Sergey Akimov

Research Associate

19962017
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Research Output 1996 2017

2017

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease

Gomez-Pastor, R., Burchfiel, E. T., Neef, D. W., Jaeger, A. M., Cabiscol, E., McKinstry, S. U., Doss, A., Aballay, A., Lo, D. C., Akimov, S. S., Ross, C. A., Eroglu, C. & Thiele, D. J. Feb 13 2017 In : Nature Communications. 8, 14405

Research output: Contribution to journalArticle

Transcription factors
Huntington Disease
Transcription Factors
shock
degradation

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Lim, R. G. , Salazar, L. L. , Wilton, D. K. , King, A. R. , Stocksdale, J. T. , Sharifabad, D. , Lau, A. L. , Stevens, B. , Reidling, J. C. , Winokur, S. T. , Casale, M. S. , Thompson, L. M. , Pardo, M. , Díaz-Barriga, A. G. G. , Straccia, M. , Sanders, P. , Alberch, J. , Canals, J. M. , Kaye, J. A. , Dunlap, M. & 31 others Jo, L., May, H., Mount, E., Anderson-Bergman, C., Haston, K., Finkbeiner, S., Kedaigle, A. J., Gipson, T. A., Yildirim, F., Ng, C. W., Milani, P., Housman, D. E., Fraenkel, E., Allen, N. D., Kemp, P. J., Atwal, R. S., Biagioli, M., Gusella, J. F., MacDonald, M. E., Akimov, S. S., Arbez, N., Stewart, J., Ross, C. A., Mattis, V. B., Tom, C. M., Ornelas, L., Sahabian, A., Lenaeus, L., Mandefro, B., Sareen, D. & The HD iPSC Consortium May 1 2017 In : Nature Neuroscience. 20, 5, p. 648-660 13 p.

Research output: Contribution to journalArticle

Huntington Disease
Pharmacology
Histone Code
Genes
Isoxazoles

PPARΔ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

Dickey, A. S., Sanchez, D. N., Arreola, M., Sampat, K. R., Fan, W., Arbez, N., Akimov, S., Van Kanegan, M. J., Ohnishi, K., Gilmore-Hall, S. K., Flores, A. L., Nguyen, J. M., Lomas, N., Hsu, C. L., Lo, D. C., Ross, C. A., Masliah, E., Evans, R. M. & La Spada, A. R. Dec 6 2017 In : Science Translational Medicine. 9, 419, eaal2332

Research output: Contribution to journalArticle

Huntington Disease
Quality Control
Energy Metabolism
Homeostasis
Retinoid X Receptors
2016

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

Dickey, A. S. , Pineda, V. V. , Tsunemi, T. , Liu, P. P. , Miranda, H. C. , Gilmore-Hall, S. K. , Lomas, N. , Sampat, K. R. , Buttgereit, A. , Torres, M. J. M. , Flores, A. L. , Arreola, M. , Arbez, N. , Akimov, S. S. , Gaasterland, T. , Lazarowski, E. R. , Ross, C. A. , Yeo, G. W. , Sopher, B. L. , Magnuson, G. K. & 3 others Pinkerton, A. B., Masliah, E. & La Spada, A. R. Jan 1 2016 In : Nature Medicine. 22, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

PPAR delta
Huntington Disease
Neurons
Chemical activation
Transcriptional Activation
2014

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

Mattis, V. B., Tom, C., Akimov, S., Saeedian, J., Østergaard, M. E., Southwell, A. L., Doty, C. N., Ornelas, L., Sahabian, A., Lenaeus, L., Mandefro, B., Sareen, D., Arjomand, J., Hayden, M. R., Ross, C. A. & Svendsen, C. N. Dec 15 2014 In : Human Molecular Genetics. 24, 11, p. 3257-3271 15 p., ddv080

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Huntington Disease
Brain-Derived Neurotrophic Factor
Glutamic Acid
trkB Receptor
Induced Pluripotent Stem Cells
Neurodegenerative Diseases
Phenotype
Aptitude
Regenerative Medicine
2012

