Seulki Lee

Associate Professor

20042019
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Research Output 2004 2019

2019

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Park, J. S., Oh, Y., Park, Y. J., Park, O., Yang, H., Slania, S., Hummers, L., Shah, A., An, H. T., Jang, J., Horton, M., Shin, J., Dietz, H. C., Song, E., Na, D. H., Park, E. J., Kim, K., Lee, K. C., Roschke, V. V., Hanes, J. S. & 2 others, Pomper, M. G. & Lee, S., Dec 1 2019, In : Nature communications. 10, 1, 1128.

Research output: Contribution to journalArticle

Open Access
TNF-Related Apoptosis-Inducing Ligand Receptors
fibrosis
Myofibroblasts
apoptosis
death
2018

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T-I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. & 13 others, Lee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature Medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

Microglia
Astrocytes
Parkinson Disease
Synucleins
Nervous System Diseases

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

Kim, D., Yoo, J. M., Hwang, H., Lee, J., Lee, S. H., Yun, S. P., Park, M. J., Lee, M. J., Choi, S., Kwon, S. H., Lee, S., Kwon, S. H., Kim, S., Park, Y. J., Kinoshita, M., Lee, Y. H., Shin, S., Paik, S. R., Lee, S. J., Lee, S. & 2 others, Hong, B. H. & Ko, H. S., Jul 9 2018, (Accepted/In press) In : Nature Nanotechnology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Parkinson disease
alpha-Synuclein
Graphite
toxicity
Graphene
Histone-Lysine N-Methyltransferase
Activating Transcription Factor 4
Transcription Factor CHOP
Euchromatin
TNF-Related Apoptosis-Inducing Ligand Receptors
Gadolinium
Liver Cirrhosis

The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model

Lee, S., Kim, S., Park, Y. J., Yun, S. P., Kwon, S. H., Kim, D., Kim, D. Y., Shin, J. S., Cho, D. J., Lee, G. Y., Ju, H. S., Yun, H. J., Park, J. H., Kim, W. R., Jung, E. A., Lee, S. & Ko, H. S., Jul 1 2018, In : Human Molecular Genetics. 27, 13, p. 2344-2356 13 p.

Research output: Contribution to journalArticle

Synucleins
Parkinson Disease
Brain
Safety
Lewy Bodies
2017

Drug delivery: Brushing off antigenicity

Lee, K. C. & Lee, S., Jan 10 2017, In : Nature Biomedical Engineering. 1, 1, 0019.

Research output: Contribution to journalShort survey

Editorial

Soo Suk, J., Suh, J., Cui, H., Kim, A. J., Lee, S. & Yeo, Y., Dec 10 2017, In : Journal of Controlled Release. 267, 1 p.

Research output: Contribution to journalEditorial

In vivo stem cell tracking with imageable nanoparticles that bind bioorthogonal chemical receptors on the stem cell surface

Lee, S., Yoon, H. I., Na, J. H., Jeon, S., Lim, S., Koo, H., Han, S. S., Kang, S. W., Park, S. J., Moon, S. H., Park, J. H., Cho, Y. W., Kim, B. S., Kim, S. K., Lee, T., Kim, D., Lee, S., Pomper, M. G., Kwon, I. C. & Kim, K., Sep 1 2017, In : Biomaterials. 139, p. 12-29 18 p.

Research output: Contribution to journalArticle

Cell Tracking
Stem cells
Nanoparticles
Stem Cells
Glycols

Nano-sized metabolic precursors for heterogeneous tumor-targeting strategy using bioorthogonal click chemistry in vivo

Lee, S., Jung, S., Koo, H., Na, J. H., Yoon, H. Y., Shim, M. K., Park, J., Kim, J. H., Lee, S., Pomper, M. G., Kwon, I. C., Ahn, C. H. & Kim, K., Dec 1 2017, In : Biomaterials. 148, p. 1-15 15 p.

Research output: Contribution to journalArticle

Click Chemistry
Tumors
Azides
Neoplasms
Bearings (structural)

PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells

Park, J. S., Oh, Y., Park, O., Foss, C., Lim, S. M., Jo, D. G., Na, D. H., Pomper, M. G., Lee, K. C. & Lee, S., 2017, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Th17 Cells
Experimental Arthritis
Regulatory T-Lymphocytes
Arthritis
2016

Biodegradable DNA Nanoparticles that Provide Widespread Gene Delivery in the Brain

Mastorakos, P., Song, E., Zhang, C., Berry, S., Park, H. W., Kim, Y. E., Park, J. S., Lee, S., Suk, J. S. & Hanes, J. S., Feb 3 2016, In : Small. 12, 5, p. 678-685 8 p.

