Shiwen Peng

Research Associate

19962020

Research output per year

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Research Output

2020

Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties

Anchoori, R. K., Tan, M., Tseng, S. H., Peng, S., Soong, R. S., Algethami, A., Foran, P., Das, S., Wang, C., Wang, T. L., Liang, H., Hung, C. F. & Roden, R. B. S., Jan 1 2020, In : PloS one. 15, 1, p. e0227727

Research output: Contribution to journalArticle

Open Access
2018

Covalent Rpn13-Binding Inhibitors for the Treatment of Ovarian Cancer

Anchoori, R., Jiang, R., Peng, S., Soong, R. S., Algethami, A., Rudek-Renaut, M., Anders, N., Hung, C-F., Chen, X., Lu, X., Kayode, O., Dyba, M., Walters, K. J. & Roden, R. S., Sep 30 2018, In : ACS Omega. 3, 9, p. 11917-11929 13 p.

Research output: Contribution to journalArticle

Epithelial boost enhances antigen expression by vaccinia virus for the generation of potent CD8+ T cell-mediated antitumor immunity following DNA priming vaccination

Qiu, J., Peng, S., Ma, Y., Yang, A., Farmer, E., Cheng, M. A., Roden, R. S., Wu, T. C., Chang, Y. N. & Hung, C-F., Dec 1 2018, In : Virology. 525, p. 205-215 11 p.

Research output: Contribution to journalArticle

Integration of oncogenes via sleeping beauty as a mouse model of HPV16þ oral tumors and immunologic control

Lin, Y. H., Yang, M. C., Tseng, S. H., Jiang, R., Yang, A., Farmer, E., Peng, S., Henkle, T., Chang, Y. N., Hung, C-F. & Wu, T. C., Mar 1 2018, In : Cancer immunology research. 6, 3, p. 305-319 15 p.

Research output: Contribution to journalArticle

Intramuscular vaccination targeting mucosal tumor draining lymph node enhances integrins-mediated CD8+ T cell infiltration to control mucosal tumor growth

Qiu, J., Peng, S., Yang, A., Ma, Y., Han, L., Cheng, M. A., Farmer, E., Hung, C-F. & Wu, T. C., May 23 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Programmed self-assembly of peptide–major histocompatibility complex for antigen-specific immune modulation

Mao, C. P., Peng, S., Yang, A., He, L., Tsai, Y. C., Hung, C-F. & Wu, T. C., Apr 24 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 17, p. E4032-E4040

Research output: Contribution to journalArticle

Prophylactic immunization with human papillomavirus vaccines induces oral immunity in mice

Ahn, J., Peng, S., Hung, C-F., Roden, R. S. & Best, S. R., Jan 1 2018, In : Laryngoscope. 128, 1, p. E16-E20

Research output: Contribution to journalArticle

2017

Characterization of HPV18 E6-specific T cell responses and establishment of HPV18 E6-expressing tumor model

Ma, Y., Yang, A., Peng, S., Qiu, J., Farmer, E., Hung, C-F. & Wu, T. C., Jul 5 2017, In : Vaccine. 35, 31, p. 3850-3858 9 p.

Research output: Contribution to journalArticle

Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation

Sun, Y., Peng, S., Yang, A., Farmer, E., Wu, T. C. & Hung, C-F., Jul 1 2017, In : Gene Therapy. 24, 7, p. 408-415 8 p.

Research output: Contribution to journalArticle

Enhancing antitumor immunogenicity of HPV16-E7 DNA vaccine by fusing DNA encoding E7-antigenic peptide to DNA encoding capsid protein L1 of Bovine papillomavirus

Yang, A., Peng, S., Farmer, E., Zeng, Q., Cheng, M. A., Pang, X., Wu, T. C. & Hung, C-F., Aug 23 2017, In : Cell and Bioscience. 7, 1, 46.

Research output: Contribution to journalArticle

Immunologic responses to a novel DNA vaccine targeting human papillomavirus-11 E6E7

Ahn, J., Peng, S., Hung, C-F., Roden, R. S., Wu, T. C. & Best, S. R., 2017, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

Spontaneous and vaccine-induced clearance of Mus musculus papillomavirus 1 infection

Jiang, R. T., Wang, J. W., Peng, S., Huang, T. C., Wang, C., Cannella, F., Chang, Y. N., Viscidi, R. P., Best, S. R., Hung, C-F. & Roden, R. S., Aug 1 2017, In : Journal of Virology. 91, 15, e00699-17.