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research

Wray, S. , Self, M. , Lewis, P. A. , Taanman, J. W. , Ryan, N. S. , Mahoney, C. J. , Liang, Y. , Devine, M. J. , Sheerin, U. M. , Houlden, H. , Morris, H. R. , Healy, D. , Marti-Masso, J. F. , Preza, E. , Barker, S. , Sutherland, M. , Corriveau, R. A. , D'Andrea, M. , Schapira, A. H. V. , Uitti, R. J. & 52 others Guttman, M., Opala, G., Jasinska-Myga, B., Puschmann, A., Nilsson, C., Espay, A. J., Slawek, J., Gutmann, L., Boeve, B. F., Boylan, K., Jon Stoessl, A., Ross, O. A., Maragakis, N. J., Van Gerpen, J., Gerstenhaber, M., Gwinn, K., Dawson, T. M., Isacson, O., Marder, K. S., Clark, L. N., Przedborski, S. E., Finkbeiner, S., Rothstein, J. D., Wszolek, Z. K., Rossor, M. N., Hardy, J., Gusella, J. F., MacDonald, M. E., Wheeler, V. C., Ross, C. A., Akimov, S., Arjomand, J., Thompson, L. M., King, A., Hermanowicz, N., Winokur, S., Svendsen, C. N., Mattis, V., Onorati, M., Cattaneo, E., Allen, N. D., Kemp, P. J., Kim, K. S., Przedborski, S., Feng, J., Lee, V. M. Y., Trojanowski, J. Q., James Surmeier, D., Henderson, C. E., Maniatis, T., Eggan, K. & Cudowicz, M. E. Aug 27 2012 In : PLoS One. 7, 8, e43099

Research output: Contribution to journalArticle

Fibroblasts
fibroblasts
nervous system diseases
mutation
Mutation

Induced pluripotent stem cells from patients with huntington’s disease show CAG repeat expansion associated phenotypes

Mattis, V. B. , Svendsen, S. P. , Ebert, A. , Svendsen, C. N. , King, A. R. , Casale, M. , Winokur, S. T. , Batugedara, G. , Vawter, M. , Donovan, P. J. , Lock, L. F. , Thompson, L. M. , Zhu, Y. , Fossale, E. , Atwal, R. S. , Gillis, T. , Mysore, J. , Li, J. H. , Seong, I. , Shen, Y. & 38 others Chen, X., Wheeler, V. C., Macdonald, M. E., Gusella, J. F., Akimov, S., Arbez, N., Juopperi, T., Ratovitski, T., Chiang, J. H., Kim, W. R., Chighladze, E., Watkin, E., Zhong, C., Makri, G., Cole, R. N., Margolis, R. L., Song, H., Ming, G., Ross, C. A., Kaye, J. A., Daub, A., Sharma, P., Mason, A. R., Finkbeiner, S., Yu, J., Thomson, J. A., Rushton, D., Brazier, S. P., Battersby, A. A., Redfern, A., Tseng, H. E., Harrison, A. W., Kemp, P. J., Allen, N. D., Onorati, M., Castiglioni, V., Cattaneo, E. & Arjomand, J. Aug 3 2012 In : Cell Stem Cell. 11, 2, p. 264-278 15 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Huntington Disease
Phenotype
Trinucleotide Repeats
Cell Line

Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts

Dashinimaev, E. B., Muchkaeva, I. A., Faizullin, R. R., Yegorov, Y. Y., Akimov, S. S., Terskikh, V. V., Vasiliev, A. V. & Kirpichnikov, M. P. 2012 In : Moscow University Biological Sciences Bulletin. 67, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

Cytology
telomerase
Telomerase
Fibroblasts
fibroblasts
2011

Fukuoka-1 strain of transmissible spongiform encephalopathy agent infects murine bone marrow-derived cells with features of mesenchymal stem cells

Cervenakova, L., Akimov, S., Vasilyeva, I., Yakovleva, O., McKenzie, C., Cervenak, J., Piccardo, P. & Asher, D. M. Aug 2011 In : Transfusion. 51, 8, p. 1755-1768 14 p.

Research output: Contribution to journalArticle

Prion Diseases
Mesenchymal Stromal Cells
Bone Marrow Cells
Cell Culture Techniques
Bone Marrow
2009

Murine bone marrow stromal cell culture with features of mesenchymal stem cells susceptible to mouse-adapted human TSE agent, Fukuoka-1

Akimov, S., Vasilyeva, I., Yakovleva, O., McKenzie, C. & Cervenakova, L. 2009 In : Folia Neuropathologica. 47, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

Prion Diseases
Mesenchymal Stromal Cells
Cell Culture Techniques
Bone Marrow
Cell- and Tissue-Based Therapy
2008

Persistent propagation of variant creutzfeldt-jakob disease agent in murine spleen stromal cell culture with features of mesenchymal stem cells

Akimov, S., Yakovleva, O., Vasilyeva, I., McKenzie, C. & Cervenakova, L. Nov 2008 In : Journal of Virology. 82, 21, p. 10959-10962 4 p.

