Seulki Lee

Associate Professor

20042019

Research output per year

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Research Output

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Article
2019

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Park, J. S., Oh, Y., Park, Y. J., Park, O., Yang, H., Slania, S., Hummers, L. K., Shah, A. A., An, H. T., Jang, J., Horton, M. R., Shin, J., Dietz, H. C., Song, E., Na, D. H., Park, E. J., Kim, K., Lee, K. C., Roschke, V. V., Hanes, J. & 2 others, Pomper, M. G. & Lee, S., Dec 1 2019, In : Nature communications. 10, 1, 1128.

Research output: Contribution to journalArticle

Open Access
2018

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T. I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S. S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. U. & 13 others, Lee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V. L., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

Kim, D., Yoo, J. M., Hwang, H., Lee, J., Lee, S. H., Yun, S. P., Park, M. J., Lee, M. J., Choi, S., Kwon, S. H., Lee, S., Kwon, S. H., Kim, S., Park, Y. J., Kinoshita, M., Lee, Y. H., Shin, S., Paik, S. R., Lee, S. J., Lee, S. & 2 others, Hong, B. H. & Ko, H. S., Sep 1 2018, In : Nature Nanotechnology. 13, 9, p. 812-818 7 p.

Research output: Contribution to journalArticle

The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model

Lee, S., Kim, S., Park, Y. J., Yun, S. P., Kwon, S. H., Kim, D., Kim, D. Y., Shin, J. S., Cho, D. J., Lee, G. Y., Ju, H. S., Yun, H. J., Park, J. H., Kim, W. R., Jung, E. A., Lee, S. & Ko, H. S., Jul 1 2018, In : Human Molecular Genetics. 27, 13, p. 2344-2356 13 p.

Research output: Contribution to journalArticle

2017

In vivo stem cell tracking with imageable nanoparticles that bind bioorthogonal chemical receptors on the stem cell surface

Lee, S., Yoon, H. I., Na, J. H., Jeon, S., Lim, S., Koo, H., Han, S. S., Kang, S. W., Park, S. J., Moon, S. H., Park, J. H., Cho, Y. W., Kim, B. S., Kim, S. K., Lee, T., Kim, D., Lee, S., Pomper, M. G., Kwon, I. C. & Kim, K., Sep 2017, In : Biomaterials. 139, p. 12-29 18 p.

Research output: Contribution to journalArticle

Nano-sized metabolic precursors for heterogeneous tumor-targeting strategy using bioorthogonal click chemistry in vivo

Lee, S., Jung, S., Koo, H., Na, J. H., Yoon, H. Y., Shim, M. K., Park, J., Kim, J. H., Lee, S., Pomper, M. G., Kwon, I. C., Ahn, C. H. & Kim, K., Dec 1 2017, In : Biomaterials. 148, p. 1-15 15 p.

Research output: Contribution to journalArticle

PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells

Park, J. S., Oh, Y., Park, O., Foss, C., Lim, S. M., Jo, D. G., Na, D. H., Pomper, M. G., Lee, K. C. & Lee, S., 2017, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

2016

Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain

Mastorakos, P., Song, E., Zhang, C., Berry, S., Park, H. W., Kim, Y. E., Park, J. S., Lee, S., Suk, J. S. & Hanes, J., Feb 3 2016, In : Small. 12, 5, p. 678-685 8 p.

Research output: Contribution to journalArticle

Bioorthogonal Copper Free Click Chemistry for Labeling and Tracking of Chondrocytes In Vivo

Yoon, H. I., Yhee, J. Y., Na, J. H., Lee, S., Lee, H., Kang, S. W., Chang, H., Ryu, J. H., Lee, S., Kwon, I. C., Cho, Y. W. & Kim, K., Apr 20 2016, In : Bioconjugate Chemistry. 27, 4, p. 927-936 10 p.

