Sharad Verma

Assistant Professor

19972018
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Research Output 1997 2018

2018

Clinical trial design for cutaneous neurofibromas

Cannon, A., Jarnagin, K., Korf, B., Widemann, B. C., Casey, D., Ko, H. S., Blakeley, J., Verma, S. & Pichard, D. C., Jul 10 2018, In : Neurology. 91, 2, p. S31-S37

Research output: Contribution to journalArticle

Open Access
Neurofibroma
Clinical Trials
Skin
Skin Diseases
Critical Pathways

Considerations for development of therapies for cutaneous neurofibroma

Verma, S., Riccardi, V. M., Plotkin, S. R., Weinberg, H., Anderson, R. R., Blakeley, J., Jarnagin, K. & Lee, J., Jul 10 2018, In : Neurology. 91, 2, p. S21-S30

Research output: Contribution to journalArticle

Open Access
Neurofibroma
Skin
Therapeutics
Pharmaceutical Preparations
Safety

Creating a comprehensive research strategy for cutaneous neurofibromas

Blakeley, J., Wolkenstein, P., Widemann, B. C., Lee, J., Le, L. Q., Jackson, R., Stathis, M. & Verma, S., Jul 10 2018, In : Neurology. 91, 2

Research output: Contribution to journalArticle

Open Access
Neurofibroma
Skin
Research
Neurofibromatoses
Therapeutics

Cutaneous neurofibromas: Current clinical and pathologic issues

Ortonne, N., Wolkenstein, P., Blakeley, J., Korf, B., Plotkin, S. R., Riccardi, V. M., Miller, D. C., Huson, S., Peltonen, J., Rosenberg, A., Carroll, S. L., Verma, S., Mautner, V., Upadhyaya, M. & Stemmer-Rachamimov, A., Jul 10 2018, In : Neurology. 91, 2, p. S5-S13

Research output: Contribution to journalArticle

Open Access
Neurofibroma
Skin
Neurofibromatosis 1
Nerve Tissue
Neoplasms

Data Descriptor: Pharmacological and genomic profiling of neurofibromatosis type 1 plexiform neurofibroma-derived schwann cells

Ferrer, M., Gosline, S. J. C., Stathis, M., Zhang, X., Guo, X., Guha, R., Ryman, D. A., Wallace, M. R., Kasch-Semenza, L., Hao, H., Ingersoll, R., Mohr, D., Thomas, C., Verma, S., Guinney, J. & Blakeley, J., Jun 12 2018, In : Scientific data. 5, 180106.

Research output: Contribution to journalArticle

deformity
Profiling
proliferation
Descriptors
Genomics

The biology of cutaneous neurofibromas: Consensus recommendations for setting research priorities

Brosseau, J. P., Pichard, D. C., Legius, E. H., Wolkenstein, P., Lavker, R. M., Blakeley, J., Riccardi, V. M., Verma, S., Brownell, I. & Le, L. Q., Jul 10 2018, In : Neurology. 91, 2, p. S14-S20

Research output: Contribution to journalArticle

Open Access
Neurofibroma
Skin
Research
Regenerative Medicine
Gonadal Steroid Hormones
2015

Inhibition of the histone lysine methyltransferase EZH2 for the treatment of cancer

Verma, S., 2015, In : Current Topics in Medicinal Chemistry. 15, 8, p. 714-719 6 p.

Research output: Contribution to journalArticle

Histone-Lysine N-Methyltransferase
Epigenomics
Neoplasms
Pharmaceutical Preparations
Enhancer of Zeste Homolog 2 Protein

Recent progress in the discovery of epigenetic inhibitors for the treatment of cancer

Verma, S., 2015, In : Methods in Molecular Biology. 1238, p. 677-688 12 p.

Research output: Contribution to journalArticle

Epigenomics
Neoplasms
Antineoplastic Agents
Enzymes
Research
2014

A687V EZH2 is a driver of histone H3 Lysine 27 (H3K27) hypertrimethylation

Ott, H. M., Graves, A. P., Pappalardi, M. B., Huddleston, M., Halsey, W. S., Hughes, A. M., Groy, A., Dul, E., Jiang, Y., Bai, Y., Annan, R., Verma, S., Knight, S. D., Kruger, R. G., Dhanak, D., Schwartz, B., Tummino, P. J., Creasy, C. L. & McCabe, M. T., Dec 1 2014, In : Molecular Cancer Therapeutics. 13, 12, p. 3062-3073 12 p.

Research output: Contribution to journalArticle

Histones
Lysine
Mutation
Cell Line
Catalytic Domain

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

MacK, S. C., Witt, H., Piro, R. M., Gu, L., Zuyderduyn, S., Stütz, A. M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jäger, N., Jones, D. T. W., Sill, M., Pugh, T. J., Ryzhova, M., Wani, K. M., Shih, D. J. H., Head, R. & 69 others, Remke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M. G., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, L., Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., Von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A. & Taylor, M. D., 2014, In : Nature. 506, 7489, p. 445-450 6 p.