Research output: Contribution to journalArticle

Creutzfeldt-Jakob Syndrome
Prion Diseases
prion diseases
stromal cells
Stromal Cells
2007

TLX1/HOX11-induced hematopoietic differentiation blockade

Riz, I., Akimov, S. S., Eaker, S. S., Baxter, K. K., Lee, H. J., Mariño-Ramírez, L., Landsman, D., Hawley, T. S. & Hawley, R. G. Jun 14 2007 In : Oncogene. 26, 28, p. 4115-4123 9 p.

Research output: Contribution to journalArticle

CREB-Binding Protein
Confocal Microscopy
Chromatin
Down-Regulation
Erythroid Precursor Cells
2005

Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells

Akimov, S. S., Ramezani, A., Hawley, T. S. & Hawley, R. G. Oct 2005 In : Stem Cells. 23, 9, p. 1423-1433 11 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Fetal Blood
Telomerase
Human papillomavirus 16
Blood Cells
2004

Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis

Belkin, A. M., Zemskov, E. A., Hang, J., Akimov, S. S., Sikora, S. & Strongin, A. Y. Sep 21 2004 In : Biochemistry®. 43, 37, p. 11760-11769 10 p.

Research output: Contribution to journalArticle

Proteolysis
Matrix Metalloproteinases
Matrix Metalloproteinase 14
Cell Adhesion
Tumors
2003
Transglutaminases
ras Genes
Adhesives
Integrins
Adhesion
2002

Antisense CD11b integrin inhibits the development of a differentiated monocyte/macrophage phenotype in human leukemia cells

Prudovsky, I., Popov, K., Akimov, S., Serov, S., Zelenin, A., Meinhardt, G., Baier, P., Sohn, C. & Hass, R. 2002 In : European Journal of Cell Biology. 81, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Integrins
U937 Cells
Monocytes
Leukemia
Macrophages

Proliferative senescence of embryo fibroblasts of Japanese senescence accelerated mice is accompanied by parallel decreasing of the response to various growth factors

Yegorov, Y. E., Semenova, I. V., Andreeva, V. V., Akimov, S. S., Prudovsky, I. A. & Zelenin, A. V. 2002 In : Molecular Biology. 36, 3, p. 365-369 5 p.

Research output: Contribution to journalArticle

Intercellular Signaling Peptides and Proteins
Embryonic Structures
Fibroblasts
Fibroblast Growth Factors
Platelet-Derived Growth Factor

Proliferativnoe starenie émbrional'nykh fibroblastov iaponskikh uskorenno stareiushchikh myshei (SAM) soprovozhdaetsia parallel'nym oslableniem otveta na razlichnye rostovye faktory.

Egorov, E. E., Semenova, I. V., Andreeva, V. V., Akimov, S. S., Prudovskiǐ, I. A. & Zelenin, A. V. May 2002 In : Molekuliarnaia biologiia. 36, 3, p. 466-471 6 p.

Research output: Contribution to journalArticle

Intercellular Signaling Peptides and Proteins
Embryonic Structures
Fibroblasts
Fibroblast Growth Factors
Platelet-Derived Growth Factor
2001

Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin

Akimov, S. S. & Belkin, A. M. Sep 1 2001 In : Blood. 98, 5, p. 1567-1576 10 p.

Research output: Contribution to journalArticle

Fibronectins
Cell Movement
Adhesion
Cells
Integrins
Transglutaminases
Gelatin
Fibronectins
Transforming Growth Factor beta
Integrins

Matrix-dependent Proteolysis of Surface Transglutaminase by Membrane-type Metalloproteinase Regulates Cancer Cell Adhesion and Locomotion

Belkin, A. M., Akimov, S. S., Zaritskaya, L. S., Ratnikov, B. I., Deryugina, E. I. & Strongin, A. Y. Jan 25 2001 In : Journal of Biological Chemistry. 276, 21, p. 18415-18422 8 p.

Research output: Contribution to journalArticle

Proteolysis
Transglutaminases
Cell adhesion
Metalloproteases
Cell Adhesion

Senescent accelerated mouse (SAM): A model that binds in vivo and in vitro aging

Yegorov, Y. E., Semenova, I. V., Karachentsev, D. N., Semenova, M. L., Akimov, S. S., Yegorova, I. N. & Zelenin, A. V. 2001 In : Journal of Anti-Aging Medicine. 4, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Embryonic Structures
Fibroblasts
Inbred CBA Mouse
Telomerase
beta-Galactosidase

Senescent Accelerated Mouse (SAM): A model that binds in vivo and in vitro aging

Yegorov, Y. E., Semenova, I. V., Karachentsev, D. N., Semenova, M. L., Akimov, S. S., Yegorova, I. N. & Zelenin, A. V. 2001 In : Rejuvenation Research. 4, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Embryonic Structures
Fibroblasts
Inbred CBA Mouse
Telomerase
beta-Galactosidase
2000

Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin

Akimov, S. S., Krylov, D., Fleischmana, L. F. & Belkin, A. M. Feb 21 2000 In : Journal of Cell Biology. 148, 4, p. 825-838 14 p.

