Research Output 1996 2017

2017

Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

Wan, J., Su, Y., Song, Q., Tung, B., Oyinlade, O., Liu, S., Ying, M., Ming, G. L., Song, H., Qian, J., Zhu, H. & Xia, S. May 29 2017 In : eLife. 6, e20068

Research output: Research - peer-reviewArticle

Transcriptional Activation
Cell Movement
Genes
GKLF protein
DNA Methylation
2016

Microarray-based phospho-proteomic profiling of complex biological systems

Goodwin, C. R., Woodard, C. L., Zhou, X., Pan, J., Olivi, A., Xia, S., Bettegowda, C., Sciubba, D. M., Pevsner, J., Zhu, H. & Laterra, J. Apr 1 2016 In : Translational Oncology. 9, 2, p. 124-129 6 p.

Research output: Research - peer-reviewArticle

Protein Array Analysis
Proteomics
Phosphotransferases
Neoplasms
Tumor Microenvironment

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151

Tilghman, J., Schiapparelli, P., Lal, B., Ying, M., Quinones-Hinojosa, A., Xia, S. & Laterra, J. 2016 In : Neoplasia. 18, 3, p. 185-198 14 p.

Research output: Research - peer-reviewArticle

Glioblastoma
Integrins
Neoplasms
Stem Cells
Cell Movement

Single-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes

Wang, J., Xia, S., Arand, B., Zhu, H., Machiraju, R., Huang, K., Ji, H. & Qian, J. Apr 1 2016 In : PLoS Computational Biology. 12, 4, e1004892

Research output: Research - peer-reviewArticle

Gene
Distinct
Module
Cell
gene

Tumor microenvironment tenascin-C promotes glioblastoma invasion and negatively regulates tumor proliferation

Xia, S., Lal, B., Tung, B., Wang, S., Goodwin, C. R. & Laterra, J. Apr 1 2016 In : Neuro-Oncology. 18, 4, p. 507-517 11 p.

Research output: Research - peer-reviewArticle

Tenascin
Tumor Microenvironment
Glioblastoma
Neoplasms
Brain Neoplasms
2015
Noise
Glioblastoma
Principal Component Analysis
Protons
Neoplasms
2014

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

Sun, P., Xia, S., Lal, B., Shi, X., Yang, K. S., Watkins, P. A. & Laterra, J. Jun 4 2014 In : BMC Cancer. 14, 1, 401

Research output: Research - peer-reviewArticle

Coenzyme A Ligases
Glioblastoma
Lipid Metabolism
Stem Cells
Maintenance
2013

Construction of human activity-based phosphorylation networks

Newman, R. H. , Hu, J. , Rho, H. S. , Xie, Z. , Woodard, C. , Neiswinger, J. , Cooper, C. , Shirley, M. , Clark, H. M. , Hu, S. , Hwang, W. , Seop Jeong, J. , Wu, G. , Lin, J. , Gao, X. , Ni, Q. , Goel, R. , Xia, S. , Ji, H. , Dalby, K. N. & 14 others Birnbaum, M. J., Cole, P. A., Knapp, S., Ryazanov, A. G., Zack, D. J., Blackshaw, S., Pawson, T., Gingras, A. C., Desiderio, S., Pandey, A., Turk, B. E., Zhang, J., Zhu, H. & Qian, J. 2013 In : Molecular Systems Biology. 9, 655

Research output: Research - peer-reviewArticle

Phosphorylation
Human
Human Activities
Phosphotransferases
phosphorylation

DNA methylation presents distinct binding sites for human transcription factors

Hu, S., Wan, J., Su, Y., Song, Q., Zeng, Y., Nguyen, H. N., Shin, J., Cox, E., Rho, H. S., Woodard, C., Xia, S., Liu, S., Lyu, H., Ming, G. L., Wade, H., Song, H., Qian, J. & Zhu, H. Sep 3 2013 In : eLife. 2013, 2, e00726

Research output: Research - peer-reviewArticle

Transcription Factors
Binding Sites
DNA Methylation
Transcription
DNA

In vivo c-Met pathway inhibition depletes human glioma xenografts of tumor-propagating stem-like cells

Rath, P., Lal, B., Ajala, O., Li, Y., Xia, S., Kim, J. & Laterra, J. Apr 2013 In : Translational Oncology. 6, 2, p. 104-111 8 p.

