Shenghan Lai

Professor

1987 …2019
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Research Output 1987 2019

2019
Cocaine
HIV Infections
HIV
Reverse Transcriptase Inhibitors
Therapeutics

Cocaine use modifies the association of antiretroviral therapy regimens with obesity in HIV-infected adults

Li, J., Lai, H., Chen, S. & Lai, S., Dec 1 2019, In : Obesity Medicine. 16, 100133.

Research output: Contribution to journalArticle

Cocaine
Obesity
HIV
HIV Infections
Therapeutics

Dietary preferences and diabetic risk in China: A large-scale nationwide Internet data-based study

Zhao, Z., Li, M., Li, C., Wang, T., Xu, Y., Zhan, Z., Dong, W., Shen, Z., Xu, M., Lu, J., Chen, Y., Lai, S., Fan, W., Bi, Y., Wang, W. & Ning, G., Jan 1 2019, (Accepted/In press) In : Journal of Diabetes.

Research output: Contribution to journalArticle

Food Preferences
Internet
China
Hypertension
Body Mass Index

Ideal Cardiovascular Health Metrics and Major Cardiovascular Events in Patients with Prediabetes and Diabetes

Wang, T., Lu, J., Su, Q., Chen, Y., Bi, Y., Mu, Y., Chen, L., Hu, R., Tang, X., Yu, X., Li, M., Xu, M., Xu, Y., Zhao, Z., Yan, L., Qin, G., Wan, Q., Chen, G., Dai, M., Zhang, D. & 22 others, Gao, Z., Wang, G., Shen, F., Luo, Z., Qin, Y., Chen, L., Huo, Y., Li, Q., Ye, Z., Zhang, Y., Liu, C., Wang, Y., Wu, S., Yang, T., Deng, H., Li, D., Lai, S., Bloomgarden, Z. T., Shi, L., Ning, G., Zhao, J. & Wang, W., Sep 2019, In : JAMA cardiology. 4, 9, p. 874-883 10 p.

Research output: Contribution to journalArticle

Prediabetic State
Health
Cardiovascular Diseases
Glucose
China
Open Access
Insurance Coverage
Nutrition Surveys
Health Insurance
Cardiovascular Diseases
Economics

Predictive value of fasting glucose, postload glucose, and hemoglobin A1c on risk of diabetes and complications in Chinese adults

4C Study Group, Aug 1 2019, In : Diabetes care. 42, 8, p. 1539-1548 10 p.

Research output: Contribution to journalArticle

Diabetes Complications
Fasting
Hemoglobins
Glucose
Cardiovascular Diseases
2018
Troponin T
HIV
Coronary Angiography
Chronic Renal Insufficiency
HIV Infections
Telomere Shortening
Cocaine
HIV Infections
HIV
Telomere

Impact of cocaine use on protease inhibitor-associated dyslipidemia in HIV-infected adults

Li, J., Lai, H. C., Chen, S. & Lai, S., Jul 1 2018, In : International Journal of STD and AIDS. 29, 8, p. 781-789 9 p.

Research output: Contribution to journalArticle

Dyslipidemias
Protease Inhibitors
Cocaine
HIV
HDL Cholesterol

MRI gadolinium dosing on basis of blood volume

Liu, C. Y., Lai, S. & Lima, J., Jan 1 2018, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Gadolinium
Blood Volume
Contrast Media
Weights and Measures
Atherosclerosis

Regional coronary endothelial dysfunction is related to the degree of local epicardial fat in people with HIV

Iantorno, M., Soleimanifard, S., Schar, M., Brown, T. T., Bonanno, G., Barditch-Crovo, P., Mathews, L., Lai, S., Gerstenblith, G., Weiss, R. G. & Hays, A., Nov 1 2018, In : Atherosclerosis. 278, p. 7-14 8 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Fats
HIV
Adipose Tissue
Exercise
Cross-Over Studies
Xanthine Oxidase
Coronary Artery Disease
Coronary Vessels
Placebos
2017
Nutrition Surveys
Stroke
Serum
Population
Odds Ratio

Association of Elevated NT-proBNP With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis (MESA)

Liu, C. Y., Heckbert, S. R., Lai, S., Ambale Venkatesh, B., Ostovaneh, M. R., McClelland, R. L., Lima, J. & Bluemke, D. A., Dec 26 2017, In : Journal of the American College of Cardiology. 70, 25, p. 3102-3109 8 p.

