Shuli Xia

Fac-Asst Prof- Staff

19962018
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Research Output 1996 2018

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2018

ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

Wang, J., Zibetti, C., Shang, P., Sripathi, S. R., Zhang, P., Cano, M., Hoang, T., Xia, S., Ji, H., Merbs, S. L., Zack, D. J., Handa, J. T., Sinha, D., Blackshaw, S. & Qian, J. Dec 1 2018 In : Nature Communications. 9, 1, 1364

Research output: Contribution to journalArticle

accessibility
analysis
pathology
risk factor
footprint

Crizotinib and erlotinib inhibits growth of c-Met+/EGFRvIII+ primary human glioblastoma xenografts

Goodwin, C. R., Rath, P., Oyinlade, O., Lopez, H., Mughal, S., Xia, S., Li, Y., Kaur, H., Zhou, X., Ahmed, A. K., Ho, S., Olivi, A. & Lal, B. Aug 1 2018 In : Clinical Neurology and Neurosurgery. 171, p. 26-33 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Heterografts
Growth
Epidermal Growth Factor Receptor
Neoplasms

Global identification of Small Ubiquitin-related Modifier (SUMO) substrates reveals crosstalk between SUMOylation and phosphorylation promotes cell migration

Uzoma, I., Hu, J., Cox, E., Xia, S., Zhou, J., Rho, H. S., Guzzo, C., Paul, C., Ajala, O., Goodwin, C. R., Jeong, J., Moore, C., Zhang, H., Meluh, P., Blackshaw, S., Matunis, M., Qian, J. & Zhu, H. May 1 2018 In : Molecular and Cellular Proteomics. 17, 5, p. 871-888 18 p.

Research output: Contribution to journalArticle

Sumoylation
Ubiquitin
Cell Movement
Phosphorylation
Rotary engines

Heterozygous IDH1R132H/WT created by “single base editing” inhibits human astroglial cell growth by downregulating YAP

Wei, S., Wang, J., Oyinlade, O., Ma, D., Wang, S., Kratz, L., Lal, B., Xu, Q., Liu, S., Shah, S. R., Zhang, H., Li, Y., Quiñones-Hinojosa, A., Zhu, H., Huang, Z. Y., Cheng, L., Qian, J. & Xia, S. May 30 2018 (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Down-Regulation
Growth
Proteins
Mutation

Krüppel-like factor 4 (KLF4) induces mitochondrial fusion and increases spare respiratory capacity of human glioblastoma cells

Wang, S., Shi, X., Wei, S., Ma, D., Oyinlade, O., Lv, S. Q., Ying, M., Zhang, Y. A., Claypool, S. M., Watkins, P. & Xia, S. Jan 1 2018 In : Journal of Biological Chemistry. 293, 17, p. 6544-6555 12 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Glioblastoma
Metabolism
Fusion reactions
Cells

MeDReaders: A database for transcription factors that bind to methylated DNA

Wang, G., Luo, X., Wang, J., Wan, J., Xia, S., Zhu, H., Qian, J. & Wang, Y. Jan 1 2018 In : Nucleic acids research. 46, D1, p. D146-D151

Research output: Contribution to journalArticle

Transcription Factors
Databases
DNA
Methylation
Biological Phenomena

Targeting UDP-α-d-glucose 6-dehydrogenase inhibits glioblastoma growth and migration

Oyinlade, O., Wei, S., Lal, B., Laterra, J., Zhu, H., Goodwin, C. R., Wang, S., Ma, D., Wan, J. & Xia, S. Feb 26 2018 (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Uridine Diphosphate Glucose Dehydrogenase
Glucose 1-Dehydrogenase
Uridine Diphosphate
Glioblastoma
Growth
2017

Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

Wan, J., Su, Y., Song, Q., Tung, B., Oyinlade, O., Liu, S., Ying, M., Ming, G. L., Song, H., Qian, J., Zhu, H. & Xia, S. May 29 2017 In : eLife. 6, e20068

Research output: Contribution to journalArticle

Transcriptional Activation
Cell Movement
DNA Methylation
Genes
Chromatin Assembly and Disassembly
2016

Microarray-based phospho-proteomic profiling of complex biological systems

Goodwin, C. R., Woodard, C. L., Zhou, X., Pan, J., Olivi, A., Xia, S., Bettegowda, C., Sciubba, D. M., Pevsner, J., Zhu, H. & Laterra, J. Apr 1 2016 In : Translational Oncology. 9, 2, p. 124-129 6 p.

Research output: Contribution to journalArticle

Protein Array Analysis
Proteomics
Phosphotransferases
Tumor Microenvironment
Glioma

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151

Tilghman, J., Schiapparelli, P., Lal, B., Ying, M., Quinones-Hinojosa, A., Xia, S. & Laterra, J. 2016 In : Neoplasia. 18, 3, p. 185-198 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Integrins
Stem Cells
Neoplasms
Cell Movement

Single-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes

Wang, J., Xia, S., Arand, B., Zhu, H., Machiraju, R., Huang, K., Ji, H. & Qian, J. Apr 1 2016 In : PLoS Computational Biology. 12, 4, e1004892

Research output: Contribution to journalArticle

Genes
Gene
Distinct
tumor
Module

Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation

Xia, S., Lal, B., Tung, B., Wang, S., Goodwin, C. R. & Laterra, J. Apr 1 2016 In : Neuro-Oncology. 18, 4, p. 507-517 11 p.

