Shawn Lupold

Associate Professor

19952019

Research output per year

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Research Output

2019

Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer

Fletcher, C. E., Sulpice, E., Combe, S., Shibakawa, A., Leach, D. A., Hamilton, M. P., Chrysostomou, S. L., Sharp, A., Welti, J., Yuan, W., Dart, D. A., Knight, E., Ning, J., Francis, J. C., Kounatidou, E. E., Gaughan, L., Swain, A., Lupold, S. E., de Bono, J. S., McGuire, S. E. & 2 others, Gidrol, X. & Bevan, C. L., Jul 11 2019, In : Oncogene. 38, 28, p. 5700-5724 25 p.

Research output: Contribution to journalArticle

Open Access

Cellular Delivery of Bioorthogonal Pretargeting Therapeutics in PSMA-Positive Prostate Cancer

Hapuarachchige, S., Huang, C. T., Donnelly, M. C., Bařinka, C., Lupold, S. E., Pomper, M. G. & Artemov, D., Jan 1 2019, (Accepted/In press) In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

PDCD4 is an androgen-repressed tumor suppressor that regulates prostate cancer growth and castration resistance

Zennami, K., Choi, S. M., Liao, R., Li, Y., Dinalankara, W., Marchionni, L., Rafiqi, F. H., Kurozumi, A., Hatano, K. & Lupold, S. E., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 618-627 10 p.

Research output: Contribution to journalArticle

2018

Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer

Kumar, B., Rosenberg, A., Choi, S. M., Fox-Talbot, K., Demarzo, A. M., Nonn, L., Brennen, W., Marchionni, L., Halushka, M. K. & Lupold, S., Dec 1 2018, In : Scientific Reports. 8, 1, 7189.

Research output: Contribution to journalArticle

Low-level endogenous PSMA expression in nonprostatic tumor xenografts is sufficient for in vivo tumor targeting and imaging

Nimmagadda, S., Pullambhatla, M., Chen, Y., Parsana, P., Lisok, A., Chatterjee, S., Mease, R., Rowe, S., Lupold, S., Pienta, K. & Pomper, M. G., Mar 1 2018, In : Journal of Nuclear Medicine. 59, 3, p. 486-493 8 p.

Research output: Contribution to journalArticle

The orally active pterocarpanquinone LQB-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress

Martino, T., Kudrolli, T. A., Kumar, B., Salviano, I., Mencalha, A., Coelho, M. G. P., Justo, G., Costa, P. R. R., Sabino, K. C. C. & Lupold, S., Feb 1 2018, In : Prostate. 78, 2, p. 140-151 12 p.

Research output: Contribution to journalArticle

2017

Differential long-term stability of microRNAs and RNU6B snRNA in 12-20 year old archived formalin-fixed paraffin-embedded specimens

Peskoe, S. B., Barber, J. R., Zheng, Q., Meeker, A. K., De Marzo, A. M., Platz, E. A. & Lupold, S. E., Jan 6 2017, In : BMC cancer. 17, 1, 32.

Research output: Contribution to journalArticle

2016

Characterization of a novel metastatic prostate cancer cell line of LNCaP origin

Castanares, M. A., Copeland, B. T., Chowdhury, W. H., Liu, M. M., Rodriguez, R., Pomper, M. G., Lupold, S. E. & Foss, C. A., Feb 1 2016, In : Prostate. 76, 2, p. 215-225 11 p.

Research output: Contribution to journalArticle

Development and application of a novel model system to study "active" and "passive" tumor targeting

Mukherjee, A., Kumar, B., Hatano, K., Russell, L. M., Trock, B. J., Searson, P. C., Meeker, A. K., Pomper, M. G. & Lupold, S. E., Oct 2016, In : Molecular cancer therapeutics. 15, 10, p. 2541-2550 10 p.

Research output: Contribution to journalArticle

Identification of miR-30b-3p and miR-30d-5p as direct regulators of Androgen Receptor signaling in Prostate Cancer by complementary functional microRNA library screening

Kumar, B., Khaleghzadegan, S., Mears, B., Hatano, K., Kudrolli, T. A., Chowdhury, W. H., Yeater, D. B., Ewing, C. M., Luo, J., Isaacs, W. B., Marchionni, L. & Lupold, S. E., Jan 1 2016, In : Oncotarget. 7, 45, p. 72593-72607 15 p.

Research output: Contribution to journalArticle

MicroRNA expression and function in prostate cancer: A review of current knowledge and opportunities for discovery

Kumar, B. & Lupold, S., Jul 1 2016, In : Asian Journal of Andrology. 18, 4, p. 559-567 9 p.

