal, S., Aug 1993, In : Indian journal of biochemistry & biophysics. 30, 4, p. 244-246 3 p.

Research output: Contribution to journalArticle

Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils

Thimmulappa, R. K., Fuchs, R. J., Malhotra, D., Scollick, C., Traore, K., Bream, J. H., Trush, M. A., Liby, K. T., Sporn, M. B., Kensler, T. W. & Biswal, S., Oct 1 2007, In : Antioxidants and Redox Signaling. 9, 11, p. 1963-1970 8 p.

Research output: Contribution to journalArticle

Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer

Kombairaju, P., Ma, J., Thimmulappa, R., Yan, G., Gabrielson, E., Singh, A. & Biswal, S., 2012, In : Journal of Carcinogenesis. 11, 8.

Research output: Contribution to journalArticle

Proteolytic loss of bcl-xL in FL5.12 cells undergoing apoptosis induced by MK886

Datta, K., Kern, J. C., Biswal, S. S. & Kehrer, J. P., Aug 1 2001, In : Toxicology and Applied Pharmacology. 174, 3, p. 273-281 9 p.

Research output: Contribution to journalArticle

Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema

Le, A., Zielinski, R., He, C., Crow, M. T., Biswal, S., Tuder, R. M. & Becker, P. M., Sep 1 2009, In : American journal of respiratory and critical care medicine. 180, 5, p. 396-406 11 p.

Research output: Contribution to journalArticle

Redox-regulation of ERK 1/2-directed phosphatase by reactive oxygen species: Role in signaling TPA-induced growth arrest in ML-1 cells

Traore, K., Sharma, R., Thimmulappa, R. K., Watson, W. H., Biswal, S. & Trush, M. A., Jul 1 2008, In : Journal of Cellular Physiology. 216, 1, p. 276-285 10 p.

Research output: Contribution to journalArticle

Regulation of Notch1 signaling by Nrf2: Implications for tissue regeneration

Wakabayashi, N., Shin, S., Slocum, S. L., Agoston, E. S., Wakabayashi, J., Kwak, M. K., Misra, V., Biswal, S., Yamamoto, M. & Kensler, T. W., Jul 13 2010, In : Science signaling. 3, 130, p. ra52

Research output: Contribution to journalArticle

Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin efficacy of recoupling nitric oxide synthase as a therapeutic strategy

Moens, A. L., Takimoto, E., Tocchetti, C. G., Chakir, K., Bedja, D., Cormaci, G., Ketner, E. A., Majmudar, M., Gabrielson, K., Halushka, M. K., Mitchell, J. B., Biswal, S., Channon, K. M., Wolin, M. S., Alp, N. J., Paolocci, N., Champion, H. C. & Kass, D. A., May 20 2008, In : Circulation. 117, 20, p. 2626-2636 11 p.

Research output: Contribution to journalArticle

Reversal of cigarette smoke extract-induced sinonasal epithelial cell barrier dysfunction through Nrf2 Activation

Tharakan, A., Halderman, A. A., Lane, A. P., Biswal, S. & Ramanathan, M., Nov 1 2016, In : International Forum of Allergy and Rhinology. 6, 11, p. 1145-1150 6 p.

Research output: Contribution to journalArticle

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

Singh, A., Boldin-Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J., Blackford, A., Goodman, S. N., Bunz, F., Watson, W. H., Gabrielson, E., Feinstein, E. & Biswal, S., Oct 1 2008, In : Cancer Research. 68, 19, p. 7975-7984 10 p.

Research output: Contribution to journalArticle

Role of lung maintenance program in the heterogeneity of lung destruction in emphysema

Tuder, R. M., Yoshida, T., Fijalkowka, I., Biswal, S. & Petrache, I., Nov 2006, In : Proceedings of the American Thoracic Society. 3, 8, p. 673-679 7 p.

Research output: Contribution to journalArticle

Role of Nrf2 in protection against intracerebral hemorrhage injury in mice

Wang, J., Fields, J., Zhao, C., Langer, J., Thimmulappa, R. K., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Aug 1 2007, In : Free Radical Biology and Medicine. 43, 3, p. 408-414 7 p.

Research output: Contribution to journalArticle

Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury

Shah, Z. A., Li, R. C., Thimmulappa, R. K., Kensler, T. W., Yamamoto, M., Biswal, S. & Doré, S., Jun 15 2007, In : Neuroscience. 147, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis

Wu, X., Biswal, S. S. & Kehrer, J. P., Jun 1 2003, In : Cell Biology and Toxicology. 19, 3, p. 135-143 9 p.