Research output: Contribution to journalArticle

Tenascin
Tumor Microenvironment
Glioblastoma
Neoplasms
Brain Neoplasms
2015
Noise
Glioblastoma
Principal Component Analysis
Protons
Neoplasms
2014

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

Sun, P., Xia, S., Lal, B., Shi, X., Yang, K. S., Watkins, P. A. & Laterra, J. Jun 4 2014 In : BMC Cancer. 14, 1, 401

Research output: Contribution to journalArticle

Coenzyme A Ligases
Glioblastoma
Lipid Metabolism
Stem Cells
Maintenance
2013

Construction of human activity-based phosphorylation networks

Newman, R. H. , Hu, J. , Rho, H. S. , Xie, Z. , Woodard, C. , Neiswinger, J. , Cooper, C. , Shirley, M. , Clark, H. M. , Hu, S. , Hwang, W. , Seop Jeong, J. , Wu, G. , Lin, J. , Gao, X. , Ni, Q. , Goel, R. , Xia, S. , Ji, H. , Dalby, K. N. & 14 others Birnbaum, M. J., Cole, P. A., Knapp, S., Ryazanov, A. G., Zack, D. J., Blackshaw, S., Pawson, T., Gingras, A. C., Desiderio, S., Pandey, A., Turk, B. E., Zhang, J., Zhu, H. & Qian, J. 2013 In : Molecular Systems Biology. 9, 655

Research output: Contribution to journalArticle

Phosphorylation
Human Activities
phosphorylation
phosphotransferases (kinases)
Phosphotransferases

DNA methylation presents distinct binding sites for human transcription factors

Hu, S., Wan, J., Su, Y., Song, Q., Zeng, Y., Nguyen, H. N., Shin, J., Cox, E., Rho, H. S., Woodard, C., Xia, S., Liu, S., Lyu, H., Ming, G. L., Wade, H., Song, H., Qian, J. & Zhu, H. Sep 3 2013 In : eLife. 2013, 2, e00726

Research output: Contribution to journalArticle

DNA Methylation
Transcription Factors
Binding Sites
Transcription
Epigenomics

In vivo c-Met pathway inhibition depletes human glioma xenografts of tumor-propagating stem-like cells

Rath, P., Lal, B., Ajala, O., Li, Y., Xia, S., Kim, J. & Laterra, J. Apr 2013 In : Translational Oncology. 6, 2, p. 104-111 8 p.

Research output: Contribution to journalArticle

Heterografts
Glioma
Stem Cells
Neoplasms
Neoplastic Stem Cells

Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling.

Woodard, C. L., Goodwin, C. R., Wan, J., Xia, S., Newman, R., Hu, J., Zhang, J., Hayward, S. D., Qian, J., Laterra, J. & Zhu, H. 2013 In : PLoS One. 8, 9, e72671

Research output: Contribution to journalArticle

hepatocyte growth factor
Hepatocyte Growth Factor
protein phosphorylation
Phosphorylation
Protein Array Analysis
2012

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

Wang, S. D., Rath, P., Lal, B., Richard, J. P., Li, Y., Goodwin, C. R., Laterra, J. & Xia, S. Dec 13 2012 In : Oncogene. 31, 50, p. 5132-5143 12 p.

Research output: Contribution to journalArticle

EphB2 Receptors
Focal Adhesion Protein-Tyrosine Kinases
Glioblastoma
Cell Movement
Cell Proliferation
Neoplastic Stem Cells
DNA-Binding Proteins
Glioblastoma
Transcription Factors
Stem Cells
2011

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

Li, Y., Li, A., Glas, M., Lal, B., Ying, M., Sang, Y., Xia, S., Trageser, D., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Scheffler, B. & Laterra, J. Jun 14 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 24, p. 9951-9956 6 p.

Research output: Contribution to journalArticle

Glioblastoma
Phenotype
Neoplastic Stem Cells
Transcription Factors
Stem Cells

Krüppel-like family of transcription factor 9, a differentiation- associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells

Ying, M., Sang, Y., Li, Y., Guerrero-Cazares, H., Quinones-Hinojosa, A., Vescovi, A. L., Eberhart, C. G., Xia, S. & Laterra, J. Jan 2011 In : Stem Cells. 29, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

Kruppel-Like Transcription Factors
Neoplastic Stem Cells
Glioblastoma
Transcription Factors
Stem Cells

PTEN reconstitution alters glioma responses to c-Met pathway inhibition

Rory Goodwin, C., Lal, B., Ho, S., Woodard, C. L., Zhou, X., Taeger, A., Xia, S. & Laterra, J. Oct 2011 In : Anti-Cancer Drugs. 22, 9, p. 905-912 8 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Glioma
Heterografts
Growth
Receptor Protein-Tyrosine Kinases

