Sharad Verma

Assistant Professor

19972015
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  • 2 Similar Profiles
Histone-Lysine N-Methyltransferase Medicine & Life Sciences
Pyridines Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Histones Medicine & Life Sciences
Lysine Medicine & Life Sciences
Phosphorylation Chemical Compounds
Polycomb Repressive Complex 2 Medicine & Life Sciences

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Research Output 1997 2015

Histone-Lysine N-Methyltransferase
Epigenomics
Neoplasms
Pharmaceutical Preparations
Enhancer of Zeste Homolog 2 Protein

Recent progress in the discovery of epigenetic inhibitors for the treatment of cancer

Verma, S. K., 2015, In : Methods in Molecular Biology. 1238, p. 677-688 12 p.

Research output: Contribution to journalArticle

Epigenomics
Neoplasms
Antineoplastic Agents
Enzymes
Research

A687V EZH2 is a driver of histone H3 Lysine 27 (H3K27) hypertrimethylation

Ott, H. M., Graves, A. P., Pappalardi, M. B., Huddleston, M., Halsey, W. S., Hughes, A. M., Groy, A., Dul, E., Jiang, Y., Bai, Y., Annan, R., Verma, S. K., Knight, S. D., Kruger, R. G., Dhanak, D., Schwartz, B., Tummino, P. J., Creasy, C. L. & McCabe, M. T., Dec 1 2014, In : Molecular Cancer Therapeutics. 13, 12, p. 3062-3073 12 p.

Research output: Contribution to journalArticle

Histones
Lysine
Mutation
Cell Line
Catalytic Domain

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

MacK, S. C. , Witt, H. , Piro, R. M. , Gu, L. , Zuyderduyn, S. , Stütz, A. M. , Wang, X. , Gallo, M. , Garzia, L. , Zayne, K. , Zhang, X. , Ramaswamy, V. , Jäger, N. , Jones, D. T. W. , Sill, M. , Pugh, T. J. , Ryzhova, M. , Wani, K. M. , Shih, D. J. H. , Head, R. & 69 others Remke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M. G., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S. K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, L., Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., Von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A. & Taylor, M. D., 2014, In : Nature. 506, 7489, p. 445-450 6 p.

Research output: Contribution to journalArticle

Ependymoma
Rhombencephalon
Epigenomics
CpG Islands
Methylation

Long residence time inhibition of EZH2 in activated polycomb repressive complex 2

Van Aller, G. S., Pappalardi, M. B., Ott, H. M., Diaz, E., Brandt, M., Schwartz, B. J., Miller, W. H., Dhanak, D., McCabe, M. T., Verma, S. K., Creasy, C. L., Tummino, P. J. & Kruger, R. G., Mar 21 2014, In : ACS Chemical Biology. 9, 3, p. 622-629 8 p.

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
Histones
Chemical activation
Histone Code
Methylation