Research output: Contribution to journalReview article

2015

A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation

Hatano, K., Kumar, B., Zhang, Y., Coulter, J. B., Hedayati, M., Mears, B., Ni, X., Kudrolli, T. A., Chowdhury, W. H., Rodriguez, R., DeWeese, T. L. & Lupold, S. E., Mar 17 2015, In : Nucleic acids research. 43, 8, p. 4075-4086 12 p.

Research output: Contribution to journalArticle

Real-time, near-infrared fluorescence imaging with an optimized dye/light source/camera combination for surgical guidance of prostate cancer

Neuman, B. P., Eifler, J. B., Castanares, M., Chowdhury, W. H., Chen, Y., Mease, R. C., Ma, R., Mukherjee, A., Lupold, S. E., Pomper, M. G. & Rodriguez, R., Feb 15 2015, In : Clinical Cancer Research. 21, 4, p. 771-780 10 p.

Research output: Contribution to journalArticle

Systemic administration and targeted radiosensitization via chemically synthetic aptamer-siRNA chimeras in human tumor xenografts

Ni, X., Zhang, Y., Zennami, K., Castanares, M., Mukherjee, A., Raval, R. R., Zhou, H., Deweese, T. L. & Lupold, S. E., Dec 1 2015, In : Molecular cancer therapeutics. 14, 12, p. 2797-2804 8 p.

Research output: Contribution to journalArticle

2014

A novel approach for detecting viable and tissue-specific circulating tumor cells through an adenovirus-based reporter vector

Wu, P., Sokoll, L. J., Kudrolli, T. A., Chowdhury, W. H., Ma, R., Liu, M. M., Rodriguez, R. & Lupold, S. E., Sep 2014, In : Prostate. 74, 13, p. 1286-1296 11 p.

Research output: Contribution to journalArticle

Correlation of Sprouty1 and Jagged1 with aggressive prostate cancer cells with different sensitivities to androgen deprivation

Terada, N., Shiraishi, T., Zeng, Y., Aw-Yong, K. M., Mooney, S. M., Liu, Z., Takahashi, S., Luo, J., Lupold, S. E., Kulkarni, P. & Getzenberg, R. H., Sep 2014, In : Journal of cellular biochemistry. 115, 9, p. 1505-1515 11 p.

Research output: Contribution to journalArticle

Development and screening of a series of antibody-conjugated and silica-coated iron oxide nanoparticles for targeting the prostate-specific membrane antigen

Mukherjee, A., Darlington, T., Baldwin, R., Holz, C., Olson, S., Kulkarni, P., Deweese, T. L., Getzenberg, R. H., Ivkov, R. & Lupold, S. E., Jul 2014, In : ChemMedChem. 9, 7, p. 1356-1360 5 p.

Research output: Contribution to journalArticle

Evaluation of prostate-specific membrane antigen as an imaging reporter

Castanares, M. A., Mukherjee, A., Chowdhury, W. H., Liu, M., Chen, Y., Mease, R. C., Wang, Y., Rodriguez, R., Lupold, S. E. & Pomper, M. G., May 1 2014, In : Journal of Nuclear Medicine. 55, 5, p. 805-811 7 p.

Research output: Contribution to journalArticle

Investigation of miR-21, miR-141, and miR-221 expression levels in prostate adenocarcinoma for associated risk of recurrence after radical prostatectomy

Zheng, Q., Peskoe, S. B., Ribas, J., Rafiqi, F., Kudrolli, T., Meeker, A. K., De Marzo, A. M., Platz, E. A. & Lupold, S. E., Dec 1 2014, In : Prostate. 74, 16, p. 1655-1662 8 p.

Research output: Contribution to journalArticle

Monitoring nanoparticle-mediated cellular hyperthermia with a high-sensitivity biosensor

Mukherjee, A., Castanares, M., Hedayati, M., Wabler, M., Trock, B., Kulkarni, P., Rodriguez, R., Getzenberg, R. H., Deweese, T. L., Ivkov, R. & Lupold, S. E., Dec 1 2014, In : Nanomedicine. 9, 18, p. 2729-2743 15 p.

Research output: Contribution to journalArticle

2013

Bicalutamide-activated oncolytic adenovirus for the adjuvant therapy of high-risk prostate cancer

Johnson, T. J., Höti, N., Liu, C., Chowdhury, W. H., Li, Y., Zhang, Y., Lupold, S. E., Deweese, T. & Rodriguez, R., Jul 1 2013, In : Cancer Gene Therapy. 20, 7, p. 394-402 9 p.