Research output: Contribution to journalArticle

CathepsinB-Specific Metabolic Precursor for InVivo Tumor-Specific Fluorescence Imaging

Shim, M. K., Yoon, H. Y., Ryu, J. H., Koo, H., Lee, S., Park, J. H., Kim, J. H., Lee, S., Pomper, M. G., Kwon, I. C. & Kim, K., 2016, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Precise Targeting of Liver Tumor Using Glycol Chitosan Nanoparticles: Mechanisms, Key Factors, and Their Implications

Na, J. H., Koo, H., Lee, S., Han, S. J., Lee, K. E., Kim, S., Lee, H., Lee, S., Choi, K., Kwon, I. C. & Kim, K., Nov 7 2016, In : Molecular Pharmaceutics. 13, 11, p. 3700-3711 12 p.

Research output: Contribution to journalArticle

ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

You, D. G., Deepagan, V. G., Um, W., Jeon, S., Son, S., Chang, H., Yoon, H. I., Cho, Y. W., Swierczewska, M., Lee, S., Pomper, M. G., Kwon, I. C., Kim, K. & Park, J. H., Mar 21 2016, In : Scientific Reports. 6, 23200.

Research output: Contribution to journalArticle

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

Oh, Y., Park, O., Swierczewska, M., Hamilton, J., Park, J. S., Kim, T. H., Lim, S. M., Eom, H., Jo, D. G., Lee, C. E., Kechrid, R., Mastorakos, P., Zhang, C., Hahn, S. K., Jeon, O. C., Byun, Y., Kim, K., Hanes, J. S., Lee, K. C., Pomper, M. G. & 2 others, Gao, B. & Lee, S., Jul 1 2016, In : Hepatology. 64, 1, p. 209-223 15 p.

Research output: Contribution to journalArticle

T1-Weighted MR imaging of liver tumor by gadolinium-encapsulated glycol chitosan nanoparticles without non-specific toxicity in normal tissues

Na, J. H., Lee, S., Koo, H., Han, H., Lee, K. E., Han, S. J., Choi, S. H., Kim, H., Lee, S., Kwon, I. C., Choi, K. & Kim, K., May 14 2016, In : Nanoscale. 8, 18, p. 9736-9745 10 p.

Research output: Contribution to journalArticle

2015

Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo

Lee, S. J., Yook, S., Yhee, J. Y., Yoon, H. Y., Kim, M. G., Ku, S. H., Kim, S. H., Park, J. H., Jeong, J. H., Kwon, I. C., Lee, S., Lee, H. & Kim, K., Dec 28 2015, In : Journal of Controlled Release. 220, p. 631-641 11 p.

Research output: Contribution to journalArticle

Delivery of tumor-homing TRAIL sensitizer with long-acting TRAIL as a therapy for TRAIL-resistant tumors

Oh, Y., Swierczewska, M., Kim, T. H., Lim, S. M., Eom, H. N., Park, J. H., Na, D. H., Kim, K., Lee, K. C., Pomper, M. G. & Lee, S., Dec 28 2015, In : Journal of Controlled Release. 220, p. 671-681 11 p.

Research output: Contribution to journalArticle

Echogenic glycol chitosan nanoparticles for ultrasound-triggered cancer theranostics

Min, H. S., You, D. G., Son, S., Jeon, S., Park, J. H., Lee, S., Kwon, I. C. & Kim, K., Jan 1 2015, In : Theranostics. 5, 12, p. 1402-1418 17 p.

Research output: Contribution to journalArticle

Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain

Mastorakos, P., Zhang, C., Berry, S., Oh, Y., Lee, S., Eberhart, C. G., Woodworth, G. F., Suk, J. S. & Hanes, J., May 1 2015, In : Advanced Healthcare Materials. 4, 7, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

Inhibition of Notch signalling ameliorates experimental inflammatory arthritis

Park, J. S., Kim, S. H., Kim, K., Jin, C. H., Choi, K. Y., Jang, J., Choi, Y., Gwon, A. R., Baik, S. H., Yun, U. J., Chae, S. Y., Lee, S., Kang, Y. M., Lee, K. C., Arumugam, T. V., Mattson, M. P., Park, J. H. & Jo, D. G., Jan 1 2015, In : Annals of the rheumatic diseases. 74, 1, p. 267-274 8 p.