Research output: Contribution to journalArticle

Natriuretic Peptides
Atherosclerosis
Fibrosis
Magnetic Resonance Spectroscopy
Gadolinium

Cocaine use may modify HIV/ART-associated myocardial steatosis and hepatic steatosis

Lai, S., Gerstenblith, G., Moore, R. D., Celentano, D. D., Bluemke, D. A., Treisman, G. J., Liu, C. Y., Li, J., Chen, S., Kickler, T. S. & Lai, H. C., Aug 1 2017, In : Drug and Alcohol Dependence. 177, p. 84-92 9 p.

Research output: Contribution to journalArticle

Cocaine
HIV
Liver
Protease Inhibitors
Triglycerides

Coronary artery endothelial dysfunction is present in HIV positive individuals without significant coronary artery disease

Iantorno, M., Schar, M., Soleimanifard, S., Brown, T. T., Moore, R. D., Barditch-crovo, P., Stuber, M., Lai, S., Gerstenblith, G., Weiss, R. G. & Hays, A., Mar 28 2017, (Accepted/In press) In : AIDS.

Research output: Contribution to journalArticle

Coronary Artery Disease
Coronary Vessels
HIV
Interleukin-6
Inflammation
Coronary Stenosis
Cocaine
African Americans
Motivation
Baltimore
Nutrition Surveys
Body Composition
Linear Models
Body Mass Index
Fats

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

Liu, R., Hong, J., Xu, X., Feng, Q., Zhang, D., Gu, Y., Shi, J., Zhao, S., Liu, W., Wang, X., Xia, H., Liu, Z., Cui, B., Liang, P., Xi, L., Jin, J., Ying, X., Wang, X., Zhao, X., Li, W. & 28 others, Jia, H., Lan, Z., Li, F., Wang, R., Sun, Y., Yang, M., Shen, Y., Jie, Z., Li, J., Chen, X., Zhong, H., Xie, H., Zhang, Y., Gu, W., Deng, X., Shen, B., Xu, X., Yang, H., Xu, G., Bi, Y., Lai, S., Wang, J., Qi, L., Madsen, L., Wang, J., Ning, G., Kristiansen, K. & Wang, W., Jul 1 2017, In : Nature Medicine. 23, 7, p. 859-868 10 p.

Research output: Contribution to journalArticle

Metabolome
Weight Loss
Glutamic Acid
Obesity
Serum

Healthy aging of the left ventricle in relationship to cardiovascular risk factors: The Multi-Ethnic Study of Atherosclerosis (MESA)

Liu, C. Y., Lai, S., Kawel-Boehm, N., Chahal, H., Ambale Venkatesh, B., Lima, J. & Bluemke, D. A., Jun 1 2017, In : PLoS One. 12, 6, e0179947.

Research output: Contribution to journalArticle

atherosclerosis
Heart Ventricles
Atherosclerosis
risk factors
Aging of materials

Metabolic syndrome among adults in China: The 2010 China Noncommunicable Disease Surveillance

Lu, J., Wang, L., Li, M., Xu, Y., Jiang, Y., Wang, W., Li, J., Mi, S., Zhang, M., Li, Y., Wang, T., Xu, M., Zhao, Z., Dai, M., Lai, S., Zhao, W., Wang, L., Bi, Y. & Ning, G., Feb 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 2, p. 507-515 9 p.

Research output: Contribution to journalArticle

China
Blood pressure
HDL Cholesterol
Coronary Disease
Blood Glucose

Rare loss-of-function variants in npc1 predispose to human obesity

Liu, R., Zou, Y., Hong, J., Cao, M., Cui, B., Zhang, H., Chen, M., Shi, J., Ning, T., Zhao, S., Liu, W., Xiong, H., Wei, C., Qiu, Z., Gu, W., Zhang, Y., Li, W., Miao, L., Sun, Y., Yang, M. & 17 others, Wang, R., Ma, Q., Xu, M., Xu, Y., Wang, T., Katie Chan, K. H., Zuo, X., Chen, H., Qi, L., Lai, S., Duan, S., Song, B., Bi, Y., Liu, S., Wang, W., Ning, G. & Wang, J., Apr 1 2017, In : Diabetes. 66, 4, p. 935-947 13 p.