Research output: Contribution to journalArticle

Nanoparticles
Brain
DNA
Genes
Transgenes

Bioorthogonal Copper Free Click Chemistry for Labeling and Tracking of Chondrocytes In Vivo

Yoon, H. I., Yhee, J. Y., Na, J. H., Lee, S., Lee, H., Kang, S. W., Chang, H., Ryu, J. H., Lee, S., Kwon, I. C., Cho, Y. W. & Kim, K., Apr 20 2016, In : Bioconjugate Chemistry. 27, 4, p. 927-936 10 p.

Research output: Contribution to journalArticle

Cell Tracking
Click Chemistry
Azides
Chondrocytes
Labeling

CathepsinB-Specific Metabolic Precursor for InVivo Tumor-Specific Fluorescence Imaging

Shim, M. K., Yoon, H. Y., Ryu, J. H., Koo, H., Lee, S., Park, J. H., Kim, J. H., Lee, S., Pomper, M. G., Kwon, I. C. & Kim, K., 2016, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Tumors
Fluorescence
Imaging techniques
Cells
Polysaccharides

Polysaccharide-based nanoparticles for theranostic nanomedicine

Swierczewska, M., Han, H. S., Kim, K., Park, J. H. & Lee, S., Apr 1 2016, In : Advanced Drug Delivery Reviews. 99, p. 70-84 15 p.

Research output: Contribution to journalArticle

Nanoparticles
Polysaccharides
Photosensitizing Agents
Chitosan
Hyaluronic Acid

Precise Targeting of Liver Tumor Using Glycol Chitosan Nanoparticles: Mechanisms, Key Factors, and Their Implications

Na, J. H., Koo, H., Lee, S., Han, S. J., Lee, K. E., Kim, S., Lee, H., Lee, S., Choi, K., Kwon, I. C. & Kim, K., Nov 7 2016, In : Molecular Pharmaceutics. 13, 11, p. 3700-3711 12 p.

Research output: Contribution to journalArticle

Nanoparticles
Liver
Neoplasms
Polystyrenes
Nude Mice

ROS-generating TiO2 nanoparticles for non-invasive sonodynamic therapy of cancer

You, D. G., Deepagan, V. G., Um, W., Jeon, S., Son, S., Chang, H., Yoon, H. I., Cho, Y. W., Swierczewska, M., Lee, S., Pomper, M. G., Kwon, I. C., Kim, K. & Park, J. H., Mar 21 2016, In : Scientific Reports. 6, 23200.

Research output: Contribution to journalArticle

Nanoparticles
Reactive Oxygen Species
Neoplasms
Photochemotherapy
Therapeutics

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

Oh, Y., Park, O., Swierczewska, M., Hamilton, J., Park, J. S., Kim, T. H., Lim, S. M., Eom, H., Jo, D. G., Lee, C. E., Kechrid, R., Mastorakos, P., Zhang, C., Hahn, S. K., Jeon, O. C., Byun, Y., Kim, K., Hanes, J. S., Lee, K. C., Pomper, M. G. & 2 others, Gao, B. & Lee, S., Jul 1 2016, In : Hepatology. 64, 1, p. 209-223 15 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Liver Cirrhosis
Half-Life
Fibrosis
Therapeutics

T1-Weighted MR imaging of liver tumor by gadolinium-encapsulated glycol chitosan nanoparticles without non-specific toxicity in normal tissues

Na, J. H., Lee, S., Koo, H., Han, H., Lee, K. E., Han, S. J., Choi, S. H., Kim, H., Lee, S., Kwon, I. C., Choi, K. & Kim, K., May 14 2016, In : Nanoscale. 8, 18, p. 9736-9745 10 p.

Research output: Contribution to journalArticle

Gadolinium
Magnetic resonance
Glycols
Chitosan
Liver
2015

Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo

Lee, S. J., Yook, S., Yhee, J. Y., Yoon, H. Y., Kim, M. G., Ku, S. H., Kim, S. H., Park, J. H., Jeong, J. H., Kwon, I. C., Lee, S., Lee, H. & Kim, K., Dec 28 2015, In : Journal of Controlled Release. 220, p. 631-641 11 p.