Research output: Contribution to journalArticle

The role of miR-21, an androgen-regulated MicroRNA, in prostate cancer

Ribas, J. & Lupold, S. E., Oct 1 2013, Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications. Springer New York, Vol. 9781461461821. p. 285-305 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts

Ribas, J., Ni, X., Castanares, M., Liu, M. M., Esopi, D., Yegnasubramanian, S., Rodriguez, R., Mendell, J. T. & Lupold, S. E., Aug 1 2012, In : Nucleic acids research. 40, 14, p. 6821-6833 13 p.

Research output: Contribution to journalArticle

A real time Metridia luciferase based non-invasive reporter assay of mammalian cell viability and cytotoxicity via the β-actin promoter and enhancer

Lupold, S. E., Johnson, T., Chowdhury, W. H. & Rodriguez, R., May 9 2012, In : PloS one. 7, 5, e36535.

Research output: Contribution to journalArticle

Mechanism of growth inhibition of prostate cancer xenografts by valproic acid

Sidana, A., Wang, M., Shabbeer, S., Chowdhury, W. H., Netto, G., Lupold, S. E., Carducci, M. & Rodriguez, R., Dec 1 2012, In : Journal of Biomedicine and Biotechnology. 2012, 180363.

Research output: Contribution to journalArticle

2011

Does valproic acid induce neuroendocrine differentiation in prostate cancer?

Rodriguez, R., Sidana, A., Wang, M., Chowdhury, W. H., Toubaji, A., Shabbeer, S., Netto, G., Carducci, M. & Lupold, S. E., Jan 5 2011, In : Journal of Biomedicine and Biotechnology. 2011, 607480.

Research output: Contribution to journalArticle

Nucleic acid aptamers: Clinical applications and promising new horizons

Ni, X., Castanares, M., Mukherjee, A. & Lupold, S. E., Sep 1 2011, In : Current medicinal chemistry. 18, 27, p. 4206-4214 9 p.

Research output: Contribution to journalReview article

Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

Ni, X., Zhang, Y., Ribas, J., Chowdhury, W. H., Castanares, M., Zhang, Z., Laiho, M., DeWeese, T. L. & Lupold, S. E., Jun 1 2011, In : Journal of Clinical Investigation. 121, 6, p. 2383-2390 8 p.

Research output: Contribution to journalArticle

2010

Adenovirus targeting to prostate-specific membrane antigen through virus-displayed, semirandom peptide library screening

Wu, P., Kudrolli, T. A., Chowdhury, W. H., Liu, M. M., Rodriguez, R. & Lupold, S. E., Dec 1 2010, In : Cancer Research. 70, 23, p. 9549-9553 5 p.

Research output: Contribution to journalArticle

Armoring CRAds with p21/Waf-1 shRNAs: The next generation of oncolytic adenoviruses

Höti, N., Chowdhury, W. H., Mustafa, S., Ribas, J., Castanares, M., Johnson, T., Liu, M., Lupold, S. E. & Rodriguez, R., Aug 1 2010, In : Cancer Gene Therapy. 17, 8, p. 585-597 13 p.

Research output: Contribution to journalArticle

Evaluation of continuous low dose rate versus acute single high dose rate radiation combined with oncolytic viral therapy for prostate cancer

Liu, C., Zhang, Y., Liu, M. M., Zhou, H., Chowdhury, W., Lupold, S. E., Deweese, T. L. & Rodriguez, R., Mar 1 2010, In : International journal of radiation biology. 86, 3, p. 220-229 10 p.

Research output: Contribution to journalArticle

The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer

Ribas, J. & Lupold, S. E., Mar 1 2010, In : Cell Cycle. 9, 5, p. 923-929 7 p.

Research output: Contribution to journalReview article

Open Access
2009

miR-21: An androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth

Ribas, J., Ni, X., Haffner, M., Wentzel, E. A., Salmasi, A. H., Chowdhury, W. H., Kudrolli, T. A., Yegnasubramanian, S., Luo, J., Rodriguez, R., Mendell, J. T. & Lupold, S. E., Oct 13 2009, In : Cancer Research. 69, 18, p. 7165-7169 5 p.