Research output: Contribution to journalArticle

Adiposity
Type C Niemann-Pick Disease
Obesity
Mutation
Fats
2016

Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus

Sun, W., Shi, L., Ye, Z., Mu, Y., Liu, C., Zhao, J., Chen, L., Li, Q., Yang, T., Yan, L., Wan, Q., Wu, S., Liu, Y., Wang, G., Luo, Z., Tang, X., Chen, G., Huo, Y., Gao, Z., Su, Q. & 20 others, Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Sun, J., Ding, L., Xu, Y., Xu, M., Dai, M., Wang, T., Zhang, D., Lu, J., Bi, Y., Lai, S., Li, D., Wang, W. & Ning, G., Mar 1 2016, In : Obesity. 24, 3, p. 703-709 7 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Body Mass Index
Confidence Intervals
Odds Ratio
Weight Loss

Association of insulin resistance with breast, ovarian, endometrial and cervical cancers in non-diabetic women

Sun, W., Lu, J., Wu, S., Bi, Y., Mu, Y., Zhao, J., Liu, C., Chen, L., Shi, L., Li, Q., Yang, T., Yan, L., Wan, Q., Liu, Y., Wang, G., Luo, Z., Tang, X., Chen, G., Huo, Y., Gao, Z. & 21 others, Su, Q., Ye, Z., Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Wang, T., Sun, J., Xu, M., Xu, Y., Chen, Y., Dai, M., Zhang, J., Zhang, D., Lai, S., Li, D., Ning, G. & Wang, W., 2016, In : American Journal of Cancer Research. 6, 10, p. 2334-2344 11 p.

Research output: Contribution to journalArticle

Endometrial Neoplasms
Uterine Cervical Neoplasms
Ovarian Neoplasms
Insulin Resistance
Breast Neoplasms

Associations of smoking and alcohol consumption with impaired β-cell function in Chinese men

Xu, M., Zhou, Y., Xu, B., Sun, J., Wang, T., Lu, J., Lai, S., Bi, Y., Wang, W. & Ning, G., May 1 2016, In : Journal of Diabetes. 8, 3, p. 434-441 8 p.

Research output: Contribution to journalArticle

Alcohol Drinking
Smoking
Cross-Sectional Studies
Odds Ratio
Confidence Intervals

Chronic Kidney Disease and Diabetes-A Potential Causal Link

Lai, S., 2016, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Medical problems

Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study

Wang, T., Xu, Y., Xu, M., Ning, G., Lu, J., Dai, M., Xu, B., Sun, J., Sun, W., Lai, S., Bi, Y. & Wang, W., Aug 15 2016, In : American Journal of Epidemiology. 184, 4, p. 295-301 7 p.

Research output: Contribution to journalArticle

Prolactin
Type 2 Diabetes Mellitus
Prospective Studies
Glucose
Social Adjustment

Cocaine Use May be Associated with Increased Depression in Persons Infected with HIV

Hammond, E. R., Lai, S., Wright, C. M. & Treisman, G. J., Feb 1 2016, In : AIDS and Behavior. 20, 2, p. 345-352 8 p.

Research output: Contribution to journalArticle

Cocaine
HIV
Odds Ratio
Baltimore
African Americans

Diabetes genetic risk score modifies effect of bisphenol a exposure on deterioration in glucose metabolism

Bi, Y., Wang, W., Xu, M., Wang, T., Lu, J., Xu, Y., Dai, M., Chen, Y., Zhang, D., Sun, W., Ding, L., Chen, Y., Huang, X., Lin, L., Qi, L., Lai, S. & Ning, G., Jan 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 1, p. 143-150 8 p.

Research output: Contribution to journalArticle

Medical problems
Metabolism
Deterioration
Type 2 Diabetes Mellitus
Glucose

Diabetes-related metabolic risk factors in internal migrant workers in China: A national surveillance study

Bi, Y., Wang, L., Xu, Y., Jiang, Y., He, J., Zhang, M., Zhou, M., Li, Y., Xu, M., Lu, J., Wang, T., Ding, L., Dai, M., Zhang, D., Chen, C. S., Lai, S., Wang, W., Wang, L. & Ning, G., Feb 1 2016, In : The Lancet Diabetes and Endocrinology. 4, 2, p. 125-135 11 p.

