Shuying Sun

Assistant Professor

20082019
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Fingerprint Dive into the research topics where Shuying Sun is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
RNA Medicine & Life Sciences
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Alternative Splicing Medicine & Life Sciences
Motor Neurons Medicine & Life Sciences
Dipeptides Medicine & Life Sciences
Exons Medicine & Life Sciences
Mutation Medicine & Life Sciences
Proteins Medicine & Life Sciences

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Research Output 2008 2019

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

Ling, S. C., Dastidar, S. G., Tokunaga, S., Ho, W. Y., Lim, K., Ilieva, H., Parone, P. A., Tyan, S. H., Tse, T. M., Chang, J. C., Platoshyn, O., Bui, N. B., Bui, A., Vetto, A., Sun, S., McAlonis-Downes, M., Han, J. S., Swing, D., Kapeli, K., Yeo, G. W. & 8 others, Tessarollo, L., Marsala, M., Shaw, C. E., Tucker-Kellogg, G., La Spada, A. R., Lagier-Tourenne, C., Da Cruz, S. & Cleveland, D. W., Feb 12 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Poisons
Autophagy
Amyotrophic Lateral Sclerosis
Lysosomes
Metabolism

PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel

Yang, J., Chen, J., Del Carmen Vitery, M., Osei-Owusu, J., Chu, J., Yu, H., Sun, S. & Qiu, Z., Apr 26 2019, In : Science (New York, N.Y.). 364, 6438, p. 395-399 5 p.

Research output: Contribution to journalArticle

Chloride Channels
Protons
Membrane Proteins
Physiological Phenomena
Nociceptive Pain

C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation

Cheng, W., Wang, S., Mestre, A. A., Fu, C., Makarem, A., Xian, F., Hayes, L., Lopez-Gonzalez, R., Drenner, K., Jiang, J., Cleveland, D. W. & Sun, S., Dec 1 2018, In : Nature Communications. 9, 1, 02495.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
phosphorylation
Phosphorylation
Dipeptides
caps

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

Ditsworth, D., Maldonado, M., McAlonis-Downes, M., Sun, S., Seelman, A., Drenner, K., Arnold, E., Ling, S. C., Pizzo, D., Ravits, J., Cleveland, D. W. & Da Cruz, S., Jun 1 2017, In : Acta Neuropathologica. 133, 6, p. 907-922 16 p.

Research output: Contribution to journalArticle

Motor Neuron Disease
Amyotrophic Lateral Sclerosis
Motor Neurons
Premature Mortality
Neuromuscular Junction

Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Jiang, J., Zhu, Q., Gendron, T. F., Saberi, S., McAlonis-Downes, M., Seelman, A., Stauffer, J. E., Jafar-nejad, P., Drenner, K., Schulte, D., Chun, S., Sun, S., Ling, S. C., Myers, B., Engelhardt, J., Katz, M., Baughn, M., Platoshyn, O., Marsala, M., Watt, A. & 21 others, Heyser, C. J., Ard, M. C., De Muynck, L., Daughrity, L. M., Swing, D. A., Tessarollo, L., Jung, C. J., Delpoux, A., Utzschneider, D. T., Hedrick, S. M., de Jong, P. J., Edbauer, D., Van Damme, P., Petrucelli, L., Shaw, C. E., Bennett, C. F., Da Cruz, S., Ravits, J., Rigo, F., Cleveland, D. W. & Lagier-Tourenne, C., May 4 2016, In : Neuron. 90, 3, p. 535-550 16 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
RNA
Dipeptides
Splenomegaly
Interpersonal Relations