Research output: Contribution to journalArticle

Ependymoma
Rhombencephalon
Epigenomics
CpG Islands
Methylation

Long residence time inhibition of EZH2 in activated polycomb repressive complex 2

Van Aller, G. S., Pappalardi, M. B., Ott, H. M., Diaz, E., Brandt, M., Schwartz, B. J., Miller, W. H., Dhanak, D., McCabe, M. T., Verma, S., Creasy, C. L., Tummino, P. J. & Kruger, R. G., Mar 21 2014, In : ACS Chemical Biology. 9, 3, p. 622-629 8 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
Histones
Chemical activation
Histone Code
Methylation

Recent progress in the discovery of epigenetic inhibitors for the treatment of cancer

Verma, S., Nov 24 2014, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis. Springer New York, p. 677-688 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenomics
Neoplasms
DNA sequences
Transcription
Antineoplastic Agents
2013

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

Béguelin, W., Popovic, R., Teater, M., Jiang, Y., Bunting, K. L., Rosen, M., Shen, H., Yang, S. N., Wang, L., Ezponda, T., Martinez-Garcia, E., Zhang, H., Zheng, Y., Verma, S., McCabe, M. T., Ott, H. M., VanAller, G. S., Kruger, R. G., Liu, Y., McHugh, C. F. & 13 others, Scott, D. W., Chung, Y. R., Kelleher, N., Shaknovich, R., Creasy, C. L., Gascoyne, R. D., Wong, K. K., Cerchietti, L., Levine, R. L., Abdel-Wahab, O., Licht, J. D., Elemento, O. & Melnick, A. M., May 13 2013, In : Cancer Cell. 23, 5, p. 677-692 16 p.

Research output: Contribution to journalArticle

Germinal Center
B-Lymphocytes
Mutation
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma

Recent progress in the discovery of small-molecule inhibitors of the HMT EZH2 for the treatment of cancer

Verma, S. & Knight, S. D., Sep 2013, In : Future Medicinal Chemistry. 5, 14, p. 1661-1670 10 p.

Research output: Contribution to journalReview article

Histone-Lysine N-Methyltransferase
Carcinogenesis
Histones
Lysine
Neoplasms
2012

Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens

Diaz, E., MacHutta, C. A., Chen, S., Jiang, Y., Nixon, C., Hofmann, G., Key, D., Sweitzer, S., Patel, M., Wu, Z., Creasy, C. L., Kruger, R. G., Lafrance, L., Verma, S., Pappalardi, M. B., Le, B., Van Aller, G. S., McCabe, M. T., Tummino, P. J., Pope, A. J. & 3 others, Thrall, S. H., Schwartz, B. & Bandt, M., Dec 2012, In : Journal of Biomolecular Screening. 17, 10, p. 1279-1292 14 p.

Research output: Contribution to journalArticle

Methylation
Nucleosomes
Assays
Throughput
Histones

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

McCabe, M. T., Ott, H. M., Ganji, G., Korenchuk, S., Thompson, C., Van Aller, G. S., Liu, Y., Pietra, A. D., LaFrance, L. V., Mellinger, M., Duquenne, C., Tian, X., Kruger, R. G., McHugh, C. F., Miller, W. H., Dhanak, D., Verma, S., Tummino, P. J., Creasy, C. L., Graves, A. P. & 1 others, Diaz, E., Dec 6 2012, In : Nature. 492, 7427, p. 108-112 5 p.

Research output: Contribution to journalLetter

Lymphoma, Large B-Cell, Diffuse
Lymphoma
Polycomb Repressive Complex 2
Mutation
Follicular Lymphoma

Identification of potent, selective, cell-Active inhibitors of the histone lysine methyltransferase EZH2

Verma, S., Tian, X., Lafrance, L. V., Duquenne, C., Suarez, D. P., Newlander, K. A., Romeril, S. P., Burgess, J. L., Grant, S. W., Brackley, J. A., Graves, A. P., Scherzer, D. A., Shu, A., Thompson, C., Ott, H. M., Van Aller, G. S., MacHutta, C. A., Diaz, E., Jiang, Y., Johnson, N. W. & 7 others, Knight, S. D., Kruger, R. G., McCabe, M. T., Dhanak, D., Tummino, P. J., Creasy, C. L. & Miller, W. H., Dec 13 2012, In : ACS Medicinal Chemistry Letters. 3, 12, p. 1091-1096 6 p.

Research output: Contribution to journalArticle

Histone-Lysine N-Methyltransferase
Methyltransferases
Drug Discovery
Gene expression
Histones
2010

2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles

Lin, H., Yamashita, D. S., Zeng, J., Xie, R., Verma, S., Luengo, J. I., Rhodes, N., Zhang, S., Robell, K. A., Choudhry, A. E., Lai, Z., Kumar, R., Minthorn, E. A., Brown, K. K. & Heerding, D. A., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 679-683 5 p.

