Shawn Lupold

Associate Professor

19952019
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Research Output 1995 2019

2019
Translational Medical Research
Biomarkers
Prostatic Neoplasms
Telomere
Tissue

Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer

Fletcher, C. E., Sulpice, E., Combe, S., Shibakawa, A., Leach, D. A., Hamilton, M. P., Chrysostomou, S. L., Sharp, A., Welti, J., Yuan, W., Dart, D. A., Knight, E., Ning, J., Francis, J. C., Kounatidou, E. E., Gaughan, L., Swain, A., Lupold, S., de Bono, J. S., McGuire, S. E. & 2 others, Gidrol, X. & Bevan, C. L., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Open Access
Androgen Receptors
MicroRNAs
Prostatic Neoplasms
Therapeutics
Luciferases

PDCD4 is an androgen-repressed tumor suppressor that regulates prostate cancer growth and castration resistance

Zennami, K., Choi, S. M., Liao, R., Li, Y., Dinalankara, W., Marchionni, L., Rafiqi, F. H., Kurozumi, A., Hatano, K. & Lupold, S., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 618-627 10 p.

Research output: Contribution to journalArticle

Castration
Androgens
Prostatic Neoplasms
Androgen Receptors
Growth
2018

Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer

Kumar, B., Rosenberg, A., Choi, S. M., Fox-Talbot, K., Demarzo, A. M., Nonn, L., Brennen, W., Marchionni, L., Halushka, M. K. & Lupold, S., Dec 1 2018, In : Scientific Reports. 8, 1, 7189.

Research output: Contribution to journalArticle

MicroRNAs
Prostate
Prostatic Neoplasms
Tumor Microenvironment
Epithelium

Low-level endogenous PSMA expression in nonprostatic tumor xenografts is sufficient for in vivo tumor targeting and imaging

Nimmagadda, S., Pullambhatla, M., Chen, Y., Parsana, P., Lisok, A., Chatterjee, S., Mease, R., Rowe, S., Lupold, S., Pienta, K. & Pomper, M. G., Mar 1 2018, In : Journal of Nuclear Medicine. 59, 3, p. 486-493 8 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
Small Cell Lung Carcinoma
Melanoma
Optical Imaging

The orally active pterocarpanquinone LQB-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress

Martino, T., Kudrolli, T. A., Kumar, B., Salviano, I., Mencalha, A., Coelho, M. G. P., Justo, G., Costa, P. R. R., Sabino, K. C. C. & Lupold, S., Feb 1 2018, In : Prostate. 78, 2, p. 140-151 12 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Prostatic Neoplasms
Reactive Oxygen Species
Neoplasms
MicroRNAs
2017

Differential long-term stability of microRNAs and RNU6B snRNA in 12-20 year old archived formalin-fixed paraffin-embedded specimens

Peskoe, S. B., Barber, J. R., Zheng, Q., Meeker, A. K., Demarzo, A. M., Platz, E. A. & Lupold, S., Jan 6 2017, In : BMC Cancer. 17, 1, 32.

Research output: Contribution to journalArticle

Small Nuclear RNA
MicroRNAs
Paraffin
Formaldehyde
RNA
2016

Characterization of a novel metastatic prostate cancer cell line of LNCaP origin

Castanares, M. A., Copeland, B. T., Chowdhury, W. H., Liu, M. M., Rodriguez, R., Pomper, M. G., Lupold, S. & Foss, C., Feb 1 2016, In : Prostate. 76, 2, p. 215-225 11 p.

Research output: Contribution to journalArticle

Nude Mice
Prostatic Neoplasms
Androgens
Cell Line
Androgen Receptors

Development and application of a novel model system to study "active" and "passive" tumor targeting

Mukherjee, A., Kumar, B., Hatano, K., Russell, L. M., Trock, B., Searson, P. C., Meeker, A. K., Pomper, M. G. & Lupold, S., Oct 1 2016, In : Molecular Cancer Therapeutics. 15, 10, p. 2541-2550 10 p.

Research output: Contribution to journalArticle

Neoplasms
Half-Life
human glutamate carboxypeptidase II
Antibodies
Heterografts

Identification of miR-30b-3p and miR-30d-5p as direct regulators of Androgen Receptor signaling in Prostate Cancer by complementary functional microRNA library screening

Kumar, B., Khaleghzadegan, S., Mears, B., Hatano, K., Kudrolli, T. A., Chowdhury, W. H., Yeater, D. B., Ewing, C. M., Luo, J., Isaacs, W. B., Marchionni, L. & Lupold, S., 2016, In : Oncotarget. 7, 45, p. 72593-72607 15 p.

