Seth Shatkin Margolis

Associate Professor

20022019
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Phosphorylation Chemical Compounds
Caspase 2 Medicine & Life Sciences
Angelman Syndrome Medicine & Life Sciences
Cyclin B Medicine & Life Sciences
Protein Phosphatase 1 Medicine & Life Sciences
Oocytes Medicine & Life Sciences
Dendritic Spines Medicine & Life Sciences
Apoptosis Medicine & Life Sciences

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Research Output 2002 2019

The emergence of Ephexin5 as a therapeutic target in Alzheimer’s disease

Cook, E. K., Sell, G. L., Schaffer, T. B. & Margolis, S. S., Jan 1 2019, In : Expert opinion on therapeutic targets.

Research output: Contribution to journalArticle

Alzheimer Disease
Therapeutics

Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome

Ramachandran, K. V., Fu, J. M., Schaffer, T. B., Na, C-H., Delannoy, M. & Margolis, S. S., Jul 5 2018, In : Molecular Cell. 71, 1, p. 169-177.e6

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Membranes
Ubiquitination
Proteins
Ribosomes

PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5

Schaffer, T. B., Smith, J. E., Cook, E. K., Phan, T. & Margolis, S. S., Nov 27 2018, In : Cell Reports. 25, 9, p. 2470-2483.e8

Research output: Contribution to journalArticle

Dendritic Spines
Phosphorylation
Protein Kinase C
Synapses
Neurons

A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth

Hamilton, A. M., Lambert, J. T., Parajuli, L. K., Vivas, O., Park, D. K., Stein, I. S., Jahncke, J. N., Greenberg, M. E., Margolis, S. S. & Zito, K., Apr 1 2017, In : Molecular and Cellular Neuroscience. 80, p. 66-74 9 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Dendritic Spines
Spine
Dendrites
Proteasome Endopeptidase Complex

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function

Ramachandran, K. V. & Margolis, S. S., Apr 1 2017, In : Nature Structural and Molecular Biology. 24, 4, p. 419-430 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Nervous System
Cell Membrane
Calcium Signaling
Membranes