Research output: Contribution to journalArticle

Indazoles
Pyridines
Phosphorylation
Hinges
Heterografts

Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines

Lin, H., Yamashita, D. S., Xie, R., Zeng, J., Wang, W., Leber, J., Safonov, I. G., Verma, S., Li, M., LaFrance, L., Venslavsky, J., Takata, D., Luengo, J. I., Kahana, J. A., Zhang, S., Robell, K. A., Levy, D., Kumar, R., Choudhry, A. E., Schaber, M. & 6 others, Lai, Z., Brown, B. S., Donovan, B. T., Minthorn, E. A., Brown, K. K. & Heerding, D. A., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 684-688 5 p.

Research output: Contribution to journalArticle

Aminopyridines
Pyridines
Tumors
Bearings (structural)
Phosphorylation
2009

A facile method for the synthesis of substituted pyrazolo[3,4-c]pyridines

Verma, S. & LaFrance, L. V., Jan 28 2009, In : Tetrahedron Letters. 50, 4, p. 383-385 3 p.

Research output: Contribution to journalArticle

Pyridines
Cyclization
5-bromo-2-fluoropyridine
2008

Molecule of the month

Verma, S., Jul 2008, In : Current Topics in Medicinal Chemistry. 8, 11, p. 1003-1004 2 p.

Research output: Contribution to journalReview article

Molecules
2007

Chapter 23 Small Molecule Inhibitors of AKT/PKB Kinase as a Strategy for Treating Cancer

Heerding, D. A., Safonov, I. G. & Verma, S., 2007, Annual Reports in Medicinal Chemistry. Vol. 42. p. 365-376 12 p. (Annual Reports in Medicinal Chemistry; vol. 42).

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphotransferases
Molecules
2005

Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors

Verma, S., Nagarathnam, D., Shao, J., Zhang, L., Zhao, J., Wang, Y., Li, T., Mull, E., Enyedy, I., Wang, C., Zhu, Q., Altieri, M., Jordan, J., Dang, T. T. A. & Reddy, S., Apr 15 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 8, p. 1973-1977 5 p.

Research output: Contribution to journalArticle

Pyrimidines
Cyclin-Dependent Kinases
Inhibitory Concentration 50
Assays
Cell Cycle
2003

Asymmetric synthesis of the carbapenam core from serine

Hart, B. P., Verma, S. & Rapoport, H., Jan 10 2003, In : Journal of Organic Chemistry. 68, 1, p. 187-190 4 p.

Research output: Contribution to journalArticle

Serine
pyrrolidine
2002

Hydroxylated pyrrolidines. Enantiospecific synthesis of all-cis 2,3,4,5-substituted pyrrolidine derivatives from serine

Verma, S., Atanes, M. N., Busto, J. H., Thai, D. L. & Rapoport, H., Feb 22 2002, In : Journal of Organic Chemistry. 67, 4, p. 1314-1318 5 p.

Research output: Contribution to journalArticle

Pyrrolidines
Serine
Derivatives
Stereochemistry
X ray analysis
2000

Oxy-Cope rearrangements of bicyclo[3.2.0]heptenones. Synthesis of bicyclo[4.2.1]non-1(4)-en-6-ones and bicyclo[5.2.1]dec-1(10)-en-5-ones

Verma, S., Nguyen, Q. H., MacDougall, J. M., Fleischer, E. B. & Moore, H. W., Jun 2 2000, In : Journal of Organic Chemistry. 65, 11, p. 3379-3386 8 p.

Research output: Contribution to journalArticle

Lithium

Synthesis of angular triquinanes from 1-alkynylbicyclo[3.2.0]hept-2-en-7-ones. A tandem alkoxy-Cope ring expansion/transannular ring closure reaction

Verma, S., Fleischer, E. B. & Moore, H. W., Dec 15 2000, In : Journal of Organic Chemistry. 65, 25, p. 8564-8573 10 p.

Research output: Contribution to journalArticle

Bicarbonates
Anions
Temperature
alkoxyl radical
propadiene
1998

Cyclobutenone-based syntheses of polyquinanes and bicyclo[6.3.0]undecanes by tandem anionic oxy-cope reactions. Total synthesis of (±)-precapnelladiene

MacDougall, J. M., Santora, V. J., Verma, S., Turnbull, P., Hernandez, C. R. & Moore, H. W., 1998, In : Journal of Organic Chemistry. 63, 20, p. 6905-6913 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Sesquiterpenes
Alkylation
Biological Products
Anions
1997

Synthesis of Highly Substituted Bicyclo[3.2.0]heptanones from 3-Homoallylcyclobutenones. A Total Synthesis of (±)-Precapnelladiene

MacDougall, J. M., Turnbull, P., Verma, S. & Moore, H. W., 1997, In : Journal of Organic Chemistry. 62, 12, p. 3792-3793 2 p.

Research output: Contribution to journalArticle

ethyl-n-butyl ketone