Research output: Contribution to journalArticle

Androgen Receptors
MicroRNAs
Prostatic Neoplasms
Castration
3' Untranslated Regions

MicroRNA expression and function in prostate cancer: A review of current knowledge and opportunities for discovery

Kumar, B. & Lupold, S., Jul 1 2016, In : Asian Journal of Andrology. 18, 4, p. 559-567 9 p.

Research output: Contribution to journalReview article

MicroRNAs
Prostatic Neoplasms
Gene Expression
Untranslated RNA
Neoplasm Genes
2015

A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation

Hatano, K., Kumar, B., Zhang, Y., Coulter, J. B., Hedayati, M., Mears, B., Ni, X., Kudrolli, T. A., Chowdhury, W. H., Rodriguez, R., DeWeese, T. & Lupold, S., Mar 17 2015, In : Nucleic Acids Research. 43, 8, p. 4075-4086 12 p.

Research output: Contribution to journalArticle

Ionizing Radiation
MicroRNAs
DNA Repair
Prostatic Neoplasms
DNA Damage

Real-time, near-infrared fluorescence imaging with an optimized dye/light source/camera combination for surgical guidance of prostate cancer

Neuman, B. P., Eifler, J. B., Castanares, M., Chowdhury, W. H., Chen, Y., Mease, R., Ma, R., Mukherjee, A., Lupold, S., Pomper, M. G. & Rodriguez, R., Feb 15 2015, In : Clinical Cancer Research. 21, 4, p. 771-780 10 p.

Research output: Contribution to journalArticle

Optical Imaging
Prostatic Neoplasms
Coloring Agents
Light
Heterografts

Systemic administration and targeted radiosensitization via chemically synthetic aptamer-siRNA chimeras in human tumor xenografts

Ni, X., Zhang, Y., Zennami, K., Castanares, M., Mukherjee, A., Raval, R. R., Zhou, H., DeWeese, T. & Lupold, S., Dec 1 2015, In : Molecular Cancer Therapeutics. 14, 12, p. 2797-2804 8 p.

Research output: Contribution to journalArticle

Heterografts
Small Interfering RNA
Membranes
Neoplasm Antigens
Neoplasms
2014

A novel approach for detecting viable and tissue-specific circulating tumor cells through an adenovirus-based reporter vector

Wu, P., Sokoll, L. J., Kudrolli, T. A., Chowdhury, W. H., Ma, R., Liu, M. M., Rodriguez, R. & Lupold, S., 2014, In : Prostate. 74, 13, p. 1286-1296 11 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Adenoviridae
Prostate
Prostatic Neoplasms
Viral Tropism

Correlation of Sprouty1 and Jagged1 with aggressive prostate cancer cells with different sensitivities to androgen deprivation

Terada, N., Shiraishi, T., Zeng, Y., Aw-Yong, K. M., Mooney, S. M., Liu, Z., Takahashi, S., Luo, J., Lupold, S., Kulkarni, P. & Getzenberg, R. H., 2014, In : Journal of Cellular Biochemistry. 115, 9, p. 1505-1515 11 p.

Research output: Contribution to journalArticle

Androgens
Prostatic Neoplasms
Cells
Clone Cells
Tumors

Development and screening of a series of antibody-conjugated and silica-coated iron oxide nanoparticles for targeting the prostate-specific membrane antigen

Mukherjee, A., Darlington, T., Baldwin, R., Holz, C., Olson, S., Kulkarni, P., DeWeese, T., Getzenberg, R. H., Ivkov, R. & Lupold, S., 2014, In : ChemMedChem. 9, 7, p. 1356-1360 5 p.

Research output: Contribution to journalArticle

Silicon Dioxide
Nanoparticles
Screening
Antibodies
Prostatic Neoplasms

Evaluation of prostate-specific membrane antigen as an imaging reporter

Castanares, M. A., Mukherjee, A., Chowdhury, W. H., Liu, M., Chen, Y., Mease, R., Wang, Y., Rodriguez, R., Lupold, S. & Pomper, M. G., May 1 2014, In : Journal of Nuclear Medicine. 55, 5, p. 805-811 7 p.

