Sergey Akimov

Research Associate

19962019

Research output per year

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Research Output

2019

Cysteamine Protects Neurons from Mutant Huntingtin Toxicity

Arbez, N., Roby, E., Akimov, S., Eddings, C., Ren, M., Wang, X. & Ross, C. A., Jan 1 2019, In : Journal of Huntington's Disease. 8, 2, p. 129-143 15 p.

Research output: Contribution to journalArticle

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor

Eddings, C. R., Arbez, N., Akimov, S., Geva, M., Hayden, M. R. & Ross, C. A., Sep 1 2019, In : Neurobiology of Disease. 129, p. 118-129 12 p.

Research output: Contribution to journalArticle

2017

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease

Gomez-Pastor, R., Burchfiel, E. T., Neef, D. W., Jaeger, A. M., Cabiscol, E., McKinstry, S. U., Doss, A., Aballay, A., Lo, D. C., Akimov, S. S., Ross, C. A., Eroglu, C. & Thiele, D. J., Feb 13 2017, In : Nature communications. 8, 14405.

Research output: Contribution to journalArticle

Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

The HD iPSC Consortium, May 1 2017, In : Nature neuroscience. 20, 5, p. 648-660 13 p.

Research output: Contribution to journalArticle

PPARΔ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

Dickey, A. S., Sanchez, D. N., Arreola, M., Sampat, K. R., Fan, W., Arbez, N., Akimov, S., Van Kanegan, M. J., Ohnishi, K., Gilmore-Hall, S. K., Flores, A. L., Nguyen, J. M., Lomas, N., Hsu, C. L., Lo, D. C., Ross, C. A., Masliah, E., Evans, R. M. & La Spada, A. R., Dec 6 2017, In : Science Translational Medicine. 9, 419, eaal2332.

Research output: Contribution to journalArticle

2016

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

Dickey, A. S., Pineda, V. V., Tsunemi, T., Liu, P. P., Miranda, H. C., Gilmore-Hall, S. K., Lomas, N., Sampat, K. R., Buttgereit, A., Torres, M. J. M., Flores, A. L., Arreola, M., Arbez, N., Akimov, S. S., Gaasterland, T., Lazarowski, E. R., Ross, C. A., Yeo, G. W., Sopher, B. L., Magnuson, G. K. & 3 others, Pinkerton, A. B., Masliah, E. & La Spada, A. R., Jan 1 2016, In : Nature medicine. 22, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

2014

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

Mattis, V. B., Tom, C., Akimov, S., Saeedian, J., Østergaard, M. E., Southwell, A. L., Doty, C. N., Ornelas, L., Sahabian, A., Lenaeus, L., Mandefro, B., Sareen, D., Arjomand, J., Hayden, M. R., Ross, C. A. & Svendsen, C. N., Dec 15 2014, In : Human molecular genetics. 24, 11, p. 3257-3271 15 p.

Research output: Contribution to journalArticle

Human-induced pluripotent stem cells: Potential for neurodegenerative diseases

Ross, C. A. & Akimov, S. S., Sep 2014, In : Human molecular genetics. 23, R1, p. R17-R26

Research output: Contribution to journalArticle

2012

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research

Wray, S., Self, M., Lewis, P. A., Taanman, J. W., Ryan, N. S., Mahoney, C. J., Liang, Y., Devine, M. J., Sheerin, U. M., Houlden, H., Morris, H. R., Healy, D., Marti-Masso, J. F., Preza, E., Barker, S., Sutherland, M., Corriveau, R. A., D'Andrea, M., Schapira, A. H. V., Uitti, R. J. & 52 others, Guttman, M., Opala, G., Jasinska-Myga, B., Puschmann, A., Nilsson, C., Espay, A. J., Slawek, J., Gutmann, L., Boeve, B. F., Boylan, K., Jon Stoessl, A., Ross, O. A., Maragakis, N. J., Van Gerpen, J., Gerstenhaber, M., Gwinn, K., Dawson, T. M., Isacson, O., Marder, K. S., Clark, L. N., Przedborski, S. E., Finkbeiner, S., Rothstein, J. D., Wszolek, Z. K., Rossor, M. N., Hardy, J., Gusella, J. F., MacDonald, M. E., Wheeler, V. C., Ross, C. A., Akimov, S., Arjomand, J., Thompson, L. M., King, A., Hermanowicz, N., Winokur, S., Svendsen, C. N., Mattis, V., Onorati, M., Cattaneo, E., Allen, N. D., Kemp, P. J., Kim, K. S., Przedborski, S., Feng, J., Lee, V. M. Y., Trojanowski, J. Q., James Surmeier, D., Henderson, C. E., Maniatis, T., Eggan, K. & Cudowicz, M. E., Aug 27 2012, In : PloS one. 7, 8, e43099.