Research output: Contribution to journalArticle

Fibronectins
Integrins
Transglutaminases
Focal Adhesions
Cell Adhesion
1999

Blockade of telomerase function in various cells

Yegorov, Y. E., Akimov, S. S., Akhmalisheva, A. K., Semenova, I. V., Smirnova, Y. B., Kraevsky, A. A. & Zelenin, A. V. Aug 1999 In : Anti-Cancer Drug Design. 14, 4, p. 305-316 12 p.

Research output: Contribution to journalArticle

Telomerase
Reverse Transcriptase Inhibitors
Fibroblasts
carbovir
Cell culture
1998

Endogenous β-galactosidase activity in continuously nonproliferating cells

Yegorov, Y. E., Akimov, S. S., Hass, R., Zelenin, A. V. & Prudovsky, I. A. Aug 25 1998 In : Experimental Cell Research. 243, 1, p. 207-211 5 p.

Research output: Contribution to journalArticle

beta-Galactosidase
Swiss 3T3 Cells
Heparin
Macrophages
Cell Proliferation

Telomerase activity of cells during alterations of their proliferative states

Yegorov, Y. E., Chernov, D. N., Akimov, S. S., Akhmalisheva, A. K., Popov, K. V., Hass, R., Prudovsky, I. A. & Zelenin, A. V. 1998 In : Membrane and Cell Biology. 12, 6, p. 793-803 11 p.

Research output: Contribution to journalArticle

Telomerase
Zidovudine
Human Activities
Fibroblasts
Cell Count

Telomerase activity of the cells during alteration of their proliferative states

Yegorov, Y. E., Chernov, D. N., Akimov, S. S., Akhmalisheva, A. K., Popov, K. V., Hass, R., Prudovsky, I. A. & Zelenin, A. V. 1998 In : Biologicheskie Membrany. 15, 6, p. 637-638 2 p.

Research output: Contribution to journalArticle

Telomerase
Cells
Biochemistry
Zidovudine
Cell proliferation
1997

Action of inhibitors of reverse transcriptases on the telomerase function in murine immortal fibroblasts

Egorov, E. E., Chernov, D. N., Akimov, S. S., Bol'Sheva, N. L., Kmevskii, A. A. & Zelenin, A. V. 1997 In : Molekuliarnaia biologiia. 31, 1, p. 130-136 7 p.

Research output: Contribution to journalArticle

Zalcitabine
Transformed Cell Line
Reverse Transcriptase Inhibitors
Zidovudine
Inbred C3H Mouse

Blockade of telomerase function by nucleoside analogs

Yegorov, Y. E., Chernov, D. N., Akimov, S. S., Akhmalisheva, A. K., Smirnova, Y. B., Shinkarev, D. B., Semenova, I. V., Yegorova, I. N. & Zelenin, A. V. 1997 In : Biochemistry (Moscow). 62, 11, p. 1296-1305 10 p.

Research output: Contribution to journalArticle

Telomerase
Nucleosides
Zidovudine
carbovir
Fibroblasts

Effect of reverse transcriptase inhibitors on telomerase function in immortal mouse fibroblasts

Egorov, E. E., Chernov, D. N., Akimov, S. S., Bol'sheva, N. L., Krayevsky, A. A. & Zelenin, A. V. Jan 1997 In : Molecular Biology. 31, 1, p. 108-113 6 p.

Research output: Contribution to journalArticle

carbovir
Reverse Transcriptase Inhibitors
Telomerase
Zidovudine
Fibroblasts
1996

Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like processes in cultured mouse fibroblasts

Yegorov, Y. E., Chernov, D. N., Akimov, S. S., Bolsheva, N. L., Krayevsky, A. A. & Zelenin, A. V. Jul 1 1996 In : FEBS Letters. 389, 2, p. 115-118 4 p.

Research output: Contribution to journalArticle

carbovir
Reverse Transcriptase Inhibitors
Telomerase
Fibroblasts
Zidovudine