Research output: Contribution to journalArticle

Recent Development of Diagnostic and Therapeutic Agents Targeting Glutamate Carboxypeptidase II (GCPII)

Byun, Y., Mease, R. C., Lupold, S. E. & Pomper, M. G., Nov 4 2009, Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications. John Wiley & Sons, Inc., p. 881-910 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2008

Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer

Chen, Y., Foss, C. A., Byun, Y., Nimmagadda, S., Pullambhatla, M., Fox, J. J., Castanares, M., Lupold, S. E., Babich, J. W., Mease, R. C. & Pomper, M. G., Dec 25 2008, In : Journal of medicinal chemistry. 51, 24, p. 7933-7943 11 p.

Research output: Contribution to journalArticle

Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA)

Banerjee, S. R., Foss, C. A., Castanares, M., Mease, R. C., Byun, Y., Fox, J. J., Hilton, J., Lupold, S. E., Kozikowski, A. P. & Pomper, M. G., Aug 14 2008, In : Journal of medicinal chemistry. 51, 15, p. 4504-4517 14 p.

Research output: Contribution to journalArticle

2007

Androgen receptor attenuation of Ad5 replication: Implications for the development of conditionally replication competent adenoviruses

Höti, N., Li, Y., Chen, C. L., Chowdhury, W. H., Johns, D. C., Xia, Q., Kabul, A., Hsieh, J. T., Berg, M., Ketner, G., Lupold, S. E. & Rodriguez, R., Aug 1 2007, In : Molecular Therapy. 15, 8, p. 1495-1503 9 p.

Research output: Contribution to journalArticle

A novel method for generating and screening peptides and libraries displayed on adenovirus fiber

Lupold, S. E., Kudrolli, T. A., Chowdhury, W. H., Wu, P. & Rodriguez, R., Nov 1 2007, In : Nucleic acids research. 35, 20, e138.

Research output: Contribution to journalArticle

2006

Valproic Acid, a Histone Deacetylase Inhibitor, Is an Antagonist for Oncolytic Adenoviral Gene Therapy

Höti, N., Chowdhury, W., Hsieh, J. T., Sachs, M. D., Lupold, S. E. & Rodriguez, R., Dec 1 2006, In : Molecular Therapy. 14, 6, p. 768-778 11 p.

Research output: Contribution to journalArticle

Valproic acid inhibits invasiveness in bladder cancer but not in prostate cancer cells

Chen, C. L., Sung, J., Cohen, M., Chowdhury, W. H., Sachs, M. D., Li, Y., Lakshmanan, Y., Yung, B. Y. M., Lupold, S. E. & Rodriguez, R., Nov 24 2006, In : Journal of Pharmacology and Experimental Therapeutics. 319, 2, p. 533-542 10 p.

Research output: Contribution to journalArticle

2004

Disulfide-constrained peptides that bind to the extracellular portion of the prostate-specific membrane antigen

Lupold, S. E. & Rodriguez, R., May 1 2004, In : Molecular cancer therapeutics. 3, 5, p. 597-603 7 p.

Research output: Contribution to journalArticle

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

Hussain, S. P., Amstad, P., He, P., Robles, A., Lupold, S., Kaneko, I., Ichimiya, M., Sengupta, S., Mechanic, L., Okamura, S., Hofseth, L. J., Moake, M., Nagashima, M., Forrester, K. S. & Harris, C. C., Apr 1 2004, In : Cancer Research. 64, 7, p. 2350-2356 7 p.

Research output: Contribution to journalArticle

2002

Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen

Lupold, S. E., Hicke, B. J., Lin, Y. & Coffey, D. S., Jul 15 2002, In : Cancer Research. 62, 14, p. 4029-4033 5 p.

Research output: Contribution to journalArticle

1996

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53

Forrester, K., Ambs, S., Lupold, S. E., Kapust, R. B., Spillare, E. A., Weinberg, W. C., Felley-Bosco, E., Wang, X. W., Geller, D. A., Tzeng, E., Billiar, T. R. & Harris, C. C., Mar 19 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 6, p. 2442-2447 6 p.

Research output: Contribution to journalArticle

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

Wang, X. W., Vermeulen, W., Coursen, J. D., Gibson, M., Lupold, S. E., Forrester, K., Xu, G., Elmore, L., Yeh, H., Hoeijmakers, J. H. J. & Harris, C. C., May 15 1996, In : Genes and Development. 10, 10, p. 1219-1232 14 p.

Research output: Contribution to journalArticle

Open Access
1995

Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent

Forrester, K., Lupold, S. E., Ott, V. L., Chay, C. H., Band, V., Wang, X. W. & Harris, C. C., Jan 1 1995, In : Oncogene. 10, 11, p. 2103-2111 9 p.

Research output: Contribution to journalArticle