Research output: Contribution to journalArticle

Induced pluripotent stem cells from patients with huntington’s disease show CAG repeat expansion associated phenotypes

Mattis, V. B., Svendsen, S. P., Ebert, A., Svendsen, C. N., King, A. R., Casale, M., Winokur, S. T., Batugedara, G., Vawter, M., Donovan, P. J., Lock, L. F., Thompson, L. M., Zhu, Y., Fossale, E., Atwal, R. S., Gillis, T., Mysore, J., Li, J. H., Seong, I., Shen, Y. & 38 others, Chen, X., Wheeler, V. C., Macdonald, M. E., Gusella, J. F., Akimov, S., Arbez, N., Juopperi, T., Ratovitski, T., Chiang, J. H., Kim, W. R., Chighladze, E., Watkin, E., Zhong, C., Makri, G., Cole, R. N., Margolis, R. L., Song, H., Ming, G., Ross, C. A., Kaye, J. A., Daub, A., Sharma, P., Mason, A. R., Finkbeiner, S., Yu, J., Thomson, J. A., Rushton, D., Brazier, S. P., Battersby, A. A., Redfern, A., Tseng, H. E., Harrison, A. W., Kemp, P. J., Allen, N. D., Onorati, M., Castiglioni, V., Cattaneo, E. & Arjomand, J., Aug 3 2012, In : Cell stem cell. 11, 2, p. 264-278 15 p.

Research output: Contribution to journalArticle

Induction of telomerase activity increase reprogramming efficiency of human dermal fibroblasts

Dashinimaev, E. B., Muchkaeva, I. A., Faizullin, R. R., Yegorov, Y. Y., Akimov, S. S., Terskikh, V. V., Vasiliev, A. V. & Kirpichnikov, M. P., Aug 6 2012, In : Moscow University Biological Sciences Bulletin. 67, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

2011

Fukuoka-1 strain of transmissible spongiform encephalopathy agent infects murine bone marrow-derived cells with features of mesenchymal stem cells

Cervenakova, L., Akimov, S., Vasilyeva, I., Yakovleva, O., McKenzie, C., Cervenak, J., Piccardo, P. & Asher, D. M., Aug 1 2011, In : Transfusion. 51, 8, p. 1755-1768 14 p.

Research output: Contribution to journalArticle

2009

Murine bone marrow stromal cell culture with features of mesenchymal stem cells susceptible to mouse-adapted human TSE agent, Fukuoka-1

Akimov, S., Vasilyeva, I., Yakovleva, O., McKenzie, C. & Cervenakova, L., Jan 1 2009, In : Folia Neuropathologica. 47, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

2008

Persistent propagation of variant creutzfeldt-jakob disease agent in murine spleen stromal cell culture with features of mesenchymal stem cells

Akimov, S., Yakovleva, O., Vasilyeva, I., McKenzie, C. & Cervenakova, L., Nov 1 2008, In : Journal of virology. 82, 21, p. 10959-10962 4 p.

Research output: Contribution to journalArticle

2007

TLX1/HOX11-induced hematopoietic differentiation blockade

Riz, I., Akimov, S. S., Eaker, S. S., Baxter, K. K., Lee, H. J., Mariño-Ramírez, L., Landsman, D., Hawley, T. S. & Hawley, R. G., Jun 14 2007, In : Oncogene. 26, 28, p. 4115-4123 9 p.

Research output: Contribution to journalArticle

2005

Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells

Akimov, S. S., Ramezani, A., Hawley, T. S. & Hawley, R. G., Oct 1 2005, In : Stem Cells. 23, 9, p. 1423-1433 11 p.

Research output: Contribution to journalArticle

2004

Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis

Belkin, A. M., Zemskov, E. A., Hang, J., Akimov, S. S., Sikora, S. & Strongin, A. Y., Sep 21 2004, In : Biochemistry. 43, 37, p. 11760-11769 10 p.

Research output: Contribution to journalArticle

2003
2002

Antisense CD11b integrin inhibits the development of a differentiated monocyte/macrophage phenotype in human leukemia cells

Prudovsky, I., Popov, K., Akimov, S., Serov, S., Zelenin, A., Meinhardt, G., Baier, P., Sohn, C. & Hass, R., Jan 1 2002, In : European journal of cell biology. 81, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

Proliferative senescence of embryo fibroblasts of Japanese senescence accelerated mice is accompanied by parallel decreasing of the response to various growth factors

Yegorov, Y. E., Semenova, I. V., Andreeva, V. V., Akimov, S. S., Prudovsky, I. A. & Zelenin, A. V., Dec 1 2002, In : Molecular Biology. 36, 3, p. 365-369 5 p.

Research output: Contribution to journalArticle

Proliferativnoe starenie émbrional'nykh fibroblastov iaponskikh uskorenno stareiushchikh myshei (SAM) soprovozhdaetsia parallel'nym oslableniem otveta na razlichnye rostovye faktory.