Research output: Contribution to journalArticle

2014

A nanoparticle formula for delivering siRNA or miRNAs to tumor cells in cell culture and in vivo

Choi, K. Y., Silvestre, O. F., Huang, X., Hida, N., Liu, G., Ho, D. N., Lee, S., Lee, S. W., Hong, J. I. & Chen, X., Aug 2014, In : Nature protocols. 9, 8, p. 1900-1915 16 p.

Research output: Contribution to journalArticle

Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA

Yoon, H. Y., Son, S., Lee, S. J., You, D. G., Yhee, J. Y., Park, J. H., Swierczewska, M., Lee, S., Kwon, I. C., Kim, S. H., Kim, K. & Pomper, M. G., Nov 3 2014, In : Scientific reports. 4, 6878.

Research output: Contribution to journalArticle

Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity

Zhu, L., Ma, Y., Kiesewetter, D. O., Wang, Y., Lang, L., Lee, S., Niu, G. & Chen, X., Feb 21 2014, In : ACS chemical biology. 9, 2, p. 510-516 7 p.

Research output: Contribution to journalArticle

The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development

Huang, X., Zhang, F., Sun, X., Choi, K. Y., Niu, G., Zhang, G., Guo, J., Lee, S. & Chen, X., Jan 1 2014, In : Biomaterials. 35, 2, p. 856-865 10 p.

Research output: Contribution to journalArticle

2013

Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots

Huang, X., Zhang, F., Zhu, L., Choi, K. Y., Guo, N., Guo, J., Tackett, K., Anilkumar, P., Liu, G., Quan, Q., Choi, H. S., Niu, G., Sun, Y. P., Lee, S. & Chen, X., Jul 23 2013, In : ACS Nano. 7, 7, p. 5684-5693 10 p.

Research output: Contribution to journalArticle

Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery

Huang, X., Zhang, F., Wang, H., Niu, G., Choi, K. Y., Swierczewska, M., Zhang, G., Gao, H., Wang, Z., Zhu, L., Choi, H. S., Lee, S. & Chen, X., Feb 1 2013, In : Biomaterials. 34, 7, p. 1772-1780 9 p.

Research output: Contribution to journalArticle

Mix to validate: A facile, reversible pegylation for fast screening of potential therapeutic proteins in vivo

Kim, T. H., Swierczewska, M., Oh, Y., Kim, A., Jo, D. G., Park, J. H., Byun, Y., Sadegh-Nasseri, S., Pomper, M. G., Lee, K. C. & Lee, S., Jul 1 2013, In : Angewandte Chemie - International Edition. 52, 27, p. 6880-6884 5 p.

Research output: Contribution to journalArticle

Noninvasive monitoring of pulmonary fibrosis by targeting matrix metalloproteinases (MMPs)

Cai, Y., Zhu, L., Zhang, F., Niu, G., Lee, S., Kimura, S. & Chen, X., Jun 3 2013, In : Molecular Pharmaceutics. 10, 6, p. 2237-2247 11 p.

Research output: Contribution to journalArticle

Oral delivery of ionic complex of ceftriaxone with bile acid derivative in non-human primates

Jeon, O. C., Hwang, S. R., Al-Hilal, T. A., Park, J. W., Moon, H. T., Lee, S., Park, J. H. & Byun, Y., Apr 1 2013, In : Pharmaceutical Research. 30, 4, p. 959-967 9 p.

Research output: Contribution to journalArticle

2012

A facile, one-step nanocarbon functionalization for biomedical applications

Swierczewska, M., Choi, K. Y., Mertz, E. L., Huang, X., Zhang, F., Zhu, L., Yoon, H. Y., Park, J. H., Bhirde, A., Lee, S. & Chen, X., Jul 11 2012, In : Nano Letters. 12, 7, p. 3613-3620 8 p.