Research output: Research - peer-reviewArticle

Heterografts
Glioma
Stem Cells
Neoplasms
Neoplastic Stem Cells

Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling.

Woodard, C. L., Goodwin, C. R., Wan, J., Xia, S., Newman, R., Hu, J., Zhang, J., Hayward, S. D., Qian, J., Laterra, J. & Zhu, H. 2013 In : PLoS One. 8, 9, e72671

Research output: Research - peer-reviewArticle

hepatocyte growth factor
proteins
Hepatocyte Growth Factor
Proteins
Phosphorylation
2012

EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase

Wang, S. D., Rath, P., Lal, B., Richard, J. P., Li, Y., Goodwin, C. R., Laterra, J. & Xia, S. Dec 13 2012 In : Oncogene. 31, 50, p. 5132-5143 12 p.

Research output: Research - peer-reviewArticle

EphB2 Receptors
Focal Adhesion Protein-Tyrosine Kinases
Glioblastoma
Cell Movement
Neoplasms
Neoplastic Stem Cells
DNA-Binding Proteins
Glioblastoma
Transcription Factors
Stem Cells
2011

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

Li, Y., Li, A., Glas, M., Lal, B., Ying, M., Sang, Y., Xia, S., Trageser, D., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Scheffler, B. & Laterra, J. Jun 14 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 24, p. 9951-9956 6 p.

Research output: Research - peer-reviewArticle

Glioblastoma
Phenotype
Neoplastic Stem Cells
Transcription Factors
Stem Cells

Krüppel-like family of transcription factor 9, a differentiation- associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells

Ying, M., Sang, Y., Li, Y., Guerrero-Cazares, H., Quinones-Hinojosa, A., Vescovi, A. L., Eberhart, C. G., Xia, S. & Laterra, J. Jan 2011 In : Stem Cells. 29, 1, p. 20-31 12 p.

Research output: Research - peer-reviewArticle

Kruppel-Like Transcription Factors
Neoplastic Stem Cells
Glioblastoma
Transcription Factors
Stem Cells

PTEN reconstitution alters glioma responses to c-Met pathway inhibition

Rory Goodwin, C., Lal, B., Ho, S., Woodard, C. L., Zhou, X., Taeger, A., Xia, S. & Laterra, J. Oct 2011 In : Anti-Cancer Drugs. 22, 9, p. 905-912 8 p.

Research output: Research - peer-reviewArticle

Hepatocyte Growth Factor
Glioma
Growth
Heterografts
Therapeutics

Regulation of glioblastoma stem cells by retinoic acid: Role for Notch pathway inhibition

Ying, M., Wang, S., Sang, Y., Sun, P., Lal, B., Goodwin, C. R., Guerrero-Cazares, H., Quinones-Hinojosa, A., Laterra, J. & Xia, S. Aug 4 2011 In : Oncogene. 30, 31, p. 3454-3467 14 p.

Research output: Research - peer-reviewArticle

Glioblastoma
Tretinoin
Stem Cells
Inhibition (Psychology)
Therapeutics
2010

Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation

Goodwin, C. R., Lal, B., Zhou, X., Ho, S., Xia, S., Taeger, A., Murray, J. & Laterra, J. Apr 1 2010 In : Cancer Research. 70, 7, p. 2932-2941 10 p.

Research output: Research - peer-reviewArticle

Hepatocyte Growth Factor
Cell Movement
Growth
Neoplasms
Glioma
2009

Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms

Li, Y., Rory Goodwin, C., Sang, Y., Rosen, E. M., Laterra, J. & Xia, S. Oct 2009 In : Anti-Cancer Drugs. 20, 9, p. 770-778 9 p.

Research output: Research - peer-reviewArticle

CD95 Antigens
Camptothecin
Medulloblastoma
Cell Death
4-dimethylamino-3',4'-dimethoxychalcone

DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation

Sun, P., Xia, S., Lal, B., Eberhart, C. G., Quinones-Hinojosa, A., Maciaczyk, J., Matsui, W., DiMeco, F., Piccirillo, S. M., Vescovi, A. L. & Laterra, J. Jul 2009 In : Stem Cells. 27, 7, p. 1473-1486 14 p.