Research output: Contribution to journalArticle

Nanoparticles
Vascular Endothelial Growth Factor A
Small Interfering RNA
Polymers
Neoplasms

Delivery of tumor-homing TRAIL sensitizer with long-acting TRAIL as a therapy for TRAIL-resistant tumors

Oh, Y., Swierczewska, M., Kim, T. H., Lim, S. M., Eom, H. N., Park, J. H., Na, D. H., Kim, K., Lee, K. C., Pomper, M. G. & Lee, S., Dec 28 2015, In : Journal of Controlled Release. 220, p. 671-681 11 p.

Research output: Contribution to journalArticle

Doxorubicin
Neoplasms
Heterografts
Therapeutics
Death Domain Receptors

Echogenic glycol chitosan nanoparticles for ultrasound-triggered cancer theranostics

Min, H. S., You, D. G., Son, S., Jeon, S., Park, J. H., Lee, S., Kwon, I. C. & Kim, K., 2015, In : Theranostics. 5, 12, p. 1402-1418 17 p.

Research output: Contribution to journalArticle

Nanoparticles
Neoplasms
Microbubbles
Pharmaceutical Preparations
Ultrasonography

Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain

Mastorakos, P., Zhang, C., Berry, S., Oh, Y., Lee, S., Eberhart, C. G., Woodworth, G. F., Suk, J. S. & Hanes, J. S., May 1 2015, In : Advanced healthcare materials. 4, 7, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

Gene transfer
Nanoparticles
Brain
DNA
Genes

Inhibition of Notch signalling ameliorates experimental inflammatory arthritis

Park, J. S., Kim, S. H., Kim, K., Jin, C. H., Choi, K. Y., Jang, J., Choi, Y., Gwon, A. R., Baik, S. H., Yun, U. J., Chae, S. Y., Lee, S., Kang, Y. M., Lee, K. C., Arumugam, T. V., Mattson, M. P., Park, J. H. & Jo, D. G., Jan 1 2015, In : Annals of the Rheumatic Diseases. 74, 1, p. 267-274 8 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Rheumatoid Arthritis
Amyloid Precursor Protein Secretases
Cytokines
Arthritis

What is the future of PEGylated therapies?

Swierczewska, M., Lee, K. C. & Lee, S., Oct 2 2015, In : Expert Opinion on Emerging Drugs. 20, 4, p. 531-536 6 p.

Research output: Contribution to journalArticle

Technology
Life Expectancy
Half-Life
Biological Therapy
Therapeutics
2014

A nanoparticle formula for delivering siRNA or miRNAs to tumor cells in cell culture and in vivo

Choi, K. Y., Silvestre, O. F., Huang, X., Hida, N., Liu, G., Ho, D. N., Lee, S., Lee, S. W., Hong, J. I. & Chen, X., 2014, In : Nature Protocols. 9, 8, p. 1900-1915 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Cell culture
Nanoparticles
Small Interfering RNA
Tumors

Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA

Yoon, H. Y., Son, S., Lee, S. J., You, D. G., Yhee, J. Y., Park, J. H., Swierczewska, M., Lee, S., Kwon, I. C., Kim, S. H., Kim, K. & Pomper, M. G., Nov 3 2014, In : Scientific Reports. 4, 6878.

Research output: Contribution to journalArticle

Nanoparticles
Doxorubicin
Small Interfering RNA
Neoplasms
Surface Properties

Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity

Zhu, L., Ma, Y., Kiesewetter, D. O., Wang, Y., Lang, L., Lee, S., Niu, G. & Chen, X., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 510-516 7 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 13
Matrix Metalloproteinases
Tumors
Metabolites
Lysine

The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development

Huang, X., Zhang, F., Sun, X., Choi, K. Y., Niu, G., Zhang, G., Guo, J., Lee, S. & Chen, X., Jan 2014, In : Biomaterials. 35, 2, p. 856-865 10 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Multiwalled carbon nanotubes (MWCN)
Fetal Development
Carbon nanotubes
Genotype
2013

Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots

Huang, X., Zhang, F., Zhu, L., Choi, K. Y., Guo, N., Guo, J., Tackett, K., Anilkumar, P., Liu, G., Quan, Q., Choi, H. S., Niu, G., Sun, Y. P., Lee, S. & Chen, X., Jul 23 2013, In : ACS Nano. 7, 7, p. 5684-5693 10 p.