Research output: Contribution to journalArticle

2016

Identification of the murine H-2Db and human HLA-A*0201 MHC class I-restricted HPV6 E7-specific cytotoxic T lymphocyte epitopes

Peng, S., Mattox, A., Best, S. R., Barbu, A. M., Burns, J. A., Akpeng, B., Jeang, J., Yang, B., Ishida, E., Hung, C. F., Wu, T. C. & Pai, S. I., Mar 1 2016, In : Cancer Immunology, Immunotherapy. 65, 3, p. 261-271 11 p.

Research output: Contribution to journalArticle

Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital Tract

Sun, Y. Y., Peng, S., Han, L., Qiu, J., Song, L., Tsai, Y., Yang, B., Roden, R. B. S., Trimble, C. L., Hung, C. F. & Wu, T. C., Feb 1 2016, In : Clinical Cancer Research. 22, 3, p. 657-669 13 p.

Research output: Contribution to journalArticle

Treatment of colon cancer with oncolytic herpes simplex virus in preclinical models

Yang, H., Peng, T., Li, J., Wang, Y., Zhang, W., Zhang, P., Peng, S., Du, T., Li, Y., Yan, Q. & Liu, B., May 1 2016, In : Gene Therapy. 23, 5, p. 450-459 10 p.

Research output: Contribution to journalArticle

2015

Immunologic Control of Mus musculus Papillomavirus Type 1

Wang, J. W., Jiang, R., Peng, S., Chang, Y. N., Hung, C. F. & Roden, R. B. S., Jan 1 2015, In : PLoS pathogens. 11, 10, e1005243.

Research output: Contribution to journalArticle

Intravaginal HPV DNA vaccination with electroporation induces local CD8+ T-cell immune responses and antitumor effects against cervicovaginal tumors

Sun, Y., Peng, S., Qiu, J., Miao, J., Yang, B., Jeang, J., Hung, C. F. & Wu, T. C., Jul 3 2015, In : Gene Therapy. 22, 7, p. 528-535 8 p.

Research output: Contribution to journalArticle

Local administration of granulocyte macrophage colony-stimulating factor induces local accumulation of dendritic cells and antigen-specific CD8+ T cells and enhances dendritic cell cross-presentation

Lee, S. J., Song, L., Yang, M. C., Mao, C. P., Yang, B., Yang, A., Jeang, J., Peng, S., Wu, T. C. & Hung, C. F., Mar 24 2015, In : Vaccine. 33, 13, p. 1549-1555 7 p.

Research output: Contribution to journalArticle

Production of furin-cleaved Papillomavirus pseudovirions and their use for in vitro neutralization assays of L1-or L2-specific antibodies

Wang, J. W., Kwak, K., Peng, S., Kemp, T., Pinto, L. & Roden, R. B. S., Jan 1 2015, In : Current Protocols in Microbiology. 2015, p. 14B.5.1-14B.5.26

Research output: Contribution to journalArticle

Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer

Peng, S., Wang, J. W., Karanam, B., Wang, C., Huh, W. K., Alvarez, R. D., Pai, S. I., Hung, C. F., Wu, T. C. & Roden, R. B. S., Jan 5 2015, In : PloS one. 10, 1, e116389.

Research output: Contribution to journalArticle

2014

Control of HPV-associated tumors by innovative therapeutic HPV DNA vaccine in the absence of CD4+ T cells

Peng, S., Song, L., Knoff, J., Wang, J. W., Chang, Y. N., Hannaman, D., Wu, T. C., Alvarez, R. D., Roden, R. B. S. & Hung, C. F., Mar 4 2014, In : Cell and Bioscience. 4, 1, 11.

Research output: Contribution to journalArticle

Corrigendum to "vaccination with hpv16 l2e6e7 fusion protein in gpi-0100 adjuvant elicits protective humoral and cell-mediated immunity" [vaccine 27 (2009) 1040-1049]

Karanam, B., Gambhira, R., Peng, S., Jagu, S., Kim, D. J., Ketner, G. W., Stern, P. L., Adams, R. J. & Roden, R. B. S., Jan 3 2014, In : Vaccine. 32, 2, 1 p.