Research output: Contribution to journalArticle

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema

Yoshida, T., Mett, I., Bhunia, A. K., Bowman, J., Perez, M., Zhang, L., Gandjeva, A., Zhen, L., Chukwueke, U., Mao, T., Richter, A., Brown, E., Ashush, H., Notkin, N., Gelfand, A., Thimmulappa, R. K., Rangasamy, T., Sussan, T., Cosgrove, G., Mouded, M. & 5 others, Shapiro, S. D., Petrache, I., Biswal, S., Feinstein, E. & Tuder, R. M., Jul 1 2010, In : Nature medicine. 16, 7, p. 767-773 7 p.

Research output: Contribution to journalArticle

Selective and nonselective packaging of cellular RNAs in retrovirus particles

Rulli, S. J., Hibbert, C. S., Mirro, J., Pederson, T., Biswal, S. & Rein, A., Jun 2007, In : Journal of virology. 81, 12, p. 6623-6631 9 p.

Research output: Contribution to journalArticle

Selective Nrf2 Gene Deletion in the Rostral Ventrolateral Medulla Evokes Hypertension and Sympathoexcitation in Mice

Gao, L., Zimmerman, M. C., Biswal, S. & Zucker, I. H., Jun 1 2017, In : Hypertension. 69, 6, p. 1198-1206 9 p.

Research output: Contribution to journalArticle

Sildenafil Inhibits Superoxide Formation and Prevents Endothelial Dysfunction in a Mouse Model of Secondhand Smoke Induced Erectile Dysfunction

Bivalacqua, T. J., Sussan, T. E., Gebska, M. A., Strong, T. D., Berkowitz, D. E., Biswal, S., Burnett, A. L. & Champion, H. C., Feb 2009, In : Journal of Urology. 181, 2, p. 899-906 8 p.

Research output: Contribution to journalArticle

Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors

Singh, A., Venkannagari, S., Oh, K. H., Zhang, Y. Q., Rohde, J. M., Liu, L., Nimmagadda, S., Sudini, K., Brimacombe, K. R., Gajghate, S., Ma, J., Wang, A., Xu, X., Shahane, S. A., Xia, M., Woo, J., Mensah, G. A., Wang, Z., Ferrer, M., Gabrielson, E. & 5 others, Li, Z., Rastinejad, F., Shen, M., Boxer, M. B. & Biswal, S., Nov 18 2016, In : ACS chemical biology. 11, 11, p. 3214-3225 12 p.

Research output: Contribution to journalArticle

S-nitrosoglutathione reductase is essential for protecting the female heart from ischemia-reperfusion injury

Casin, K. M., Fallica, J., Mackowski, N., Veenema, R. J., Chan, A., St. Paul, A., Zhu, G., Bedja, D., Biswal, S. & Kohr, M. J., Jan 1 2018, In : Circulation research. 123, 11, p. 1232-1243 12 p.

Research output: Contribution to journalArticle

Source of biomass cooking fuel determines pulmonary response to household air pollution

Sussan, T. E., Ingole, V., Kim, J. H., McCormick, S., Negherbon, J., Fallica, J., Akulian, J., Yarmus, L., Feller-Kopman, D., Wills-Karp, M., Horton, M. R., Breysse, P. N., Agrawal, A., Juvekar, S., Salvi, S. & Biswal, S., Mar 2014, In : American journal of respiratory cell and molecular biology. 50, 3, p. 538-548 11 p.

Research output: Contribution to journalArticle

Open Access

Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease

Acquaah-Mensah, G. K., Malhotra, D., Vulimiri, M., McDermott, J. E. & Biswal, S., Jul 2012, In : PLoS computational biology. 8, 7, e1002597.

Research output: Contribution to journalArticle

Synthesis and biological activity evaluation of N-protected isatin derivatives as inhibitors of ICAM-1 expression on human endothelial cells

Malhotra, S., Balwani, S., Dhawan, A., Singh, B. K., Kumar, S., Thimmulappa, R., Biswal, S., Olsen, C. E., Van Der Eycken, E., Prasad, A. K., Ghosh, B. & Parmar, V. S., Aug 2011, In : MedChemComm. 2, 8, p. 743-751 9 p.

Research output: Contribution to journalArticle

Systemic activation of NRF2 alleviates lethal autoimmune inflammation in scurfy mice

Suzuki, T., Murakami, S., Biswal, S. S., Sakaguchi, S., Harigae, H., Yamamoto, M. & Motohashi, H., Aug 1 2017, In : Molecular and cellular biology. 37, 15, e00063-17.

Research output: Contribution to journalArticle

Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smokeinduced lung inflammation

Reddy, N. M., Vegiraju, S., Irving, A., Paun, B. C., Luzina, I. G., Atamas, S. P., Biswal, S., Ana, N. A., Mitzner, W. & Reddy, S. P., Feb 2012, In : American Journal of Pathology. 180, 2, p. 562-574 13 p.

Research output: Contribution to journalArticle