Research output: Contribution to journalArticle

clearances
Tumors
tumors
Carbon
routes

Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery

Huang, X., Zhang, F., Wang, H., Niu, G., Choi, K. Y., Swierczewska, M., Zhang, G., Gao, H., Wang, Z., Zhu, L., Choi, H. S., Lee, S. & Chen, X., Feb 2013, In : Biomaterials. 34, 7, p. 1772-1780 9 p.

Research output: Contribution to journalArticle

Cell engineering
Cell Engineering
Stem cells
Mesenchymal Stromal Cells
Silicon Dioxide

Mix to validate: A facile, reversible pegylation for fast screening of potential therapeutic proteins in vivo

Kim, T. H., Swierczewska, M., Oh, Y., Kim, A., Jo, D. G., Park, J. H., Byun, Y., Sadegh-Nasseri, S., Pomper, M. G., Lee, K. C. & Lee, S., Jul 1 2013, In : Angewandte Chemie - International Edition. 52, 27, p. 6880-6884 5 p.

Research output: Contribution to journalArticle

Screening
Proteins
Nitrilotriacetic Acid
TNF-Related Apoptosis-Inducing Ligand
Animals

Nanotheranostics for personalized medicine

Kim, T. H., Lee, S. & Chen, X., Apr 2013, In : Expert Review of Molecular Diagnostics. 13, 3, p. 257-269 13 p.

Research output: Contribution to journalArticle

Precision Medicine
Biomarkers
Nanotechnology
Expert Testimony
Nanoparticles

Noninvasive monitoring of pulmonary fibrosis by targeting matrix metalloproteinases (MMPs)

Cai, Y., Zhu, L., Zhang, F., Niu, G., Lee, S., Kimura, S. & Chen, X., Jun 3 2013, In : Molecular Pharmaceutics. 10, 6, p. 2237-2247 11 p.

Research output: Contribution to journalArticle

Pulmonary Fibrosis
Matrix Metalloproteinases
Bleomycin
Fluorescence
Matrix Metalloproteinase 2

Oral delivery of ionic complex of ceftriaxone with bile acid derivative in non-human primates

Jeon, O. C., Hwang, S. R., Al-Hilal, T. A., Park, J. W., Moon, H. T., Lee, S., Park, J. H. & Byun, Y., Apr 2013, In : Pharmaceutical Research. 30, 4, p. 959-967 9 p.

Research output: Contribution to journalArticle

Ceftriaxone
Bile Acids and Salts
Primates
Derivatives
Caco-2 Cells
2012

Activatable optical probes for cancer imaging

Lee, S. & Chen, X., Jan 1 2012, Molecular Imaging Probes for Cancer Research. World Scientific Publishing Co., p. 519-543 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Molecular physics
Biotechnology
Imaging techniques
Neoplasms

A facile, one-step nanocarbon functionalization for biomedical applications

Swierczewska, M., Choi, K. Y., Mertz, E. L., Huang, X., Zhang, F., Zhu, L., Yoon, H. Y., Park, J. H., Bhirde, A., Lee, S. & Chen, X., Jul 11 2012, In : Nano Letters. 12, 7, p. 3613-3620 8 p.

Research output: Contribution to journalArticle

Single-walled carbon nanotubes (SWCN)
carbon nanotubes
Fluorescence
fluorescence
enzymes

Design and fabrication of N-Alkyl-polyethylenimine-stabilized iron oxide nanoclusters for gene delivery

Liu, G., Wang, Z., Lee, S., Ai, H. & Chen, X., 2012, In : Methods in Enzymology. 509, p. 263-276 14 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Nanoclusters
Genes
Fabrication
Nanoparticles

Dynamic PET and optical imaging and compartment modeling using a Dual-labeled cyclic RGD peptide probe

Zhu, L., Guo, N., Li, Q., Ma, Y., Jacboson, O., Lee, S., Choi, H. S., Mansfield, J. R., Niu, G. & Chen, X., 2012, In : Theranostics. 2, 8, p. 746-756 11 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Optical Imaging
Integrins
Coloring Agents
Chelating Agents

High-sensitivity nanosensors for biomarker detection

Swierczewska, M., Liu, G., Lee, S. & Chen, X., Apr 7 2012, In : Chemical Society Reviews. 41, 7, p. 2641-2655 15 p.