Research output: Contribution to journalArticle

Adenoviridae
Suspensions
Thymidine Kinase
Optical Imaging
Simplexvirus

Investigation of miR-21, miR-141, and miR-221 expression levels in prostate adenocarcinoma for associated risk of recurrence after radical prostatectomy

Zheng, Q., Peskoe, S. B., Ribas, J., Rafiqi, F., Kudrolli, T., Meeker, A. K., Demarzo, A. M., Platz, E. A. & Lupold, S., Dec 1 2014, In : Prostate. 74, 16, p. 1655-1662 8 p.

Research output: Contribution to journalArticle

Prostatectomy
MicroRNAs
Prostate
Adenocarcinoma
Recurrence

Monitoring nanoparticle-mediated cellular hyperthermia with a high-sensitivity biosensor

Mukherjee, A., Castanares, M., Hedayati, M., Wabler, M., Trock, B., Kulkarni, P., Rodriguez, R., Getzenberg, R. H., DeWeese, T., Ivkov, R. & Lupold, S., Dec 1 2014, In : Nanomedicine. 9, 18, p. 2729-2743 15 p.

Research output: Contribution to journalArticle

reporter
Biosensing Techniques
heat pump
Biosensors
Nanoparticles
2013

Bicalutamide-activated oncolytic adenovirus for the adjuvant therapy of high-risk prostate cancer

Johnson, T. J., Höti, N., Liu, C., Chowdhury, W. H., Li, Y., Zhang, Y., Lupold, S., DeWeese, T. & Rodriguez, R., Jul 2013, In : Cancer Gene Therapy. 20, 7, p. 394-402 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Adenoviridae
Prostatic Neoplasms
Androgens
Point Mutation

The role of miR-21, an androgen-regulated MicroRNA, in prostate cancer

Ribas, J. & Lupold, S., Oct 1 2013, Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications. Springer New York, Vol. 9781461461821. p. 285-305 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

MicroRNAs
Androgens
Prostatic Neoplasms
Gene Expression
Small Untranslated RNA
2012

A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts

Ribas, J., Ni, X., Castanares, M., Liu, M. M., Esopi, D., Yegnasubramanian, S., Rodriguez, R., Mendell, J. T. & Lupold, S., Aug 2012, In : Nucleic Acids Research. 40, 14, p. 6821-6833 13 p.

Research output: Contribution to journalArticle

Polyadenylation
Vacuoles
Membrane Proteins
Genes
MicroRNAs

A real time Metridia luciferase based non-invasive reporter assay of mammalian cell viability and cytotoxicity via the β-actin promoter and enhancer

Lupold, S., Johnson, T., Chowdhury, W. H. & Rodriguez, R., May 9 2012, In : PLoS One. 7, 5, e36535.

Research output: Contribution to journalArticle

Metridia
luciferase
Cytotoxicity
Luciferases
cell viability

Mechanism of growth inhibition of prostate cancer xenografts by valproic acid

Sidana, A., Wang, M., Shabbeer, S., Chowdhury, W. H., Netto, G., Lupold, S., Carducci, M. A. & Rodriguez, R., 2012, In : Journal of Biomedicine and Biotechnology. 2012, 180363.

Research output: Contribution to journalArticle

Valproic Acid
Heterografts
Prostatic Neoplasms
Growth
Tumors
2011

Does valproic acid induce neuroendocrine differentiation in prostate cancer?

Rodriguez, R., Sidana, A., Wang, M., Chowdhury, W. H., Toubaji, A., Shabbeer, S., Netto, G., Carducci, M. A. & Lupold, S., 2011, In : Journal of Biomedicine and Biotechnology. 2011, 607480.

Research output: Contribution to journalArticle

Valproic Acid
Prostatic Neoplasms
Chromogranin A
Neural Cell Adhesion Molecules
Synaptophysin

Nucleic acid aptamers: Clinical applications and promising new horizons

Ni, X., Castanares, M., Mukherjee, A. & Lupold, S., Sep 2011, In : Current Medicinal Chemistry. 18, 27, p. 4206-4214 9 p.