Research output: Contribution to journalArticle

China
Abdominal Obesity
Population
Dyslipidemias
Obesity

Glycemic status and chronic kidney disease in Chinese adults: Findings from the REACTION study

Lin, L., Lu, J., Chen, L., Mu, Y., Ye, Z., Liu, C., Chen, G., Shi, L., Zhao, J., Li, Q., Yang, T., Yan, L., Wan, Q., Wu, S., Liu, Y., Wang, G., Luo, Z., Tang, X., Huo, Y., Gao, Z. & 21 others, Su, Q., Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Xu, Y., Xu, M., Peng, K., Du, R., Dai, M., Li, M., Wang, T., Zhao, Z., Lai, S., Li, D., Bi, Y., Wang, W. & Ning, G., 2016, (Accepted/In press) In : Journal of Diabetes.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Prediabetic State
Odds Ratio
Confidence Intervals
Glucose
Nutrition Surveys
Gonadal Steroid Hormones
Type 2 Diabetes Mellitus
Insulin Resistance
Testosterone

Measures of outcome for stimulant trials: ACTTION recommendations and research agenda

Kiluk, B. D., Carroll, K. M., Duhig, A., Falk, D. E., Kampman, K., Lai, S., Litten, R. Z., McCann, D. J., Montoya, I. D., Preston, K. L., Skolnick, P., Weisner, C., Woody, G., Chandler, R., Detke, M. J., Dunn, K., Dworkin, R. H., Fertig, J., Gewandter, J., Moeller, F. G. & 4 others, Ramey, T., Ryan, M., Silverman, K. & Strain, E. C., Jan 1 2016, In : Drug and Alcohol Dependence. 158, p. 1-7 7 p.

Research output: Contribution to journalArticle

Drug therapy
Analgesics
Anesthetics
Innovation
Alcohols

Obesity Is Associated With Progression of Atherosclerosis During Statin Treatment

Sandfort, V., Lai, S., Ahlman, M. A., Mallek, M., Liu, S., Sibley, C. T., Turkbey, E. B., Lima, J. & Bluemke, D. A., Jul 13 2016, In : Journal of the American Heart Association. 5, 7

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Atherosclerosis
Obesity
Odds Ratio
Atherosclerotic Plaques

Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults

for the 2010 China Noncommunicable Disease Surveillance Group, May 1 2016, In : Journal of Diabetes. 8, 3, p. 378-386 9 p.

Research output: Contribution to journalArticle

Hemoglobins
Fasting
Glucose
Glucose Tolerance Test
Waist Circumference

Prevalence of Diabetes and Cardiometabolic Disorders in Spouses of Diabetic Individuals

Sun, J., Lu, J., Wang, W., Mu, Y., Zhao, J., Liu, C., Chen, L., Shi, L., Li, Q., Yang, T., Yan, L., Wan, Q., Wu, S., Liu, Y., Wang, G., Luo, Z., Tang, X., Chen, G., Huo, Y., Gao, Z. & 17 others, Su, Q., Ye, Z., Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Bi, Y., Xu, M., Xu, Y., Dai, M., Wang, T., Zhang, D., Lai, S. & Ning, G., Sep 1 2016, In : American Journal of Epidemiology. 184, 5, p. 400-409 10 p.

Research output: Contribution to journalArticle

Spouses
Odds Ratio
Confidence Intervals
Life Style
Glucose Tolerance Test
Cardiovascular Diseases
Kidney
Glomerular Filtration Rate
Coronary Disease
Chronic Renal Insufficiency
2015

Association of bisphenol a exposure with hypertension and early macrovascular diseases in Chinese adults: A cross-sectional study

Wang, T., Xu, M., Xu, Y., Lu, J., Li, M., Chen, Y., Wang, W., Lai, S., Bi, Y. & Ning, G., 2015, In : Medicine (United States). 94, 43, e1814.

Research output: Contribution to journalArticle

Cross-Sectional Studies
Odds Ratio
Hypertension
Carotid Intima-Media Thickness
Vascular Stiffness

Associations of depression with impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in Chinese adults

Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal (REACTION) Study group, 2015, In : Diabetic Medicine. 32, 7, p. 935-943 9 p.

Research output: Contribution to journalArticle

Glucose
Odds Ratio
Medicine
Confidence Intervals
Insulin

Awareness, treatment and control of cardiometabolic disorders in Chinese adults with diabetes: A national representative population study

Wang, T., Xu, Y., Xu, M., Wang, W., Bi, Y., Lu, J., Dai, M., Zhang, D., Ding, L., Xu, B., Sun, J., Zhao, W., Jiang, Y., Wang, L., Li, Y., Zhang, M., Lai, S., Wang, L. & Ning, G., Feb 26 2015, In : Cardiovascular Diabetology. 14, 1, 28.