Research output: Contribution to journalArticle

Dynamic PET and optical imaging and compartment modeling using a Dual-labeled cyclic RGD peptide probe

Zhu, L., Guo, N., Li, Q., Ma, Y., Jacboson, O., Lee, S., Choi, H. S., Mansfield, J. R., Niu, G. & Chen, X., Sep 14 2012, In : Theranostics. 2, 8, p. 746-756 11 p.

Research output: Contribution to journalArticle

Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes

Huang, X., Zhang, F., Lee, S., Swierczewska, M., Kiesewetter, D. O., Lang, L., Zhang, G., Zhu, L., Gao, H., Choi, H. S., Niu, G. & Chen, X., Jun 1 2012, In : Biomaterials. 33, 17, p. 4370-4378 9 p.

Research output: Contribution to journalArticle

Multiplex imaging of an intracellular proteolytic cascade by using a broad-spectrum nanoquencher

Huang, X., Swierczewska, M., Choi, K. Y., Zhu, L., Bhirde, A., Park, J., Kim, K., Xie, J., Niu, G., Lee, K. C., Lee, S. & Chen, X., Feb 13 2012, In : Angewandte Chemie - International Edition. 51, 7, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles

Zhang, F., Huang, X., Zhu, L., Guo, N., Niu, G., Swierczewska, M., Lee, S., Xu, H., Wang, A. Y., Mohamedali, K. A., Rosenblum, M. G., Lu, G. & Chen, X., Jul 1 2012, In : Biomaterials. 33, 21, p. 5414-5422 9 p.

Research output: Contribution to journalArticle

Nuclear mapping of nanodrug delivery systems in dynamic cellular environments

Bhirde, A. A., Kapoor, A., Liu, G., Iglesias-Bartolome, R., Jin, A., Zhang, G., Xing, R., Lee, S., Leapman, R. D., Gutkind, J. S. & Chen, X., Jun 26 2012, In : ACS Nano. 6, 6, p. 4966-4972 7 p.

Research output: Contribution to journalArticle

PEG-transferrin conjugated TRAIL (TNF-related apoptosis-inducing ligand) for therapeutic tumor targeting

Kim, T. H., Jo, Y. G., Jiang, H. H., Lim, S. M., Youn, Y. S., Lee, S., Chen, X., Byun, Y. & Lee, K. C., Sep 10 2012, In : Journal of Controlled Release. 162, 2, p. 422-428 7 p.

Research output: Contribution to journalArticle

Real-time monitoring of caspase cascade activation in living cells

Zhu, L., Huang, X., Choi, K. Y., Ma, Y., Zhang, F., Liu, G., Lee, S. & Chen, X., Oct 10 2012, In : Journal of Controlled Release. 163, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

Site-specific PEGylated exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects

Kim, T. H., Jiang, H. H., Lim, S. M., Youn, Y. S., Choi, K. Y., Lee, S., Chen, X., Byun, Y. & Lee, K. C., Nov 21 2012, In : Bioconjugate Chemistry. 23, 11, p. 2214-2220 7 p.

Research output: Contribution to journalArticle

Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Liu, G., Choi, K. Y., Bhirde, A., Swierczewska, M., Yin, J., Lee, S. W., Park, J. H., Hong, J. I., Xie, J., Niu, G., Kiesewetter, D. O., Lee, S. & Chen, X., Jan 9 2012, In : Angewandte Chemie - International Edition. 51, 2, p. 445-449 5 p.

Research output: Contribution to journalArticle

Theranostic nanoparticles based on PEGylated hyaluronic acid for the diagnosis, therapy and monitoring of colon cancer

Choi, K. Y., Jeon, E. J., Yoon, H. Y., Lee, B. S., Na, J. H., Min, K. H., Kim, S. Y., Myung, S. J., Lee, S., Chen, X., Kwon, I. C., Choi, K., Jeong, S. Y., Kim, K. & Park, J. H., Sep 1 2012, In : Biomaterials. 33, 26, p. 6186-6193 8 p.