Research output: Contribution to journalArticle

Nanosensors
Biomarkers
Magnetic relaxation
Signal detection
Nanotechnology

Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes

Huang, X., Zhang, F., Lee, S., Swierczewska, M., Kiesewetter, D. O., Lang, L., Zhang, G., Zhu, L., Gao, H., Choi, H. S., Niu, G. & Chen, X., Jun 2012, In : Biomaterials. 33, 17, p. 4370-4378 9 p.

Research output: Contribution to journalArticle

Multimodal Imaging
Nanoprobes
Silicon Dioxide
Tumors
Silica

Multiplex imaging of an intracellular proteolytic cascade by using a broad-spectrum nanoquencher

Huang, X., Swierczewska, M., Choi, K. Y., Zhu, L., Bhirde, A., Park, J., Kim, K., Xie, J., Niu, G., Lee, K. C., Lee, S. & Chen, X., Feb 13 2012, In : Angewandte Chemie - International Edition. 51, 7, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

Coloring Agents
Dyes
Proteolysis
Imaging techniques
Silicon Dioxide

Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles

Zhang, F., Huang, X., Zhu, L., Guo, N., Niu, G., Swierczewska, M., Lee, S., Xu, H., Wang, A. Y., Mohamedali, K. A., Rosenblum, M. G., Lu, G. & Chen, X., Jul 2012, In : Biomaterials. 33, 21, p. 5414-5422 9 p.

Research output: Contribution to journalArticle

Glioblastoma
Iron oxides
Nanoparticles
Tumors
Monitoring

Nuclear mapping of nanodrug delivery systems in dynamic cellular environments

Bhirde, A. A., Kapoor, A., Liu, G., Iglesias-Bartolome, R., Jin, A., Zhang, G., Xing, R., Lee, S., Leapman, R. D., Gutkind, J. S. & Chen, X., Jun 26 2012, In : ACS Nano. 6, 6, p. 4966-4972 7 p.

Research output: Contribution to journalArticle

delivery
drugs
Nanoparticles
Cells
Pharmaceutical Preparations

PEG-transferrin conjugated TRAIL (TNF-related apoptosis-inducing ligand) for therapeutic tumor targeting

Kim, T. H., Jo, Y. G., Jiang, H. H., Lim, S. M., Youn, Y. S., Lee, S., Chen, X., Byun, Y. & Lee, K. C., Sep 10 2012, In : Journal of Controlled Release. 162, 2, p. 422-428 7 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Transferrin
Neoplasms
Therapeutics
Transferrin Receptors

Protease-activated drug development

Choi, K. Y., Swierczewska, M., Lee, S. & Chen, X., 2012, In : Theranostics. 2, 2, p. 156-179 24 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Prodrugs
Pharmaceutical Preparations
Disease Progression
Neoplasms

Protease activity: Meeting its theranostic potential

Lee, S. & Kim, K., 2012, In : Theranostics. 2, 2, p. 125-126 2 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Research
Pharmaceutical Preparations
Theranostic Nanomedicine

Real-time monitoring of caspase cascade activation in living cells

Zhu, L., Huang, X., Choi, K. Y., Ma, Y., Zhang, F., Liu, G., Lee, S. & Chen, X., Oct 10 2012, In : Journal of Controlled Release. 163, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

Caspases
Peptide Hydrolases
Transfection
Initiator Caspases
Effector Caspases

Site-specific PEGylated exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects

Kim, T. H., Jiang, H. H., Lim, S. M., Youn, Y. S., Choi, K. Y., Lee, S., Chen, X., Byun, Y. & Lee, K. C., Nov 21 2012, In : Bioconjugate Chemistry. 23, 11, p. 2214-2220 7 p.

Research output: Contribution to journalArticle

Therapeutic Uses
Hypoglycemic Agents
Polyethylene glycols
Molecular Weight
Molecular weight

Sticky nanoparticles: A platform for siRNA delivery by a bis(zinc(II) dipicolylamine)-functionalized, self-assembled nanoconjugate

Liu, G., Choi, K. Y., Bhirde, A., Swierczewska, M., Yin, J., Lee, S. W., Park, J. H., Hong, J. I., Xie, J., Niu, G., Kiesewetter, D. O., Lee, S. & Chen, X., Jan 9 2012, In : Angewandte Chemie - International Edition. 51, 2, p. 445-449 5 p.

Research output: Contribution to journalArticle

Nanoconjugates
Small Interfering RNA
Zinc
Nanoparticles
Hyaluronic acid