Research output: Contribution to journalArticle

Dyslipidemias
Hypertension
Population
Therapeutics
Blood Pressure

Chronic cocaine use and its association with myocardial steatosis evaluated by 1H magnetic resonance spectroscopy in African Americans

Lai, S., Gerstenblith, G., Li, J., Zhu, H., Bluemke, D. A., Liu, C. Y., Zimmerman, S., Chen, S., Lai, H. C. & Treisman, G. J., Jan 1 2015, In : Journal of Addiction Medicine. 9, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Cocaine
African Americans
Magnetic Resonance Spectroscopy
Triglycerides
Obesity
Cocaine
African Americans
Endothelin-1
Coronary Stenosis
Baltimore

Coronary plaque burden at coronary ct angiography in asymptomatic men and women1

Rodriguez, K., Kwan, A. C., Lai, S., Lima, J., Vigneault, D., Sandfort, V., Pattanayak, P., Ahlman, M. A., Mallek, M., Sibley, C. T. & Bluemke, D. A., Oct 1 2015, In : Radiology. 277, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Coronary Angiography
LDL Cholesterol
Blood Pressure
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Coronary Vessels

Sleep duration and snoring associate with hypertension and glycaemic control in patients with diabetes

Wang, T., Lu, J., Wang, W., Mu, Y., Zhao, J., Liu, C., Chen, L., Shi, L., Li, Q., Yang, T., Yan, L., Wan, Q., Wu, S., Liu, Y., Wang, G., Luo, Z., Tang, X., Chen, G., Huo, Y., Gao, Z. & 17 others, Su, Q., Ye, Z., Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Xu, M., Sun, J., Bi, Y., Lai, S., Bloomgarden, Z. T., Li, D., Ning, G. & the REACTION Study Group, REACTION. S. G., 2015, In : Diabetic Medicine. 32, 8, p. 1001-1007 7 p.

Research output: Contribution to journalArticle

Snoring
Sleep
Hypertension
Blood Pressure
Antihypertensive Agents

Status of cardiovascular health in Chinese adults

Bi, Y., Jiang, Y., He, J., Xu, Y., Wang, L., Xu, M., Zhang, M., Li, Y., Wang, T., Dai, M., Lu, J., Li, M., Chen, C. S., Lai, S., Wang, W., Wang, L. & Ning, G., Mar 17 2015, In : Journal of the American College of Cardiology. 65, 10, p. 1013-1025 13 p.

Research output: Contribution to journalArticle

Health Status
Health
Smoking
American Heart Association
Ideal Body Weight
2014

Cohort profile: Risk evaluation of cancers in Chinese diabetic individuals: A longitudinal (REACTION) study

Bi, Y., Lu, J., Wang, W., Mu, Y., Zhao, J., Liu, C., Chen, L., Shi, L., Li, Q., Wan, Q., Wu, S., Yang, T., Yan, L., Liu, Y., Wang, G., Luo, Z., Tang, X., Chen, G., Huo, Y., Gao, Z. & 19 others, Su, Q., Ye, Z., Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Zhang, J., Sun, J., Dai, M., Xu, M., Xu, Y., Chen, Y., Lai, S., Bloomgarden, Z. T., Li, D. & Ning, G., Mar 2014, In : Journal of Diabetes. 6, 2, p. 147-157 11 p.

Research output: Contribution to journalArticle

Longitudinal Studies
Neoplasms
Glucose
Life Style
China
Glipizide
Metformin
Type 2 Diabetes Mellitus
Coronary Artery Disease

Interscan reproducibility of quantitative coronary plaque volume and composition from CT coronary angiography using an automated method

Schuhbaeck, A., Dey, D., Otaki, Y., Slomka, P., Kral, B. G., Achenbach, S., Berman, D. S., Fishman, E. K., Lai, S. & Lai, H. C., 2014, In : European Radiology. 24, 9, p. 2300-2308 9 p.

Research output: Contribution to journalArticle

Cone-Beam Computed Tomography
Coronary Angiography
Software
Atherosclerotic Plaques
Disease Progression

Lipid profiling reveals different therapeutic effects of metformin and glipizide in patients with type 2 diabetes and coronary artery disease

Zhang, Y., Hu, C., Hong, J., Zeng, J., Lai, S., Lv, A., Su, Q., Dong, Y., Zhou, Z., Tang, W., Zhao, J., Cui, L., Zou, D., Wang, D., Li, H., Liu, C., Wu, G., Shen, J., Zhu, D., Wang, W. & 3 others, Shen, W., Ning, G. & Xu, G., Oct 1 2014, In : Diabetes Care. 37, 10, p. 2804-2812 9 p.

Research output: Contribution to journalArticle

Glipizide
Metformin
Therapeutic Uses
Type 2 Diabetes Mellitus
Coronary Artery Disease