Research output: Contribution to journalComment/debate

Enhanced cancer radiotherapy through immunosuppressive stromal cell destruction in tumors

Wu, C. Y., Yang, L. H., Yang, H. Y., Knoff, J., Peng, S., Lin, Y. H., Wang, C., Alvarez, R. D., Pai, S. I., Roden, R. B. S., Hung, C. F. & Wu, T. C., Feb 11 2014, In : Clinical Cancer Research. 20, 3, p. 644-657 14 p.

Research output: Contribution to journalArticle

Mhc-ig induces memory t cell formation in vivo and inhibits tumour growth

Schütz, C., Zoso, A., Peng, S., Bennett, J. D., Schneck, J. P. & Oelke, M., Jan 1 2014, In : Immunity Inflammation and Disease. 2, 3

Research output: Contribution to journalArticle

Open Access

Preparation and properties of a papillomavirus infectious intermediate and its utility for neutralization studies

Wang, J. W., Jagu, S., Kwak, K., Wang, C., Peng, S., Kirnbauer, R. & Roden, R. B. S., Jan 20 2014, In : Virology. 449, p. 304-316 13 p.

Research output: Contribution to journalArticle

2013

A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer

Anchoori, R. K., Karanam, B., Peng, S., Wang, J. W., Jiang, R., Tanno, T., Orlowski, R. Z., Matsui, W., Zhao, M., Rudek, M. A., Hung, C. F., Chen, X., Walters, K. J. & Roden, R. B. S., Dec 9 2013, In : Cancer cell. 24, 6, p. 791-805 15 p.

Research output: Contribution to journalArticle

Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma

Lyford-Pike, S., Peng, S., Young, G. D., Taube, J. M., Westra, W. H., Akpeng, B., Bruno, T. C., Richmon, J. D., Wang, H., Bishop, J. A., Chen, L., Drake, C. G., Topalian, S. L., Pardoll, D. M. & Pai, S. I., Mar 15 2013, In : Cancer Research. 73, 6, p. 1733-1741 9 p.

Research output: Contribution to journalArticle

Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine

Peng, S., Lyford-Pike, S., Akpeng, B., Wu, A., Hung, C. F., Hannaman, D., Saunders, J. R., Wu, T. C. & Pai, S. I., Jan 1 2013, In : Cancer Immunology, Immunotherapy. 62, 1, p. 171-182 12 p.

Research output: Contribution to journalArticle

2012

Development of a DNA vaccine targeting Merkel cell polyomavirus

Zeng, Q., Gomez, B. P., Viscidi, R. P., Peng, S., He, L., Ma, B., Wu, T. C. & Hung, C. F., Feb 8 2012, In : Vaccine. 30, 7, p. 1322-1329 8 p.

Research output: Contribution to journalArticle

2011

Control of cervicovaginal HPV-16 E7-expressing tumors by the combination of therapeutic HPV vaccination and vascular disrupting agents

Zeng, Q., Peng, S., Monie, A., Yang, M., Pang, X., Hung, C-F. & Wu, T. C., Jul 1 2011, In : Human Gene Therapy. 22, 7, p. 809-819 11 p.

Research output: Contribution to journalArticle

Innovative DNA vaccine for human papillomavirus (HPV)-associated head and neck cancer

Wu, A., Zeng, Q., Kang, T. H., Peng, S., Roosinovich, E., Pai, S. I. & Hung, C. F., Mar 1 2011, In : Gene Therapy. 18, 3, p. 304-312 9 p.

Research output: Contribution to journalArticle

In vivo microRNA-155 expression influences antigen-specific T cell-mediated immune responses generated by DNA vaccination

Mao, C. P., He, L., Tsai, Y. C., Peng, S., Kang, T. H., Pang, X., Monie, A., Hung, C. F. & Wu, T. C., Jan 18 2011, In : Cell and Bioscience. 1, 1, 3.