Research output: Contribution to journalArticle

Nucleic Acids
Molecules
Macular Degeneration
Clinical Trials
Nanotechnology

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

Ni, X., Zhang, Y., Ribas, J., Chowdhury, W. H., Castanares, M., Zhang, Z., Laiho, M., DeWeese, T. & Lupold, S., Jun 1 2011, In : Journal of Clinical Investigation. 121, 6, p. 2383-2390 8 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Ionizing Radiation
Heterografts
Small Interfering RNA
Prostate
Antigens
Radioisotopes
Membranes
Imaging techniques
human glutamate carboxypeptidase II
2010

Adenovirus targeting to prostate-specific membrane antigen through virus-displayed, semirandom peptide library screening

Wu, P., Kudrolli, T. A., Chowdhury, W. H., Liu, M. M., Rodriguez, R. & Lupold, S., Dec 1 2010, In : Cancer Research. 70, 23, p. 9549-9553 5 p.

Research output: Contribution to journalArticle

Peptide Library
Adenoviridae
Viruses
Peptides
Virus Diseases

Armoring CRAds with p21/Waf-1 shRNAs: The next generation of oncolytic adenoviruses

Höti, N., Chowdhury, W. H., Mustafa, S., Ribas, J., Castanares, M., Johnson, T., Liu, M., Lupold, S. & Rodriguez, R., Aug 2010, In : Cancer Gene Therapy. 17, 8, p. 585-597 13 p.

Research output: Contribution to journalArticle

Adenoviridae
RNA Interference
Small Interfering RNA
Prostatic Neoplasms
Neoplasms

Evaluation of continuous low dose rate versus acute single high dose rate radiation combined with oncolytic viral therapy for prostate cancer

Liu, C., Zhang, Y., Liu, M. M., Zhou, H., Chowdhury, W., Lupold, S., DeWeese, T. & Rodriguez, R., Mar 2010, In : International Journal of Radiation Biology. 86, 3, p. 220-229 10 p.

Research output: Contribution to journalArticle

Adenoviridae
Prostatic Neoplasms
Radiation
Therapeutics
Prostate

The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer

Ribas, J. & Lupold, S., Mar 1 2010, In : Cell cycle (Georgetown, Tex.). 9, 5, p. 923-929 7 p.

Research output: Contribution to journalArticle

Androgen Receptors
MicroRNAs
Prostatic Neoplasms
Androgens
Nucleic Acid Regulatory Sequences
2009

miR-21: An androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth

Ribas, J., Ni, X., Haffner, M., Wentzel, E. A., Salmasi, A. H., Chowdhury, W. H., Kudrolli, T. A., Yegnasubramanian, S., Luo, J., Rodriguez, R., Mendell, J. T. & Lupold, S., 2009, In : Cancer Research. 69, 18, p. 7165-7169 5 p.

Research output: Contribution to journalArticle

Androgen Receptors
MicroRNAs
Androgens
Prostatic Neoplasms
Hormones

Recent Development of Diagnostic and Therapeutic Agents Targeting Glutamate Carboxypeptidase II (GCPII)

Byun, Y., Mease, R., Lupold, S. & Pomper, M. G., Nov 4 2009, Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications. John Wiley & Sons, Inc., p. 881-910 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glutamate Carboxypeptidase II
Therapeutics
2008

Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer

Chen, Y., Foss, C., Byun, Y., Nimmagadda, S., Pullambhatla, M., Fox, J. J., Castanares, M., Lupold, S., Babich, J. W., Mease, R. & Pomper, M. G., Dec 25 2008, In : Journal of Medicinal Chemistry. 51, 24, p. 7933-7943 11 p.

Research output: Contribution to journalArticle

Urea
Prostatic Neoplasms
Acids
Single-Photon Emission-Computed Tomography
Positron-Emission Tomography

Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA)

Ray, S., Foss, C., Castanares, M., Mease, R., Byun, Y., Fox, J. J., Hilton, J., Lupold, S., Kozikowski, A. P. & Pomper, M. G., Aug 14 2008, In : Journal of Medicinal Chemistry. 51, 15, p. 4504-4517 14 p.

Research output: Contribution to journalArticle

Rhenium
Technetium
Chelating Agents
Tumors
Tissue
2007

Androgen receptor attenuation of Ad5 replication: Implications for the development of conditionally replication competent adenoviruses

Höti, N., Li, Y., Chen, C. L., Chowdhury, W. H., Johns, D. C., Xia, Q., Kabul, A., Hsieh, J. T., Berg, M., Ketner, G. W., Lupold, S. & Rodriguez, R., Aug 2007, In : Molecular Therapy. 15, 8, p. 1495-1503 9 p.