Research output: Contribution to journalArticle

Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

Lee, S. J., Huh, M. S., Lee, S. Y., Min, S., Lee, S., Koo, H., Chu, J. U., Lee, K. E., Jeon, H., Choi, Y., Choi, K., Byun, Y., Jeong, S. Y., Park, K., Kim, K. & Kwon, I. C., Jul 16 2012, In : Angewandte Chemie - International Edition. 51, 29, p. 7203-7207 5 p.

Research output: Contribution to journalArticle

2011

Chimeric ferritin nanocages for multiple function loading and multimodal imaging

Lin, X., Xie, J., Niu, G., Zhang, F., Gao, H., Yang, M., Quan, Q., Aronova, M. A., Zhang, G., Lee, S., Leapman, R. & Chen, X., Feb 9 2011, In : Nano Letters. 11, 2, p. 814-819 6 p.

Research output: Contribution to journalArticle

Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressions

Zhu, L., Xie, J., Swierczewska, M., Zhang, F., Lin, X., Fang, X., Niu, G., Lee, S. & Chen, X., Jun 15 2011, In : Bioconjugate Chemistry. 22, 6, p. 1001-1005 5 p.

Research output: Contribution to journalArticle

High-affinity peptide against MT1-MMP for in vivo tumor imaging

Zhu, L., Wang, H., Wang, L., Wang, Y., Jiang, K., Li, C., Ma, Q., Gao, S., Wang, L., Li, W., Cai, M., Wang, H., Niu, G., Lee, S., Yang, W., Fang, X. & Chen, X., Mar 30 2011, In : Journal of Controlled Release. 150, 3, p. 248-255 8 p.

Research output: Contribution to journalArticle

HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy

Quan, Q., Xie, J., Gao, H., Yang, M., Zhang, F., Liu, G., Lin, X., Wang, A., Eden, H. S., Lee, S., Zhang, G. & Chen, X., Oct 3 2011, In : Molecular Pharmaceutics. 8, 5, p. 1669-1676 8 p.

Research output: Contribution to journalArticle

Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Lin, X., Xie, J., Zhu, L., Lee, S., Niu, G., Ma, Y., Kim, K. & Chen, X., Feb 11 2011, In : Angewandte Chemie - International Edition. 50, 7, p. 1569-1572 4 p.

Research output: Contribution to journalArticle

Improved biological half-life and anti-tumor activity of TNF-related apoptosis-inducing ligand (TRAIL) using PEG-exposed nanoparticles

Lim, S. M., Kim, T. H., Jiang, H. H., Park, C. W., Lee, S., Chen, X. & Lee, K. C., May 1 2011, In : Biomaterials. 32, 13, p. 3538-3546 9 p.

Research output: Contribution to journalArticle

In vivo optical imaging of membrane-type matrix metalloproteinase (MT-MMP) activity

Zhu, L., Zhang, F., Ma, Y., Liu, G., Kim, K., Fang, X., Lee, S. & Chen, X., Dec 5 2011, In : Molecular Pharmaceutics. 8, 6, p. 2331-2338 8 p.

Research output: Contribution to journalArticle

Manipulating the power of an additional phase: A flower-like au-Fe 3O4 optical nanosensor for imaging protease expressions in vivo

Xie, J., Zhang, F., Aronova, M., Zhu, L., Lin, X., Quan, Q., Liu, G., Zhang, G., Choi, K. Y., Kim, K., Sun, X., Lee, S., Sun, S., Leapman, R. & Chen, X., Apr 26 2011, In : ACS Nano. 5, 4, p. 3043-3051 9 p.

Research output: Contribution to journalArticle

Mono-PEGylated dimeric exendin-4 as high receptor binding and long-acting conjugates for type 2 anti-diabetes therapeutics

Kim, T. H., Jiang, H. H., Lee, S., Youn, Y. S., Park, C. W., Byun, Y., Chen, X. & Lee, K. C., Apr 20 2011, In : Bioconjugate Chemistry. 22, 4, p. 625-632 8 p.

Research output: Contribution to journalArticle