Research output: Contribution to journalArticle

Stressing the ubiquitin-proteasome system without 20s proteolytic inhibition Selectively Kills cervical cancer cells

Anchoori, R. K., Khan, S. R., Sueblinvong, T., Felthauser, A., Iizuka, Y., Gavioli, R., Destro, F., Vogel, R. I., Peng, S., Roden, R. B. S. & Bazzaro, M., Sep 7 2011, In : PloS one. 6, 8, e23888.

Research output: Contribution to journalArticle

Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines

Peng, S., Monie, A., Pang, X., Hung, C. F. & Wu, T. C., Mar 14 2011, In : Journal of biomedical science. 18, 1, 21.

Research output: Contribution to journalArticle

2010

Characterization of human papillomavirus type 11-specific immune responses in a preclinical model

Peng, S., Best, S. R., Hung, C-F., Loyo, M., Lyford-Pike, S., Flint, P. W., Tunkel, D. E., Saunders, J. R., Wu, T. C. & Pai, S. I., Mar 2010, In : Laryngoscope. 120, 3, p. 504-510 7 p.

Research output: Contribution to journalArticle

Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis

Lyford-Pike, S., Westra, W. H., Loyo, M., Peng, S., Hung, C-F., Wu, A. A., Flint, P. W., Tunkel, D. E., Saunders, J. R. & Pai, S. I., Nov 2010, In : Histopathology. 57, 5, p. 768-770 3 p.

Research output: Contribution to journalArticle

Efficient delivery of DNA vaccines using human papillomavirus pseudovirions

Peng, S., Monie, A., Kang, T. H., Hung, C. F., Roden, R. & Wu, T. C., Dec 1 2010, In : Gene Therapy. 17, 12, p. 1453-1464 12 p.

Research output: Contribution to journalArticle

Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3

Trimble, C. L., Peng, S., Thoburn, C., Kos, F. & Wu, T. C., May 1 2010, In : Cancer Immunology, Immunotherapy. 59, 5, p. 799-803 5 p.

Research output: Contribution to journalArticle

Papillomavirus infection requires γ secretase

Karanam, B., Peng, S., Li, T., Buck, C., Day, P. M. & Roden, R. B. S., Oct 1 2010, In : Journal of virology. 84, 20, p. 10661-10670 10 p.

Research output: Contribution to journalArticle

2009

Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery

Best, S. R., Peng, S., Juang, C. M., Hung, C. F., Hannaman, D., Saunders, J. R., Wu, T. C. & Pai, S. I., Sep 4 2009, In : Vaccine. 27, 40, p. 5450-5459 10 p.

Research output: Contribution to journalArticle

A phase I trial of a human papillomavirus DNA vaccine for HPV16+Cervical intraepithelial neoplasia 2/3

Trimble, C. L., Peng, S., Kos, F., Gravitt, P., Viscidi, R., Sugar, E., Pardoll, D. & Wu, T. C., Jan 1 2009, In : Clinical Cancer Research. 15, 1, p. 361-367 7 p.

Research output: Contribution to journalArticle

Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment

Lin, Z., Bazzaro, M., Wang, M. C., Chan, K. C., Peng, S. & Roden, R. B. S., Jan 15 2009, In : Clinical Cancer Research. 15, 2, p. 570-577 8 p.

Research output: Contribution to journalArticle

Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunity

Karanam, B., Gambhira, R., Peng, S., Jagu, S., Kim, D. J., Ketner, G. W., Stern, P. L., Adams, R. J. & Roden, R. B. S., Feb 11 2009, In : Vaccine. 27, 7, p. 1040-1049 10 p.

Research output: Contribution to journalArticle

2008

Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects

Peng, S., Trimble, C., Alvarez, R. D., Huh, W. K., Lin, Z., Monie, A., Hung, C. F. & Wu, T. C., Aug 13 2008, In : Gene Therapy. 15, 16, p. 1156-1166 11 p.

Research output: Contribution to journalArticle

RNA interference-mediated in vivo silencing of Fas ligand as a strategy for the enhancement of DNA vaccine potency

Huang, B., Mao, C. P., Peng, S., Hung, C. F. & Wu, T. C., Aug 1 2008, In : Human gene therapy. 19, 8, p. 763-773 11 p.

Research output: Contribution to journalArticle