Research output: Contribution to journalArticle

Androgen Receptors
Adenoviridae
Prostate
Viral Genes
Genetic Therapy

A novel method for generating and screening peptides and libraries displayed on adenovirus fiber

Lupold, S., Kudrolli, T. A., Chowdhury, W. H., Wu, P. & Rodriguez, R., Nov 2007, In : Nucleic Acids Research. 35, 20, e138.

Research output: Contribution to journalArticle

Peptide Library
Adenoviridae
Viral Genome
Genes
Capsid
2006

Valproic Acid, a Histone Deacetylase Inhibitor, Is an Antagonist for Oncolytic Adenoviral Gene Therapy

Höti, N., Chowdhury, W., Hsieh, J. T., Sachs, M. D., Lupold, S. & Rodriguez, R., Dec 2006, In : Molecular Therapy. 14, 6, p. 768-778 11 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Valproic Acid
Genetic Therapy
Coxsackie and Adenovirus Receptor-Like Membrane Protein
Neoplasms

Valproic acid inhibits invasiveness in bladder cancer but not in prostate cancer cells

Chen, C. L., Sung, J., Cohen, M., Chowdhury, W. H., Sachs, M. D., Li, Y., Lakshmanan, Y., Yung, B. Y. M., Lupold, S. & Rodriguez, R., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 319, 2, p. 533-542 10 p.

Research output: Contribution to journalArticle

Valproic Acid
Urinary Bladder Neoplasms
Prostatic Neoplasms
Histone Deacetylase Inhibitors
Cell Line
2004

Disulfide-constrained peptides that bind to the extracellular portion of the prostate-specific membrane antigen

Lupold, S. & Rodriguez, R., May 2004, In : Molecular Cancer Therapeutics. 3, 5, p. 597-603 7 p.

Research output: Contribution to journalArticle

Disulfides
Peptides
Prostatic Neoplasms
Bacteriophages
Carboxypeptidases

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

Hussain, S. P., Amstad, P., He, P., Robles, A., Lupold, S., Kaneko, I., Ichimiya, M., Sengupta, S., Mechanic, L., Okamura, S., Hofseth, L. J., Moake, M., Nagashima, M., Forrester, K. S. & Harris, C. C., Apr 1 2004, In : Cancer Research. 64, 7, p. 2350-2356 7 p.

Research output: Contribution to journalArticle

Catalase
Superoxide Dismutase
Oxidative Stress
Up-Regulation
Apoptosis
2002

Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen

Lupold, S., Hicke, B. J., Lin, Y. & Coffey, D. S., Jul 15 2002, In : Cancer Research. 62, 14, p. 4029-4033 5 p.

Research output: Contribution to journalArticle

Ribonucleases
Prostatic Neoplasms
Nucleotide Aptamers
antineoplaston A10
Acids
1996

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53

Forrester, K., Ambs, S., Lupold, S., Kapust, R. B., Spillare, E. A., Weinberg, W. C., Felley-Bosco, E., Wang, X. W., Geller, D. A., Tzeng, E., Billiar, T. R. & Harris, C. C., Mar 19 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 6, p. 2442-2447 6 p.

Research output: Contribution to journalArticle

Nitric Oxide Synthase Type II
DNA Damage
Nitric Oxide
Mutagens
Nitric Oxide Donors

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

Wang, X. W., Vermeulen, W., Coursen, J. D., Gibson, M., Lupold, S., Forrester, K., Xu, G., Elmore, L., Yeh, H., Hoeijmakers, J. H. J. & Harris, C. C., May 15 1996, In : Genes & development. 10, 10, p. 1219-1232 14 p.

Research output: Contribution to journalArticle

DNA Helicases
Apoptosis
Fibroblasts
Microinjections
Genes
1995

Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent

Forrester, K., Lupold, S., Ott, V. L., Chay, C. H., Band, V., Wang, X. W. & Harris, C. C., 1995, In : Oncogene. 10, 11, p. 2103-2111 9 p.

Research output: Contribution to journalArticle

Transcriptional Activation
Cell Line
Tumor Cell Line
Carcinoma
Mesothelioma