Translated title of the contribution: Proliferative senescence of embryo fibroblasts of Japanese senescence accelerated mice (SAM) is accompanied by parallel decreasing of response to various growth factorsEgorov, E. E., Semenova, I. V., Andreeva, V. V., Akimov, S. S., Prudovskii, I. A. & Zelenin, A. V., Jan 1 2002, In : Molekuliarnaia biologiia. 36, 3, p. 466-471 6 p.

Research output: Contribution to journalArticle

2001

Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin

Akimov, S. S. & Belkin, A. M., Sep 1 2001, In : Blood. 98, 5, p. 1567-1576 10 p.

Research output: Contribution to journalArticle

Matrix-dependent Proteolysis of Surface Transglutaminase by Membrane-type Metalloproteinase Regulates Cancer Cell Adhesion and Locomotion

Belkin, A. M., Akimov, S. S., Zaritskaya, L. S., Ratnikov, B. I., Deryugina, E. I. & Strongin, A. Y., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18415-18422 8 p.

Research output: Contribution to journalArticle

Senescent accelerated mouse (SAM): A model that binds in vivo and in vitro aging

Yegorov, Y. E., Semenova, I. V., Karachentsev, D. N., Semenova, M. L., Akimov, S. S., Yegorova, I. N. & Zelenin, A. V., Jan 1 2001, In : Journal of Anti-Aging Medicine. 4, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Senescent Accelerated Mouse (SAM): A model that binds in vivo and in vitro aging

Yegorov, Y. E., Semenova, I. V., Karachentsev, D. N., Semenova, M. L., Akimov, S. S., Yegorova, I. N. & Zelenin, A. V., Dec 1 2001, In : Rejuvenation research. 4, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

2000

Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin

Akimov, S. S., Krylov, D., Fleischmana, L. F. & Belkin, A. M., Feb 21 2000, In : Journal of Cell Biology. 148, 4, p. 825-838 14 p.

Research output: Contribution to journalArticle

1999

Blockade of telomerase function in various cells

Yegorov, Y. E., Akimov, S. S., Akhmalisheva, A. K., Semenova, I. V., Smirnova, Y. B., Kraevsky, A. A. & Zelenin, A. V., Aug 1 1999, In : Anti-Cancer Drug Design. 14, 4, p. 305-316 12 p.

Research output: Contribution to journalArticle

1998

Endogenous β-galactosidase activity in continuously nonproliferating cells

Yegorov, Y. E., Akimov, S. S., Hass, R., Zelenin, A. V. & Prudovsky, I. A., Aug 25 1998, In : Experimental cell research. 243, 1, p. 207-211 5 p.

Research output: Contribution to journalArticle

Telomerase activity of cells during alterations of their proliferative states

Yegorov, Y. E., Chernov, D. N., Akimov, S. S., Akhmalisheva, A. K., Popov, K. V., Hass, R., Prudovsky, I. A. & Zelenin, A. V., Dec 1 1998, In : Membrane and Cell Biology. 12, 6, p. 793-803 11 p.

Research output: Contribution to journalArticle

Telomerase activity of the cells during alteration of their proliferative states

Yegorov, Y. E., Chernov, D. N., Akimov, S. S., Akhmalisheva, A. K., Popov, K. V., Hass, R., Prudovsky, I. A. & Zelenin, A. V., Dec 1 1998, In : Biologicheskie Membrany. 15, 6, p. 637-638 2 p.

Research output: Contribution to journalArticle

1997

Action of inhibitors of reverse transcriptases on the telomerase function in murine immortal fibroblasts

Egorov, E. E., Chernov, D. N., Akimov, S. S., Bol'Sheva, N. L., Kmevskii, A. A. & Zelenin, A. V., Dec 1 1997, In : Molekulyarnaya Biologiya. 31, 1, p. 130-136 7 p.

Research output: Contribution to journalArticle

Blockade of telomerase function by nucleoside analogs

Yegorov, Y. E., Chernov, D. N., Akimov, S. S., Akhmalisheva, A. K., Smirnova, Y. B., Shinkarev, D. B., Semenova, I. V., Yegorova, I. N. & Zelenin, A. V., Jan 1 1997, In : Biochemistry (Moscow). 62, 11, p. 1296-1305 10 p.

Research output: Contribution to journalArticle

Effect of reverse transcriptase inhibitors on telomerase function in immortal mouse fibroblasts

Egorov, E. E., Chernov, D. N., Akimov, S. S., Bol'sheva, N. L., Krayevsky, A. A. & Zelenin, A. V., Jan 1 1997, In : Molecular Biology. 31, 1, p. 108-113 6 p.

Research output: Contribution to journalArticle

1996

Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like processes in cultured mouse fibroblasts

Yegorov, Y. E., Chernov, D. N., Akimov, S. S., Bolsheva, N. L., Krayevsky, A. A. & Zelenin, A. V., Jul 1 1996, In : FEBS Letters. 389, 2, p. 115-118 4 p.

Research output: Contribution to journalArticle