Research output: Research - peer-reviewArticle

Glioblastoma
Cell Differentiation
Genes
Neoplasms
Neoplastic Stem Cells
2008

Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5

Li, Y., Fan, X., Rory, C. R., Laterra, J. & Xia, S. Nov 7 2008 In : BMC Cancer. 8, 325

Research output: Research - peer-reviewArticle

Death Domain Receptors
Hepatocyte Growth Factor
Apoptosis
Cell Death
Medulloblastoma

Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor

Reznik, T. E., Sang, Y., Ma, Y., Abounader, R., Rosen, E. M., Xia, S. & Laterra, J. Jan 1 2008 In : Molecular Cancer Research. 6, 1, p. 139-150 12 p.

Research output: Research - peer-reviewArticle

Hepatocyte Growth Factor
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Heparin
Intercellular Signaling Peptides and Proteins
2007
Anisomycin
Death Domain Receptors
JNK Mitogen-Activated Protein Kinases
Glioblastoma
Cell Death
2006

Hepatocyte growth factor increases mitochondrial mass in glioblastoma cells

Xia, S. & Laterra, J. Jul 14 2006 In : Biochemical and Biophysical Research Communications. 345, 4, p. 1358-1364 7 p.

Research output: Research - peer-reviewArticle

Hepatocyte Growth Factor
Glioblastoma
Camptothecin
Enzymes
Phosphotransferases
2005

Identification of new targets of Drosophila pre-mRNA adenosine deaminase

Xia, S., Yang, J., Su, Y., Qian, J., Ma, E. & Haddad, G. G. Apr 2005 In : Physiological Genomics. 20, p. 195-202 8 p.

Research output: Research - peer-reviewArticle

Adenosine Deaminase
RNA Precursors
Drosophila
Messenger RNA
Diptera

Sensitization of glioma cells to fas-dependent apoptosis by chemotherapy-induced oxidative stress

Xia, S., Rosen, E. M. & Laterra, J. Jun 15 2005 In : Cancer Research. 65, 12, p. 5248-5255 8 p.

Research output: Research - peer-reviewArticle

Glioma
Oxidative Stress
Apoptosis
Drug Therapy
4-dimethylamino-3',4'-dimethoxychalcone

Targeting the c-Met pathway potentiates glioblastoma responses to γ-radiation

Lal, B., Xia, S., Abounader, R. & Laterra, J. Jun 15 2005 In : Clinical Cancer Research. 11, 12, p. 4479-4486 8 p.

Research output: Research - peer-reviewArticle

Hepatocyte Growth Factor
Gamma Rays
Glioblastoma
Catalytic RNA
Heterografts
2002

Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons

Xiao, A. Y., Wei, L., Xia, S., Rothman, S. & Yu, S. P. Feb 15 2002 In : Journal of Neuroscience. 22, 4, p. 1350-1362 13 p.

Research output: Research - peer-reviewArticle

Ouabain
Necrosis
Apoptosis
Neurons
Adenosine Triphosphatases

Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation

Xia, S., Lampe, P. A., Deshmukh, M., Yang, A., Brown, B. S., Rothman, S. M., Johnson, E. M. & Yu, S. P. Jan 1 2002 In : Journal of Neuroscience. 22, 1, p. 114-122 9 p.

Research output: Research - peer-reviewArticle

linopirdine
Nerve Growth Factor
Apoptosis
Neuroprotection
Membranes

The estrogen receptor is not essential for all estrogen neuroprotection: New evidence from a new analog

Xia, S., Cai, Z. Y., Thio, L. L., Kim-Han, J. S., Dugan, L. L., Covey, D. F. & Rothman, S. M. 2002 In : Neurobiology of Disease. 9, 3, p. 282-293 12 p.

Research output: Research - peer-reviewArticle

Estrogen Receptors
Estrogens
ZYC 5
Neuroprotection
N-Methylaspartate
1996

Characterization of the insulin and transferrin receptors of two cancer cell lines

Tang, Y. H., Zhang, X., Xia, S. L., Jing, N. H. & Feng, Y. M. 1996 In : Acta Biochimica et Biophysica Sinica. 28, 4, p. 441 1 p.

Research output: Research - peer-reviewArticle

Transferrin Receptors
Insulin Receptor
Cell Line
Neoplasms
Cells