Regulation of glioblastoma stem cells by retinoic acid: Role for Notch pathway inhibition

Ying, M., Wang, S., Sang, Y., Sun, P., Lal, B., Goodwin, C. R., Guerrero-Cazares, H., Quinones-Hinojosa, A., Laterra, J. & Xia, S. Aug 4 2011 In : Oncogene. 30, 31, p. 3454-3467 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Tretinoin
Stem Cells
Neoplastic Stem Cells
Down-Regulation
2010

Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation

Goodwin, C. R., Lal, B., Zhou, X., Ho, S., Xia, S., Taeger, A., Murray, J. & Laterra, J. Apr 1 2010 In : Cancer Research. 70, 7, p. 2932-2941 10 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Cell Movement
Glioma
Growth
Small Interfering RNA
2009

Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms

Li, Y., Rory Goodwin, C., Sang, Y., Rosen, E. M., Laterra, J. & Xia, S. Oct 2009 In : Anti-Cancer Drugs. 20, 9, p. 770-778 9 p.

Research output: Contribution to journalArticle

CD95 Antigens
Camptothecin
Medulloblastoma
irinotecan
Cell Death

DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation

Sun, P., Xia, S., Lal, B., Eberhart, C. G., Quinones-Hinojosa, A., Maciaczyk, J., Matsui, W., DiMeco, F., Piccirillo, S. M., Vescovi, A. L. & Laterra, J. Jul 2009 In : Stem Cells. 27, 7, p. 1473-1486 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Differentiation
Neoplastic Stem Cells
Genes
Neoplasms
2008

Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5

Li, Y., Fan, X., Rory, C. R., Laterra, J. & Xia, S. Nov 7 2008 In : BMC Cancer. 8, 325

Research output: Contribution to journalArticle

Death Domain Receptors
Hepatocyte Growth Factor
Apoptosis
Cell Death
Medulloblastoma

Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor

Reznik, T. E., Sang, Y., Ma, Y., Abounader, R., Rosen, E. M., Xia, S. & Laterra, J. Jan 1 2008 In : Molecular Cancer Research. 6, 1, p. 139-150 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Heparin
Intercellular Signaling Peptides and Proteins
2007
Anisomycin
Death Domain Receptors
JNK Mitogen-Activated Protein Kinases
Glioblastoma
Cell Death
2006

Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells

Xia, S. & Laterra, J. Jul 14 2006 In : Biochemical and Biophysical Research Communications. 345, 4, p. 1358-1364 7 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Glioblastoma
Camptothecin
Phosphotransferases
Enzymes
2005

Identification of new targets of Drosophila pre-mRNA adenosine deaminase

Xia, S., Yang, J., Su, Y., Qian, J., Ma, E. & Haddad, G. G. Apr 2005 In : Physiological Genomics. 20, p. 195-202 8 p.

Research output: Contribution to journalArticle

Adenosine Deaminase
RNA Precursors
Drosophila
Inosine
Diptera

Sensitization of glioma cells to fas-dependent apoptosis by chemotherapy-induced oxidative stress

Xia, S., Rosen, E. M. & Laterra, J. Jun 15 2005 In : Cancer Research. 65, 12, p. 5248-5255 8 p.

Research output: Contribution to journalArticle

irinotecan
Glioma
Camptothecin
Oxidative Stress
Glioblastoma

Targeting the c-Met pathway potentiates glioblastoma responses to γ-radiation

Lal, B., Xia, S., Abounader, R. & Laterra, J. Jun 15 2005 In : Clinical Cancer Research. 11, 12, p. 4479-4486 8 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Gamma Rays
Glioblastoma
Catalytic RNA
Heterografts
2002

Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons

Xiao, A. Y., Wei, L., Xia, S., Rothman, S. & Yu, S. P. Feb 15 2002 In : Journal of Neuroscience. 22, 4, p. 1350-1362 13 p.

Research output: Contribution to journalArticle

Ouabain
Necrosis
Adenosine Triphosphatases
Apoptosis
Neurons

Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation

Xia, S., Lampe, P. A., Deshmukh, M., Yang, A., Brown, B. S., Rothman, S. M., Johnson, E. M. & Yu, S. P. Jan 1 2002 In : Journal of Neuroscience. 22, 1, p. 114-122 9 p.

Research output: Contribution to journalArticle

linopirdine
Nerve Growth Factor
Apoptosis
Tetrodotoxin
Nifedipine

The estrogen receptor is not essential for all estrogen neuroprotection: New evidence from a new analog

Xia, S., Cai, Z. Y., Thio, L. L., Kim-Han, J. S., Dugan, L. L., Covey, D. F. & Rothman, S. M. 2002 In : Neurobiology of Disease. 9, 3, p. 282-293 12 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Necrosis
1996

Characterization of the insulin and transferrin receptors of two cancer cell lines

Tang, Y. H., Zhang, X., Xia, S. L., Jing, N. H. & Feng, Y. M. 1996 In : Acta Biochimica et Biophysica Sinica. 28, 4, p. 441 1 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Insulin Receptor
Cells
Cell Line
Neoplasms